Details of the Drug

General Information of Drug (ID: DMQLT4N)

Drug Name
Brimonidine
Synonyms
brimonidine; 59803-98-4; Bromoxidine; UK 14,304; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine; 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline; UK-14304; AGN 190342; UNII-E6GNX3HHTE; Brimonidine [INN:BAN]; UK 14304; C11H10BrN5; MLS000069370; 6-Quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-; E6GNX3HHTE; CHEMBL844; AGN-190342; BRN 0751629; SMR000058355; CHEBI:3175; LK 14304-18; Brimonidine, 98%; NCGC00016069-09; EN300-50880; DSSTox_RID_80758; Brimonidine (bioerodible, extended release); [3H]brimonidine
Indication
Disease Entry ICD 11 Status REF
Ocular hypertension 9C61.01 Approved [1]
Glaucoma/ocular hypertension 9C61 Phase 3 [2]
Affected Organisms
Humans and other mammals
ATC Code
D11AX21: Brimonidine
D11AX: Other dermatologicals
D11A: OTHER DERMATOLOGICAL PREPARATIONS
D11: OTHER DERMATOLOGICAL PREPARATIONS
D: DERMATOLOGICALS
S01EA05: Brimonidine
S01EA: Sympathomimetics in glaucoma therapy
S01E: ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01: OPHTHALMOLOGICALS
S: SENSORY ORGANS
S01GA07: Brimonidine
S01GA: Sympathomimetics used as decongestants
S01G: DECONGESTANTS AND ANTIALLERGICS
S01: OPHTHALMOLOGICALS
S: SENSORY ORGANS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 292.13
Logarithm of the Partition Coefficient (xlogp) 0.6
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 3
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 0.417 +/- 0.264 mcgh/L [3]
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 46 +/- 62 ng/L [3]
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 1-4 h [3]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [4]
Elimination
10% of drug is excreted from urine in the unchanged form [4]
Half-life
The concentration or amount of drug in body reduced by one-half in 3 hours [5]
Metabolism
The drug is metabolized via the hepatic []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.011 micromolar/kg/day [6]
Water Solubility
The ability of drug to dissolve in water is measured as 1.5 mg/mL [4]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Platelet aggregation Not Available ADRA2A OTZFGOTP [7]
Chemical Identifiers
Formula
C11H10BrN5
IUPAC Name
5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine
Canonical SMILES
C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br
InChI
InChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
InChIKey
XYLJNLCSTIOKRM-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
2435
ChEBI ID
CHEBI:3175
CAS Number
59803-98-4
UNII
E6GNX3HHTE
DrugBank ID
DB00484
TTD ID
D0AE3X
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor Alpha-2 (ADRA2) TTQ8AFT NOUNIPROTAC Agonist [8]
Adrenergic receptor alpha-2C (ADRA2C) TT2NUT5 ADA2C_HUMAN Modulator [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-2A adrenergic receptor (ADRA2A) OTZFGOTP ADA2A_HUMAN Drug Response [7]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Ocular hypertension
ICD Disease Classification 9C61.01
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 1.76E-01 -0.06 -0.28
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Brimonidine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Methylene blue DMJAPE7 Moderate Additive hypertensive effects by the combination of Brimonidine and Methylene blue. Acquired methaemoglobinaemia [3A93] [9]
Oliceridine DM6MDCF Moderate Additive CNS depression effects by the combination of Brimonidine and Oliceridine. Acute pain [MG31] [10]
Scopolamine DMOM8AL Moderate Additive CNS depression effects by the combination of Brimonidine and Scopolamine. Addictive disorder [6C50-6C5Z] [10]
Mepyramine DMB4SFH Moderate Additive CNS depression effects by the combination of Brimonidine and Mepyramine. Allergic/hypersensitivity disorder [4A80-4A8Z] [10]
Phenyltoloxamine DMKAEQW Moderate Additive CNS depression effects by the combination of Brimonidine and Phenyltoloxamine. Allergic/hypersensitivity disorder [4A80-4A8Z] [10]
Tripelennamine DMZBU15 Moderate Additive CNS depression effects by the combination of Brimonidine and Tripelennamine. Allergic/hypersensitivity disorder [4A80-4A8Z] [10]
Buspirone DMBS632 Moderate Additive CNS depression effects by the combination of Brimonidine and Buspirone. Anxiety disorder [6B00-6B0Z] [10]
Clorazepate DMC3JST Moderate Additive CNS depression effects by the combination of Brimonidine and Clorazepate. Anxiety disorder [6B00-6B0Z] [10]
Methylphenobarbital DMDSWAG Moderate Additive CNS depression effects by the combination of Brimonidine and Methylphenobarbital. Anxiety disorder [6B00-6B0Z] [10]
Hydroxyzine DMF8Y74 Moderate Additive CNS depression effects by the combination of Brimonidine and Hydroxyzine. Anxiety disorder [6B00-6B0Z] [10]
Halazepam DMPFWO6 Moderate Additive CNS depression effects by the combination of Brimonidine and Halazepam. Anxiety disorder [6B00-6B0Z] [10]
Chlormezanone DMTWUXR Moderate Additive CNS depression effects by the combination of Brimonidine and Chlormezanone. Anxiety disorder [6B00-6B0Z] [10]
Oxazepam DMXNZM4 Moderate Additive CNS depression effects by the combination of Brimonidine and Oxazepam. Anxiety disorder [6B00-6B0Z] [10]
Desipramine DMT2FDC Moderate Additive CNS depression effects by the combination of Brimonidine and Desipramine. Attention deficit hyperactivity disorder [6A05] [10]
Linezolid DMGFPU2 Moderate Additive hypertensive effects by the combination of Brimonidine and Linezolid. Bacterial infection [1A00-1C4Z] [9]
Retigabine DMGNYIH Moderate Additive CNS depression effects by the combination of Brimonidine and Retigabine. Behcet disease [4A62] [10]
Lamotrigine DM8SXYG Moderate Additive CNS depression effects by the combination of Brimonidine and Lamotrigine. Bipolar disorder [6A60] [10]
Cariprazine DMJYDVK Moderate Additive CNS depression effects by the combination of Brimonidine and Cariprazine. Bipolar disorder [6A60] [10]
Diphenoxylate DMO5SZX Moderate Additive CNS depression effects by the combination of Brimonidine and Diphenoxylate. Bowel habit change [ME05] [10]
Loperamide DMOJZQ9 Moderate Additive CNS depression effects by the combination of Brimonidine and Loperamide. Bowel habit change [ME05] [10]
Dihydrocodeine DMB0FWL Moderate Additive CNS depression effects by the combination of Brimonidine and Dihydrocodeine. Chronic pain [MG30] [10]
Levetiracetam DMTGDN8 Moderate Additive CNS depression effects by the combination of Brimonidine and Levetiracetam. Chronic pain [MG30] [10]
Olopatadine DMKMWQG Moderate Additive CNS depression effects by the combination of Brimonidine and Olopatadine. Conjunctiva disorder [9A60] [10]
Azelastine DMXTMBJ Moderate Additive CNS depression effects by the combination of Brimonidine and Azelastine. Conjunctiva disorder [9A60] [10]
Propofol DMB4OLE Moderate Additive CNS depression effects by the combination of Brimonidine and Propofol. Corneal disease [9A76-9A78] [10]
Thiopental DMGP8AX Moderate Additive CNS depression effects by the combination of Brimonidine and Thiopental. Corneal disease [9A76-9A78] [10]
Ketamine DMT5HA4 Moderate Additive CNS depression effects by the combination of Brimonidine and Ketamine. Corneal disease [9A76-9A78] [10]
Alfentanil DMVO0UB Moderate Additive CNS depression effects by the combination of Brimonidine and Alfentanil. Corneal disease [9A76-9A78] [10]
Remifentanil DMZTXCH Moderate Additive CNS depression effects by the combination of Brimonidine and Remifentanil. Corneal disease [9A76-9A78] [10]
Dextromethorphan DMUDJZM Moderate Additive CNS depression effects by the combination of Brimonidine and Dextromethorphan. Cough [MD12] [10]
Chlophedianol DMXGJEI Moderate Additive CNS depression effects by the combination of Brimonidine and Chlophedianol. Cough [MD12] [10]
Ethanol DMDRQZU Moderate Additive CNS depression effects by the combination of Brimonidine and Ethanol. Cystitis [GC00] [10]
Trimipramine DM1SC8M Moderate Additive CNS depression effects by the combination of Brimonidine and Trimipramine. Depression [6A70-6A7Z] [10]
Cyclobenzaprine DM1YBRM Moderate Additive CNS depression effects by the combination of Brimonidine and Cyclobenzaprine. Depression [6A70-6A7Z] [10]
Nortriptyline DM4KDYJ Moderate Additive CNS depression effects by the combination of Brimonidine and Nortriptyline. Depression [6A70-6A7Z] [10]
Nefazodone DM4ZS8M Moderate Additive CNS depression effects by the combination of Brimonidine and Nefazodone. Depression [6A70-6A7Z] [10]
Selegiline DM6034S Moderate Additive hypertensive effects by the combination of Brimonidine and Selegiline. Depression [6A70-6A7Z] [9]
Isocarboxazid DMAF1NB Moderate Additive hypertensive effects by the combination of Brimonidine and Isocarboxazid. Depression [6A70-6A7Z] [9]
Tranylcypromine DMGB5RE Moderate Additive hypertensive effects by the combination of Brimonidine and Tranylcypromine. Depression [6A70-6A7Z] [9]
OPC-34712 DMHG57U Moderate Additive CNS depression effects by the combination of Brimonidine and OPC-34712. Depression [6A70-6A7Z] [10]
Phenelzine DMHIDUE Moderate Additive hypertensive effects by the combination of Brimonidine and Phenelzine. Depression [6A70-6A7Z] [9]
Clomipramine DMINRKW Moderate Additive CNS depression effects by the combination of Brimonidine and Clomipramine. Depression [6A70-6A7Z] [10]
Trazodone DMK1GBJ Moderate Additive CNS depression effects by the combination of Brimonidine and Trazodone. Depression [6A70-6A7Z] [10]
Amoxapine DMKITQE Moderate Additive CNS depression effects by the combination of Brimonidine and Amoxapine. Depression [6A70-6A7Z] [10]
Doxepin DMPI98T Moderate Additive CNS depression effects by the combination of Brimonidine and Doxepin. Depression [6A70-6A7Z] [10]
Maprotiline DMPWB7T Moderate Additive CNS depression effects by the combination of Brimonidine and Maprotiline. Depression [6A70-6A7Z] [10]
Esketamine DMVU687 Moderate Additive CNS depression effects by the combination of Brimonidine and Esketamine. Depression [6A70-6A7Z] [10]
Heroin diacetylmorphine DMDBWHY Moderate Additive CNS depression effects by the combination of Brimonidine and Heroin diacetylmorphine. Dissociative neurological symptom disorder [6B60] [10]
Tetrabenazine DMYWQ0O Moderate Additive CNS depression effects by the combination of Brimonidine and Tetrabenazine. Dissociative neurological symptom disorder [6B60] [10]
Meclizine DMS7T13 Moderate Additive CNS depression effects by the combination of Brimonidine and Meclizine. Dizziness and giddiness [MB48] [10]
Diazepam DM08E9O Moderate Additive CNS depression effects by the combination of Brimonidine and Diazepam. Epilepsy/seizure [8A61-8A6Z] [10]
Zonisamide DM0DTF7 Moderate Additive CNS depression effects by the combination of Brimonidine and Zonisamide. Epilepsy/seizure [8A61-8A6Z] [10]
Primidone DM0WX6I Moderate Additive CNS depression effects by the combination of Brimonidine and Primidone. Epilepsy/seizure [8A61-8A6Z] [10]
Felbamate DM1V5ZS Moderate Additive CNS depression effects by the combination of Brimonidine and Felbamate. Epilepsy/seizure [8A61-8A6Z] [10]
Oxcarbazepine DM5PU6O Moderate Additive CNS depression effects by the combination of Brimonidine and Oxcarbazepine. Epilepsy/seizure [8A61-8A6Z] [10]
Mephenytoin DM5UGDK Moderate Additive CNS depression effects by the combination of Brimonidine and Mephenytoin. Epilepsy/seizure [8A61-8A6Z] [10]
Methsuximide DM6L5VO Moderate Additive CNS depression effects by the combination of Brimonidine and Methsuximide. Epilepsy/seizure [8A61-8A6Z] [10]
Gabapentin DM6T924 Moderate Additive CNS depression effects by the combination of Brimonidine and Gabapentin. Epilepsy/seizure [8A61-8A6Z] [10]
Ethosuximide DMDZ9LT Moderate Additive CNS depression effects by the combination of Brimonidine and Ethosuximide. Epilepsy/seizure [8A61-8A6Z] [10]
Cenobamate DM8KLU9 Moderate Additive CNS depression effects by the combination of Brimonidine and Cenobamate. Epilepsy/seizure [8A61-8A6Z] [10]
Tiagabine DMKSQG0 Moderate Additive CNS depression effects by the combination of Brimonidine and Tiagabine. Epilepsy/seizure [8A61-8A6Z] [10]
Stiripentol DMMSDOY Moderate Additive CNS depression effects by the combination of Brimonidine and Stiripentol. Epilepsy/seizure [8A61-8A6Z] [10]
Phenacemide DMOHS9P Moderate Additive CNS depression effects by the combination of Brimonidine and Phenacemide. Epilepsy/seizure [8A61-8A6Z] [10]
Fosphenytoin DMOX3LB Moderate Additive CNS depression effects by the combination of Brimonidine and Fosphenytoin. Epilepsy/seizure [8A61-8A6Z] [10]
Paramethadione DMR5ZUP Moderate Additive CNS depression effects by the combination of Brimonidine and Paramethadione. Epilepsy/seizure [8A61-8A6Z] [10]
Brivaracetam DMSEPK8 Moderate Additive CNS depression effects by the combination of Brimonidine and Brivaracetam. Epilepsy/seizure [8A61-8A6Z] [10]
Clonazepam DMTO13J Moderate Additive CNS depression effects by the combination of Brimonidine and Clonazepam. Epilepsy/seizure [8A61-8A6Z] [10]
Rufinamide DMWE60C Moderate Additive CNS depression effects by the combination of Brimonidine and Rufinamide. Epilepsy/seizure [8A61-8A6Z] [10]
Ethotoin DMXWOCP Moderate Additive CNS depression effects by the combination of Brimonidine and Ethotoin. Epilepsy/seizure [8A61-8A6Z] [10]
Phenobarbital DMXZOCG Moderate Additive CNS depression effects by the combination of Brimonidine and Phenobarbital. Epilepsy/seizure [8A61-8A6Z] [10]
Vigabatrin DMYT0OG Moderate Additive CNS depression effects by the combination of Brimonidine and Vigabatrin. Epilepsy/seizure [8A61-8A6Z] [10]
Carbamazepine DMZOLBI Moderate Additive CNS depression effects by the combination of Brimonidine and Carbamazepine. Epilepsy/seizure [8A61-8A6Z] [10]
Cannabidiol DM0659E Moderate Additive CNS depression effects by the combination of Brimonidine and Cannabidiol. Epileptic encephalopathy [8A62] [10]
Diphenhydramine DMKQTBA Moderate Additive CNS depression effects by the combination of Brimonidine and Diphenhydramine. Episodic vestibular syndrome [AB31] [10]
Dantrolene DM1D8XY Moderate Additive CNS depression effects by the combination of Brimonidine and Dantrolene. Fever [MG26] [10]
Procarbazine DMIK367 Moderate Additive hypertensive effects by the combination of Brimonidine and Procarbazine. Hodgkin lymphoma [2B30] [9]
Amantadine DMS3YE9 Moderate Additive CNS depression effects by the combination of Brimonidine and Amantadine. Influenza [1E30-1E32] [10]
Suvorexant DM0E6S3 Moderate Additive CNS depression effects by the combination of Brimonidine and Suvorexant. Insomnia [7A00-7A0Z] [10]
Amobarbital DM0GQ8N Moderate Additive CNS depression effects by the combination of Brimonidine and Amobarbital. Insomnia [7A00-7A0Z] [10]
Ramelteon DM7IW9J Moderate Additive CNS depression effects by the combination of Brimonidine and Ramelteon. Insomnia [7A00-7A0Z] [10]
Flurazepam DMAL4G0 Moderate Additive CNS depression effects by the combination of Brimonidine and Flurazepam. Insomnia [7A00-7A0Z] [10]
Triazolam DMETYK5 Moderate Additive CNS depression effects by the combination of Brimonidine and Triazolam. Insomnia [7A00-7A0Z] [10]
Zaleplon DMGFWSM Moderate Additive CNS depression effects by the combination of Brimonidine and Zaleplon. Insomnia [7A00-7A0Z] [10]
Propiomazine DMKY8V1 Moderate Additive CNS depression effects by the combination of Brimonidine and Propiomazine. Insomnia [7A00-7A0Z] [10]
Tasimelteon DMLOQ1V Moderate Additive CNS depression effects by the combination of Brimonidine and Tasimelteon. Insomnia [7A00-7A0Z] [10]
Paraldehyde DMOC1BX Moderate Additive CNS depression effects by the combination of Brimonidine and Paraldehyde. Insomnia [7A00-7A0Z] [10]
ITI-007 DMUQ1DO Moderate Additive CNS depression effects by the combination of Brimonidine and ITI-007. Insomnia [7A00-7A0Z] [10]
Nabilone DMVRYT2 Moderate Additive CNS depression effects by the combination of Brimonidine and Nabilone. Insomnia [7A00-7A0Z] [10]
Quazepam DMY4D87 Moderate Additive CNS depression effects by the combination of Brimonidine and Quazepam. Insomnia [7A00-7A0Z] [10]
Estazolam DMZGXUM Moderate Additive CNS depression effects by the combination of Brimonidine and Estazolam. Insomnia [7A00-7A0Z] [10]
Remimazolam DMLVSYX Moderate Additive CNS depression effects by the combination of Brimonidine and Remimazolam. Labour/delivery anaesthesia complication [JB0C] [10]
Allopregnanolone DMNLHAC Moderate Additive CNS depression effects by the combination of Brimonidine and Allopregnanolone. Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z] [10]
Flibanserin DM70DTN Moderate Additive CNS depression effects by the combination of Brimonidine and Flibanserin. Mood disorder [6A60-6E23] [10]
Dexmedetomidine DM93L4X Moderate Additive CNS depression effects by the combination of Brimonidine and Dexmedetomidine. Mood/affect symptom [MB24] [10]
Midazolam DMXOELT Moderate Additive CNS depression effects by the combination of Brimonidine and Midazolam. Mood/affect symptom [MB24] [10]
Thalidomide DM70BU5 Moderate Additive CNS depression effects by the combination of Brimonidine and Thalidomide. Multiple myeloma [2A83] [10]
Ozanimod DMT6AM2 Moderate Additive hypertensive effects by the combination of Brimonidine and Ozanimod. Multiple sclerosis [8A40] [9]
Phenindamine DMDTC7R Moderate Additive CNS depression effects by the combination of Brimonidine and Phenindamine. Nasopharyngitis [CA00] [10]
Dimenhydrinate DM264B3 Moderate Additive CNS depression effects by the combination of Brimonidine and Dimenhydrinate. Nausea/vomiting [MD90] [10]
Promethazine DM6I5GR Moderate Additive CNS depression effects by the combination of Brimonidine and Promethazine. Nausea/vomiting [MD90] [10]
Cyclizine DM9G7BS Moderate Additive CNS depression effects by the combination of Brimonidine and Cyclizine. Nausea/vomiting [MD90] [10]
Metoclopramide DMFA5MY Moderate Additive CNS depression effects by the combination of Brimonidine and Metoclopramide. Nausea/vomiting [MD90] [10]
E-2007 DMJDYNQ Moderate Additive CNS depression effects by the combination of Brimonidine and E-2007. Neuropathy [8C0Z] [10]
Sibutramine DMFJTDI Moderate Additive CNS depression effects by the combination of Brimonidine and Sibutramine. Obesity [5B80-5B81] [10]
Levomethadyl Acetate DM06HG5 Moderate Additive CNS depression effects by the combination of Brimonidine and Levomethadyl Acetate. Opioid use disorder [6C43] [10]
Lofexidine DM1WXA6 Moderate Additive CNS depression effects by the combination of Brimonidine and Lofexidine. Opioid use disorder [6C43] [10]
Pentazocine DM1XBHS Moderate Additive CNS depression effects by the combination of Brimonidine and Pentazocine. Pain [MG30-MG3Z] [10]
Dextropropoxyphene DM23HCX Moderate Additive CNS depression effects by the combination of Brimonidine and Dextropropoxyphene. Pain [MG30-MG3Z] [10]
Butorphanol DM5KYPJ Moderate Additive CNS depression effects by the combination of Brimonidine and Butorphanol. Pain [MG30-MG3Z] [10]
Oxymorphone DM65AGJ Moderate Additive CNS depression effects by the combination of Brimonidine and Oxymorphone. Pain [MG30-MG3Z] [10]
Levorphanol DMGS80V Moderate Additive CNS depression effects by the combination of Brimonidine and Levorphanol. Pain [MG30-MG3Z] [10]
Dezocine DMJDB0Y Moderate Additive CNS depression effects by the combination of Brimonidine and Dezocine. Pain [MG30-MG3Z] [10]
Flavoxate DMKV4NL Moderate Additive CNS depression effects by the combination of Brimonidine and Flavoxate. Pain [MG30-MG3Z] [10]
Nalbuphine DMOSQGU Moderate Additive CNS depression effects by the combination of Brimonidine and Nalbuphine. Pain [MG30-MG3Z] [10]
Buprenorphine DMPRI8G Moderate Additive CNS depression effects by the combination of Brimonidine and Buprenorphine. Pain [MG30-MG3Z] [10]
Hydrocodone DMQ2JO5 Moderate Additive CNS depression effects by the combination of Brimonidine and Hydrocodone. Pain [MG30-MG3Z] [10]
Ziconotide DMSLJP4 Moderate Additive CNS depression effects by the combination of Brimonidine and Ziconotide. Pain [MG30-MG3Z] [10]
Oxycodone DMXLKHV Moderate Additive CNS depression effects by the combination of Brimonidine and Oxycodone. Pain [MG30-MG3Z] [10]
Safinamide DM0YWJC Moderate Additive hypertensive effects by the combination of Brimonidine and Safinamide. Parkinsonism [8A00] [9]
Pergolide DM14MAE Moderate Additive CNS depression effects by the combination of Brimonidine and Pergolide. Parkinsonism [8A00] [10]
Opicapone DM1BKA6 Moderate Additive CNS depression effects by the combination of Brimonidine and Opicapone. Parkinsonism [8A00] [10]
Rasagiline DM3WKQ4 Moderate Additive hypertensive effects by the combination of Brimonidine and Rasagiline. Parkinsonism [8A00] [9]
Biperiden DME78OA Moderate Additive CNS depression effects by the combination of Brimonidine and Biperiden. Parkinsonism [8A00] [10]
Entacapone DMLBVKQ Moderate Additive CNS depression effects by the combination of Brimonidine and Entacapone. Parkinsonism [8A00] [10]
Levodopa DMN3E57 Moderate Additive CNS depression effects by the combination of Brimonidine and Levodopa. Parkinsonism [8A00] [10]
Bromocriptine DMVE3TK Moderate Additive CNS depression effects by the combination of Brimonidine and Bromocriptine. Parkinsonism [8A00] [10]
Orphenadrine DMW542E Moderate Additive CNS depression effects by the combination of Brimonidine and Orphenadrine. Parkinsonism [8A00] [10]
Apomorphine DMX38HQ Moderate Additive CNS depression effects by the combination of Brimonidine and Apomorphine. Parkinsonism [8A00] [10]
Levomepromazine DMIKFEL Moderate Additive CNS depression effects by the combination of Brimonidine and Levomepromazine. Psychotic disorder [6A20-6A25] [10]
Fluphenazine DMIT8LX Moderate Additive CNS depression effects by the combination of Brimonidine and Fluphenazine. Psychotic disorder [6A20-6A25] [10]
Triflupromazine DMKFQJP Moderate Additive CNS depression effects by the combination of Brimonidine and Triflupromazine. Psychotic disorder [6A20-6A25] [10]
Neupro DMHEAB1 Moderate Additive CNS depression effects by the combination of Brimonidine and Neupro. Restless legs syndrome [7A80] [10]
Quetiapine DM1N62C Moderate Additive CNS depression effects by the combination of Brimonidine and Quetiapine. Schizophrenia [6A20] [10]
Mesoridazine DM2ZGAN Moderate Additive CNS depression effects by the combination of Brimonidine and Mesoridazine. Schizophrenia [6A20] [10]
Thioridazine DM35M8J Moderate Additive CNS depression effects by the combination of Brimonidine and Thioridazine. Schizophrenia [6A20] [10]
Aripiprazole DM3NUMH Moderate Additive CNS depression effects by the combination of Brimonidine and Aripiprazole. Schizophrenia [6A20] [10]
Iloperidone DM6AUFY Moderate Additive CNS depression effects by the combination of Brimonidine and Iloperidone. Schizophrenia [6A20] [10]
Paliperidone DM7NPJS Moderate Additive CNS depression effects by the combination of Brimonidine and Paliperidone. Schizophrenia [6A20] [10]
Haloperidol DM96SE0 Moderate Additive CNS depression effects by the combination of Brimonidine and Haloperidol. Schizophrenia [6A20] [10]
Perphenazine DMA4MRX Moderate Additive CNS depression effects by the combination of Brimonidine and Perphenazine. Schizophrenia [6A20] [10]
Molindone DMAH70G Moderate Additive CNS depression effects by the combination of Brimonidine and Molindone. Schizophrenia [6A20] [10]
Thiothixene DMDINC4 Moderate Additive CNS depression effects by the combination of Brimonidine and Thiothixene. Schizophrenia [6A20] [10]
Trifluoperazine DMKBYWI Moderate Additive CNS depression effects by the combination of Brimonidine and Trifluoperazine. Schizophrenia [6A20] [10]
Risperidone DMN6DXL Moderate Additive CNS depression effects by the combination of Brimonidine and Risperidone. Schizophrenia [6A20] [10]
Asenapine DMSQZE2 Moderate Additive CNS depression effects by the combination of Brimonidine and Asenapine. Schizophrenia [6A20] [10]
Pimozide DMW83TP Moderate Additive CNS depression effects by the combination of Brimonidine and Pimozide. Schizophrenia [6A20] [10]
Fentanyl DM8WAHT Moderate Additive CNS depression effects by the combination of Brimonidine and Fentanyl. Sensation disturbance [MB40] [10]
Sufentanil DMU7YEL Moderate Additive CNS depression effects by the combination of Brimonidine and Sufentanil. Sensation disturbance [MB40] [10]
Chlorpheniramine DM5URA2 Moderate Additive CNS depression effects by the combination of Brimonidine and Chlorpheniramine. Vasomotor/allergic rhinitis [CA08] [10]
Methdilazine DMAUHQX Moderate Additive CNS depression effects by the combination of Brimonidine and Methdilazine. Vasomotor/allergic rhinitis [CA08] [10]
Carbinoxamine DMCT31R Moderate Additive CNS depression effects by the combination of Brimonidine and Carbinoxamine. Vasomotor/allergic rhinitis [CA08] [10]
Trimeprazine DMEMV9D Moderate Additive CNS depression effects by the combination of Brimonidine and Trimeprazine. Vasomotor/allergic rhinitis [CA08] [10]
Brompheniramine DMFOVSD Moderate Additive CNS depression effects by the combination of Brimonidine and Brompheniramine. Vasomotor/allergic rhinitis [CA08] [10]
Acrivastine DMTIGA0 Moderate Additive CNS depression effects by the combination of Brimonidine and Acrivastine. Vasomotor/allergic rhinitis [CA08] [10]
Azatadine DMZ80SB Moderate Additive CNS depression effects by the combination of Brimonidine and Azatadine. Vasomotor/allergic rhinitis [CA08] [10]
⏷ Show the Full List of 155 DDI Information of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 520).
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Cantor LB: The evolving pharmacotherapeutic profile of brimonidine, an alpha 2-adrenergic agonist, after four years of continuous use. Expert Opin Pharmacother. 2000 May;1(4):815-34. doi: 10.1517/14656566.1.4.815 .
4 BDDCS applied to over 900 drugs
5 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
6 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
7 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
8 Increased alpha2-adrenergic constriction of isolated arterioles in diffuse scleroderma. Arthritis Rheum. 2000 Aug;43(8):1886-90.
9 Coleman AL, Robin AL, Pollack IP, Rudikoff MT, Enger C, Mayer PR "Cardiovascular and intraocular pressure effects and plasma concentrations of apraclonidine." Arch Ophthalmol 108 (1990): 1264-7. [PMID: 2205182]
10 Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.