Details of the Drug Combinations

General Information of This Drug (ID: DMVGPMX)

Drug Name
Fosfomycin   DMVGPMX
Synonyms
FCM; Phosphomycin; Phosphonemycin; Phosphonomycin; Priomicina; Veramina; Disodium fosfomycin; Disodium phosphonomycin; Fosfocina disodium salt; Fosfomycin disodium; Fosfomycin disodium salt; Fosfomycin sodium; Fosfomycin sodium salt; Fosmicin S; Phosphomycin disodium salt; Phosphonomycin disodium salt; Phosphonomycin sodium; Sodium fosfomycin; MK 955; FOM-Na; Fosfomycin sodium (JP15); Fosmicin S (TN); Fosfomycin (USAN/INN); L-cis-1,2-epoxypropylphosphonic acid; Disodium (1R,2S)-(1,2-epoxypropyl)phosphonate; Disodium[(2r,3s)-3-methyloxiran-2-yl]phosphonate; [(2R,3S)-3-methyloxiran-2-yl]phosphonic acid; Phosphonic acid, (3-methyloxiranyl)-, disodium salt, (2R-cis)-(9CI); (-)-(1R,2S)-(1,2-Epoxypropyl)phosphonicacid; (1R,2S)(-)-(1,2-Epoxypropyl)phosphonic acid disodium salt; (1R,2S)-(1,2-Epoxypropyl)phosphonic acid; (1R,2S)-epoxypropylphosphonate; (1R,2S)-epoxypropylphosphonic acid; (2R-cis)-(3-Methyloxiranyl)phosphonic acid disodium salt
Indication
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [1]
Urinary tract infection GC08 Approved [2]
Therapeutic Class
Antibiotics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

52 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Fosfomycin DCZHCJ7 Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acitretin + Fosfomycin DC8P1GH Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Brincidofovir + Fosfomycin DCLX9DC Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
BRL-15572 + Fosfomycin DCARU5J BRL-15572 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cerivastatin + Fosfomycin DCXBTNO Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chlorzoxazone + Fosfomycin DCW4LBD Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Clascoterone + Fosfomycin DCZHCTG Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cytarabine + Fosfomycin DCWP8IE Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Everolimus + Fosfomycin DCFDJQF Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Ribavirin-TP DCRQLOA Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Mebutamate DCPMC1I Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Primidone DC6QSHV Primidone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Gefitinib DCB6IFU Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Dantrolene DCCQ2HR Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Tacrine DC08NRC Tacrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + IT-141 DCS6SZL IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Pamidronate DCWK2ON Pamidronate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Metyrosine DC6UY0V Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Amodiaquine DC1SXBX Amodiaquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Docetaxel DCDIM8O Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Galantamine DC5B0RS Galantamine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Phensuximide DCXCTHH Phensuximide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Ciprofibrate DCVWXWU Ciprofibrate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + BIO-300 DCC7SUE BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Trazodone DCHUWH3 Trazodone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Abacavir DCH2524 Abacavir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Brincidofovir DCJJJFT Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Hyodeoxycholic acid DCB5VTY Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Quinine DC055AY Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Pomalidomide DCTQ8AF Pomalidomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Mycophenolic acid DCIPZBF Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Mefloquine DCNBG49 Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Auranofin DCY18O7 Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Estramustine DCLFMP2 Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Busulfan DCB7O9U Busulfan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fosfomycin + Hydroxychloroquine DCLDLW2 Hydroxychloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imatinib + Fosfomycin DCHXBH5 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Kanamycin + Fosfomycin DCU6ESN Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
L-165041 + Fosfomycin DC44ZMS L-165041 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Levamisole + Fosfomycin DCIRC78 Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mebendazole + Fosfomycin DCF963V Mebendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methylene blue + Fosfomycin DCFBXQO Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
PF-02545920 + Fosfomycin DC19H4W PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Phenprocoumon + Fosfomycin DCVOJ8B Phenprocoumon Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Silver sulfadiazine + Fosfomycin DCE85MQ Silver sulfadiazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Fosfomycin DCKO85P Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Terameprocol + Fosfomycin DCBDHM5 Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Terazosin + Fosfomycin DCATVRH Terazosin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triapine + Fosfomycin DCSAXX3 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Fosfomycin DC0ET92 Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Vinblastine + Fosfomycin DC376GF Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zileuton + Fosfomycin DC3D80F Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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⏷ Show the Full List of 52 DrugCom(s)
1 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Daptomycin + Fosfomycin DCZEPZT Daptomycin Staph Aureus Methicillin Resistant Bacteremia [5]
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References

1 Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
2 Fosfomycin FDA Label
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5 ClinicalTrials.gov (NCT01898338) Efficacy of Daptomycin Plus Fosfomycin Versus Daptomycin for Treatment of MRSA Bacteremia