Details of the Drug

General Information of Drug (ID: DMR24MI)

Drug Name
GSK-2256098
Synonyms Focal adhesion kinase inhibitor (oral, cancer), GlaxoSmithKline
Indication
Disease Entry ICD 11 Status REF
Pulmonary arterial hypertension BB01.0 Phase 1 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1 [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 414.9
Logarithm of the Partition Coefficient (xlogp) 4.5
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 6
Chemical Identifiers
Formula
C20H23ClN6O2
IUPAC Name
2-[[5-chloro-2-[(5-methyl-2-propan-2-ylpyrazol-3-yl)amino]pyridin-4-yl]amino]-N-methoxybenzamide
Canonical SMILES
CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C
InChI
InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)
InChIKey
BVAHPPKGOOJSPU-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
46214930
CAS Number
1224887-10-8
UNII
R7O0O4110G
DrugBank ID
DB16106
TTD ID
D0B9MR
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Focal adhesion kinase 1 (FAK) TTON5IT FAK1_HUMAN Inhibitor [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC2 4.5599 6.8101 0.8475 0.5478
CHSA8926 GDSC2 2.2146 4.9382 0.3997 5.8574
CAL-78 GDSC2 2.299 5.3833 0.243 6.6254
SK-PN-DW GDSC2 2.6903 5.6857 0.3664 5.0269
SK-ES-1 GDSC2 3.0696 4.8145 0.9755 1.1429
ES5 GDSC2 3.1642 5.7499 0.6248 2.7409
A-673 GDSC2 3.3219 4.5183 1.1965 0.2204
SaOS-2 GDSC2 3.4436 5.2148 0.987 0.7687
CAL-72 GDSC2 3.5117 5.2242 1.0125 0.6338
EW-24 GDSC2 3.6464 4.9007 1.1816 0.1528
EW-3 GDSC2 3.6976 5.7772 0.8795 0.968
HOS GDSC2 3.7782 5.1476 1.1438 0.1826
TC-71 GDSC2 3.7992 5.2999 1.0983 0.2628
CADO-ES1 GDSC2 3.8654 5.6665 0.9918 0.4942
EW-7 GDSC2 3.9371 5.5485 1.062 0.2919
MG-63 GDSC2 4.0371 5.5268 1.106 0.1804
U2OS GDSC2 4.0664 6.1788 0.8828 0.704
NY GDSC2 4.0762 10.3037 -0.9143 9.5286
MHH-ES-1 GDSC2 4.1622 5.8808 1.0284 0.2857
G-292 clone A141B1 GDSC2 4.211 5.9318 1.0286 0.2701
EW-13 GDSC2 4.2117 6.0205 0.9976 0.3331
HuO9 GDSC2 4.3051 7.591 0.4318 2.2525
ES8 GDSC2 4.3863 6.289 0.9678 0.3355
EW-16 GDSC2 4.3935 6.5678 0.8705 0.5648
NOS-1 [Human HNSCC] GDSC2 4.5083 6.9219 0.7859 0.7442
EW-22 GDSC2 4.5457 6.682 0.8882 0.4535
EW-1 GDSC2 4.5518 6.594 0.9218 0.3756
EW-18 GDSC2 4.6237 6.4988 0.9814 0.24
HuO-3N1 GDSC2 4.6738 7.1705 0.7605 0.7285
EW-11 GDSC2 4.7555 7.5324 0.6585 0.9918
ES6 GDSC2 4.7706 6.6032 0.9977 0.1817
H-EMC-SS GDSC2 4.7774 7.096 0.8282 0.5018
ES7 GDSC2 4.9108 7.3026 0.8051 0.5029
ES4 GDSC2 5.0872 7.0102 0.9704 0.1591
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-220 GDSC2 2.4238 4.5375 0.7355 3.3722
KYSE-50 GDSC2 3.0354 5.6974 0.5748 3.208
OACM5.1 C GDSC2 3.216 5.8348 0.6161 2.7109
TE-12 GDSC2 3.5687 7.03 0.284 3.942
OACP4 C GDSC2 3.8789 6.3191 0.7469 1.3299
ESO-26 GDSC2 4.1384 5.5922 1.1194 0.1386
ESO-51 GDSC2 4.1833 5.8752 1.0382 0.2601
KYAE-1 GDSC2 4.2957 6.0817 1.0072 0.2855
FLO-1 GDSC2 4.3184 6.8429 0.7366 1.0213
SK-GT-4 GDSC2 4.5673 6.9622 0.7947 0.6868
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC2 4.1666 6.3293 0.8676 0.6921
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 GDSC2 2.0864 4.474 0.5341 5.3294
SJNB-13 GDSC2 2.3887 4.148 0.8952 2.5089
KP-N-YN GDSC2 2.545 6.576 -0.1627 8.5192
SK-N-DZ GDSC2 2.6985 4.5503 0.8952 2.0002
Kelly GDSC2 2.9886 4.5722 1.0357 0.9643
NB(TU)1 GDSC2 3.0397 5.5849 0.6278 2.9128
CHP-134 GDSC2 3.2602 4.7485 1.0875 0.5503
SJNB-14 GDSC2 3.2866 4.6442 1.1373 0.3826
SK-N-AS GDSC2 3.4806 5.0585 1.062 0.497
NB69 GDSC2 3.5425 5.7996 0.7992 1.4293
SJNB-7 GDSC2 3.5655 5.1093 1.0773 0.4087
NH-12 GDSC2 3.6924 5.8056 0.866 1.0225
SiMa GDSC2 3.8021 5.8552 0.8947 0.8357
SK-N-BE(2)-M17 GDSC2 3.8966 5.7073 0.9892 0.4858
TGW GDSC2 3.9735 5.8195 0.9785 0.4773
SJNB-10 GDSC2 4.0357 5.9577 0.9525 0.5173
IMR-5 GDSC2 4.0651 5.9247 0.976 0.4417
GOTO GDSC2 4.3287 6.322 0.9344 0.4319
GI-ME-N GDSC2 4.5416 6.8695 0.8186 0.6333
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC2 2.9688 5.1817 0.7669 2.2798
Cancer Drug Sensitivity Data Curated from 42 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC1187 GDSC2 2.3105 4.3251 0.7622 3.439
HCC38 GDSC2 2.3785 4.9781 0.4955 4.9025
CAL-85-1 GDSC2 2.5042 6.3748 -0.0938 8.1994
HCC1806 GDSC2 2.6746 4.5524 0.8808 2.1132
BT-549 GDSC2 2.7793 5.0555 0.715 2.8524
Hs 578T GDSC2 2.7937 5.9511 0.3084 5.1639
HCC2157 GDSC2 2.825 4.6109 0.9377 1.6051
MDA-MB-157 GDSC2 3.1118 5.458 0.7241 2.299
BT-474 GDSC2 3.2277 4.5476 1.1494 0.3791
HCC1419 GDSC2 3.2935 4.901 1.0433 0.6781
DU4475 GDSC2 3.3761 4.5642 1.2004 0.1941
MRK-nu-1 GDSC2 3.4436 4.7545 1.1583 0.2599
MDA-MB-453 GDSC2 3.4668 5.3729 0.9354 0.942
HCC1954 GDSC2 3.5084 5.4135 0.9381 0.8985
MDA-MB-468 GDSC2 3.561 5.4014 0.9657 0.7589
AU565 GDSC2 3.5901 6.2257 0.6458 2.0724
JIMT-1 GDSC2 3.7375 5.0991 1.1459 0.1899
HDQ-P1 GDSC2 3.7875 5.7576 0.9258 0.7401
OCUB-M GDSC2 3.8009 5.4822 1.0337 0.413
MDA-MB-231 GDSC2 3.8558 5.7596 0.9534 0.6105
BT-20 GDSC2 3.8833 5.7166 0.9805 0.5166
HCC1428 GDSC2 3.8907 5.2575 1.1462 0.1514
CAMA-1 GDSC2 3.9201 5.4393 1.094 0.2329
Evsa-T GDSC2 3.9732 5.4051 1.1249 0.1654
HCC1937 GDSC2 3.9822 6.27 0.8124 0.9961
MCF-7 GDSC2 4.0005 5.9501 0.9413 0.5666
HCC70 GDSC2 4.0058 5.6268 1.0599 0.2731
MDA-MB-361 GDSC2 4.0212 5.9215 0.96 0.504
CAL-120 GDSC2 4.0364 5.5461 1.0991 0.1919
HCC1500 GDSC2 4.0622 5.6718 1.0648 0.2457
MDA-MB-415 GDSC2 4.0639 5.6889 1.0595 0.2555
EFM-192A GDSC2 4.1055 5.7867 1.0406 0.2796
EFM-19 GDSC2 4.1215 6.2844 0.8659 0.7237
MDA-MB-330 GDSC2 4.1281 6.228 0.8897 0.6477
CAL-51 GDSC2 4.1478 5.8148 1.0463 0.2554
MDA-MB-436 GDSC2 4.1785 5.9626 1.0057 0.3275
T-47D GDSC2 4.2202 6.4773 0.8342 0.7636
ZR-75-30 GDSC2 4.3152 6.0817 1.0144 0.2659
COLO 824 GDSC2 4.3498 6.2893 0.9541 0.3782
MFM-223 GDSC2 4.4296 6.0872 1.0534 0.1724
HCC1569 GDSC2 4.4841 6.6628 0.8714 0.5206
HCC1143 GDSC2 4.9658 7.2979 0.8275 0.4318
⏷ Show the Full List of 42 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LN-229 GDSC2 2.4005 4.8167 0.5878 4.2984
CAS-1 GDSC2 2.43 4.5958 0.7121 3.4983
LN-18 GDSC2 2.6297 3.7623 1.1948 0.6402
GI-1 GDSC2 2.6305 5.0222 0.6399 3.5391
42-MG-BA GDSC2 2.6435 5.2643 0.5349 4.1261
U-87MG ATCC GDSC2 2.6743 4.4784 0.9135 1.9393
KS-1 [Human Krukenberg tumour] GDSC2 2.7167 9.4701 -1.4588 15.3977
SK-MG-1 GDSC2 3.0254 5.2161 0.7827 2.1186
DBTRG-05MG GDSC2 3.0603 5.1499 0.83 1.8345
D-263MG GDSC2 3.239 4.5582 1.15 0.3716
LN-405 GDSC2 3.274 4.7024 1.1106 0.4682
D283 Med GDSC2 3.3502 4.7502 1.1237 0.3884
YH-13 GDSC2 3.4355 8.1129 -0.2957 7.3966
DK-MG GDSC2 3.4996 5.2239 1.0075 0.6583
SF539 GDSC2 3.5128 5.1279 1.0493 0.517
GB-1 GDSC2 3.6801 5.2445 1.0729 0.3672
8-MG-BA GDSC2 3.6874 5.8651 0.8403 1.126
U-251MG GDSC2 3.7317 5.1591 1.1229 0.2351
Becker GDSC2 3.8927 5.7867 0.9583 0.5752
Daoy GDSC2 3.9337 5.4078 1.1099 0.2001
H4 GDSC2 3.9457 5.9141 0.9325 0.6225
T98G GDSC2 3.9478 5.6243 1.039 0.3385
U-118MG GDSC2 3.9649 5.4186 1.1173 0.1795
AM-38 GDSC2 3.9733 6.1195 0.8665 0.8151
SW1088 GDSC2 3.9915 6.0598 0.8967 0.7056
ONS-76 GDSC2 4.1639 5.7102 1.0882 0.1786
GaMG GDSC2 4.3502 6.0194 1.0485 0.1976
D-392MG GDSC2 4.3573 6.7247 0.7978 0.795
A-172 GDSC2 4.5349 6.161 1.0651 0.1367
KINGS-1 GDSC2 4.5493 6.6502 0.9009 0.4226
SF268 GDSC2 4.5502 6.4386 0.9757 0.2695
PFSK-1 GDSC2 4.5696 6.5934 0.9287 0.3549
KALS-1 GDSC2 4.7238 6.8603 0.8919 0.3792
M059J GDSC2 4.8167 6.4377 1.069 0.0921
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC2 4.1084 5.9348 0.9891 0.3914
ETK-1 GDSC2 4.431 6.6075 0.8708 0.5465
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RL95-2 GDSC2 2.5532 4.9482 0.6255 3.7686
ESS-1 GDSC2 3.2719 5.2167 0.908 1.2312
MFE-319 GDSC2 3.6959 5.2421 1.0799 0.3432
AN3-CA GDSC2 3.866 5.683 0.986 0.51
MFE-296 GDSC2 4.0223 5.9044 0.9667 0.4855
EN GDSC2 4.1625 5.943 1.0066 0.331
KLE GDSC2 4.2891 6.2203 0.9557 0.3975
MFE-280 GDSC2 4.6504 7.0983 0.7778 0.6916
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 128 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U266B1 GDSC2 1.6374 3.4759 0.6829 5.5607
RPMI-8226 GDSC2 1.7288 3.6511 0.6692 5.3936
HDLM-2 GDSC2 1.9093 4.1695 0.552 5.6554
LC4-1 GDSC2 1.9143 4.1262 0.5773 5.4842
OPM-2 GDSC2 2.0277 3.8084 0.8171 3.7154
Jurkat GDSC2 2.0897 3.8518 0.8397 3.4375
SUP-T1 GDSC2 2.1139 3.8308 0.8664 3.222
MOLT-13 GDSC2 2.1941 3.7805 0.9439 2.5921
IM-9 GDSC2 2.2281 3.7163 0.9957 2.223
DoHH2 GDSC2 2.2385 3.9987 0.8696 2.9443
L-540 GDSC2 2.2748 4.3867 0.7089 3.8323
KY821 GDSC2 2.3225 5.5205 0.1928 6.878
BL-41 GDSC2 2.3251 3.8658 0.9864 2.1014
OCI-AML-2 GDSC2 2.3517 4.2034 0.8462 2.8615
Raji GDSC2 2.354 5.8931 0.0333 7.781
SR GDSC2 2.3672 4.1684 0.8724 2.6801
SUP-M2 GDSC2 2.371 3.6685 1.1024 1.3889
Namalwa GDSC2 2.417 4.0135 0.974 2.0144
DEL GDSC2 2.431 3.626 1.1534 1.0451
MHH-PREB-1 GDSC2 2.4462 4.2043 0.9044 2.3552
KMS-12-BM GDSC2 2.4796 4.2264 0.9144 2.2422
NALM-6 GDSC2 2.4867 4.3702 0.8528 2.5766
DB GDSC2 2.5247 4.7285 0.7103 3.3276
JSC-1 GDSC2 2.6056 4.3292 0.9411 1.8956
MM1.S GDSC2 2.6074 4.5689 0.8344 2.4746
BC-1 GDSC2 2.632 5.4685 0.4312 4.7604
MOLP-8 GDSC2 2.6389 4.7283 0.7805 2.7222
SUP-HD1 GDSC2 2.6921 5.0158 0.6809 3.1928
JJN-3 GDSC2 2.7056 4.424 0.9547 1.6795
SU-DHL-5 GDSC2 2.7508 3.9066 1.1924 0.5461
L-1236 GDSC2 2.8008 5.0273 0.7404 2.6773
ALL-PO GDSC2 2.8044 6.138 0.2269 5.6226
CTV-1 GDSC2 2.8078 4.4651 0.9911 1.365
Hs 445 GDSC2 2.8109 4.8577 0.822 2.2212
KE-37 GDSC2 2.8307 4.2658 1.0854 0.9075
RC-K8 GDSC2 2.8451 4.6277 0.941 1.5625
SU-DHL-10 GDSC2 2.8711 3.7605 1.296 0.1659
EJM GDSC2 2.8758 4.5497 0.99 1.2893
ME1 GDSC2 2.8772 4.2091 1.1298 0.6821
RPMI-8866 GDSC2 2.9496 4.8913 0.8828 1.7159
Ku812 GDSC2 2.9808 4.8795 0.9041 1.5724
HL-60 GDSC2 3.0078 4.3232 1.1428 0.5335
Karpas-422 GDSC2 3.0094 4.1915 1.1933 0.3693
ST486 GDSC2 3.0158 4.3637 1.1307 0.5703
A4/Fukuda GDSC2 3.0184 4.6657 1.0119 1.037
AMO1 GDSC2 3.0669 4.2907 1.1798 0.3777
LP-1 GDSC2 3.0693 4.7725 0.9926 1.0692
PF-382 GDSC2 3.0961 5.8211 0.5543 3.2226
P32/ISH GDSC2 3.1017 4.3449 1.1737 0.3764
DG-75 GDSC2 3.1049 5.0031 0.9148 1.3771
JURL-MK1 GDSC2 3.1586 4.9552 0.9606 1.1178
SCC-3 GDSC2 3.1643 4.4243 1.1695 0.3552
A3/Kawakami GDSC2 3.1662 4.2035 1.2495 0.1635
HEL GDSC2 3.2034 5.462 0.7712 1.9415
OCI-AML-3 GDSC2 3.2332 4.6318 1.1203 0.4624
Reh GDSC2 3.2413 4.7248 1.0885 0.5591
JVM-2 GDSC2 3.2417 5.6536 0.709 2.1998
HAL-01 GDSC2 3.2769 5.0495 0.9777 0.9378
Jiyoye GDSC2 3.2893 5.0657 0.9769 0.93
H9 GDSC2 3.2909 5.4544 0.819 1.6091
MOLT-16 GDSC2 3.3014 4.7874 1.09 0.5163
Farage GDSC2 3.3119 4.9391 1.0365 0.6889
ATN-1 GDSC2 3.3127 4.6562 1.1433 0.3532
697 GDSC2 3.3766 4.9319 1.0667 0.5438
WSU-NHL GDSC2 3.4134 4.8359 1.1173 0.3746
GA-10 GDSC2 3.4197 4.7761 1.1415 0.3093
GDM-1 GDSC2 3.4514 5.4223 0.9089 1.0587
OCI-AML-5 GDSC2 3.4524 4.5118 1.2458 0.0996
Ramos.2G6.4C10 GDSC2 3.4542 4.9403 1.0951 0.4151
HC-1 GDSC2 3.4741 5.1763 1.0149 0.6506
Karpas-620 GDSC2 3.5029 4.9057 1.1268 0.3101
WIL2 NS GDSC2 3.5148 4.7977 1.1696 0.2111
SKM-1 GDSC2 3.523 5.0083 1.0974 0.3752
BE-13 GDSC2 3.5243 5.2749 0.9985 0.672
SU-DHL-8 GDSC2 3.5348 5.2552 1.0104 0.6257
Karpas-231 GDSC2 3.5685 4.9559 1.1338 0.2682
KCL-22 GDSC2 3.5842 5.1535 1.0685 0.4234
TUR GDSC2 3.5846 4.8771 1.1675 0.1939
P12-Ichikawa GDSC2 3.642 5.0107 1.1418 0.2259
OCI-M1 GDSC2 3.6514 4.7826 1.2235 0.0925
LAMA-84 GDSC2 3.6605 5.727 0.8827 0.9852
Loucy GDSC2 3.7063 5.1413 1.1197 0.2498
Karpas-1106P GDSC2 3.7103 5.2683 1.076 0.3465
NCI-H929 GDSC2 3.7508 5.6276 0.9597 0.6534
EM-2 GDSC2 3.7585 5.4577 1.026 0.4535
Karpas-299 GDSC2 3.762 5.3594 1.0631 0.3564
CML-T1 GDSC2 3.7714 5.0618 1.1708 0.1407
EB2 GDSC2 3.7724 5.3825 1.0587 0.3625
U-698-M GDSC2 3.7968 5.6478 0.9711 0.5908
CESS GDSC2 3.7973 5.6542 0.9689 0.5973
P30/OHK GDSC2 3.8234 5.4036 1.0706 0.3142
ALL-SIL GDSC2 3.8294 5.7043 0.9633 0.5958
K-562 GDSC2 3.8496 5.3649 1.0942 0.2546
SUP-B15 GDSC2 3.861 5.4249 1.0772 0.286
MHH-CALL-2 GDSC2 3.8744 5.2353 1.148 0.1524
NOMO-1 GDSC2 3.8802 5.6739 0.9949 0.4782
CCRF-CEM GDSC2 3.8958 5.3548 1.1146 0.2022
TK [Human B-cell lymphoma] GDSC2 3.9105 5.2756 1.147 0.1459
RPMI-6666 GDSC2 3.9118 5.6771 1.0062 0.4334
EoL-1 GDSC2 3.9301 5.3105 1.142 0.1491
Daudi GDSC2 3.9396 5.5694 1.0555 0.305
BALL-1 GDSC2 3.9478 5.5646 1.0603 0.2918
CA46 GDSC2 3.9599 5.7054 1.0146 0.3913
SU-DHL-6 GDSC2 3.9603 5.6178 1.0461 0.318
JVM-3 GDSC2 3.9655 5.7409 1.0039 0.4153
HH [Human lymphoma] GDSC2 3.9869 6.1872 0.8464 0.8737
ML-2 GDSC2 3.9904 5.7198 1.0211 0.3633
Kasumi-1 GDSC2 4.0006 5.8265 0.9866 0.4436
Granta-519 GDSC2 4.0127 5.6178 1.0656 0.2595
KOPN-8 GDSC2 4.0209 5.72 1.0326 0.3255
ARH-77 GDSC2 4.0383 5.7562 1.0263 0.3331
L-363 GDSC2 4.0536 5.2915 1.1909 0.0703
VL51 GDSC2 4.0889 5.8766 1.0025 0.3678
MOLM-13 GDSC2 4.1014 5.6903 1.0727 0.2202
MLMA GDSC2 4.1028 6.0164 0.9574 0.4723
KM-H2 GDSC2 4.1522 5.7957 1.0545 0.2388
DND-41 GDSC2 4.158 5.7864 1.0598 0.2275
MN-60 GDSC2 4.1837 6.0847 0.9641 0.4204
RS4;11 GDSC2 4.2187 6.1971 0.937 0.4723
MOLT-4 GDSC2 4.2272 5.9697 1.0212 0.2794
L-428 GDSC2 4.2925 5.8875 1.0731 0.1728
KMOE-2 GDSC2 4.2961 5.9014 1.0697 0.1771
Karpas-45 GDSC2 4.3582 6.0042 1.0565 0.1832
SK-MM-2 GDSC2 4.3626 5.9714 1.0692 0.1636
KG-1 GDSC2 4.4053 6.1317 1.0296 0.2148
VAL GDSC2 4.534 6.2199 1.0449 0.1632
GR-ST GDSC2 4.6028 6.9863 0.8 0.6539
MEG-01 GDSC2 4.8855 6.9064 0.9348 0.2516
⏷ Show the Full List of 128 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BFTC-909 GDSC2 2.2267 4.6714 0.5383 4.9765
LB996-RCC GDSC2 2.8029 5.5958 0.4809 4.1396
A-498 GDSC2 2.8733 5.1392 0.732 2.6088
RCC10RGB GDSC2 3.1788 4.8875 0.9974 0.9456
CAL-54 GDSC2 3.2036 5.1911 0.8854 1.4021
SW13 GDSC2 3.496 5.0158 1.084 0.4248
VMRC-RCZ GDSC2 3.6275 5.2297 1.0577 0.4314
KMRC-20 GDSC2 4.0286 5.5754 1.0861 0.2163
769-P GDSC2 4.0608 5.6621 1.0677 0.2407
OS-RC-2 GDSC2 4.1981 6.6153 0.7724 0.9815
KTCTL-195 GDSC2 4.2068 6.0366 0.9901 0.3512
A-704 GDSC2 4.2379 6.0275 1.0049 0.3087
SN12C GDSC2 4.2465 5.9353 1.0403 0.238
NCC010 GDSC2 4.2902 6.5985 0.8175 0.7735
RXF 393L GDSC2 4.3131 6.59 0.8301 0.7219
786-O GDSC2 4.3274 6.2787 0.9494 0.3974
ACHN GDSC2 4.591 6.2543 1.0532 0.1419
HA7-RCC GDSC2 5.1815 7.3126 0.9009 0.2358
TK-10 GDSC2 5.2665 7.5709 0.8424 0.3099
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 46 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-1040 GDSC2 2.1658 3.9626 0.8385 3.2803
LS411N GDSC2 2.708 4.3841 0.9733 1.5813
GP5d GDSC2 2.7252 4.4365 0.9599 1.6262
SNU-C1 GDSC2 2.7591 4.8986 0.7742 2.5593
KM12 GDSC2 2.8401 4.4895 0.9973 1.2967
CL-11 GDSC2 2.9218 5.045 0.8011 2.169
DiFi GDSC2 3.154 5.6785 0.6506 2.6205
HCC2998 GDSC2 3.1685 5.5165 0.7293 2.1952
SW48 GDSC2 3.2203 25.2465 -8.9121 34.3588
LoVo GDSC2 3.2471 5.855 0.6243 2.6239
SW1116 GDSC2 3.3447 5.1814 0.9561 0.9643
HT-29 GDSC2 3.3907 4.7283 1.1475 0.3068
LS513 GDSC2 3.4092 5.8627 0.707 1.9978
SW1463 GDSC2 3.5008 5.2237 1.0081 0.6556
SW948 GDSC2 3.5298 5.1005 1.0663 0.4574
HCT 116 GDSC2 3.5337 4.9667 1.1167 0.3217
COLO205 GDSC2 3.5705 5.1518 1.0637 0.4436
MDST8 GDSC2 3.6189 4.7617 1.2193 0.1035
HT-55 GDSC2 3.6228 5.0141 1.1335 0.2494
HT115 GDSC2 3.6717 5.1321 1.11 0.2827
RKO GDSC2 3.6862 5.4375 1.0044 0.5533
SNU-81 GDSC2 3.7627 5.516 1.0062 0.5063
HCT 15 GDSC2 3.7701 5.0997 1.1574 0.1619
CW-2 GDSC2 3.8215 5.7565 0.9405 0.6711
SNU-175 GDSC2 3.8333 5.7497 0.9479 0.6406
CCK-81 GDSC2 4.0078 5.9544 0.9426 0.5592
LS1034 GDSC2 4.0342 5.4194 1.1415 0.1287
RCM-1 [Human ESC] GDSC2 4.0474 5.3498 1.1695 0.0926
SW626 GDSC2 4.0687 5.9149 0.981 0.4276
COLO 320HSR GDSC2 4.0959 5.8995 0.997 0.3778
SNU-407 GDSC2 4.1076 6.2882 0.8587 0.7547
LS123 GDSC2 4.1224 5.728 1.0672 0.2242
COLO 678 GDSC2 4.1438 6.149 0.9252 0.5385
SW837 GDSC2 4.1622 6.1719 0.9241 0.5326
SK-CO-1 GDSC2 4.1984 5.854 1.051 0.232
T84 GDSC2 4.202 6.11 0.962 0.4177
SW620 GDSC2 4.216 5.8004 1.0758 0.1859
NCI-H747 GDSC2 4.2232 6.5163 0.8207 0.8044
SNU-61 GDSC2 4.2587 5.8891 1.0606 0.2001
SW1417 GDSC2 4.2781 5.8414 1.0838 0.1603
CaR-1 GDSC2 4.284 6.2362 0.9481 0.4175
SNU-C5 GDSC2 4.3368 6.5634 0.8495 0.6516
LS180 GDSC2 4.4289 6.2848 0.985 0.2874
NCI-H716 GDSC2 4.4289 6.3805 0.9514 0.3555
C2BBe1 GDSC2 4.5719 6.6651 0.9042 0.4069
SNU-C2B GDSC2 5.3607 7.7165 0.826 0.3134
⏷ Show the Full List of 46 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC2 4.2179 5.8874 1.0465 0.2348
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 GDSC2 2.6307 3.5239 1.288 0.3002
HuH-1 GDSC2 3.0649 5.1088 0.85 1.7308
SK-HEP-1 GDSC2 3.1 4.3595 1.1676 0.3954
Hep 3B2.1-7 GDSC2 3.2037 4.5674 1.1323 0.4427
SNU-423 GDSC2 3.275 7.8308 -0.2667 7.5494
Hep-G2/C3A GDSC2 3.5308 4.8607 1.1534 0.2391
Huh-7 GDSC2 3.545 4.8766 1.1531 0.235
SNU-398 GDSC2 3.5827 5.7309 0.8459 1.1956
JHH-1 GDSC2 3.6253 4.8386 1.1954 0.136
SNU-387 GDSC2 3.7654 5.4604 1.0277 0.4454
JHH-7 GDSC2 4.011 5.6661 1.0479 0.296
HLE GDSC2 4.2109 5.9637 1.0173 0.2923
JHH-2 GDSC2 4.2502 6.255 0.9283 0.4804
SNU-449 GDSC2 4.4598 6.2273 1.0162 0.2233
JHH-4 GDSC2 4.6929 6.3558 1.0542 0.124
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 129 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COR-L311 GDSC2 1.5698 3.2636 0.733 5.4387
Lu-99A GDSC2 1.7729 3.6918 0.6838 5.1825
NCI-H1781 GDSC2 2.1998 4.9436 0.3864 5.9747
NCI-H1876 GDSC2 2.4635 4.1596 0.9352 2.1532
DMS 273 GDSC2 2.5515 4.3501 0.9006 2.1999
HOP-92 GDSC2 2.626 4.917 0.686 3.2817
NCI-H1650 GDSC2 2.75 5.3689 0.5533 3.8191
NCI-H2731 GDSC2 2.7897 5.0442 0.7263 2.7729
SW1271 GDSC2 2.8117 6.9222 -0.1434 7.8014
NCI-H345 GDSC2 2.8546 3.8988 1.2394 0.3188
NCI-H2373 GDSC2 2.9062 6.213 0.2576 5.2416
LXF 289 GDSC2 2.9459 6.4067 0.192 5.547
NCI-H2122 GDSC2 2.9725 4.7657 0.9479 1.374
SBC-5 GDSC2 2.9803 3.9922 1.2548 0.218
NCI-H596 GDSC2 3.0341 4.9343 0.9081 1.4891
Calu-3 GDSC2 3.0436 5.1187 0.8346 1.8331
NCI-H3122 GDSC2 3.0684 5.7179 0.5846 3.1016
HCC366 GDSC2 3.0696 5.4823 0.6903 2.5349
NCI-H1155 GDSC2 3.1656 5.1206 0.896 1.3959
NCI-H1568 GDSC2 3.1987 5.402 0.7943 1.8346
NCI-H82 GDSC2 3.2006 4.6931 1.0834 0.6042
NCI-H3255 GDSC2 3.2058 5.3779 0.8082 1.7596
NCI-H2228 GDSC2 3.2405 6.0645 0.5281 3.14
NCI-H1975 GDSC2 3.2711 5.2378 0.899 1.2711
NCI-H2135 GDSC2 3.2988 5.2658 0.9008 1.2355
HOP-62 GDSC2 3.3015 7.7494 -0.211 7.1783
NCI-H1563 GDSC2 3.3092 5.1821 0.9395 1.0626
CPC-N GDSC2 3.3258 5.5739 0.7865 1.7203
DMS 79 GDSC2 3.3363 5.1724 0.9559 0.9726
NCI-H524 GDSC2 3.34 4.8684 1.0754 0.5386
LCLC-103H GDSC2 3.3456 4.6627 1.1538 0.3108
COR-L23 GDSC2 3.3661 4.7924 1.1145 0.4061
NCI-H720 GDSC2 3.3816 4.6178 1.1835 0.2271
NCI-H2405 GDSC2 3.3973 6.0393 0.6252 2.4137
HCC78 GDSC2 3.4046 5.7145 0.767 1.7204
NCI-H2227 GDSC2 3.4192 5.1651 0.9956 0.7558
KNS-62 GDSC2 3.4543 5.049 1.0548 0.5343
HCC15 GDSC2 3.4555 5.5087 0.8762 1.1883
NCI-H2029 GDSC2 3.4872 5.0374 1.0725 0.4622
SHP-77 GDSC2 3.4931 5.0097 1.0851 0.4233
NCI-H1435 GDSC2 3.4948 5.1727 1.025 0.6039
NCI-H196 GDSC2 3.5247 5.2318 1.0151 0.6171
HARA [Human squamous cell lung carcinoma] GDSC2 3.5268 7.3873 0.098 5.0229
NCI-H1092 GDSC2 3.5405 5.1871 1.0384 0.5339
NCI-H2369 GDSC2 3.5548 4.8734 1.1578 0.222
IA-LM GDSC2 3.5785 4.9447 1.1415 0.2478
Lu-165 GDSC2 3.6036 5.148 1.0781 0.3883
Lu-135 GDSC2 3.6402 5.3127 1.0322 0.4968
A-549 GDSC2 3.6459 5.8203 0.8392 1.1662
NCI-H2722 GDSC2 3.6694 5.6055 0.9338 0.7935
NCI-H2591 GDSC2 3.6826 6.2435 0.6845 1.7891
NCI-H2023 GDSC2 3.6929 5.6977 0.9083 0.8662
NCI-H1793 GDSC2 3.6971 5.2439 1.0797 0.3432
NCI-H810 GDSC2 3.7183 5.0897 1.1422 0.202
Lu-65 GDSC2 3.7343 5.3408 1.0591 0.3781
NCI-H1915 GDSC2 3.7347 5.1791 1.1169 0.2461
NCI-H1048 GDSC2 3.7362 5.4429 1.0226 0.474
DMS 53 GDSC2 3.7434 5.4382 1.0271 0.4578
EMC-BAC-2 GDSC2 3.7551 6.765 0.5017 2.5629
NCI-H1755 GDSC2 3.7611 5.5419 0.996 0.5368
NCI-H526 GDSC2 3.8083 5.2161 1.1309 0.197
NCI-H1693 GDSC2 3.8092 5.7426 0.9406 0.6781
NCI-H1963 GDSC2 3.8164 5.7942 0.9241 0.7271
NCI-H1993 GDSC2 3.8253 5.6366 0.9868 0.5289
NCI-H650 GDSC2 3.8423 5.4234 1.0707 0.3068
NCI-H2170 GDSC2 3.8612 5.4533 1.0672 0.3077
NCI-H358 GDSC2 3.8648 5.6866 0.9841 0.5158
NCI-H522 GDSC2 3.8788 5.6095 1.0179 0.4184
Calu-6 GDSC2 3.8885 5.6757 0.9976 0.4671
NCI-H841 GDSC2 3.8896 5.6616 1.0031 0.4518
DMS 114 GDSC2 3.8946 5.5304 1.0524 0.3284
NCI-H209 GDSC2 3.9045 5.7925 0.9609 0.5612
NCI-H1651 GDSC2 3.9089 5.8717 0.9333 0.6413
VMRC-LCD GDSC2 3.9375 5.701 1.0075 0.4185
NCI-H1666 GDSC2 3.9467 6.2555 0.8025 1.0591
SBC-3 GDSC2 3.9525 5.7414 0.9987 0.4342
NCI-H1694 GDSC2 3.9868 5.4344 1.1198 0.1704
NCI-H727 GDSC2 3.9985 5.5667 1.0782 0.2394
NCI-H2087 GDSC2 4.013 6.3869 0.7805 1.089
NCI-H2818 GDSC2 4.0182 5.9785 0.9379 0.5671
NCI-H1792 GDSC2 4.0642 5.8434 1.0049 0.3717
LOU-NH91 GDSC2 4.067 5.9467 0.9688 0.4592
NCI-H2795 GDSC2 4.0801 6.1205 0.9102 0.6139
LK-2 GDSC2 4.0855 5.682 1.0698 0.2298
NCI-H2461 GDSC2 4.0912 6.1513 0.9033 0.6282
NCI-H2803 GDSC2 4.1003 6.047 0.9453 0.5053
SK-LU-1 GDSC2 4.11 6.053 0.9469 0.4964
Ms-1 GDSC2 4.1156 5.7623 1.0528 0.2526
EBC-1 GDSC2 4.1308 5.954 0.9907 0.3786
NCI-H226 GDSC2 4.1424 5.4683 1.1623 0.0868
Lu-139 GDSC2 4.1475 5.9626 0.994 0.3646
HCC827 GDSC2 4.1506 6.0802 0.9529 0.4622
UMC-11 GDSC2 4.1582 5.6344 1.112 0.1448
NCI-H1581 GDSC2 4.1778 5.9163 1.0217 0.2942
NCI-H250 GDSC2 4.1817 5.962 1.007 0.3234
NCI-H520 GDSC2 4.1907 6.0493 0.9794 0.3813
NCI-H2141 GDSC2 4.206 5.8844 1.0432 0.244
PC-14 GDSC2 4.2184 6.0025 1.0064 0.312
SK-MES-1 GDSC2 4.2475 5.7988 1.0875 0.1613
NCI-H441 GDSC2 4.2604 5.9329 1.0461 0.224
NCI-H2085 GDSC2 4.2681 6.1731 0.9646 0.3853
COR-L105 GDSC2 4.2835 6.6829 0.7829 0.8886
NCI-H1355 GDSC2 4.2837 6.5348 0.8387 0.7126
HCC44 GDSC2 4.2898 6.3136 0.9224 0.4777
NCI-H211 GDSC2 4.2961 6.0711 1.011 0.2779
NCI-H513 GDSC2 4.2995 6.2255 0.9578 0.3888
COLO 668 GDSC2 4.3098 6.5835 0.8312 0.7205
RERF-LC-KJ GDSC2 4.3134 5.9321 1.0653 0.1799
NCI-H2595 GDSC2 4.3334 6.3267 0.9345 0.4298
NCI-H1869 GDSC2 4.34 6.2322 0.9706 0.3456
NCI-H446 GDSC2 4.3476 6.3001 0.9494 0.3895
NCI-H1299 GDSC2 4.3653 6.1576 1.0062 0.2665
NCI-H2810 GDSC2 4.3964 6.8109 0.7815 0.8222
NCI-H1944 GDSC2 4.4233 6.4577 0.9218 0.4235
NCI-H23 GDSC2 4.4371 6.3339 0.9709 0.3126
NCI-H2804 GDSC2 4.4702 6.5019 0.9239 0.4008
NCI-H322M GDSC2 4.4799 6.7468 0.8391 0.6077
SW1573 GDSC2 4.5017 6.772 0.8385 0.5986
NCI-H1623 GDSC2 4.511 6.4526 0.9565 0.3177
EPLC-272H GDSC2 4.5351 7.1863 0.6974 1.0068
A-427 GDSC2 4.5448 6.5191 0.9456 0.3285
NCI-H661 GDSC2 4.5541 6.3813 0.9969 0.2316
NCI-H2869 GDSC2 4.6415 6.8415 0.8676 0.4637
IST-SL2 GDSC2 4.6558 6.8953 0.8538 0.4906
EKVX GDSC2 4.7422 7.4645 0.6786 0.936
LCLC-97TM1 GDSC2 4.784 6.9035 0.899 0.345
ABC-1 GDSC2 4.7991 7.052 0.8522 0.4383
LC-1/sq GDSC2 4.9104 7.2351 0.829 0.4485
RERF-LC-Sq1 GDSC2 4.9589 7.8004 0.6418 0.9214
⏷ Show the Full List of 129 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC2 4.4526 6.5909 0.8852 0.4998
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-1 GDSC2 3.0655 4.7863 0.9851 1.1052
OE19 GDSC2 3.3235 4.6393 1.1537 0.3209
KYSE-180 GDSC2 3.4339 11.3095 -1.8358 15.5305
KYSE-520 GDSC2 3.55 5.6323 0.8703 1.1262
TE-9 GDSC2 3.6367 5.1055 1.1063 0.3046
COLO 680N GDSC2 3.7052 5.3352 1.0498 0.4154
EC-GI-10 GDSC2 3.7116 5.2054 1.099 0.2925
KYSE-450 GDSC2 3.7384 5.0547 1.1615 0.1629
KYSE-70 GDSC2 3.9363 5.5314 1.0677 0.2802
KYSE-270 GDSC2 4.0104 6.3353 0.7994 1.0221
TE-8 GDSC2 4.1131 6.2108 0.89 0.6552
TE-5 GDSC2 4.2408 5.8762 1.0587 0.2077
TE-4 GDSC2 4.4164 6.0031 1.0773 0.1423
KYSE-510 GDSC2 4.4223 5.9728 1.0895 0.1259
OE21 GDSC2 4.4942 6.5844 0.9035 0.4381
KYSE-140 GDSC2 4.5286 6.7319 0.8636 0.5207
KYSE-410 GDSC2 4.59 6.6495 0.9165 0.3736
OE33 GDSC2 4.6377 6.2351 1.0756 0.1087
TE-15 GDSC2 4.685 7.2897 0.7207 0.8398
TE-6 GDSC2 4.78 6.5157 1.0305 0.1377
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
EFO-21 GDSC2 2.356 4.7152 0.6064 4.2796
A2780 GDSC2 2.4542 5.075 0.5004 4.7116
OAW42 GDSC2 2.4601 5.1539 0.4666 4.9026
OVISE GDSC2 2.8163 4.2554 1.0828 0.9335
IGROV-1 GDSC2 3.1832 5.2415 0.8542 1.5686
OVK18 GDSC2 3.1849 5.311 0.8258 1.7004
OV56 GDSC2 3.2473 4.2096 1.2765 0.0976
EFO-27 GDSC2 3.3415 9.4 -0.9732 11.3553
DOV13 GDSC2 3.4495 5.1186 1.0265 0.6282
TOV-21G GDSC2 3.4789 5.2574 0.9858 0.747
OVTOKO GDSC2 3.5777 11.2333 -1.6962 14.535
OVCAR-5 GDSC2 3.6218 5.0565 1.1181 0.2833
ES-2 GDSC2 3.6858 5.1453 1.1106 0.2762
SK-OV-3 GDSC2 3.9349 5.3633 1.1257 0.1733
OAW28 GDSC2 3.9416 6.1369 0.8463 0.9057
OV-90 GDSC2 3.9879 5.6815 1.0338 0.3351
TYK-nu GDSC2 3.9961 5.4977 1.1013 0.1985
OVCAR-3 GDSC2 4.2497 5.8514 1.0703 0.1867
Kuramochi GDSC2 4.4704 6.3127 0.9904 0.2653
OVCAR-4 GDSC2 4.5135 6.7811 0.8398 0.5895
TOV-112D GDSC2 4.5147 6.2712 1.0207 0.2028
OVCAR-8 GDSC2 4.5278 6.4785 0.9536 0.3181
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HPAC GDSC2 2.2768 4.1774 0.81 3.2221
QGP-1 GDSC2 2.3442 3.9929 0.9395 2.3349
YAPC GDSC2 2.439 4.2074 0.8986 2.4004
PaTu 8988t GDSC2 2.6302 4.9951 0.6523 3.468
KP-2 GDSC2 3.2937 4.6714 1.1301 0.3994
MIA PaCa-2 GDSC2 3.3116 5.0424 0.9961 0.8371
Panc 02.03 GDSC2 3.5631 6.723 0.417 3.2479
SUIT-2 GDSC2 3.5977 4.9181 1.158 0.2081
SU.86.86 GDSC2 3.6052 4.8841 1.1725 0.1788
PaTu 8902 GDSC2 3.6837 4.9124 1.1909 0.13
DAN-G GDSC2 3.7331 5.341 1.0585 0.38
PSN1 GDSC2 3.7489 5.3795 1.0507 0.3928
PL4 GDSC2 3.8117 5.5875 0.9995 0.5001
HuP-T3 GDSC2 3.843 5.7175 0.9639 0.5862
KP-4 GDSC2 3.9094 5.4689 1.0797 0.2645
Capan-1 GDSC2 3.9625 5.3981 1.1236 0.1701
KP-1N GDSC2 4.1148 6.2599 0.8724 0.7077
HPAF-II GDSC2 4.2292 6.0993 0.9762 0.3739
HuP-T4 GDSC2 4.2573 6.2473 0.9338 0.4635
Panc 10.05 GDSC2 4.2601 6.384 0.885 0.591
CFPAC-1 GDSC2 4.2677 5.9621 1.0386 0.2351
Capan-2 GDSC2 4.4143 6.3991 0.9394 0.387
Panc 08.13 GDSC2 4.4756 6.5396 0.9124 0.4247
AsPC-1 GDSC2 4.7206 6.9613 0.8548 0.4622
KP-3 GDSC2 4.7419 6.6582 0.9688 0.2313
BxPC-3 GDSC2 4.7705 6.8569 0.9103 0.3271
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC2 3.2079 6.4582 0.3313 4.2702
MPP 89 GDSC2 3.9677 5.5705 1.0656 0.274
IST-Mes1 GDSC2 4.0899 6.0239 0.9496 0.4988
NCI-H2052 GDSC2 4.1513 6.1325 0.9342 0.5107
NCI-H28 GDSC2 4.3435 6.7334 0.7888 0.8315
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VCaP GDSC2 3.8401 5.5096 1.039 0.3823
PC-3 GDSC2 3.9367 7.4693 0.2944 3.3535
22Rv1 GDSC2 4.1723 6.2726 0.891 0.6199
DU145 GDSC2 4.7801 6.683 0.9739 0.2145
LNCaP clone FGC GDSC2 5.2672 7.4781 0.8746 0.2567
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC2 3.8555 5.565 1.0249 0.4108
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
GAK GDSC2 2.3505 4.3717 0.7663 3.3344
Mel JuSo GDSC2 2.4734 3.9786 1.0223 1.6616
UACC-62 GDSC2 2.5213 4.9941 0.5833 4.0794
A2058 GDSC2 2.6178 4.0433 1.0724 1.2061
IGR-37 GDSC2 2.7415 4.1221 1.1014 0.9288
HT-144 GDSC2 2.8401 5.4644 0.5647 3.5928
SK-MEL-2 GDSC2 2.9312 4.9163 0.8623 1.8425
RPMI-7951 GDSC2 3.0311 11.3514 -2.1517 17.95
A101D GDSC2 3.125 4.445 1.1459 0.4473
WT2-iPS GDSC2 3.1762 4.7294 1.0587 0.7101
COLO 829 GDSC2 3.3145 6.0607 0.5711 2.804
SK-MEL-5 GDSC2 3.4005 4.7665 1.1375 0.3276
WM115 GDSC2 3.4519 5.3536 0.9364 0.9505
WM278 GDSC2 3.6117 6.248 0.6474 2.0398
G-361 GDSC2 3.633 5.4389 0.982 0.6557
SK-MEL-24 GDSC2 3.6357 5.8524 0.8217 1.2461
CP66-MEL GDSC2 3.6388 4.8988 1.1796 0.158
UACC-257 GDSC2 3.6455 4.7937 1.2177 0.1007
SH-4 GDSC2 3.6582 5.5593 0.9467 0.7568
WM793 GDSC2 3.8057 5.4631 1.0425 0.3884
M14 GDSC2 3.8068 5.3145 1.096 0.265
WM1552C GDSC2 3.8667 5.6428 1.001 0.4684
G-mel GDSC2 3.9546 5.5832 1.0562 0.2981
WM35 GDSC2 3.9585 5.8402 0.965 0.5216
COLO 679 GDSC2 4.0576 5.7361 1.0406 0.2954
A-375 GDSC2 4.1275 5.6099 1.1096 0.1545
LOX-IMVI GDSC2 4.1651 5.7301 1.0818 0.1885
CHL-1 GDSC2 4.1896 6.1394 0.9466 0.461
IGR-1 GDSC2 4.2415 6.0162 1.0102 0.2968
COLO 792 GDSC2 4.3574 6.5555 0.8607 0.6093
HMV-II GDSC2 4.4739 6.78 0.8245 0.651
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC2 3.1554 4.8989 0.982 1.0306
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW982 GDSC2 2.3738 7.0559 -0.5242 11.0917
SW872 GDSC2 2.4336 6.3348 -0.1252 8.5558
Rh41 GDSC2 2.5181 4.3721 0.8709 2.4206
GCT GDSC2 2.7274 7.8268 -0.6426 10.9159
KYM-1 GDSC2 2.7686 4.6223 0.9024 1.8609
SW684 GDSC2 2.7992 4.6317 0.9149 1.7543
EW-8 GDSC2 2.855 4.7762 0.8822 1.8447
G-401 GDSC2 3.1886 5.9231 0.5616 3.0396
MES-SA GDSC2 3.4495 4.6662 1.1917 0.1884
RKN GDSC2 3.4834 4.7554 1.1729 0.2147
Rh30 GDSC2 3.5209 5.3838 0.9552 0.8257
HT-1080 GDSC2 3.6446 5.241 1.0603 0.416
VA-ES-BJ GDSC2 3.6456 5.2612 1.0533 0.4346
SK-LMS-1 GDSC2 4.233 5.9805 1.0196 0.2808
SK-UT-1 GDSC2 4.3761 6.2129 0.9908 0.2925
A-204 GDSC2 4.5903 6.7222 0.8907 0.4301
RD GDSC2 4.9536 7.038 0.9139 0.2694
G-402 GDSC2 5.0934 7.0848 0.9474 0.1875
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ECC10 GDSC2 2.1896 4.1613 0.7592 3.7096
IM95 GDSC2 2.3029 4.6678 0.5931 4.4736
MKN1 GDSC2 2.852 5.1172 0.7296 2.6547
MKN45 GDSC2 2.8737 3.9705 1.2204 0.3654
Hs 746.T GDSC2 2.9172 4.8381 0.8886 1.729
KATO III GDSC2 2.9181 4.8855 0.8686 1.8282
SNU-5 GDSC2 2.9957 4.4029 1.1066 0.6736
23132/87 GDSC2 3.2721 4.8852 1.0401 0.7053
RERF-GC-1B GDSC2 3.3673 6.3843 0.4575 3.324
OCUM-1 GDSC2 3.4187 5.5302 0.8501 1.3338
GCIY GDSC2 3.7409 6.0989 0.7714 1.3556
NUGC-4 GDSC2 3.9616 5.6895 1.0209 0.3753
NUGC-3 GDSC2 4.0141 5.6416 1.0577 0.2747
HGC-27 GDSC2 4.037 5.6974 1.0466 0.2899
SNU-1 GDSC2 4.2939 6.2111 0.9608 0.3841
AGS GDSC2 4.3107 14.261 -2.6503 17.1745
RF-48 GDSC2 4.3328 6.0678 1.0256 0.2404
NCI-N87 GDSC2 4.4768 6.7411 0.8399 0.6069
MKN28 GDSC2 4.577 6.8172 0.8516 0.5297
SK-GT-2 GDSC2 4.7617 6.7739 0.936 0.2819
SNG-M GDSC2 3.2797 5.1739 0.9291 1.1338
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BHT-101 GDSC2 2.7504 4.8298 0.8001 2.4317
FTC-133 GDSC2 2.8725 4.6659 0.939 1.5375
ASH-3 GDSC2 2.9086 8.3338 -0.7601 11.1584
B-CPAP GDSC2 3.5765 5.2774 1.0194 0.5714
8305C GDSC2 3.5814 5.4714 0.9475 0.8084
CAL-62 GDSC2 3.5894 5.0424 1.1108 0.3128
K5 GDSC2 3.804 5.8852 0.884 0.8719
WRO GDSC2 3.978 5.5838 1.0647 0.2724
TT2609-C02 GDSC2 4.0241 6.1049 0.8932 0.697
IHH-4 GDSC2 4.0414 5.3866 1.1551 0.1102
HTC-C3 GDSC2 4.3474 6.1016 1.0191 0.248
8505C GDSC2 4.3483 6.4959 0.879 0.5639
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UPCI-SCC-090 GDSC2 1.6453 10.9585 -3.0516 25.3627
CAL-33 GDSC2 2.5553 10.7556 -2.2189 19.4588
NCI-H3118 GDSC2 2.6874 5.1106 0.6343 3.4674
HO-1-N-1 GDSC2 2.9737 4.7909 0.938 1.4194
Detroit 562 GDSC2 2.9921 5.3183 0.7195 2.495
HSC-3 GDSC2 3.0308 4.4622 1.0989 0.6745
BB49-HNC GDSC2 3.1277 8.2813 -0.581 9.6509
FaDu GDSC2 3.1611 4.5379 1.1258 0.4888
HSC-2 GDSC2 3.2 4.6596 1.0959 0.5619
HSC-4 GDSC2 3.3333 4.6702 1.1463 0.3356
CAL-27 GDSC2 3.3538 5.1535 0.9713 0.8976
DOK GDSC2 3.5506 5.6822 0.8506 1.2056
SCC-15 GDSC2 3.5664 6.0285 0.7165 1.7711
OSC-20 GDSC2 3.793 5.653 0.9676 0.6038
SCC-4 GDSC2 3.8041 5.4386 1.0507 0.3687
BICR 10 GDSC2 3.8324 5.6177 0.9966 0.4976
BICR 22 GDSC2 3.8663 5.2594 1.1368 0.1719
JHU-022 GDSC2 4.0924 6.6903 0.6965 1.3438
SCC-9 GDSC2 4.1585 5.6871 1.0942 0.1707
PCI-04B GDSC2 4.3168 6.5828 0.8343 0.7073
SAS GDSC2 4.3505 6.1436 1.0056 0.2719
LB771-HNC GDSC2 4.3706 6.3662 0.9345 0.4148
Ca9-22 GDSC2 4.4397 6.3056 0.9817 0.2905
SKN-3 GDSC2 4.7082 6.734 0.9304 0.3075
BICR 78 GDSC2 4.8848 6.7498 0.9879 0.1728
SAT [Human HNSCC] GDSC2 4.9812 7.3832 0.803 0.4802
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW780 GDSC2 2.6789 5.045 0.6593 3.3393
RT-4 GDSC2 2.7725 5.4012 0.5523 3.7837
J82 GDSC2 2.8221 4.9646 0.7808 2.4247
639V GDSC2 2.8313 4.0498 1.172 0.559
HT-1197 GDSC2 2.9336 4.5356 1.0244 1.0688
BFTC-905 GDSC2 3.2305 4.7356 1.0798 0.5957
CAL-29 GDSC2 3.3651 4.7475 1.1306 0.3621
647V GDSC2 3.6391 5.1862 1.0781 0.3721
KU-19-19 GDSC2 3.6627 5.0572 1.1332 0.2367
RT-112 GDSC2 3.6934 5.134 1.1175 0.2588
5637 GDSC2 4.1367 5.7549 1.0631 0.2276
TCCSUP GDSC2 4.4461 6.106 1.0528 0.1698
SW1710 GDSC2 4.6535 6.5114 0.9877 0.2223
⏷ Show the Full List of 13 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PA-1 GDSC2 1.643 3.0146 0.9179 4.0575
HeLa GDSC2 1.9767 3.3561 1.0008 2.7028
NEC8 GDSC2 3.0602 4.5757 1.0674 0.7707
SiHa GDSC2 3.2529 4.4449 1.1965 0.246
MS751 GDSC2 3.2619 5.2348 0.8957 1.2946
C-4-I GDSC2 3.383 5.0798 1.0129 0.7206
OVCA420 GDSC2 3.4236 5.3815 0.9124 1.0693
DoTc2 4510 GDSC2 3.4332 5.3612 0.9249 1.0112
PWR-1E GDSC2 3.4661 5.4807 0.8923 1.1125
LB831-BLC GDSC2 3.6193 5.3718 1.0016 0.6015
HEC-1 GDSC2 3.6689 5.0329 1.1439 0.2134
SW756 GDSC2 3.7425 5.2128 1.1079 0.2621
SKG-IIIa GDSC2 3.7765 5.5441 1.0014 0.5128
HT-3 GDSC2 3.7925 5.8449 0.8945 0.8431
TC-YIK GDSC2 3.8184 5.6132 0.9927 0.5157
HEY GDSC2 4.085 6.0703 0.9307 0.5526
DSH1 GDSC2 4.2775 6.1084 0.9911 0.324
CAL-39 GDSC2 4.3237 6.4291 0.8937 0.5364
SiSo GDSC2 4.3265 6.4407 0.8906 0.5433
BPH-1 GDSC2 4.5013 6.7743 0.8375 0.6015
SKN GDSC2 4.5618 6.3868 0.9978 0.2282
ME-180 GDSC2 4.5868 7.2238 0.7049 0.9488
Ca Ski GDSC2 4.7556 6.9885 0.8584 0.4407
OVMIU GDSC2 4.7965 7.0331 0.8579 0.4265
C-33 A GDSC2 4.8393 6.6384 1.0098 0.153
PEO1 GDSC2 4.8747 6.9037 0.9319 0.2592
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7939).
3 A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells. Cell Cycle. 2014;13(19):3143-9.