Details of the Drug Combinations

General Information of This Drug (ID: DMX6RTG)

• Drug Name: Trospium (DMX6RTG)
• Synonyms: Spasmex; Spasmoplex; Trosec; Regurin (TN); Sanctura (TN); Spasmex (TN); Spasmoplex (TN); Trosec (TN); Trospium chloride (JAN/USAN/INN); Spiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium), 3-hydroxy-, chloride, benzilate; Spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl 2-hydroxy-2,2-diphenylacetate; Spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl 2-hydroxy-2,2-diphenylacetate chloride; 3-Hydroxyspiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium) chloride benzilate; 6,10-Ethano-5-azoniaspiro(4.5)decan-8-ol, chloride, benzilate; 8-Benziloyloxy-6,10-ethano-5-azoniaspiro(4.5)decane chloride

Indication

Overactive bladder; ICD 11: GC50.0; Status: Approved [1]; Spasm; ICD 11: MB47.3; Status: Approved [1]; Neurogenic detrusor overactivity; ICD 11: GC01; Status: Phase 1 [2]; Priapism; ICD 11: N.A.; Status: Investigative [3]

• Therapeutic Class: Parasympatholytics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Xanomeline tartrate + Trospium	DCYFGJT	Xanomeline tartrate	Schizophrenia	[4]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7480).
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Trospium FDA Label
• [4] ClinicalTrials.gov (NCT02831231) Pilot Study Comparing Effects of Xanomeline Alone to Xanomeline Plus Trospium