Details of the Drug Formulations

General Information of Drug (ID: DM2JGQ3)

• Drug Name: Trametinib Drug Info
• Synonyms: GSK 1120212; GSK-1120212; GSK1120212; JTP 74057; JTP-74057; Mekinist; Trametinib (GSK1120212); Trametinib (GSK1120212JTP 74057); Trametinib (MEK inhibitor); 33E86K87QN; A1-01871; AK174783; CHEBI:75998; UNII-33E86K87QN

Indication

Disease Entry	ICD 11	Status	REF
Melanoma	2C30	Approved	[1]
Metastatic melanoma	2E2Z	Approved	[2]
Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[3]
Severe acute respiratory syndrome (SARS)	1D65	Investigative	[3]

• Cross-matching ID:
  PubChem CID: 11707110
  ChEBI ID: CHEBI:75998
  CAS Number: 871700-17-3
  TTD ID: D04XVN
  ACDINA ID: D00694

Full List of Drug Formulations Containing This Drug

Trametinib 0.5 mg tablet

Company	Formulation ID	FDA Description
Novartis Pharmaceuticals Corporation	F21554	Sodium lauryl sulfate; Magnesium stearate; Mannitol; Ferric oxide red; Ferric oxide yellow; Croscarmellose sodium; Polysorbate 80; Silicon dioxide; Hypromelloses; Microcrystalline cellulose; Polyethylene glycols
GlaxoSmithKline	F21553	Sodium lauryl sulfate; Magnesium stearate; Mannitol; Ferric oxide yellow; Titanium dioxide; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols

Trametinib 2 mg tablet

Company	Formulation ID	FDA Description
GlaxoSmithKline	F21556	Sodium lauryl sulfate; Magnesium stearate; Mannitol; Ferric oxide red; Titanium dioxide; Croscarmellose sodium; Polysorbate 80; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
Novartis Pharmaceuticals Corporation	F21557	Sodium lauryl sulfate; Magnesium stearate; Mannitol; Ferric oxide red; Ferric oxide yellow; Titanium dioxide; Croscarmellose sodium; Silicon dioxide; Hypromelloses; Microcrystalline cellulose

Trametinib 1 mg tablet

Company	Formulation ID	FDA Description
GlaxoSmithKline	F21555	Sodium lauryl sulfate; Magnesium stearate; Mannitol; Titanium dioxide; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols

Trametinib Dimethyl Sulfoxide eq 2mg tablet

Company	Formulation ID	FDA Description
Novartis	F23581	Colloidal Silicon Dioxide; Croscarmellose Sodium; Hypromellose; Magnesium Stearate (Vegetable Source); Mannitol; Microcrystalline Cellulose; Sodium Lauryl Sulfate; Hypromellose; Polyethylene Glycol; Titanium Dioxide; Iron Oxide Red; Polysorbate 80

Trametinib Dimethyl Sulfoxide eq 0.5mg tablet

Company	Formulation ID	FDA Description
Novartis	F23582	Colloidal Silicon Dioxide; Croscarmellose Sodium; Hypromellose; Magnesium Stearate (Vegetable Source); Mannitol; Microcrystalline Cellulose; Sodium Lauryl Sulfate; Hypromellose; Polyethylene Glycol; Titanium Dioxide; Iron Oxide Yellow

Trametinib Dimethyl Sulfoxide eq 1mg tablet

Company	Formulation ID	FDA Description
Novartis	F23580	Colloidal Silicon Dioxide; Croscarmellose Sodium; Hypromellose; Magnesium Stearate (Vegetable Source); Mannitol; Microcrystalline Cellulose; Sodium Lauryl Sulfate; Hypromellose; Polyethylene Glycol; Titanium Dioxide

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6495).
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.