Details of the Drug Combinations

General Information of This Drug (ID: DMYQUIP)

Drug Name
PAC1   DMYQUIP
Synonyms PAC-1
Indication
Disease Entry ICD 11 Status REF
Anaplastic astrocytoma 2A00.0 Phase 1 [1]
Recurrent glioblastoma 2A00.00 Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

13 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Afatinib + PAC1 DCRAF7O Afatinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
PAC1 + Trametinib DCNYFPL Trametinib Glioblastoma (Cell Line: JHH-136) [2]
PAC1 + Carfilzomib DCNXK68 Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
PAC1 + Carfilzomib DCMNI52 Carfilzomib Glioblastoma (Cell Line: JHH-136) [2]
PAC1 + Ixazomib DCVS3M3 Ixazomib Glioblastoma (Cell Line: JHH-136) [2]
PAC1 + RTB101 DCTJGSM RTB101 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
PAC1 + Daporinad DCXQE8M Daporinad Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
PAC1 + Idarubicin DCREEYH Idarubicin Glioblastoma? (Cell Line: T98G) [2]
PAC1 + GSK2126458 DC0OKG0 GSK2126458 Glioblastoma (Cell Line: JHH-136) [2]
PAC1 + ABT-263 DCQ73C9 ABT-263 Glioblastoma (Cell Line: JHH-136) [2]
PAC1 + Mebendazole DCKLRIS Mebendazole Glioblastoma (Cell Line: JHH-136) [2]
PAC1 + BIIB-021 DCRKG08 BIIB-021 Glioblastoma (Cell Line: JHH-136) [2]
Rotenone + PAC1 DCPG65E Rotenone Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
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⏷ Show the Full List of 13 DrugCom(s)

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.