Details of the Drug

General Information of Drug (ID: DMX6RTG)

• Drug Name: Trospium
• Synonyms: Spasmex; Spasmoplex; Trosec; Regurin (TN); Sanctura (TN); Spasmex (TN); Spasmoplex (TN); Trosec (TN); Trospium chloride (JAN/USAN/INN); Spiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium), 3-hydroxy-, chloride, benzilate; Spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl 2-hydroxy-2,2-diphenylacetate; Spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl 2-hydroxy-2,2-diphenylacetate chloride; 3-Hydroxyspiro(8-azoniabicyclo(3.2.1)octane-8,1'-pyrrolidinium) chloride benzilate; 6,10-Ethano-5-azoniaspiro(4.5)decan-8-ol, chloride, benzilate; 8-Benziloyloxy-6,10-ethano-5-azoniaspiro(4.5)decane chloride

Indication

Disease Entry	ICD 11	Status	REF
Overactive bladder	GC50.0	Approved	[1]
Spasm	MB47.3	Approved	[1]
Neurogenic detrusor overactivity	GC01	Phase 1	[2]
Priapism	N.A.	Investigative	[3]

• Therapeutic Class: Parasympatholytics
• Affected Organisms: Humans and other mammals
• ATC Code:
  G04BD09: Trospium
  G04BD: Drugs for urinary frequency and incontinence
  G04B: UROLOGICALS
  G04: UROLOGICALS
  G: GENITO URINARY SYSTEM AND SEX HORMONES
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 392.5
  Logarithm of the Partition Coefficient (xlogp); 4.4
  Rotatable Bond Count (rotbonds); 5
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 3
• ADMET Property:
  Absorption: The absorption of drug is 9.60% []
  Clearance: The renal clearance of drug is 29.07 L/h []
  Half-life: The concentration or amount of drug in body reduced by one-half in 20 hours [4]
  Metabolism: The drug is not metabolised []
  Vd: The volume of distribution (Vd) of drug is 395 +/- 140 L []
• Chemical Identifiers:
  Formula: C25H30NO3+
  IUPAC Name: [(1R,5S)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl] 2-hydroxy-2,2-diphenylacetate
  Canonical SMILES: C1CC[N+]2(C1)[C@@H]3CC[C@H]2CC(C3)OC(=O)C(C4=CC=CC=C4)(C5=CC=CC=C5)O
  InChI: InChI=1S/C25H30NO3/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26/h1-6,9-12,21-23,28H,7-8,13-18H2/q+1/t21-,22+,23?
  InChIKey: OYYDSUSKLWTMMQ-AIZNXBIQSA-N
• Cross-matching ID:
  PubChem CID: 5284632
  ChEBI ID: CHEBI:145791
  CAS Number: 47608-32-2
  UNII: T4Y8ORK057
  DrugBank ID: DB00209
  TTD ID: D05TIB
  ACDINA ID: D00710
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M5 (CHRM5)	TTH18TF	ACM5_HUMAN	Antagonist	[5]

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Trospium (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Bethanechol	DMCLHO0	Moderate	Antagonize the effect of Trospium when combined with Bethanechol.	Abnormal micturition [MF50]	[6]
Oliceridine	DM6MDCF	Moderate	Additive CNS depression effects by the combination of Trospium and Oliceridine.	Acute pain [MG31]	[7]
Scopolamine	DMOM8AL	Moderate	Additive anticholinergic effects by the combination of Trospium and Scopolamine.	Addictive disorder [6C50-6C5Z]	[8]
Mepyramine	DMB4SFH	Moderate	Additive anticholinergic effects by the combination of Trospium and Mepyramine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[9]
Phenyltoloxamine	DMKAEQW	Moderate	Additive anticholinergic effects by the combination of Trospium and Phenyltoloxamine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[9]
Tripelennamine	DMZBU15	Moderate	Additive anticholinergic effects by the combination of Trospium and Tripelennamine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[8]
Tacrine	DM51FY6	Moderate	Antagonize the effect of Trospium when combined with Tacrine.	Alzheimer disease [8A20]	[10]
Memantine	DMD9WSC	Moderate	Additive anticholinergic effects by the combination of Trospium and Memantine.	Alzheimer disease [8A20]	[8]
Galantamine	DMEO794	Moderate	Antagonize the effect of Trospium when combined with Galantamine.	Alzheimer disease [8A20]	[10]
Rivastigmine	DMG629M	Moderate	Antagonize the effect of Trospium when combined with Rivastigmine.	Alzheimer disease [8A20]	[10]
Donepezil	DMIYG7Z	Moderate	Antagonize the effect of Trospium when combined with Donepezil.	Alzheimer disease [8A20]	[10]
Hydroxyzine	DMF8Y74	Moderate	Additive anticholinergic effects by the combination of Trospium and Hydroxyzine.	Anxiety disorder [6B00-6B0Z]	[8]
Promazine	DMZAL7W	Moderate	Additive anticholinergic effects by the combination of Trospium and Promazine.	Appearance/behaviour symptom [MB23]	[8]
Desipramine	DMT2FDC	Moderate	Additive anticholinergic effects by the combination of Trospium and Desipramine.	Attention deficit hyperactivity disorder [6A05]	[8]
Cariprazine	DMJYDVK	Moderate	Additive anticholinergic effects by the combination of Trospium and Cariprazine.	Bipolar disorder [6A60]	[8]
Loperamide	DMOJZQ9	Moderate	Additive antimotility effects by the combination of Trospium and Loperamide.	Bowel habit change [ME05]	[11]
Sotalol	DML60TN	Moderate	Additive CNS depression effects by the combination of Trospium and Sotalol.	Cardiac arrhythmia [BC9Z]	[12]
Acetylcholine	DMDF79Z	Moderate	Antagonize the effect of Trospium when combined with Acetylcholine.	Cataract [9B10]	[13]
Umeclidinium	DM4E8O9	Moderate	Additive anticholinergic effects by the combination of Trospium and Umeclidinium.	Chronic obstructive pulmonary disease [CA22]	[14]
Tiotropium	DMFDC0Q	Moderate	Additive anticholinergic effects by the combination of Trospium and Tiotropium.	Chronic obstructive pulmonary disease [CA22]	[14]
Ipratropium	DMFQ320	Moderate	Additive anticholinergic effects by the combination of Trospium and Ipratropium.	Chronic obstructive pulmonary disease [CA22]	[14]
Revefenacin	DMMP5SI	Moderate	Additive anticholinergic effects by the combination of Trospium and Revefenacin.	Chronic obstructive pulmonary disease [CA22]	[14]
Dihydrocodeine	DMB0FWL	Moderate	Additive CNS depression effects by the combination of Trospium and Dihydrocodeine.	Chronic pain [MG30]	[15]
Morphine	DMRMS0L	Moderate	Additive CNS depression effects by the combination of Trospium and Morphine.	Chronic pain [MG30]	[7]
Alfentanil	DMVO0UB	Moderate	Additive antimotility effects by the combination of Trospium and Alfentanil.	Corneal disease [9A76-9A78]	[7]
Remifentanil	DMZTXCH	Moderate	Additive CNS depression effects by the combination of Trospium and Remifentanil.	Corneal disease [9A76-9A78]	[16]
Arbutamine	DMCY8AF	Moderate	Increased risk of rapid heart rate by the combination of Trospium and Arbutamine.	Coronary atherosclerosis [BA80]	[17]
Methadone	DMTW6IU	Moderate	Additive CNS depression effects by the combination of Trospium and Methadone.	Cough [MD12]	[16]
Ethanol	DMDRQZU	Moderate	Additive CNS depression effects by the combination of Trospium and Ethanol.	Cystitis [GC00]	[18]
Trimipramine	DM1SC8M	Moderate	Additive anticholinergic effects by the combination of Trospium and Trimipramine.	Depression [6A70-6A7Z]	[8]
Cyclobenzaprine	DM1YBRM	Moderate	Additive anticholinergic effects by the combination of Trospium and Cyclobenzaprine.	Depression [6A70-6A7Z]	[8]
Imipramine	DM2NUH3	Moderate	Additive anticholinergic effects by the combination of Trospium and Imipramine.	Depression [6A70-6A7Z]	[8]
Nortriptyline	DM4KDYJ	Moderate	Additive anticholinergic effects by the combination of Trospium and Nortriptyline.	Depression [6A70-6A7Z]	[8]
OPC-34712	DMHG57U	Moderate	Additive anticholinergic effects by the combination of Trospium and OPC-34712.	Depression [6A70-6A7Z]	[8]
Clomipramine	DMINRKW	Moderate	Additive anticholinergic effects by the combination of Trospium and Clomipramine.	Depression [6A70-6A7Z]	[8]
Amitriptyline	DMK7F9S	Moderate	Additive anticholinergic effects by the combination of Trospium and Amitriptyline.	Depression [6A70-6A7Z]	[8]
Amoxapine	DMKITQE	Moderate	Additive anticholinergic effects by the combination of Trospium and Amoxapine.	Depression [6A70-6A7Z]	[8]
Protriptyline	DMNHTZI	Moderate	Additive anticholinergic effects by the combination of Trospium and Protriptyline.	Depression [6A70-6A7Z]	[8]
Doxepin	DMPI98T	Moderate	Additive anticholinergic effects by the combination of Trospium and Doxepin.	Depression [6A70-6A7Z]	[8]
Maprotiline	DMPWB7T	Moderate	Additive anticholinergic effects by the combination of Trospium and Maprotiline.	Depression [6A70-6A7Z]	[8]
Nitroglycerin	DMQ2491	Minor	Decreased dissolution of Trospium taken sublingually caused by Nitroglycerin.	Diabetic foot ulcer [BD54]	[19]
Hyoscyamine	DM804UR	Moderate	Additive anticholinergic effects by the combination of Trospium and Hyoscyamine.	Digestive system disease [DE2Z]	[8]
Mepenzolate	DM8YU2F	Moderate	Additive anticholinergic effects by the combination of Trospium and Mepenzolate.	Digestive system disease [DE2Z]	[8]
Oxybutynine	DMJPBAX	Moderate	Additive anticholinergic effects by the combination of Trospium and Oxybutynine.	Discovery agent [N.A.]	[8]
Meclizine	DMS7T13	Moderate	Additive anticholinergic effects by the combination of Trospium and Meclizine.	Dizziness and giddiness [MB48]	[8]
Trihexyphenidyl	DMB19L8	Moderate	Additive anticholinergic effects by the combination of Trospium and Trihexyphenidyl.	Dystonic disorder [8A02]	[8]
Zonisamide	DM0DTF7	Major	Additive CNS depression effects by the combination of Trospium and Zonisamide.	Epilepsy/seizure [8A61-8A6Z]	[20]
Diphenhydramine	DMKQTBA	Moderate	Additive anticholinergic effects by the combination of Trospium and Diphenhydramine.	Episodic vestibular syndrome [AB31]	[8]
Timolol	DM3NXRU	Moderate	Altered absorption of Trospium due to GI dynamics variation caused by Timolol.	Essential hypertension [BA00]	[12]
Bendroflumethiazide	DM7EVLC	Minor	Altered absorption of Trospium due to GI dynamics variation caused by Bendroflumethiazide.	Essential hypertension [BA00]	[21]
Benzthiazide	DMQWZ0H	Minor	Altered absorption of Trospium due to GI dynamics variation caused by Benzthiazide.	Essential hypertension [BA00]	[21]
Nadolol	DMW6GVL	Moderate	Antagonize the effect of Trospium when combined with Nadolol.	Essential hypertension [BA00]	[12]
Tolterodine	DMSHPW8	Moderate	Additive anticholinergic effects by the combination of Trospium and Tolterodine.	Functional bladder disorder [GC50]	[8]
Darifenacin	DMWXLYZ	Moderate	Additive anticholinergic effects by the combination of Trospium and Darifenacin.	Functional bladder disorder [GC50]	[8]
Ketoconazole	DMPZI3Q	Moderate	Decreased absorption of Trospium due to altered gastric pH caused by Ketoconazole.	Fungal infection [1F29-1F2F]	[22]
Propantheline	DM2EN6G	Moderate	Additive anticholinergic effects by the combination of Trospium and Propantheline.	Gastric ulcer [DA60]	[8]
Isoflurophate	DMBSK7X	Moderate	Antagonize the effect of Trospium when combined with Isoflurophate.	Glaucoma [9C61]	[13]
Carteolol	DMFMDOB	Moderate	Antagonize the effect of Trospium when combined with Carteolol.	Glaucoma [9C61]	[12]
Pilocarpine	DMV9ADG	Moderate	Antagonize the effect of Trospium when combined with Pilocarpine.	Glaucoma [9C61]	[6]
Carvedilol	DMHTEAO	Moderate	Antagonize the effect of Trospium when combined with Carvedilol.	Heart failure [BD10-BD1Z]	[12]
Chlorothiazide	DMLHESP	Minor	Altered absorption of Trospium due to GI dynamics variation caused by Chlorothiazide.	Heart failure [BD10-BD1Z]	[21]
Hydroflumethiazide	DMVPUQI	Minor	Altered absorption of Trospium due to GI dynamics variation caused by Hydroflumethiazide.	Heart failure [BD10-BD1Z]	[21]
Acebutolol	DM0TI4U	Moderate	Antagonize the effect of Trospium when combined with Acebutolol.	Hypertension [BA00-BA04]	[12]
Bisoprolol	DM3UZ95	Moderate	Antagonize the effect of Trospium when combined with Bisoprolol.	Hypertension [BA00-BA04]	[12]
Penbutolol	DM4ES8F	Moderate	Additive CNS depression effects by the combination of Trospium and Penbutolol.	Hypertension [BA00-BA04]	[12]
Nebivolol	DM7F1PA	Moderate	Antagonize the effect of Trospium when combined with Nebivolol.	Hypertension [BA00-BA04]	[12]
Pindolol	DMD2NV7	Moderate	Antagonize the effect of Trospium when combined with Pindolol.	Hypertension [BA00-BA04]	[12]
Indapamide	DMGN1PW	Minor	Altered absorption of Trospium due to GI dynamics variation caused by Indapamide.	Hypertension [BA00-BA04]	[21]
Trichlormethiazide	DMHAQCO	Minor	Altered absorption of Trospium due to GI dynamics variation caused by Trichlormethiazide.	Hypertension [BA00-BA04]	[21]
Labetalol	DMK8U72	Moderate	Antagonize the effect of Trospium when combined with Labetalol.	Hypertension [BA00-BA04]	[12]
Atenolol	DMNKG1Z	Moderate	Antagonize the effect of Trospium when combined with Atenolol.	Hypertension [BA00-BA04]	[12]
Metoprolol	DMOJ0V6	Moderate	Antagonize the effect of Trospium when combined with Metoprolol.	Hypertension [BA00-BA04]	[12]
Hydrochlorothiazide	DMUSZHD	Minor	Altered absorption of Trospium due to GI dynamics variation caused by Hydrochlorothiazide.	Hypertension [BA00-BA04]	[21]
Potassium chloride	DMMTAJC	Major	Increased risk of GI mucosal injury/bleeding risk by the combination of Trospium and Potassium chloride.	Hypo-kalaemia [5C77]	[23]
Belladonna	DM2RBWK	Moderate	Additive anticholinergic effects by the combination of Trospium and Belladonna.	Infectious gastroenteritis/colitis [1A40]	[8]
Amantadine	DMS3YE9	Moderate	Additive anticholinergic effects by the combination of Trospium and Amantadine.	Influenza [1E30-1E32]	[24]
Propiomazine	DMKY8V1	Moderate	Additive anticholinergic effects by the combination of Trospium and Propiomazine.	Insomnia [7A00-7A0Z]	[8]
ITI-007	DMUQ1DO	Moderate	Additive anticholinergic effects by the combination of Trospium and ITI-007.	Insomnia [7A00-7A0Z]	[8]
R0-93877	DMM4U9G	Moderate	Antagonize the effect of Trospium when combined with R0-93877.	Irritable bowel syndrome [DD91]	[25]
Clidinium	DMUMQZ0	Moderate	Additive anticholinergic effects by the combination of Trospium and Clidinium.	Irritable bowel syndrome [DD91]	[8]
Dicyclomine	DMZSDGX	Moderate	Additive anticholinergic effects by the combination of Trospium and Dicyclomine.	Irritable bowel syndrome [DD91]	[8]
Physostigmine	DM2N0TO	Moderate	Antagonize the effect of Trospium when combined with Physostigmine.	Lips/oral mucosa miscellaneous disorder [DA02]	[10]
Propranolol	DM79NTF	Moderate	Additive CNS depression effects by the combination of Trospium and Propranolol.	Migraine [8A80]	[26]
Doxylamine	DMKOXFE	Moderate	Additive anticholinergic effects by the combination of Trospium and Doxylamine.	Morning sickness disorder [SC00]	[8]
Neostigmine	DM6T2J3	Moderate	Antagonize the effect of Trospium when combined with Neostigmine.	Myasthenia gravis [8C6Y]	[27]
Pyridostigmine	DM8HO1L	Moderate	Antagonize the effect of Trospium when combined with Pyridostigmine.	Myasthenia gravis [8C6Y]	[27]
Edrophonium	DMCRQHB	Moderate	Antagonize the effect of Trospium when combined with Edrophonium.	Myasthenia gravis [8C6Y]	[27]
Ambenonium	DMOP0BL	Moderate	Antagonize the effect of Trospium when combined with Ambenonium.	Myasthenia gravis [8C6Y]	[27]
Phenindamine	DMDTC7R	Moderate	Additive anticholinergic effects by the combination of Trospium and Phenindamine.	Nasopharyngitis [CA00]	[8]
Dimenhydrinate	DM264B3	Moderate	Additive anticholinergic effects by the combination of Trospium and Dimenhydrinate.	Nausea/vomiting [MD90]	[8]
Prochlorperazine	DM53SRA	Moderate	Additive anticholinergic effects by the combination of Trospium and Prochlorperazine.	Nausea/vomiting [MD90]	[8]
Promethazine	DM6I5GR	Moderate	Additive anticholinergic effects by the combination of Trospium and Promethazine.	Nausea/vomiting [MD90]	[8]
Cyclizine	DM9G7BS	Moderate	Additive anticholinergic effects by the combination of Trospium and Cyclizine.	Nausea/vomiting [MD90]	[8]
Metoclopramide	DMFA5MY	Moderate	Antagonize the effect of Trospium when combined with Metoclopramide.	Nausea/vomiting [MD90]	[28]
Thiethylperazine	DMU3IET	Moderate	Additive anticholinergic effects by the combination of Trospium and Thiethylperazine.	Nausea/vomiting [MD90]	[8]
Chlorthalidone	DM4DMBT	Minor	Altered absorption of Trospium due to GI dynamics variation caused by Chlorthalidone.	Oedema [MG29]	[21]
Metolazone	DMB39LO	Minor	Altered absorption of Trospium due to GI dynamics variation caused by Metolazone.	Oedema [MG29]	[21]
Levomethadyl Acetate	DM06HG5	Moderate	Additive CNS depression effects by the combination of Trospium and Levomethadyl Acetate.	Opioid use disorder [6C43]	[29]
Pentazocine	DM1XBHS	Moderate	Additive CNS depression effects by the combination of Trospium and Pentazocine.	Pain [MG30-MG3Z]	[7]
Dextropropoxyphene	DM23HCX	Moderate	Additive CNS depression effects by the combination of Trospium and Dextropropoxyphene.	Pain [MG30-MG3Z]	[29]
Butorphanol	DM5KYPJ	Moderate	Additive antimotility effects by the combination of Trospium and Butorphanol.	Pain [MG30-MG3Z]	[7]
Oxymorphone	DM65AGJ	Moderate	Additive CNS depression effects by the combination of Trospium and Oxymorphone.	Pain [MG30-MG3Z]	[7]
Levorphanol	DMGS80V	Moderate	Additive CNS depression effects by the combination of Trospium and Levorphanol.	Pain [MG30-MG3Z]	[7]
Hydromorphone	DMHP21E	Moderate	Additive CNS depression effects by the combination of Trospium and Hydromorphone.	Pain [MG30-MG3Z]	[16]
Dezocine	DMJDB0Y	Moderate	Additive CNS depression effects by the combination of Trospium and Dezocine.	Pain [MG30-MG3Z]	[7]
Codeine	DMJX6ZG	Moderate	Additive antimotility effects by the combination of Trospium and Codeine.	Pain [MG30-MG3Z]	[7]
Flavoxate	DMKV4NL	Moderate	Additive anticholinergic effects by the combination of Trospium and Flavoxate.	Pain [MG30-MG3Z]	[8]
Nalbuphine	DMOSQGU	Moderate	Additive CNS depression effects by the combination of Trospium and Nalbuphine.	Pain [MG30-MG3Z]	[7]
Buprenorphine	DMPRI8G	Moderate	Additive antimotility effects by the combination of Trospium and Buprenorphine.	Pain [MG30-MG3Z]	[7]
Hydrocodone	DMQ2JO5	Moderate	Additive CNS depression effects by the combination of Trospium and Hydrocodone.	Pain [MG30-MG3Z]	[16]
Acetaminophen	DMUIE76	Minor	Altered absorption of Trospium due to GI dynamics variation caused by Acetaminophen.	Pain [MG30-MG3Z]	[30]
Meperidine	DMX4GND	Moderate	Additive antimotility effects by the combination of Trospium and Meperidine.	Pain [MG30-MG3Z]	[7]
Oxycodone	DMXLKHV	Moderate	Additive CNS depression effects by the combination of Trospium and Oxycodone.	Pain [MG30-MG3Z]	[7]
Biperiden	DME78OA	Moderate	Additive anticholinergic effects by the combination of Trospium and Biperiden.	Parkinsonism [8A00]	[8]
Benztropine	DMGZOVN	Moderate	Additive anticholinergic effects by the combination of Trospium and Benztropine.	Parkinsonism [8A00]	[9]
Procyclidine	DMHFJDT	Moderate	Additive anticholinergic effects by the combination of Trospium and Procyclidine.	Parkinsonism [8A00]	[8]
Levodopa	DMN3E57	Moderate	Altered absorption of Trospium due to GI dynamics variation caused by Levodopa.	Parkinsonism [8A00]	[31]
Orphenadrine	DMW542E	Moderate	Additive anticholinergic effects by the combination of Trospium and Orphenadrine.	Parkinsonism [8A00]	[8]
Methylscopolamine	DM5VWOB	Moderate	Additive anticholinergic effects by the combination of Trospium and Methylscopolamine.	Peptic ulcer [DA61]	[8]
Levomepromazine	DMIKFEL	Moderate	Additive anticholinergic effects by the combination of Trospium and Levomepromazine.	Psychotic disorder [6A20-6A25]	[8]
Fluphenazine	DMIT8LX	Moderate	Additive anticholinergic effects by the combination of Trospium and Fluphenazine.	Psychotic disorder [6A20-6A25]	[8]
Triflupromazine	DMKFQJP	Moderate	Additive anticholinergic effects by the combination of Trospium and Triflupromazine.	Psychotic disorder [6A20-6A25]	[8]
Cyproheptadine	DM92AH3	Moderate	Additive anticholinergic effects by the combination of Trospium and Cyproheptadine.	Rheumatoid arthritis [FA20]	[8]
Quetiapine	DM1N62C	Moderate	Additive anticholinergic effects by the combination of Trospium and Quetiapine.	Schizophrenia [6A20]	[8]
Mesoridazine	DM2ZGAN	Moderate	Additive anticholinergic effects by the combination of Trospium and Mesoridazine.	Schizophrenia [6A20]	[8]
Thioridazine	DM35M8J	Moderate	Additive anticholinergic effects by the combination of Trospium and Thioridazine.	Schizophrenia [6A20]	[8]
Aripiprazole	DM3NUMH	Moderate	Additive anticholinergic effects by the combination of Trospium and Aripiprazole.	Schizophrenia [6A20]	[8]
Iloperidone	DM6AUFY	Moderate	Additive anticholinergic effects by the combination of Trospium and Iloperidone.	Schizophrenia [6A20]	[8]
Paliperidone	DM7NPJS	Moderate	Additive anticholinergic effects by the combination of Trospium and Paliperidone.	Schizophrenia [6A20]	[8]
Loxapine	DM8AI9U	Moderate	Additive anticholinergic effects by the combination of Trospium and Loxapine.	Schizophrenia [6A20]	[8]
Haloperidol	DM96SE0	Moderate	Additive anticholinergic effects by the combination of Trospium and Haloperidol.	Schizophrenia [6A20]	[8]
Perphenazine	DMA4MRX	Moderate	Additive anticholinergic effects by the combination of Trospium and Perphenazine.	Schizophrenia [6A20]	[8]
Molindone	DMAH70G	Moderate	Additive anticholinergic effects by the combination of Trospium and Molindone.	Schizophrenia [6A20]	[8]
Chlorpromazine	DMBGZI3	Moderate	Additive anticholinergic effects by the combination of Trospium and Chlorpromazine.	Schizophrenia [6A20]	[8]
Thiothixene	DMDINC4	Moderate	Additive anticholinergic effects by the combination of Trospium and Thiothixene.	Schizophrenia [6A20]	[8]
Clozapine	DMFC71L	Moderate	Additive anticholinergic effects by the combination of Trospium and Clozapine.	Schizophrenia [6A20]	[8]
Trifluoperazine	DMKBYWI	Moderate	Additive anticholinergic effects by the combination of Trospium and Trifluoperazine.	Schizophrenia [6A20]	[8]
Ziprasidone	DMM58JY	Moderate	Additive anticholinergic effects by the combination of Trospium and Ziprasidone.	Schizophrenia [6A20]	[8]
Risperidone	DMN6DXL	Moderate	Additive anticholinergic effects by the combination of Trospium and Risperidone.	Schizophrenia [6A20]	[8]
Asenapine	DMSQZE2	Moderate	Additive anticholinergic effects by the combination of Trospium and Asenapine.	Schizophrenia [6A20]	[8]
Pimozide	DMW83TP	Moderate	Additive anticholinergic effects by the combination of Trospium and Pimozide.	Schizophrenia [6A20]	[8]
Fentanyl	DM8WAHT	Moderate	Additive antimotility effects by the combination of Trospium and Fentanyl.	Sensation disturbance [MB40]	[7]
Topiramate	DM82Z30	Major	Increased risk of hyperpyrexia by the combination of Trospium and Topiramate.	Substance abuse [6C40]	[32]
Pramlintide	DM0EZ9Q	Moderate	Altered absorption of Trospium due to GI dynamics variation caused by Pramlintide.	Type-1/2 diabete [5A10-5A11]	[33]
Atropine	DMEN6X7	Moderate	Additive anticholinergic effects by the combination of Trospium and Atropine.	Unspecific substance harmful effect [NE6Z]	[8]
Nitrofurantoin	DM7PQIK	Minor	Altered absorption of Trospium due to GI dynamics variation caused by Nitrofurantoin.	Urinary tract infection [GC08]	[34]
Chlorpheniramine	DM5URA2	Moderate	Additive anticholinergic effects by the combination of Trospium and Chlorpheniramine.	Vasomotor/allergic rhinitis [CA08]	[8]
Triprolidine	DM7SWIA	Moderate	Additive anticholinergic effects by the combination of Trospium and Triprolidine.	Vasomotor/allergic rhinitis [CA08]	[8]
Methdilazine	DMAUHQX	Moderate	Additive anticholinergic effects by the combination of Trospium and Methdilazine.	Vasomotor/allergic rhinitis [CA08]	[8]
Clemastine	DMBZWQL	Moderate	Additive anticholinergic effects by the combination of Trospium and Clemastine.	Vasomotor/allergic rhinitis [CA08]	[8]
Carbinoxamine	DMCT31R	Moderate	Additive anticholinergic effects by the combination of Trospium and Carbinoxamine.	Vasomotor/allergic rhinitis [CA08]	[8]
Trimeprazine	DMEMV9D	Moderate	Additive anticholinergic effects by the combination of Trospium and Trimeprazine.	Vasomotor/allergic rhinitis [CA08]	[9]
Brompheniramine	DMFOVSD	Moderate	Additive anticholinergic effects by the combination of Trospium and Brompheniramine.	Vasomotor/allergic rhinitis [CA08]	[8]
Dexbrompheniramine	DMKVWGE	Moderate	Additive anticholinergic effects by the combination of Trospium and Dexbrompheniramine.	Vasomotor/allergic rhinitis [CA08]	[8]
Acrivastine	DMTIGA0	Moderate	Additive anticholinergic effects by the combination of Trospium and Acrivastine.	Vasomotor/allergic rhinitis [CA08]	[8]
Azatadine	DMZ80SB	Moderate	Additive anticholinergic effects by the combination of Trospium and Azatadine.	Vasomotor/allergic rhinitis [CA08]	[8]
Disopyramide	DM5SYZP	Moderate	Additive anticholinergic effects by the combination of Trospium and Disopyramide.	Ventricular tachyarrhythmia [BC71]	[8]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Allura red AC dye	E00338	33258	Colorant
Calcium carbonate	E00198	10112	Binding agent; Buffering agent; Diluent; Opacifying agent
D&C red no. 28	E00491	6097185	Colorant
FD&C blue no. 1	E00263	19700	Colorant
FD&C blue no. 2	E00446	2723854	Colorant
Quinoline yellow WS	E00309	24671	Colorant
Sodium lauryl sulfate	E00464	3423265	Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Stearic acid	E00079	5281	Emulsifying agent; Solubilizing agent; Viscosity-controlling agent; lubricant
Sucralose	E00370	71485	Flavoring agent
Sunset yellow FCF	E00255	17730	Colorant
Butyl alcohol	E00011	263	Flavoring agent; Solvent
Carboxymethylcellulose sodium	E00621	Not Available	Adsorbent; Binding agent; Disintegrant; Emulsifying agent; Suspending agent; Viscosity-controlling agent
Carmellose sodium	E00625	Not Available	Disintegrant
Eisenoxyd	E00585	56841934	Colorant
Ferric hydroxide oxide yellow	E00539	23320441	Colorant
Ferrosoferric oxide	E00231	14789	Colorant
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium aluminum silicate	E00462	3084116	Adsorbent; Binding agent; Disintegrant; Suspending agent; Viscosity-controlling agent
Magnesium stearate	E00208	11177	lubricant
Polyethylene glycol 3350	E00652	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 400	E00653	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 4000	E00654	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 6000	E00655	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polysorbate 80	E00665	Not Available	Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Polyvinyl alcohol	E00666	Not Available	Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Potassium hydroxide	E00233	14797	Alkalizing agent
Povidone	E00667	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Propylene glycol	E00040	1030	Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Saccharose	E00091	5988	Binding agent; Coating agent; Cryoprotectant; Diluent; Flavoring agent; Suspending agent; Viscosity-controlling agent
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium chloride	E00077	5234	Diluent; Tonicity agent
Talc	E00520	16211421	Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide	E00322	26042	Coating agent; Colorant; Opacifying agent
Triethyl citrate	E00128	6506	Plasticizing agent; Solvent
Xylitol	E00136	6912	Coating agent; Diluent; Emollient; Flavoring agent; Humectant

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Trospium 60 mg capsule	60 mg	24 HR Extended Release Oral Capsule	Oral
Trospium 20 mg tablet	20 mg	Oral Tablet	Oral
Trospium 60 mg capsule	60 mg	24 HR Extended Release Capsule	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7480).
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Trospium FDA Label
• [4] Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
• [5] Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
• [6] Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255. [PMID: 376469]
• [7] Product Information. Apadaz (acetaminophen-benzhydrocodone). KemPharm, Inc, Coralville, IA.
• [8] Cohen MA, Alfonso CA, Mosquera M. Development of urinary retention during treatment with clozapine and meclizine [published correction appears in Am J Psychiatry 1994 Jun;151(6):952]. Am J Psychiatry. 1994;151(4):619-620. [PMID: 8147469]
• [9] Kulik AV, Wilbur R "Delirium and stereotypy from anticholinergic antiparkinson drugs." Prog Neuropsychopharmacol Biol Psychiatry 6 (1982): 75-82. [PMID: 7202232]
• [10] Beers MH, Ouslander JG, Rollingher I, Reuben DB, Brooks J, Beck JC "Explicit criteria for determining inappropriate medication use in nursing home residents." Arch Intern Med 151 (1991): 1825-32. [PMID: 1888249]
• [11] Eronen M, Putkonen H, Hallikainen T, Vartiainen H "Lethal gastroenteritis associated with clozapine and loperamide." Am J Psychiatry 160 (2003): 2242-2243. [PMID: 14638602]
• [12] Cerner Multum, Inc. "UK Summary of Product Characteristics.".
• [13] Multum Information Services, Inc. Expert Review Panel.
• [14] Cole JM, Sheehan AH, Jordan JK "Concomitant use of ipratropium and tiotropium in chronic obstructive plmonary disease." Ann Pharmacother 46 (2012): 1717-21. [PMID: 23170031]
• [15] Product Information. Lortab (acetaminophen-hydrocodone). Akorn Inc, Buffalo Grove, IL.
• [16] Product Information. Levorphanol Tartrate (levorphanol). Sentynl Therapeutics, Solana Beach, CA.
• [17] Product Information. GenESA (arbutamine). Gensia Inc, San Diego, CA.
• [18] Linnoila M "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol 6 (1973): 107-12. [PMID: 4588850]
• [19] Product Information. Nitrostat (nitroglycerin). Parke-Davis, Morris Plains, NJ.
• [20] Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
• [21] Beermann B, Groschinsky-Grind M "Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline." Eur J Clin Pharmacol 13 (1978): 385-7. [PMID: 668798]
• [22] Product Information. Nizoral (ketoconazole). Janssen Pharmaceutica, Titusville, NJ.
• [23] Farquharson-Roberts MA, Giddings AE, Nunn AJ "Perforation of small bowel due to slow release potassium chloride (slow-K)." Br Med J 3 (1975): 206. [PMID: 1148734]
• [24] Postma JU, van Tilburg W "Visual hallucinations and delirium during treatment with amantadine (Symmetrel)." J Am Geriatr Soc 23 (1975): 212-5. [PMID: 123540]
• [25] EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
• [26] Cerner Multum, Inc. "Australian Product Information.".
• [27] Product Information. Mestinon (pyridostigmine). ICN Pharmaceuticals Inc, Cost Mesa, CA.
• [28] Product Information. Motilium (domperidone). Janssen-Ortho Inc, Toronto, ON.
• [29] Product Information. Exalgo (hydromorphone). Covidien, Mansfield, MA.
• [30] Clark JM, Seager SJ "Gastric emptying following premedication with glycopyrrolate or atropine." Br J Anaesth 55 (1983): 1195-9. [PMID: 6652009]
• [31] Algeri S, Cerletti C, Curcio M, et al. "Effect of anticholinergic drugs on gastro-intestinal absorption of L-dopa in rats and man." Eur J Pharmacol 35 (1976): 293-9. [PMID: 1248506]
• [32] Product Information. Topamax (topiramate). Ortho Pharmaceutical Corporation, Raritan, NJ.
• [33] Product Information. Symlin (pramlintide). Amphastar Pharmaceuticals Inc, South El Monte, CA.
• [34] Jaffe JM "Effect of propantheline on nitrofurantoin absorption." J Pharm Sci 64 (1975): 1729-30. [PMID: 1185550]