Details of the Drug Combinations

General Information of This Drug (ID: DMUAZWG)

Drug Name

Leucovorin DMUAZWG

Synonyms

5-formyltetrahydrofolate; Citrovorum factor; Folinic acid

Indication

Disease Entry	ICD 11	Status	REF
Colon adenocarcinoma	N.A.	Approved	[1]
Pervasive developmental disorder	6A00-6A0Z	Approved	[1]
Rectal adenocarcinoma	2B92	Approved	[1]
Rectum mucinous adenocarcinoma	N.A.	Approved	[1]
Colon cancer	2B90.Z	Investigative	[1]
Colon mucinous adenocarcinoma	N.A.	Investigative	[1]
Megaloblastic anemia	N.A.	Investigative	[1]
Methotrexate toxicity	N.A.	Investigative	[1]
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Therapeutic Class

Vitamins

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

11 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Arfolitixorin + Leucovorin	DCHX15Z	Arfolitixorin	Osteosarcoma	[2]
Leucovorin + UFT	DCBBS20	UFT	Colorectal Cancer	[3]
Leucovorin + Dasatinib	DCMZ23K	Dasatinib	Pancreatic Cancer Metastatic	[4]
Methotrexate + Leucovorin	DCF4EMZ	Methotrexate	Brain Tumor	[5]
Methotrexate + Leucovorin	DCZI61X	Methotrexate	Rheumatoid Arthritis	[6]
Pyrimethamine + Leucovorin	DC9DZ77	Pyrimethamine	Gangliosidoses, GM2	[7]
Pyrimethamine + Leucovorin	DC8AF7L	Pyrimethamine	Toxoplasmosis	[8]
Tivantinib + Leucovorin	DCZJJKW	Tivantinib	Malignant Solid Tumour	[9]
Capecitabine + Leucovorin	DCLU65L	Capecitabine	Liver Metastases	[10]
Losartan + Leucovorin	DC4IQ3M	Losartan	Pancreatic Cancer	[11]
Methotrexate + Leucovorin	DCKS8UJ	Methotrexate	Osteosarcoma	[12]
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1 Approved Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Leucovorin + Fluorouracil	DCZGWGK	Fluorouracil	Colon cancer	[13]
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References

1	Leucovorin FDA Label
2	ClinicalTrials.gov (NCT01987102) Investigation of [6R] 5,10-methylenetetrahydrofolate (Arfolitixorin) as Rescue Therapy for Osteosarcoma Patients Treated With HDMTX.
3	ClinicalTrials.gov (NCT00209742) Randomized Phase III Adjuvant Study for Stage III Colorectal Cancer
4	ClinicalTrials.gov (NCT01652976) Phase II Study of 5-FU, Oxaliplatin Plus Dasatinib in Metastatic Pancreatic Adenocarcinoma
5	ClinicalTrials.gov (NCT01737671) Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study
6	ClinicalTrials.gov (NCT03131973) Effects of Concomitant Administration of BMS-986195 on Methotrexate, Caffeine, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin
7	ClinicalTrials.gov (NCT01102686) Pyrimethamine as a Treatment for Late-Onset GM2-gangliosidosis (Tay-Sachs and Sandhoff Disease)
8	ClinicalTrials.gov (NCT03258762) Phase I Study of Pyrimethamine in Healthy Japanese and Caucasian Subjects
9	ClinicalTrials.gov (NCT01611857) Phase I/II Trial of Tivantinib With FOLFOX for the Treatment of Advanced Solid Tumors and Previously Untreated Metastatic Adenocarcinoma of the Distal Esophagus, Gastroesophageal Junction or Stomach
10	ClinicalTrials.gov (NCT05062317) ctDNA-Directed Post-Hepatectomy Chemotherapy for Patients With Resectable Colorectal Liver Metastases
11	ClinicalTrials.gov (NCT01821729) Proton w/FOLFIRINOX-Losartan for Pancreatic Cancer
12	ClinicalTrials.gov (NCT02022358) Will Glucarpidase After Methotrexate Treatment for Bone Sarcoma Lead to Fewer Side Effects and Reduce Chemotherapy Delays?
13	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.