Details of the Drug Combinations

General Information of This Drug (ID: DMR24MI)

Drug Name

GSK-2256098 DMR24MI

Synonyms

Focal adhesion kinase inhibitor (oral, cancer), GlaxoSmithKline

Indication

Disease Entry	ICD 11	Status	REF
Pulmonary arterial hypertension	BB01.0	Phase 1	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

3 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
GSK-2256098 + Carfilzomib	DCJC9DM	Carfilzomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
GSK-2256098 + RTB101	DC1WW0D	RTB101	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
GSK-2256098 + ONC201	DCIXC8N	ONC201	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7939).
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.