Details of the Drug Combinations

General Information of This Drug (ID: DMS9503)

Drug Name
Benzylpenicillin   DMS9503
Synonyms
penicillin g; Benzylpenicillinic acid; Free penicillin II; Pencillin G; 61-33-6; Benzylpenicillin G; Bencilpenicilina; Benzylpenicillinum; Benzyl penicillin; Free penicillin G; Dropcillin; Pharmacillin; Gelacillin; Liquacillin; Benzopenicillin; Cilopen; Pradupen; Benzylpenicilline; Specilline G; Cilloral; Cosmopen; Ursopen; Galofak; Free benzylpenicillin; Compocillin G; Phenylacetamidopenicillanic acid; 6-(2-Phenylacetamido)penicillanic acid; Pfizerpen; Benzyl-6-aminopenicillinic acid
Indication
Disease Entry ICD 11 Status REF
Actinomycosis N.A. Approved [1]
Acute otitis media AB00 Approved [2]
Anthrax 1B97 Approved [3]
Bacterial endocarditis N.A. Approved [4]
Botulism 1A11 Approved [5]
Cervicofacial actinomycosis N.A. Approved [6]
Congenital syphilis N.A. Approved [7]
Cutaneous anthrax N.A. Approved [8]
Erysipelas N.A. Approved [9]
Erysipelothrix rhusiopathiae infectious disease N.A. Approved [10]
Gastrointestinal anthrax N.A. Approved [11]
Gonococcal infection of joint N.A. Approved [12]
Inhalational anthrax N.A. Approved [3]
Late latent syphilis N.A. Approved [13]
Latent syphilis N.A. Approved [14]
Latent yaws N.A. Approved [15]
Listeria meningitis N.A. Approved [16]
Lung abscess N.A. Approved [17]
Meningococcal meningitis N.A. Approved [18]
Meningococcemia N.A. Approved [19]
Neonatal sepsis N.A. Approved [20]
Neurosyphilis N.A. Approved [21]
Pasteurella multocida infectious disease N.A. Approved [22]
Pasteurellosis N.A. Approved [23]
Pneumococcal meningitis N.A. Approved [16]
Psoriasis EA90 Approved [24]
Rat-bite fever N.A. Approved [25]
Respiratory tract infection CA45 Approved [26]
Staphylococcus aureus infection N.A. Approved [27]
Streptococcal pneumonia N.A. Approved [28]
Streptococcal toxic-shock syndrome N.A. Approved [29]
Streptococcus infection 1B53 Approved [30]
Syphilis N.A. Approved [31]
Tertiary lesion of yaws N.A. Approved [32]
Yaws N.A. Approved [33]
Bejel N.A. Investigative [34]
Latent early syphilis N.A. Investigative [35]
Secondary syphilis N.A. Investigative [36]
Tertiary syphilis N.A. Investigative [37]
Tetanus 1C13 Investigative [38]
⏷ Show the Full List of Indication(s)
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Gentamicin + Benzylpenicillin DCSWFI2 Gentamicin Malnutrition Severe [39]
Doxycycline + Benzylpenicillin DC3SWUO Doxycycline Early Syphilis [40]
------------------------------------------------------------------------------------

References

1 Abdominal actinomycosis after reparative surgery for cholecystogastric fistula in an immunosuppressed patient. BMJ Case Rep. 2021 Jul 23;14(7):e243445.
2 Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children with acute otitis media in Japan from 2014 to 2017. J Infect Chemother. 2019 Mar;25(3):229-232.
3 Human Anthrax: Update of the Diagnosis and Treatment. Diagnostics (Basel). 2023 Mar 10;13(6):1056.
4 Optimisation of the prevention and treatment of bacterial endocarditis. Drugs Aging. 2001;18(6):415-24.
5 Clinical Serum Therapy: Benefits, Cautions, and Potential Applications. Keio J Med. 2017 Dec 25;66(4):57-64.
6 Cervicofacial actinomycosis: a report of 14 patients observed at the Dermatology Unit of the University of Milan, Italy. Int J Dermatol. 2020 Oct;59(10):1222-1225.
7 Congenital syphilis in a preterm newborn with gastrointestinal disorders and postnatal growth restriction. Ital J Pediatr. 2022 Dec 29;48(1):205.
8 Cutaneous Anthrax. J Emerg Med. 2017 Feb;52(2):240-241.
9 [Streptococcus pyogenes--much more than the aetiological agent of scarlet fever]. Med Monatsschr Pharm. 2009 Nov;32(11):408-16; quiz 417-8.
10 Erysipelothrix rhusiopathiae bloodstream infection - A 22-year experience at Mayo Clinic, Minnesota. Zoonoses Public Health. 2017 Nov;64(7):e65-e72.
11 Inhalational, gastrointestinal, and cutaneous anthrax in children: a systematic review of cases: 1900 to 2005. Arch Pediatr Adolesc Med. 2007 Sep;161(9):896-905.
12 Infectious arthritis. Infect Dis Clin North Am. 1990 Sep;4(3):523-38.
13 Syphilis. Lancet. 2023 Jul 22;402(10398):336-346.
14 Diagnosis, treatment, and notification of syphilis during pregnancy in the state of Gois, Brazil, between 2007 and 2017. Rev Saude Publica. 2021 Oct 29;55:68.
15 Yaws. 2023 Jul 10. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 JanC.
16 Meningitis in adults: diagnosis and management. Intern Med J. 2018 Nov;48(11):1294-1307.
17 Spontaneous Clostridium perfringens lung abscess unresponsive to penicillin. Anaesth Intensive Care. 1993 Feb;21(1):117-9.
18 Meningococcal meningitis and diabetes insipidus. Scand J Infect Dis. 1988;20(3):341-3.
19 [An unusual cause of fever: chronic meningococcemia]. Ned Tijdschr Geneeskd. 1996 Apr 6;140(14):785-7.
20 Antibiotic regimens for early-onset neonatal sepsis. Cochrane Database Syst Rev. 2021 May 17;5(5):CD013837.
21 Ceftriaxone compared with benzylpenicillin in the treatment of neurosyphilis in France: a retrospective multicentre study. Lancet Infect Dis. 2021 Oct;21(10):1441-1447.
22 Pasteurella multocida pneumonia. Semin Respir Infect. 1997 Mar;12(1):54-6.
23 Pasteurella Multocida. 2023 May 16. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 JanC.
24 A review of antibiotics and psoriasis: induction, exacerbation, and amelioration. Expert Rev Clin Pharmacol. 2019 Oct;12(10):981-989.
25 Rat-Bite Fever. 2023 Mar 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 JanC.
26 Benzylpenicillin versus wide-spectrum beta-lactam antibiotics as empirical treatment of Haemophilus influenzae-associated lower respiratory tract infections in adults; a retrospective propensity score-matched study. Eur J Clin Microbiol Infect Dis. 2018 Sep;37(9):1761-1775.
27 In vivo synergy between 6 beta-amidinopenicillanic acid derivatives and other antibiotics. Antimicrob Agents Chemother. 1976 Apr;9(4):589-94.
28 Pathogenesis, treatment, and prevention of pneumococcal pneumonia. Lancet. 2009 Oct 31;374(9700):1543-56.
29 [Beta-hemolytic streptococcal bacteremia in adults]. Duodecim. 2013;129(14):1477-84.
30 Prevalence and treatment of group B streptococcus colonization based on risk factors versus intrapartum culture screening. Eur J Obstet Gynecol Reprod Biol. 2019 Sep;240:178-181.
31 Diagnosis and treatment of syphilis in pregnant women at the services of Primary Care. Cien Saude Colet. 2022 Aug;27(8):3331-3340.
32 A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
33 Yaws Osteoperiostitis Treated with Single-Dose Azithromycin. Am J Trop Med Hyg. 2017 May;96(5):1039-1041.
34 2020 European guideline on the management of syphilis. J Eur Acad Dermatol Venereol. 2021 Mar;35(3):574-588.
35 Syphilis. Enferm Infecc Microbiol Clin (Engl Ed). 2019 Jun-Jul;37(6):398-404.
36 Secondary Syphilis. Clin Pract Cases Emerg Med. 2020 Nov;4(4):675-676.
37 A rare case of tertiary syphilis spondylodiscitis of the upper cervical spine: Diagnostic and therapeutic complexity, review of literature. Orthop Rev (Pavia). 2020 Jun 25;12(Suppl 1):8675.
38 Benzathine penicillin, metronidazole and benzyl penicillin in the treatment of tetanus: a randomized, controlled trial. Ann Trop Med Parasitol. 2004 Jan;98(1):59-63.
39 ClinicalTrials.gov (NCT03174236) First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition
40 ClinicalTrials.gov (NCT05980871) Treatment Responses of Early Syphilis to Ceftriaxone Plus Doxycycline