Details of the Drug Combinations

General Information of This Drug (ID: DMRFWGK)

Drug Name
Novobiocin   DMRFWGK
Synonyms
Albamix; Albamycin; Cardelmycin; Cathocin; Cathomycin; Inamycin; NOV; Novobiocina; Novobiocine; Novobiocinum; Robiocina; Sirbiocina; Spheromycin; Stilbiocina; Streptonivicin; Crystallinic acid; Novobiocin sodium salt; PA 93; U 6391; Albamycin (TN); Antibiotic PA-93; Novo-R; Novobiocin [INN:BAN]; Novobiocina [INN-Spanish]; Novobiocine [INN-French]; Novobiocinum [INN-Latin]; Streptonivicin (*Sodium salt*); [(3R,4S,5R,6R)-5-hydroxy-6-[2-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-4-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] carbamate; N-[7-[[3-O-(Aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-.beta.-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl); (3R,4S,5R,6R)-5-hydroxy-6-{[4-hydroxy-3-({[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]carbonyl}amino)-8-methyl-2-oxo-2H-chromen-7-yl]oxy}-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate; (3r,4s,5r,6r)-5-hydroxy-6-[(2-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]amino}-8-methyl-4-oxo-4h-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyltetrahydro-2h-pyran-4-yl carbamate(non-preferred name); 7-(3-(O-Carbamoyl)-4-(O-methyl)-5,5-dimethyl-alpha-L-lyxopyranosyloxy)-4-hydroxy-3-(4-hydroxy-3-(3-methyl-2-butenyl)benzamidol)-8-methylcumarin; 7-(Carbamoyltetrahydro-3-hydroxy-5-methoxy-6,6-dimethylpyran-2-yloxy)-4-hydroxy-3-(4-hydroxy-3-(3-methylbut-2-enyl)benzamide)-8-methyl-2H-chromen-2-one
Indication
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [1]
Therapeutic Class
Antibiotics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

49 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Allopurinol + Novobiocin DCV6JHY Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Amodiaquine + Novobiocin DCUNON9 Amodiaquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Anamorelin + Novobiocin DCMCD93 Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aprepitant + Novobiocin DCF886S Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + Novobiocin DC4D01S BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Novobiocin DCQ15RZ Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chloroquine + Novobiocin DCCEDAS Chloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Novobiocin DCKNAHM Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diphenidol + Novobiocin DCDETCS Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + Novobiocin DCTF1CZ Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + Novobiocin DCD8NCJ IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
L-165041 + Novobiocin DCHN7VY L-165041 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + Novobiocin DCCQBRX Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metaxalone + Novobiocin DC01S5R Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methotrexate + Novobiocin DCE3N9R Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methylene blue + Novobiocin DCVX3X0 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + Novobiocin DC9TD3D Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ML323 + Novobiocin DCKWVMM ML323 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Diethylcarbamazine DCUV1XN Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + PMID28460551-Compound-2 DCKKTRK PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Pazopanib HCl DCL38JR Pazopanib HCl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Everolimus DCA1G5P Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Rifampin DCN1OUB Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Docetaxel DC5S6OY Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Dichlorphenamide DCT7L30 Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Procarbazine DCRWJBC Procarbazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Idarubicin DCOE9QH Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Mycophenolic acid DCVW7NE Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Mefloquine DC32WOL Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Lacosamide DC5UQLW Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Doxorubicin DCYVHEL Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Iloprost DCEV4L7 Iloprost Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Zileuton DCZBX68 Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + PMID28870136-Compound-43 DC4Z1MP PMID28870136-Compound-43 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Vorinostat DCOCGB4 Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Novobiocin + Enoxacin DC2E7BR Enoxacin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Oxandrolone + Novobiocin DCTIHNQ Oxandrolone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pazopanib + Novobiocin DCH34NK Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Novobiocin DCI33DT Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PF-02545920 + Novobiocin DCSQ2FP PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Novobiocin DC0HLU6 Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrazinamide + Novobiocin DCLANX8 Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ribavirin-TP + Novobiocin DCWU4DP Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Theophylline + Novobiocin DCX42K4 Theophylline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + Novobiocin DCFP0C5 Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triapine + Novobiocin DCO5ZES Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triflupromazine + Novobiocin DCDEDOL Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trimethobenzamide + Novobiocin DC1OZK8 Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vinblastine + Novobiocin DC5EZ5W Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 49 DrugCom(s)

References

1 How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73.
2 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
3 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976