Details of the Drug Combinations

General Information of This Drug (ID: DMV74ZH)

Drug Name
Pizotyline   DMV74ZH
Synonyms
Pizotifen; PIZOTYLINE; 15574-96-6; Sandomigran; Litec; Sandomygran; Pizotifenum; Pizotifeno; Polomigran; Pizotifene; BC-105; BC 105; Pizotyline [USAN]; Pizotifan; Pizotifene [INN-French]; Pizotifenum [INN-Latin]; Pizotifeno [INN-Spanish]; UNII-0BY8440V3N; EINECS 239-632-9; BRN 0753534; C19H21NS; CHEBI:50212; FIADGNVRKBPQEU-UHFFFAOYSA-N; Pizotifen (INN); Pizotifen [INN]; 0BY8440V3N; Pizotyline (USAN); 4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidine
Indication
Disease Entry ICD 11 Status REF
Headache 8A80-8A84 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

64 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acitretin + Pizotyline DCU2XGQ Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Armodafinil + Pizotyline DC6FHKI Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Artemisinin + Pizotyline DCPXGAW Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Pizotyline DCAG96U Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + Pizotyline DCMAXIZ BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + Pizotyline DC5BTSJ Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Pizotyline DCSEDR2 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorzoxazone + Pizotyline DCXHWEO Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cisatracurium + Pizotyline DCBFOE1 Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Pizotyline DCM8DND Crotamiton Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Pizotyline DCMPL2E Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diethylcarbamazine + Pizotyline DCNJ59L Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dihydroergotamine + Pizotyline DC4KNO3 Dihydroergotamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Pizotyline DCOMXOH Ethambutol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Etonogestrel + Pizotyline DC9C034 Etonogestrel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fomepizole + Pizotyline DCZH6VH Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Hydralazine + Pizotyline DCPPXJ3 Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Iloprost + Pizotyline DCXQ6S2 Iloprost Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + Pizotyline DCY3ZNI Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + Pizotyline DCMTMTX JZL195 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + Pizotyline DCEFZR0 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mebendazole + Pizotyline DCTUHPI Mebendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mebutamate + Pizotyline DCAB56T Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mephenytoin + Pizotyline DCGVSG1 Mephenytoin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + Pizotyline DC8T92I Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Paromomycin + Pizotyline DC9R57Y Paromomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pentamidine + Pizotyline DCH9110 Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Pizotyline DCZO0BU Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Aprepitant DCFT33A Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Gefitinib DC2DB9G Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Epinephrine DCGFI6O Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Panobinostat DCK0WZ5 Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Pizotyline + Pazopanib HCl DC9JJFC Pazopanib HCl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Ezetimibe DCP8EEK Ezetimibe Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Triapine DCA1TZA Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Diltiazem DCF75CD Diltiazem DD2 (Cell Line: DD2) [2]
Pizotyline + Terameprocol DC1Q1Z2 Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Itraconazole DCU5ANF Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Diphenidol DCY8FHG Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Diazoxide DCUOHD9 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Idarubicin DCEWGQ1 Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + BRL-15572 DC0N8UC BRL-15572 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Methylene blue DC2KMKW Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Tropisetron DCOXFG2 Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Dopamine DC3K9EY Dopamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Leflunomide DCIBB8Z Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Brincidofovir DCWVHAK Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Asenapine DC3BPF6 Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Mycophenolic acid DCY1Y1V Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Mefloquine DCXSAH9 Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Lacosamide DCX0WN4 Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Doxorubicin DCBBQDG Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Zileuton DCVASWS Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Testolactone DCXK2NA Testolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Aciclovir DCM02BB Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PMID28460551-Compound-2 + Pizotyline DC3993A PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Quinine + Pizotyline DCRFC2A Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Pizotyline DCL3RIL Tacrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Theophylline + Pizotyline DCXA7WZ Theophylline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tolazoline + Pizotyline DCKWIDF Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triflupromazine + Pizotyline DCUXIUT Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trihexyphenidyl + Pizotyline DCJ3BSR Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vorinostat + Pizotyline DCE33CL Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Pizotyline DC079OF WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 64 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 93).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.