Details of the Drug Combinations

General Information of This Drug (ID: DMVOY6B)

Drug Name

AMD-070 DMVOY6B

Synonyms

AMD 070; AMD070; AMD11070; S14-0353; N-(1H-benzoimidazol-2-ylmethyl)-N-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine; N'-(1H-Benzo[d]imidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine Trihydrobromide Dihydrate

Indication

Disease Entry	ICD 11	Status	REF
Whim syndrome	4A00.Y	Phase 3	[1]
Human immunodeficiency virus infection	1C62	Phase 1/2	[2]
Melanoma	2C30	Phase 1/2	[3]
Merkel cell carcinoma	2C34	Phase 1/2	[3]
Renal cell carcinoma	2C90	Phase 1/2	[3]
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[3]
------------------------------------------------------------------------------------


⏷ Show the Full List of Indication(s)

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ritonavir + AMD-070	DCKPDCJ	Ritonavir	HIV Infections	[4]
------------------------------------------------------------------------------------

References

1	ClinicalTrials.gov (NCT03995108) Efficacy and Safety Study of Mavorixafor in Participants With Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome. U.S. National Institutes of Health.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8580).
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	ClinicalTrials.gov (NCT00063804) Safety of AMD070 When Administered Alone or Boosted With Low-Dose Ritonavir in HIV Uninfected Men