Details of the Drug

General Information of Drug (ID: DM2JGQ3)

Drug Name
Trametinib
Synonyms
GSK 1120212; GSK-1120212; GSK1120212; JTP 74057; JTP-74057; Mekinist; Trametinib (GSK1120212); Trametinib (GSK1120212JTP 74057); Trametinib (MEK inhibitor); 33E86K87QN; A1-01871; AK174783; CHEBI:75998; UNII-33E86K87QN
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Approved [1]
Metastatic melanoma 2E2Z Approved [2]
Middle East Respiratory Syndrome (MERS) 1D64 Investigative [3]
Severe acute respiratory syndrome (SARS) 1D65 Investigative [3]
Affected Organisms
Humans and other mammals
ATC Code
L01EE01: Trametinib
L01EE: Mitogen-activated protein kinase (MEK) inhibitors
L01E: PROTEIN KINASE INHIBITORS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 615.4
Logarithm of the Partition Coefficient (xlogp) 3.4
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 6
ADMET Property
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 22.2 mcg/L []
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 1.5 h []
Bioavailability
The bioavailability of drug is 72% []
Clearance
The apparent clearance of drug is 4.9 L/h []
Elimination
80% of the dose is excreted in the feces, and less than 20% of the dose is excreted in the urine with <0.1% of the excreted dose in the form of the parent compound []
Half-life
The concentration or amount of drug in body reduced by one-half in 3.9 - 4.8 days []
Metabolism
The drug is metabolized via the deacetylation alone or with mono-oxygenation or in combination with glucuronidation biotransformation pathways in vitro []
Vd
The volume of distribution (Vd) of drug is 214 L []
Chemical Identifiers
Formula
C26H23FIN5O4
IUPAC Name
N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide
Canonical SMILES
CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5
InChI
InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
InChIKey
LIRYPHYGHXZJBZ-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
11707110
ChEBI ID
CHEBI:75998
CAS Number
871700-17-3
UNII
33E86K87QN
DrugBank ID
DB08911
TTD ID
D04XVN
ACDINA ID
D00694
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
MAPK/ERK kinase kinase (MAP3K) TTROQ37 NOUNIPROTAC Modulator [4]
HUMAN ERK activator kinase 1 (MEK1) TTAW3TO MP2K1_HUMAN Inhibitor [3]
HUMAN ERK activator kinase 2 (MEK2) TTWX403 MP2K2_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [5]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Drug Response [6]
Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) OTOODWTU GNAQ_HUMAN Drug Response [5]
Guanine nucleotide-binding protein subunit alpha-11 (GNA11) OT0K99TO GNA11_HUMAN Drug Response [5]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [5]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [5]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [5]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [5]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Post-Translational Modifications [5]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Post-Translational Modifications [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 1.0818 8.9437 -3.6054 18.2677
CHSA0011 GDSC1; GDSC2 -3.4129 3.4333 -5.0086 39.6672
U2OS GDSC1; GDSC2 -2.8937 1.8008 -3.7829 33.1921
CHSA8926 GDSC1; GDSC2 0.2651 8.1196 -3.841 21.565
CAL-72 GDSC1; GDSC2 0.5384 9.1527 -4.1358 22.0504
SJSA-1 GDSC1; GDSC2 0.6034 15.921 -7.4634 31.6413
G-292 clone A141B1 GDSC1; GDSC2; CTRP2 0.7019 6.3034 0.1412 34.9776
H-EMC-SS GDSC1; GDSC2 0.8471 10.5587 -4.5911 23.0128
NOS-1 [Human HNSCC] GDSC1; GDSC2 1.0273 13.935 -6.131 27.492
U-CH2 GDSC2 1.3063 7.9653 -2.9533 14.498
CAL-78 GDSC1; GDSC2 1.6186 5.0633 -1.3436 4.7831
EW-24 GDSC1; GDSC2 1.7227 3.011 -0.4217 0.3037
NY GDSC1; GDSC2 1.7707 5.4487 -1.4282 4.9913
CHSA0108 GDSC1; GDSC2 1.7788 11.9644 -4.5722 20.6168
EW-7 GDSC1; GDSC2 1.7814 5.8667 -1.6151 6.025
HuO9 GDSC1; GDSC2 1.7824 7.7864 -2.5265 11.1269
HuO-3N1 GDSC1; GDSC2 1.8618 6.1804 -1.7107 6.4159
EW-22 GDSC1; GDSC2 1.9598 4.0484 -0.7175 1.1423
CADO-ES1 GDSC1; GDSC2 2.1045 3.7463 -0.54 0.4357
EW-18 GDSC1; GDSC2 2.1295 5.2921 -1.1529 2.9604
EW-1 GDSC1; GDSC2 2.1524 5.1883 -1.0961 2.6479
SK-PN-DW GDSC1; GDSC2 2.1683 4.2879 -0.7183 0.972
EW-12 GDSC2 2.1717 4.4131 -0.766 1.1506
MHH-ES-1 GDSC1; GDSC2 2.1868 8.7443 -2.7114 11.247
EW-16 GDSC1; GDSC2 2.2092 11.7799 -4.1657 18.0109
EW-11 GDSC1; GDSC2 2.2257 10.5378 -3.549 15.2821
ES1 GDSC1; GDSC2 2.3039 4.141 -0.6057 0.5171
ES8 GDSC1; GDSC2 2.4849 4.9923 -0.8539 1.229
ES7 GDSC1; GDSC2 2.6133 5.9206 -1.1704 2.4475
EW-13 GDSC1; GDSC2 2.6328 4.4639 -0.5952 0.3478
TC-71 GDSC1; GDSC2 2.664 10.8593 -3.402 13.6691
EW-3 GDSC1; GDSC2 2.7079 7.9549 -2.0115 6.5667
ES4 GDSC1; GDSC2 2.7421 10.4943 -3.1755 12.4384
ES5 GDSC1; GDSC2 2.9198 5.3427 -0.8027 0.7569
ES6 GDSC1; GDSC2 3.2004 12.2279 -3.6965 13.9312
TC71 CTRP2 7.2853 11.499 4.2692 5.3768
MG-63 GDSC2; CTRP2 7.9965 9.4108 5.5829 0.1892
SK-N-MC CTRP2 8.1042 9.1641 5.7067 0.0446
SaOS-2 GDSC1; GDSC2; CTRP2 8.1744 12.4994 4.3719 3.5869
Hs 888.T CTRP2 8.1938 20.0441 0.7451 16.9928
SK-ES-1 GDSC1; GDSC2; CTRP2 8.2319 9.9766 5.4692 0.3058
HOS GDSC1; GDSC2; CTRP2 8.7467 15.6898 3.2449 6.9407
Hs 822.T CTRP2 9.9446 22.5464 0.7741 14.2726
A-673 GDSC1; GDSC2; CTRP2 12.7914 38.7576 -5.0874 23.016
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 195 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MEC1 CTRP2 5.3718 13.9445 1.5208 19.7028
JM1 GDSC1; GDSC2; CTRP2 5.0653 8.3431 4.0035 10.0096
SIG-M5 GDSC2; CTRP2 -14.1819 -0.0697 -14.7105 84.9228
HuT 78 CTRP2 -12.5306 1.9701 -13.2777 82.3734
OCI-Ly7 GDSC2 -11.503 -9.9958 -11.503 99.3051
OCI-AML-2 GDSC1; GDSC2 -10.4693 -7.5783 -10.4702 93.1419
NB4 GDSC1; GDSC2 -10.4269 0.2685 -11.4536 73.8267
OCI-AML-3 GDSC1; GDSC2; CTRP2 -9.6529 -3.5204 -9.6729 86.9766
KMOE-2 GDSC1; GDSC2 -8.6499 -6.2973 -8.6506 84.0466
Ku812 GDSC1; GDSC2 -7.8985 -3.5419 -7.971 73.6189
SKM-1 GDSC1; GDSC2 -7.5374 0.7783 -8.4508 64.4323
EoL-1 GDSC1; GDSC2; CTRP2 -7.2454 0.5768 -7.4118 75.0341
JURL-MK1 GDSC1; GDSC2 -6.9596 -4.2735 -6.9678 68.874
HL-60 GDSC1; GDSC2; CTRP2 -6.6066 21.1544 -13.5669 58.8081
KO52 CTRP2 -5.6729 76.9631 -39.5979 52.7879
LAMA-84 GDSC1; GDSC2 -5.6044 -2.8593 -5.6323 56.0049
KMS-20 CTRP2 -5.2882 11.453 -8.1294 61.4426
MV4-11 GDSC1; GDSC2 -5.2404 1.3477 -6.1365 51.7614
IM-9 GDSC1; GDSC2 -5.2161 3.3637 -6.8662 51.3205
NCI-H929 GDSC1; GDSC2 -5.0965 3.5461 -6.8138 50.641
MOLM-13 GDSC1; GDSC2 -5.0487 -1.4418 -5.1937 50.6033
A4/Fukuda GDSC1; GDSC2; CTRP2 -5.0347 2.9503 -5.364 65.054
MEG-01 GDSC1; GDSC2 -4.6767 1.4624 -5.5666 47.8157
AML-193 CTRP2 -4.4929 9.4427 -6.5344 60.5836
ML-2 GDSC1; GDSC2 -4.3912 11.1823 -9.5697 47.9972
NOMO-1 GDSC1; GDSC2 -4.316 84.2283 -45.7628 49.5871
H9 GDSC1; GDSC2 -3.9194 12.0274 -9.5269 46.4808
Kasumi-1 GDSC1; GDSC2; CTRP2 -3.7923 10.4999 -6.1679 56.2404
PL-21 GDSC1; GDSC2 -3.4524 14.7792 -10.4327 45.5351
NU-DHL-1 CTRP2 -3.3612 16.1526 -8.0401 55.0366
HD-MY-Z CTRP2 -3.212 7.8753 -4.6108 57.3221
NKM-1 GDSC1; GDSC2 -2.8705 9.0069 -7.0733 40.9631
F-36P CTRP2 -2.2026 20.5497 -8.8592 51.716
SU-DHL-1 GDSC2 -2.191 4.7694 -4.3891 32.2709
Karpas-620 GDSC1; GDSC2 -1.9209 13.7879 -8.5536 39.8448
KCL-22 GDSC1; GDSC2 -1.8111 6.9034 -5.0569 32.9102
JSC-1 GDSC1; GDSC2 -1.7618 11.1996 -7.1282 37.3713
BV-173 GDSC1; GDSC2 -1.6939 8.1307 -5.5509 33.8471
OPM-2 GDSC1; GDSC2; CTRP2 -1.5294 3.945 -1.7571 47.5178
MOLT-13 GDSC1; GDSC2 -1.4878 12.2227 -7.3916 36.9887
TALL-1 [Human adult T-ALL] GDSC2 -1.3808 8.918 -5.6562 33.0513
SUP-M2 GDSC1; GDSC2; CTRP2 -0.9428 6.8364 -1.811 44.8563
EM-2 GDSC1; GDSC2 -0.8097 15.8026 -8.5858 36.9768
SUP-B15 GDSC2; CTRP2 -0.8033 9.1705 -2.4662 44.9021
KOPN-8 GDSC1; GDSC2 -0.6035 14.0922 -7.5551 34.8208
P31/FUJ GDSC1; GDSC2 -0.5314 23.6235 -12.2575 40.1749
CML-T1 GDSC1; GDSC2 -0.4936 7.817 -4.3271 25.8843
Mono-Mac-6 GDSC1; GDSC2 -0.4692 9.4377 -5.1154 28.5811
MOLM-16 GDSC1; GDSC2 -0.2285 16.007 -8.1947 34.9606
KY821 GDSC1; GDSC2 -0.2019 40.1791 -20.258 43.572
AMO1 GDSC1; GDSC2 -0.1983 8.6868 -4.5097 25.6621
OCI-Ly19 GDSC1; GDSC2; CTRP2 -0.1982 29.2138 -11.0804 46.8079
BONNA-12 GDSC2 -0.1705 11.0403 -5.6628 29.3456
SCC-3 GDSC2 0.3627 5.0564 -2.2326 12.9462
MOLP-8 GDSC1; GDSC2; CTRP2 0.4165 21.1448 -6.5891 44.0803
THP-1 GDSC1; GDSC2 0.6563 18.6038 -8.7608 33.8402
OCI-AML-5 GDSC1; GDSC2; CTRP2 0.7276 35.7251 -13.4304 45.8769
P12-Ichikawa GDSC1; GDSC2 0.7294 6.7525 -2.7893 15.1002
KE-37 GDSC1; GDSC2 0.752 8.0321 -3.4079 18.2034
Raji GDSC1; GDSC2 0.7613 3.5269 -1.1764 5.502
MC116 GDSC1; GDSC2 0.7665 3.2692 -1.0483 4.7109
P32/ISH GDSC1; GDSC2 0.7728 2.3269 -0.5999 2.0527
WIL2 NS GDSC1; GDSC2 0.8384 5.6671 -2.1688 11.3177
Farage GDSC1; GDSC2 0.8628 3.8597 -1.2667 5.8269
JVM-3 GDSC1; GDSC2 0.9124 22.9185 -10.708 35.961
SU-DHL-10 GDSC1; GDSC2 0.9137 5.0022 -1.7865 8.8615
EHEB GDSC1 0.9157 14.7343 -6.6186 31.9204
MY-M12 GDSC2 0.941 8.0218 -3.2562 16.9594
SU-DHL-5 GDSC1; GDSC2 0.9413 11.06 -4.7665 23.4142
Hs 445 GDSC1; GDSC2 0.9837 4.4914 -1.4881 6.9003
SU-DHL-16 GDSC1; GDSC2 1.0188 4.0594 -1.2563 5.4295
MHH-CALL-4 GDSC2 1.0366 15.1201 -6.7145 28.963
SET-2 CTRP2 1.0604 10.7247 -1.1263 38.5295
NU-DUL-1 GDSC1; GDSC2 1.107 4.5491 -1.4313 6.2907
YT GDSC1; GDSC2 1.1434 4.2218 -1.2509 5.1424
Sc-1 GDSC1 1.2128 4.3983 -1.2891 6.4909
Karpas-1106P GDSC1; GDSC2 1.2286 4.7668 -1.4536 6.1692
PF-382 GDSC1; GDSC2 1.2353 4.9909 -1.5562 6.7631
MOLT-16 GDSC1; GDSC2 1.2491 6.4748 -2.2647 10.8764
CTV-1 GDSC1; GDSC2 1.2741 8.1666 -3.0762 15.2087
BC-3 GDSC2 1.3069 3.2194 -0.6953 1.7569
HC-1 GDSC1; GDSC2 1.3098 13.1834 -5.5345 25.0686
DEL GDSC1; GDSC2 1.3102 7.0709 -2.512 12.1216
HAL-01 GDSC1; GDSC2 1.3622 16.4806 -7.1344 29.1914
NK-92MI GDSC2 1.3753 3.0437 -0.586 1.1537
GDM-1 GDSC1; GDSC2 1.3969 13.088 -5.4194 24.4949
SU-DHL-6 GDSC1; GDSC2 1.4166 3.646 -0.8217 2.2519
MHH-CALL-2 GDSC1; GDSC2 1.4169 2.9742 -0.5377 0.9035
SUP-B8 GDSC1; GDSC2 1.4301 4.7127 -1.2979 4.8641
MHH-PREB-1 GDSC1; GDSC2 1.4399 3.5203 -0.7545 1.8781
DoHH2 GDSC2 1.4418 3.0652 -0.5628 0.9848
RS4;11 GDSC1; GDSC2 1.4453 3.8835 -0.9106 2.6774
KMS-11 GDSC1; GDSC2 1.4505 10.4022 -4.0473 19.2965
TUR GDSC1; GDSC2 1.4568 9.1418 -3.421 16.4601
VL51 GDSC1; GDSC2 1.4619 14.293 -5.9677 25.9965
SR GDSC1; GDSC2 1.4656 9.5402 -3.6106 17.3285
RC-K8 GDSC1; GDSC2 1.4714 6.7399 -2.2365 10.208
TF-1 CTRP2 1.4837 12.1802 -1.3335 37.5221
697 GDSC1; GDSC2; CTRP2 1.5122 9.5273 -0.1504 33.1291
RPMI-8226 GDSC1; GDSC2 1.5189 16.0391 -6.7916 28.0366
RCH-ACV GDSC1; GDSC2 1.5381 3.5924 -0.7342 1.6557
Karpas-45 GDSC1; GDSC2 1.5387 4.1396 -0.9717 2.8622
SU-DHL-8 GDSC1; GDSC2 1.5628 2.9918 -0.4795 0.565
Jiyoye GDSC1; GDSC2 1.5698 4.1195 -0.9454 2.677
ATN-1 GDSC1; GDSC2 1.5794 3.829 -0.8137 1.9907
DG-75 GDSC1; GDSC2 1.5892 5.2883 -1.4663 5.5349
L-363 GDSC1; GDSC2 1.606 3.1143 -0.5081 0.6338
WSU-NHL GDSC1; GDSC2 1.6246 4.2456 -0.9706 2.7295
SU-DHL-4 GDSC1; GDSC2 1.6414 2.901 -0.4135 0.3193
Reh GDSC1; GDSC2 1.6451 3.213 -0.5293 0.6806
KM-H2 GDSC1; GDSC2 1.6522 3.6608 -0.7057 1.3937
TK [Human B-cell lymphoma] GDSC1; GDSC2 1.6559 3.4367 -0.6127 0.9912
Ramos.2G6.4C10 GDSC1; GDSC2 1.6599 3.0672 -0.4675 0.4642
Jurkat GDSC1; GDSC2 1.6679 3.3718 -0.5814 0.8569
ALL-SIL GDSC1; GDSC2 1.6924 9.7738 -3.5582 16.5407
BL-41 GDSC1; GDSC2 1.7088 3.3472 -0.5536 0.7207
SEM CTRP2 1.7152 10.5474 -0.3731 34.8759
HEL GDSC1; GDSC2 1.7516 4.1122 -0.8451 1.9283
ALL-PO GDSC1; GDSC2 1.7767 5.9931 -1.677 6.3849
CESS GDSC1; GDSC2 1.7876 9.4684 -3.3397 15.2849
Karpas-231 GDSC1; GDSC2 1.7882 3.1989 -0.4645 0.3858
KG-1 GDSC1; GDSC2 1.8215 12.7155 -4.9109 21.767
CRO-AP2 GDSC1; GDSC2 1.8244 6.0199 -1.6594 6.1959
L-1236 GDSC1; GDSC2 1.8458 4.7371 -1.0647 2.902
KMS-12-BM GDSC2 1.859 3.9463 -0.7233 1.2598
SUP-T1 GDSC1; GDSC2 1.8675 4.3514 -0.887 1.9889
GR-ST GDSC1; GDSC2 1.902 5.2834 -1.2754 3.9322
BALL-1 GDSC1; GDSC2 1.9349 3.4444 -0.4964 0.4006
VAL GDSC1; GDSC2 1.9437 4.5071 -0.914 2.0261
RPMI-8402 GDSC1; GDSC2 2.0311 3.5454 -0.4956 0.3538
BE-13 GDSC1; GDSC2 2.0713 7.0289 -1.9747 7.4986
SK-MM-2 GDSC1; GDSC2 2.0721 3.9101 -0.6142 0.6769
EB2 GDSC1; GDSC2 2.0851 3.8023 -0.5684 0.5261
P30/OHK GDSC1; GDSC2 2.0887 3.7858 -0.5608 0.5021
JVM-2 GDSC1; GDSC2 2.1652 14.5947 -5.5809 23.2291
CCRF-CEM GDSC1; GDSC2 2.2031 4.1128 -0.6362 0.6653
CTB-1 GDSC1; GDSC2 2.2181 5.7728 -1.3147 3.6639
MN-60 GDSC1; GDSC2 2.2258 4.3255 -0.7078 0.891
U-698-M GDSC1; GDSC2 2.2297 4.1651 -0.6449 0.6767
ME1 GDSC1; GDSC2 2.262 24.7046 -10.5215 33.2688
ROS-50 GDSC1; GDSC2 2.2736 4.6419 -0.8106 1.2384
HDLM-2 GDSC1; GDSC2 2.3869 5.2569 -1.0064 1.9538
A3/Kawakami GDSC1; GDSC2; CTRP2 2.548 12.5005 -0.4168 30.8558
MM1.S GDSC2 2.6128 13.4158 -4.6747 19.1308
MOLT-4 GDSC1; GDSC2 2.615 9.8955 -2.9749 11.7133
GA-10 GDSC1; GDSC2; CTRP2 2.6549 5.2123 2.5348 21.5566
K-562 GDSC1; GDSC2; CTRP2 2.6588 13.4921 -0.7748 31.4091
L-540 GDSC1; GDSC2 2.6592 4.5391 -0.6119 0.3753
Loucy GDSC1; GDSC2 2.6757 13.8741 -4.8533 19.6552
ARH-77 GDSC1; GDSC2 2.8263 15.3775 -5.4794 21.4856
LC4-1 GDSC1; GDSC2 3.0383 16.581 -5.9149 22.4076
Karpas-299 GDSC1; GDSC2 3.0421 13.0143 -4.1796 16.2948
RPMI-8866 GDSC1; GDSC2 3.1341 14.883 -5.019 19.2975
HH [Human lymphoma] GDSC1; GDSC2; CTRP2 3.2329 6.3184 2.8972 18.6717
DB GDSC1; GDSC2; CTRP2 3.4277 6.1332 3.164 17.2124
Pfeiffer CTRP2 3.4736 5.619 3.3425 17.5785
Mino CTRP2 3.6655 6.8691 3.1841 17.5822
MLMA GDSC1; GDSC2 3.6967 13.0465 -3.7597 13.2696
EB1 CTRP2 3.78 7.1641 3.1974 17.2061
MOLT-3 CTRP2 3.8878 17.2227 -1.4301 31.252
M-07e CTRP2 4.017 21.235 -3.3003 34.2611
DND-41 GDSC1; GDSC2; CTRP2 4.0339 16.7537 -1.0659 28.8
WSU-DLCL2 GDSC1; GDSC2 4.0507 16.3274 -5.0845 17.7583
Daudi GDSC1; GDSC2; CTRP2 4.0941 6.5091 3.7731 13.2579
BL-70 CTRP2 4.2232 5.9975 4.0695 12.6694
ST486 GDSC1; GDSC2; CTRP2 4.2291 8.914 2.9132 16.0561
CA46 GDSC1; GDSC2; CTRP2 4.3492 6.9278 3.8956 12.1413
NALM-6 GDSC1; GDSC2 4.3503 23.7753 -8.4859 26.2942
U266B1 GDSC1; GDSC2; CTRP2 4.6083 21.6993 -3.0098 31.4281
BCP-1 CTRP2 4.6158 21.4049 -2.8566 32.3141
OCI-M1 GDSC1; GDSC2; CTRP2 4.8651 16.2249 -0.0592 24.4935
QIMR-WIL GDSC1; GDSC2 4.9388 17.895 -5.2422 16.7325
OCI-Ly10 CTRP2 5.0948 25.7925 -4.6317 34.018
Toledo CTRP2 5.0961 11.9995 2.2438 17.6681
JeKo-1 GDSC1; GDSC2; CTRP2 5.1669 8.1398 4.1986 9.035
BC-1 GDSC1; GDSC2 5.2356 26.4979 -9.1797 26.2113
Namalwa GDSC1; GDSC2; CTRP2 5.241 7.7887 4.4371 7.9558
HT GDSC1; GDSC2 5.3841 19.2126 -5.5753 17.088
OCI-Ly3 CTRP2 6.0975 26.4594 -4.1189 31.5248
Granta-519 GDSC1; GDSC2; CTRP2 7.3897 19.5574 0.3737 18.5547
Ci-1 CTRP2 7.4137 8.2827 5.7641 0.0814
LP-1 GDSC1; GDSC2; CTRP2 7.4147 11.3413 4.4325 4.2579
EJM GDSC1; GDSC2; CTRP2 7.4189 18.4292 0.9568 16.7367
MOTN-1 CTRP2 7.7338 9.8203 5.3093 0.9867
Hs 611.T CTRP2 7.8973 10.1611 5.2483 1.0516
L-428 GDSC1; GDSC2; CTRP2 8.0384 9.6233 5.522 0.2753
HuNS1 CTRP2 8.0626 18.6839 1.3176 15.3595
Kasumi-2 CTRP2 8.0954 29.2537 -3.8984 27.9247
JJN-3 GDSC1; GDSC2; CTRP2 10.2645 22.5502 0.9882 12.5339
HEL 92.1.7 CTRP2 10.3239 17.86 3.2069 5.6858
RPMI-6666 GDSC1; GDSC2; CTRP2 10.5072 33.1338 -3.9849 23.8891
Karpas-422 GDSC1; GDSC2; CTRP2 10.9303 27.6482 -1.0065 17.136
RL GDSC1; GDSC2; CTRP2 11.4538 23.2159 1.4387 9.7743
SUP-HD1 GDSC1; GDSC2; CTRP2 11.579 26.2246 0.11 13.4516
CMK GDSC1; CTRP2 14.0791 30.5454 -0.3341 12.4427
⏷ Show the Full List of 195 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 27 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 7.6856 47.9104 -13.5371 37.922
OE21 GDSC1; GDSC2; CTRP2 -1.574 12.4869 -4.6143 48.6613
TE-4 GDSC1; GDSC2 -0.6758 6.9238 -4.04 25.3253
TE-8 GDSC1; GDSC2 -0.5992 11.7594 -6.3863 32.4318
T.T GDSC1; GDSC2 0.0927 10.3082 -5.0771 26.8002
TE-15 GDSC1; GDSC2 0.2923 11.0483 -5.2825 26.9061
KYSE-140 GDSC2 0.2937 6.8971 -3.207 18.49
TE-10 GDSC1; GDSC2 1.1746 14.2197 -6.1562 27.2041
TE-1 GDSC1; GDSC2 1.2372 15.656 -6.8223 28.7527
KYSE-180 GDSC1; GDSC2 1.5417 9.6242 -3.5955 17.0736
TE-5 GDSC1; GDSC2; CTRP2 1.6051 11.8862 -1.0784 34.9287
TE-9 GDSC1; GDSC2 1.7321 9.1327 -3.2157 14.81
KYSE-270 GDSC1; GDSC2 2.0395 12.0363 -4.4146 19.3993
OE33 GDSC1; GDSC2; CTRP2 2.1427 12.7872 -0.951 33.1617
KYSE-30 CTRP2 2.3057 64.4892 -26.3492 46.697
KYSE-410 GDSC2 2.3334 16.5667 -6.4282 25.3261
TE-11 GDSC1; GDSC2; CTRP2 2.3499 20.0363 -4.227 37.846
TE-6 GDSC1; GDSC2 2.7187 12.4565 -4.1338 16.7737
COLO 680N GDSC1; GDSC2 3.6136 16.7468 -5.5866 20.2571
KYSE-70 GDSC1; GDSC2 3.6649 14.7173 -4.5739 16.6252
TE-14 CTRP2 4.4789 26.7149 -5.6228 36.3072
KYSE-520 GDSC1; GDSC2; CTRP2 7.9851 30.791 -4.7511 28.5734
EC-GI-10 GDSC1; GDSC2; CTRP2 8.1835 36.6659 -7.5223 31.8723
KYSE-150 GDSC1; GDSC2; CTRP2 8.4037 15.2444 3.2309 7.4218
KYSE-510 GDSC1; GDSC2; CTRP2 8.5432 10.3086 5.4697 0.219
OE19 GDSC1; GDSC2; CTRP2 10.3726 23.0874 0.8041 12.9476
KYSE-450 GDSC1; GDSC2; CTRP2 14.2739 31.6992 -0.746 12.7449
⏷ Show the Full List of 27 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 -1.1781 23.8445 -9.4125 49.4012
PSN1 GDSC1; GDSC2; CTRP2 -4.9221 3.6913 -5.3731 63.8838
PaTu 8988s CTRP2 -4.7568 13.9675 -8.5631 58.9967
HPAF-II GDSC1; GDSC2 -4.3267 3.0029 -5.7815 45.7345
HPAC GDSC2 -3.6128 4.7936 -5.8144 42.0958
PK-45H CTRP2 -3.1856 22.5206 -10.7481 53.5586
PL4 GDSC1; GDSC2 -2.1849 5.6415 -4.7988 33.4998
SUIT-2 GDSC1; GDSC2 -1.1519 6.1392 -4.0755 27.0283
AsPC-1 GDSC1; GDSC2; CTRP2 -0.7204 16.7443 -5.627 46.3559
QGP-1 GDSC1; GDSC2 -0.5819 19.6814 -10.3298 38.5543
MIA PaCa-2 GDSC1; GDSC2; CTRP2 -0.4567 11.4967 -3.0319 44.074
Hs 766T GDSC1; GDSC2; CTRP2 -0.3349 24.2101 -8.7807 46.4792
Panc 02.03 GDSC1; GDSC2; CTRP2 -0.2931 11.2211 -2.7455 43.2689
Capan-1 GDSC2; CTRP2 0.1894 14.2568 -3.5789 42.5438
BxPC-3 GDSC1; GDSC2 0.3889 12.9532 -6.1554 29.1118
MZ-PC-1 GDSC1; GDSC2 0.6054 13.7234 -6.3639 29.0969
SU.86.86 GDSC1; GDSC2 0.8555 11.4391 -5.0232 24.49
SW1990 GDSC1; GDSC2; CTRP2 1.3496 12.057 -1.414 36.2561
CFPAC-1 GDSC1; GDSC2 1.4051 11.5221 -4.6361 21.7106
KP-4 GDSC1; GDSC2 1.6585 9.7598 -3.5762 16.6604
PaTu 8902 GDSC1; GDSC2 1.77 14.52 -5.8429 24.8726
Panc 04.03 GDSC2; CTRP2 1.7967 16.458 -3.0199 37.5826
HuP-T3 GDSC1; GDSC2; CTRP2 1.8428 20.7302 -5.0386 39.7666
KP-3 GDSC1; GDSC2 2.1791 7.4222 -2.0903 7.9054
HuP-T4 GDSC2 2.2698 17.0442 -6.7123 26.1594
KP-1N GDSC1; GDSC2 3.4575 12.8612 -3.8278 13.9728
Panc 10.05 GDSC1; GDSC2; CTRP2 3.7055 25.5687 -5.7294 36.7538
Capan-2 GDSC1; GDSC2; CTRP2 3.8295 31.0418 -8.3449 38.8546
YAPC GDSC1; GDSC2 4.2499 13.298 -3.5295 11.2757
Panc 03.27 GDSC1; GDSC2; CTRP2 4.692 24.6833 -4.4247 33.3891
Panc 08.13 GDSC1; GDSC2; CTRP2 5.0013 16.4032 -0.028 24.0841
DAN-G GDSC2; CTRP2 5.2757 21.259 -2.2126 28.6473
KP-2 GDSC1; GDSC2; CTRP2 8.1945 55.6183 -16.9743 38.5553
PaTu 8988t GDSC1; GDSC2; CTRP2 12.2859 38.549 -5.3455 23.9649
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 71 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 -12.1532 21.3386 -19.3754 66.5558
WM88 CTRP2 -17.017 -3.0365 -17.3476 90.5804
WM983B CTRP2 -15.7843 14.3409 -20.4658 73.5237
UACC-62 GDSC1; GDSC2; CTRP2 -12.7393 12.9973 -16.6999 70.8492
WT2-iPS GDSC1; GDSC2; CTRP2 -12.6698 0.2908 -13.1444 83.4607
UACC-257 GDSC1; GDSC2; CTRP2 -11.814 33.6634 -24.479 61.5464
Malme-3M CTRP2 -11.5995 15.1681 -16.2924 69.1718
M14 GDSC1; GDSC2 -10.5919 -0.3049 -11.4774 75.1273
WM266-4 CTRP2 -10.4405 20.7978 -17.363 64.9714
CP50-MEL-B GDSC1; GDSC2 -10.3113 2.4363 -12.0015 70.4521
G-mel GDSC1; GDSC2 -9.8608 -7.3168 -9.8612 91.4138
COLO 800 GDSC1; GDSC2; CTRP2 -9.5271 1.7334 -9.996 77.9124
COLO 679 GDSC1; GDSC2 -9.1784 4.0362 -11.3495 65.9618
HT-144 GDSC1; GDSC2; CTRP2 -9.0947 20.5265 -15.8508 62.5863
WM35 GDSC1; GDSC2 -8.8566 0.3829 -9.7727 69.6699
SH-4 GDSC1; GDSC2 -8.7656 -3.0105 -8.9438 75.989
IPC-298 GDSC1; GDSC2 -8.3246 -3.2479 -8.4471 74.8893
SK-MEL-28 GDSC1; GDSC2 -7.9764 2.5846 -9.5261 63.964
A-375 GDSC1; GDSC2 -7.9621 5.8231 -10.7607 61.107
SK-MEL-24 GDSC1; GDSC2; CTRP2 -7.9391 24.9856 -16.6348 59.6254
Mel Ho GDSC1; GDSC2 -7.718 1.1518 -8.7634 64.6812
HMV-II GDSC1; GDSC2 -7.6852 0.4559 -8.5159 65.4572
COLO 829 GDSC1; GDSC2; CTRP2 -7.4402 15.1491 -11.8711 62.4374
451Lu GDSC1; GDSC2 -6.853 4.4179 -9.0203 58.387
COLO 792 GDSC1; GDSC2; CTRP2 -6.831 3.22 -7.3488 70.4247
MZ-MEL-7 GDSC1; GDSC2 -6.8154 3.9049 -8.7765 58.574
SK-MEL-30 GDSC1; GDSC2 -6.5569 0.729 -7.3673 59.9355
G-361 GDSC1; GDSC2 -6.43 5.9242 -9.2024 56.0181
CP66-MEL GDSC1; GDSC2 -6.3944 6.7137 -9.5063 55.5733
MMAc-SF GDSC1; GDSC2 -6.2578 6.9324 -9.4615 55.0097
SK-MEL-1 GDSC1; GDSC2 -6.1574 7.9 -9.7884 54.3616
WM115 GDSC1; GDSC2; CTRP2 -6.0866 1.412 -6.2764 70.4413
LB2518-MEL GDSC1; GDSC2 -5.8183 -0.1598 -6.3067 56.2456
GAK GDSC1; GDSC2 -5.5758 0.5742 -6.2511 54.2281
COLO 783 GDSC1; GDSC2 -5.1327 4.2042 -7.1237 50.7944
Hs 938.T GDSC1; GDSC2 -5.0568 34.4177 -21.5856 50.1028
MZ-MEL-2 GDSC1; GDSC2 -4.5625 3.9874 -6.4378 47.6201
LOX-IMVI GDSC1; GDSC2; CTRP2 -4.4324 2.7258 -4.6838 62.8219
SK-MEL-2 GDSC1; GDSC2; CTRP2 -3.9668 4.6197 -4.5277 59.5845
LB373-MEL-D GDSC1; GDSC2 -2.6219 7.6054 -6.1603 38.5933
MeWo GDSC1; GDSC2; CTRP2 -2.2252 23.6311 -10.3257 50.542
WM278 GDSC1; GDSC2 -2.0108 44.4225 -23.9084 46.5064
SK-MEL-5 GDSC1; GDSC2 -1.8105 29.366 -16.2177 44.4901
A-431 GDSC1; GDSC2 -1.4455 7.7685 -5.1461 31.8588
RVH-421 GDSC1; GDSC2; CTRP2 -0.8795 632.8381 -313.1409 49.9063
Mel JuSo GDSC1; GDSC2 -0.8236 13.7188 -7.5573 35.4094
WM793 GDSC1; GDSC2 -0.5057 24.1328 -12.4904 40.3026
IST-MEL1 GDSC1; GDSC2 -0.4335 15.6555 -8.1919 35.4576
RPMI-7951 GDSC2 0.0403 9.5756 -4.7542 25.8452
WM1552C GDSC1; GDSC2 0.1331 13.2479 -6.5134 30.7276
IGR-1 GDSC2; CTRP2 0.2021 54.4691 -23.1938 47.8314
IGR-37 GDSC1; GDSC2; CTRP2 0.2531 497.7202 -244.6361 49.7556
DJM-1 GDSC1; GDSC2 0.5101 10.4239 -4.7932 24.6595
A-388 GDSC1; GDSC2 0.7627 9.8359 -4.2977 22.0977
SK-MEL-31 GDSC1; GDSC2 0.9652 12.6561 -5.5428 25.9467
CHL-1 GDSC1; GDSC2 1.8759 11.6481 -4.3443 19.4984
K029AX CTRP2 2.2416 66.3237 -27.3201 46.848
VMRC-MELG GDSC1; GDSC2 2.256 11.4401 -3.9663 17.0687
Hs 294T CTRP2 4.0668 41.1432 -13.1791 42.0111
Hs 895.T CTRP2 5.9189 20.5512 -1.3138 26.6631
IGR-39 CTRP2 7.5043 12.2129 4.0756 5.8392
Hs 934.T CTRP2 7.5061 19.7296 0.3785 19.2688
HMCB CTRP2 7.7413 18.4998 1.1682 16.3873
Hs 688(A).T CTRP2 8.3044 15.8941 2.852 9.4784
A101D GDSC1; GDSC2; CTRP2 8.4187 48.1284 -13.0531 36.2316
Hs 839.T CTRP2 8.4519 22.6977 -0.3709 19.8142
Hs 940.T GDSC1; GDSC2; CTRP2 8.9562 21.3559 0.6588 15.2875
CJM [Human melanoma] CTRP2 9.2444 21.7441 0.6751 15.578
A2058 GDSC2; CTRP2 10.3123 37.2035 -6.1371 27.4699
SK-MEL-3 GDSC1; GDSC2; CTRP2 11.3816 61.8469 -17.5433 36.0028
EquiPSC Line K2 GDSC1; GDSC2 -8.5058 2.8636 -10.1966 65.3452
⏷ Show the Full List of 71 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ESO-51 GDSC1; GDSC2 -3.9046 0.1428 -4.301 40.6029
OACP4 C GDSC1; GDSC2 -3.6032 5.7152 -6.224 42.7371
SK-GT-4 GDSC1; GDSC2 -3.2775 26.1387 -15.892 46.8565
KYSE-220 GDSC1; GDSC2 -1.8025 12.7816 -7.9488 38.7422
TE-12 GDSC1; GDSC2 0.0756 14.2707 -7.0724 32.128
KYSE-50 GDSC1; GDSC2 1.2468 9.3227 -3.6674 18.1319
ESO-26 GDSC1; GDSC2 1.5842 7.7175 -2.6315 12.137
HCE-4 GDSC1; GDSC2 1.9065 4.4577 -0.9121 2.0614
OACM5.1 C GDSC1; GDSC2 1.9386 8.2634 -2.649 11.4446
FLO-1 GDSC1; GDSC2 2.0827 21.4539 -9.0445 31.3953
KYAE-1 GDSC1; GDSC2 2.4226 3.9118 -0.4792 0.1881
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2; CTRP2 5.5689 7.6029 4.8404 5.6817
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CHP-212 GDSC1; GDSC2; CTRP2 -11.9882 0.1207 -12.3912 83.1629
NB69 GDSC2 -7.971 -1.6578 -8.3089 70.0524
NB(TU)1 GDSC1; GDSC2 -7.3882 2.6535 -8.9167 61.7897
SK-N-AS GDSC1; GDSC2; CTRP2 -6.5709 26.2624 -15.8425 57.4791
SK-N-BE(2) CTRP2 -6.0056 8.338 -7.7971 65.2611
LA-N-6 GDSC1; GDSC2 -3.1796 6.3457 -6.098 40.7119
SK-N-BE(2)-M17 GDSC1; GDSC2 -1.447 6.7163 -4.629 30.2186
GI-ME-N GDSC1; GDSC2 -1.3813 11.3896 -6.8832 35.7737
SK-N-FI GDSC1; GDSC2; CTRP2 -1.3689 22.324 -8.8738 48.6889
SJNB-10 GDSC1; GDSC2 -1.3341 10.4624 -6.3807 34.6137
NH-12 GDSC2 -0.9997 7.8356 -4.7792 29.1744
SiMa GDSC1; GDSC2 -0.3859 12.1744 -6.4117 31.8888
SJNB-5 GDSC1; GDSC2 0.3789 16.9494 -8.1611 33.4689
MHH-NB-11 GDSC2 0.5779 9.2007 -4.1281 21.9091
SJNB-14 GDSC1; GDSC2 0.651 8.3752 -3.6582 19.6561
KP-N-RT-BM-1 GDSC2 1.014 3.7089 -1.0928 4.4649
KP-N-YS GDSC2 1.1418 3.2757 -0.8125 2.6213
CHP-134 GDSC2 1.4113 3.0207 -0.5592 0.9992
Kelly GDSC1; GDSC2 1.6068 10.697 -4.0756 19.0351
SJNB-6 GDSC2 1.6273 3.3148 -0.5771 0.8745
TGW GDSC1; GDSC2 1.6291 7.5857 -2.5359 11.5174
GOTO GDSC1; GDSC2 1.6697 4.756 -1.1728 3.7449
CHP-126 GDSC1; GDSC2 1.7079 3.5842 -0.6479 1.0878
SK-N-MC-IXC GDSC1; GDSC2 1.8857 3.2224 -0.4353 0.2691
SJNB-12 GDSC1; GDSC2 1.8899 10.7647 -3.9001 17.6135
NB1 GDSC1; GDSC2 1.9554 6.8186 -1.95 7.5826
IMR-5 GDSC1; GDSC2 2.008 10.6343 -3.7507 16.6839
SJNB-13 GDSC1; GDSC2 2.111 4.0168 -0.6385 0.7318
SJNB-17 GDSC1; GDSC2 2.1208 4.1373 -0.6805 0.8708
SJNB-7 GDSC1; GDSC2 2.276 3.9869 -0.5604 0.4093
SK-N-DZ GDSC1; GDSC2; CTRP2 4.4495 12.4857 1.4141 20.9157
IMR-32 CTRP2 8.4828 21.8122 0.0888 18.4871
NH-6 CTRP2 9.0722 34.2046 -5.5988 29.0886
KP-N-YN GDSC1; GDSC2; CTRP2 9.5506 25.7621 -1.067 19.1218
SK-N-SH GDSC1; GDSC2; CTRP2 9.8209 28.5275 -2.2261 21.3978
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 -2.4949 10.9829 -7.6878 40.4951
SNU-869 CTRP2 5.5052 23.2769 -3.0252 30.8497
Cancer Drug Sensitivity Data Curated from 87 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DU4475 GDSC1; GDSC2; CTRP2 -10.2242 -8.0803 -10.2242 96.4433
MDA-MB-175-VII GDSC1; GDSC2 -1.4121 8.0131 -5.2366 31.9377
MDA-MB-231 GDSC1; GDSC2 -1.3596 10.8819 -6.6118 35.1145
UACC-893 GDSC1; GDSC2 -0.9792 7.9162 -4.8011 29.1113
HDQ-P1 GDSC1; GDSC2 -0.4278 14.0481 -7.3837 33.9937
HCC1569 GDSC1; GDSC2 0.1961 6.188 -2.9322 17.2988
HCC1143 GDSC1; GDSC2 0.271 13.0296 -6.2904 29.7665
MFM-223 GDSC1; GDSC2 0.4547 5.3639 -2.3131 13.1225
CAL-85-1 GDSC1; GDSC2; CTRP2 1.3872 16.6132 -3.4895 39.2102
CAL-148 GDSC2 1.5865 3.2573 -0.5729 0.8899
COLO 824 GDSC1; GDSC2 1.6847 8.4979 -2.9399 13.4922
MRK-nu-1 GDSC1; GDSC2 1.6925 3.2327 -0.5165 0.6003
MDA-MB-330 GDSC1; GDSC2 1.7094 4.1412 -0.8793 2.1404
OCUB-M GDSC1; GDSC2 1.7242 4.3872 -0.978 2.6169
BT-474 GDSC1; GDSC2 1.7814 4.3868 -0.947 2.3827
HCC1806 GDSC1; GDSC2 1.7946 18.1246 -7.6136 29.2516
CAMA-1 GDSC1; GDSC2 1.8006 5.2579 -1.3231 4.3412
MCF-7 GDSC1; GDSC2 1.8101 4.3656 -0.9228 2.2252
HCC1187 GDSC1; GDSC2 1.8414 5.1018 -1.2289 3.7632
HCC1599 GDSC2 1.9441 3.5177 -0.5197 0.4592
EFM-19 GDSC1; GDSC2 1.9963 5.0426 -1.1162 2.9458
UACC-812 GDSC2 2.063 6.86 -1.901 7.0821
BT-483 GDSC1; GDSC2 2.0632 3.5987 -0.5024 0.3556
HCC2157 GDSC1; GDSC2 2.0993 5.0201 -1.0518 2.49
Evsa-T GDSC1; GDSC2 2.1906 3.9524 -0.5815 0.5057
CAL-51 GDSC1; GDSC2 2.21 12.0373 -4.2909 18.4769
YMB-1-E GDSC2 2.2832 7.6035 -2.1092 7.8387
JIMT-1 GDSC1; GDSC2 2.3209 12.5343 -4.4539 18.8775
CAL-120 GDSC1; GDSC2 2.3472 12.7617 -4.5462 19.1769
HCC1954 GDSC1; GDSC2 2.4262 10.6519 -3.4647 14.4198
HCC1395 GDSC1; GDSC2 2.4883 11.9315 -4.0408 16.8357
HCC70 GDSC1; GDSC2 3.2737 19.7828 -7.3134 25.6257
HCC1937 GDSC1; GDSC2 3.3333 14.6321 -4.7589 17.9226
HCC2218 GDSC1; GDSC2; CTRP2 3.4607 9.6854 1.7901 21.9145
MDA-MB-436 GDSC1; GDSC2 4.0224 14.4018 -4.188 14.422
SK-BR-3 CTRP2 5.0957 6.8412 4.7194 7.7211
Hs 578T GDSC1; GDSC2; CTRP2 5.4922 22.9607 -2.8782 29.4974
MDA-MB-157 GDSC1; GDSC2; CTRP2 5.7806 13.3804 2.1543 15.5568
AU565 GDSC2; CTRP2 5.9212 10.8208 3.5527 10.012
BT-20 GDSC1; GDSC2; CTRP2 6.049 15.82 1.1604 18.4568
HCC1500 GDSC1; GDSC2; CTRP2 6.8856 13.3903 3.0468 10.2921
EFM-192A GDSC1; GDSC2; CTRP2 6.9417 18.0546 0.7698 18.0903
Hs 578Bst CTRP2 7.4594 12.3925 3.9583 6.3748
HCC1419 GDSC1; GDSC2; CTRP2 7.684 14.4214 3.1312 8.7529
MDA-MB-453 GDSC1; GDSC2; CTRP2 7.7257 17.9313 1.4374 14.668
HCC202 GDSC1; CTRP2 7.8574 11.3636 4.7007 2.9597
HCC38 GDSC1; GDSC2; CTRP2 7.9836 10.9788 4.9443 1.8352
ZR-75-30 GDSC1; GDSC2; CTRP2 8.4252 9.9327 5.5582 0.131
HCC1428 GDSC1; GDSC2; CTRP2 8.6751 14.4126 3.7965 5.0532
MDA-MB-415 GDSC1; GDSC2; CTRP2 8.8798 22.4628 0.0616 17.0994
MDA-MB-468 GDSC1; GDSC2; CTRP2 10.8474 32.6906 -3.5188 22.5931
BT-549 GDSC1; GDSC2; CTRP2 11.7303 25.8539 0.3825 12.507
T-47D GDSC1; GDSC2; CTRP2 12.0339 23.9458 1.4557 9.093
MDA-MB-361 GDSC1; GDSC2; CTRP2 12.6377 28.3926 -0.2292 13.1339
BT 286 CTRP2 -8.4865 -3.3442 -8.4959 87.5457
BT 440 CTRP2 -6.1735 0.2062 -6.2587 75.4214
BT 482 CTRP2 -6.043 1.0641 -6.1935 73.7061
BT 145 CTRP2 -5.9402 63.0078 -32.9523 53.546
BT 428 CTRP2 -4.6313 11.3839 -7.4013 59.8853
BT 416 CTRP2 -2.1999 1.2906 -2.2175 54.8352
BT 239 CTRP2 -2.0441 16.869 -7.0147 51.5941
BT 444 CTRP2 -0.9433 14.7269 -4.9376 48.3377
BT 271 CTRP2 0.0176 9.4485 -1.6973 43.1055
BT 159 CTRP2 0.4749 9.9237 -1.4034 41.0156
BT 340 CTRP2 0.5692 12.6304 -2.4638 42.0278
BT 228 CTRP2 0.7697 9.7889 -1.038 39.3803
BT 245 CTRP2 0.8655 13.3704 -2.4958 41.1259
BT 232 CTRP2 1.7705 11.9357 -0.9334 35.8907
BT164 CTRP2 2.1512 48.5964 -18.5572 45.7825
BT 330 CTRP2 2.2177 16.1647 -2.4751 37.2501
BT 139 CTRP2 2.2439 9.0625 0.8092 30.0952
BT147 CTRP2 3.8737 21.7196 -3.6684 35.0921
BT 172 CTRP2 4.3193 25.9522 -5.3813 36.3347
BT 131 CTRP2 5.5061 18.5123 -0.6436 25.8881
BT 504 CTRP2 6.1672 29.4134 -5.5379 33.3303
BT 498 CTRP2 6.704 10.7747 4.2039 6.5499
BT 179 CTRP2 6.7531 41.6878 -11.1902 37.5799
BT 231 CTRP2 7.23 30.5049 -5.2124 31.2314
BT 320 CTRP2 7.5365 18.0685 1.226 16.5448
BT 112 CTRP2 7.6793 21.8655 -0.5484 21.565
BT 248 CTRP2 7.8547 19.9927 0.5155 18.2599
BT 333 CTRP2 8.3344 26.2774 -2.2327 24.4393
BT 224 CTRP2 9.7886 23.8844 0.0193 16.7094
BT 328 CTRP2 10.6504 27.9069 -1.3268 19.0057
BT 359 CTRP2 11.1937 30.6833 -2.2922 20.4685
BT 216 CTRP2 11.8547 29.3037 -1.172 17.0697
BT 422 CTRP2 13.5224 30.6589 -0.7292 14.0327
⏷ Show the Full List of 87 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 61 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ONS-76 GDSC1; GDSC2 -6.1943 -2.2327 -6.3068 60.6265
KALS-1 GDSC1; GDSC2 -1.8304 6.7406 -4.9954 32.8004
D-245MG GDSC2 -1.5792 4.0879 -3.4734 26.0756
D-247MG GDSC1; GDSC2 -1.201 3.9078 -3.027 22.4363
CAS-1 GDSC1; GDSC2 -0.6562 7.1119 -4.1166 25.5749
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 -0.5536 7.2898 -4.116 25.2378
MOG-G-UVW GDSC1; GDSC2 -0.4507 7.1049 -3.9347 24.1509
AM-38 GDSC1; GDSC2 -0.0023 16.1122 -8.058 34.1877
SF539 GDSC1; GDSC2; CTRP2 0.3259 8.9239 -1.1653 39.1163
D-502MG GDSC1; GDSC2 0.5353 20.7314 -9.9231 35.7456
D-392MG GDSC1; GDSC2 0.599 16.6305 -7.8215 32.3489
NMC-G1 GDSC1; GDSC2 0.6269 11.547 -5.2597 25.9294
H4 GDSC1; GDSC2 0.6957 9.2489 -4.0583 21.2949
D-566MG GDSC1; GDSC2 0.6963 5.2258 -2.0577 11.022
LNZTA3WT4 GDSC1; GDSC2 0.8271 9.7635 -4.2108 21.5742
D-263MG GDSC1; GDSC2 1.2169 10.804 -4.4244 21.4168
D-542MG GDSC1; GDSC2 1.2821 8.5058 -3.2374 15.9976
GaMG GDSC1; GDSC2 1.4643 12.0958 -4.8751 22.4906
GI-1 GDSC1; GDSC2 1.4863 9.1089 -3.3829 16.2063
KINGS-1 GDSC1; GDSC2 1.5656 13.8431 -5.664 24.8558
KNS-81-FD GDSC1; GDSC2 1.6157 11.8445 -4.6356 21.2451
U-87MG ATCC GDSC1; GDSC2 1.6563 16.6017 -6.9641 28.1439
Onda 10 GDSC1; GDSC2 1.7162 8.3408 -2.8411 12.9476
LN-405 GDSC1; GDSC2 1.7702 8.9746 -3.1113 14.2042
DBTRG-05MG GDSC1; GDSC2 1.7972 17.6023 -7.3519 28.7245
D-336MG GDSC1; GDSC2 1.8266 11.3597 -4.2388 19.1882
MOG-G-CCM GDSC1; GDSC2 1.8732 9.9226 -3.5 15.8476
DK-MG GDSC1; GDSC2; CTRP2 1.9595 17.0009 -3.1236 37.3698
SF295 GDSC1; GDSC2 2.0791 12.6043 -4.6645 20.2704
Onda 11 GDSC1; GDSC2 2.084 12.0212 -4.3746 19.1395
D-423MG GDSC1; GDSC2 2.1067 5.2512 -1.1474 2.9633
SF126 GDSC1; GDSC2 2.3428 11.3148 -3.8438 16.3478
M059J GDSC1; GDSC2 2.3795 9.9862 -3.1762 13.1854
PFSK-1 GDSC2 2.434 6.5252 -1.5269 4.4507
LN-229 GDSC1; GDSC2 2.5406 15.3958 -5.6968 22.7751
YKG-1 GDSC1; GDSC2; CTRP2 2.8569 16.9508 -2.2493 33.8604
SW1088 GDSC1; GDSC2 2.9186 11.7396 -3.6518 14.2906
LN-18 GDSC1; GDSC2 3.0858 11.8932 -3.6133 13.7864
SK-MG-1 GDSC1; GDSC2 3.1436 13.4543 -4.3218 16.6638
Daoy GDSC1; GDSC2 3.5661 9.8576 -2.3697 7.0149
Hs 683 GDSC1; GDSC2; CTRP2 4.3213 14.1548 0.4768 24.1475
D283 Med GDSC1; GDSC2; CTRP2 4.8038 13.5335 1.2216 20.7816
GB-1 GDSC1; GDSC2 5.2321 17.3074 -4.7791 14.6332
A-172 GDSC1; GDSC2; CTRP2 5.4851 22.4618 -2.6349 29.103
SF268 GDSC1; GDSC2; CTRP2 6.385 15.7496 1.4726 16.8421
SW1783 GDSC1; GDSC2; CTRP2 6.5899 12.6806 3.1693 10.3374
YH-13 GDSC1; GDSC2; CTRP2 7.7566 19.1574 0.8545 16.5087
U-118MG GDSC1; GDSC2; CTRP2 7.8161 11.285 4.712 2.7792
KG-1-C CTRP2 8.374 53.1259 -15.5842 38.2825
U-251MG GDSC1; GDSC2; CTRP2 8.9251 31.2761 -4.2585 26.4617
CCF-STTG1 CTRP2 9.5655 18.9433 2.2404 9.9658
KNS-42 GDSC1; GDSC2; CTRP2 9.6211 19.1471 2.1803 9.5478
TM-31 CTRP2 11.339 39.3923 -6.4491 27.3566
GMS-10 CTRP2 11.4297 24.6744 0.7439 12.4373
8-MG-BA GDSC1; GDSC2; CTRP2 12.1852 27.4989 -0.0987 13.3142
SNB-75 GDSC1; GDSC2; CTRP2 12.6895 31.591 -1.7057 16.6764
M059K CTRP2 13.4762 27.2837 0.7927 10.0307
Becker GDSC1; GDSC2; CTRP2 13.9357 41.5664 -5.6476 22.6625
42-MG-BA GDSC1; GDSC2; CTRP2 14.4799 37.6304 -3.3929 18.2417
T98G GDSC1; GDSC2; CTRP2 14.5744 28.2358 0.9924 8.0355
GOS-3 CTRP2 16.235 35.9199 -1.4976 13.1196
⏷ Show the Full List of 61 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC24TKB GDSC1; GDSC2 -0.4887 12.5583 -6.6909 32.8062
TGBC1TKB GDSC1; GDSC2 2.0297 9.9042 -3.3795 14.9236
ETK-1 GDSC1; GDSC2 2.1451 12.8914 -4.7571 20.4654
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-3 CTRP2 -2.3837 8.4695 -3.9137 53.9342
RL95-2 GDSC1; GDSC2 -1.0387 15.4936 -8.6286 37.6091
MFE-280 GDSC1; GDSC2 1.7809 6.5495 -1.9361 7.8474
KLE GDSC1; GDSC2 2.2307 11.5512 -4.0386 17.4319
JHUEM-1 CTRP2 4.712 9.6051 3.0603 15.3444
JHUEM-7 CTRP2 5.096 23.6008 -3.5361 32.4586
MFE-296 GDSC1; GDSC2; CTRP2 6.2563 14.4595 2.0121 15.2113
ESS-1 GDSC1; GDSC2; CTRP2 6.3788 17.2158 0.7349 19.2267
HEC-1-A CTRP2 6.9391 21.6571 -1.0294 24.0802
EN GDSC1; GDSC2; CTRP2 8.5241 17.5565 2.201 10.9203
AN3-CA GDSC1; GDSC2; CTRP2 10.1301 27.9588 -1.7225 19.8711
MFE-319 GDSC1; GDSC2; CTRP2 10.4726 26.9285 -0.977 17.6526
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RXF 393L GDSC1; GDSC2 -2.2835 3.2282 -3.7646 30.277
UO-31 GDSC1; GDSC2; CTRP2 -2.153 6.0407 -2.9007 50.9518
SW13 GDSC1; GDSC2 -0.5721 12.5113 -6.7386 33.1407
KTCTL-140 GDSC1; GDSC2 -0.4735 12.6917 -6.7446 32.8808
769-P GDSC1; GDSC2 -0.0753 8.9544 -4.5401 25.4059
NCC021 GDSC1; GDSC2 0.0942 7.5733 -3.7085 21.4739
TK-10 GDSC1; GDSC2 0.0945 8.8441 -4.3436 24.1535
BB65-RCC GDSC1; GDSC2 0.1772 6.5471 -3.1271 18.4229
KTCTL-26A GDSC1; GDSC2 0.576 10.7047 -4.8802 24.7883
LB1047-RCC GDSC1; GDSC2 0.703 13.5036 -6.1753 28.4137
KTCTL-1M GDSC1; GDSC2 0.7487 9.8918 -4.3367 22.291
A-704 GDSC1; GDSC2 0.837 6.5891 -2.6257 13.9237
LB996-RCC GDSC1; GDSC2 0.9788 11.4127 -4.9126 23.8394
KTCTL-21 GDSC1; GDSC2 1.206 12.0901 -5.0718 23.8155
SN12C GDSC1; GDSC2 1.2182 12.6335 -5.3325 24.6522
LB2241-RCC GDSC1; GDSC2 1.6507 8.6831 -3.0545 14.195
KTCTL-13 GDSC1; GDSC2 1.6625 10.1603 -3.77 17.5755
BFTC-909 GDSC1; GDSC2 1.6751 13.1391 -5.2311 23.2165
NCC010 GDSC1; GDSC2 1.8653 12.1926 -4.6202 20.5961
KMRC-2 CTRP2 2.1654 13.328 -1.1803 35.203
SW156 GDSC1; GDSC2 2.3039 11.5236 -3.9729 16.9909
HA7-RCC GDSC1; GDSC2 2.4898 15.6637 -5.8661 23.3987
KTCTL-195 GDSC1; GDSC2 2.4991 13.1952 -4.6486 19.2774
VMRC-RCW GDSC2 2.5146 12.4597 -4.2789 17.8013
CAL-54 GDSC1; GDSC2; CTRP2 4.016 21.8787 -3.6208 33.5611
OS-RC-2 GDSC1; GDSC2 4.2732 19.0525 -6.2429 21.0209
KMRC-20 GDSC1; GDSC2 5.0147 16.8753 -4.7144 14.7546
A-498 GDSC1; GDSC2; CTRP2 5.166 18.9496 -1.1541 26.6364
VMRC-RCZ GDSC1; GDSC2; CTRP2 6.6858 17.0788 1.0522 17.6824
KMRC-3 CTRP2 6.8939 25.016 -2.7431 27.833
TUHR14TKB CTRP2 8.3086 22.8511 -0.5547 20.5344
786-O GDSC1; GDSC2; CTRP2 9.0389 19.6603 1.5417 12.4163
KMRC-1 GDSC2; CTRP2 9.369 25.8429 -1.2393 19.7951
Caki-2 CTRP2 10.3201 28.9082 -2.0496 21.1139
Caki-1 GDSC1; GDSC2; CTRP2 12.1458 30.0648 -1.3405 16.4602
RCC10RGB GDSC1; GDSC2; CTRP2 13.868 38.1235 -4.0365 20.069
ACHN GDSC1; GDSC2; CTRP2 14.93 29.4836 0.6394 8.656
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HCC-56 CTRP2 -10.6707 16.1199 -15.6774 67.5538
COLO205 GDSC1; GDSC2 -8.3077 1.2519 -9.4368 66.5745
NCI-H747 GDSC1; GDSC2; CTRP2 -8.0172 3.8163 -8.7555 72.368
SK-CO-1 GDSC1; GDSC2 -7.9123 -2.4664 -8.108 71.2434
HT-29 GDSC1; GDSC2 -7.4912 1.9719 -8.7877 62.7702
MDST8 GDSC1; GDSC2 -7.3039 3.2252 -9.0366 60.8746
CL-11 GDSC1; GDSC2 -7.2868 0.734 -8.1643 63.3167
HCC2998 GDSC1; GDSC2 -7.217 1.1331 -8.2124 62.5525
LS513 GDSC1; GDSC2 -7.0225 -1.8236 -7.2541 65.4944
SNU-C1 GDSC1; GDSC2; CTRP2 -6.3662 11.9094 -9.4556 62.0318
SW1463 GDSC1; GDSC2 -5.9643 0.6994 -6.7127 56.5029
LS411N GDSC1; GDSC2 -5.7313 4.7545 -7.9797 53.51
HCT 116 GDSC1; GDSC2 -5.2595 -0.3088 -5.6585 52.0853
SW1417 GDSC1; GDSC2; CTRP2 -5.2096 7.7155 -6.7314 61.7474
HT-55 GDSC2 -4.9817 4.253 -6.9867 49.9022
LoVo GDSC1; GDSC2 -4.9169 5.7747 -7.5786 49.6069
SW620 GDSC1; GDSC2 -4.6709 5.9117 -7.389 48.4308
DiFi GDSC1; GDSC2 -4.5018 3.9796 -6.3713 47.1622
LS1034 GDSC1; GDSC2; CTRP2 -4.4054 3.1156 -4.7143 62.3132
SW48 GDSC1; GDSC2 -4.3133 10.2577 -9.0531 47.5291
SW948 GDSC1; GDSC2; CTRP2 -4.1647 9.0597 -6.0451 57.884
RKO GDSC1; GDSC2 -3.842 6.1147 -6.646 44.2129
RCM-1 [Human ESC] GDSC1; GDSC2; CTRP2 -3.6108 12.0082 -6.5601 55.1856
KM12 GDSC1; GDSC2 -3.5427 4.9354 -5.8076 41.756
SW1116 GDSC1; GDSC2 -3.4572 5.1689 -5.8276 41.394
NCI-H716 GDSC1; GDSC2; CTRP2 -3.1259 7.699 -4.4597 54.7959
SW837 GDSC1; GDSC2 -3.0671 4.4575 -5.1117 38.1495
T84 GDSC1; GDSC2; CTRP2 -2.7373 4.5899 -3.1849 53.945
LS180 GDSC1; GDSC2 -2.6913 6.2104 -5.5583 37.5582
COLO 678 GDSC1; GDSC2; CTRP2 -2.5699 16.5677 -7.4136 51.5882
SNU-407 GDSC1; GDSC2 -2.3394 14.0617 -9.0644 41.4887
NCI-H508 GDSC1; GDSC2 -2.0815 16.9139 -10.2487 41.8592
LS123 GDSC1; GDSC2 -2.0526 11.9062 -7.7397 39.1325
SW626 GDSC1; GDSC2 -1.9756 11.777 -7.6063 38.771
SNU-175 GDSC2 -1.4469 15.799 -9.1355 39.217
SNU-61 GDSC1; GDSC2 -1.302 9.9463 -6.0959 33.8747
HT115 GDSC1; GDSC2 -1.0733 3.887 -2.8972 21.2175
CCK-81 GDSC1; GDSC2 -0.6318 9.6178 -5.345 29.7246
SNU-C5 GDSC1; GDSC2 -0.4717 13.9865 -7.3901 34.1204
SNU-1033 CTRP2 -0.4659 30.991 -12.1976 48.3023
CW-2 GDSC1; GDSC2 -0.0939 9.6517 -4.9044 26.7009
GP2d CTRP2 0.1387 202.0105 -96.9025 49.565
GP5d GDSC1; GDSC2 0.1555 17.4079 -8.5747 34.6161
SNU-C2B GDSC1; GDSC2 0.1855 11.8215 -5.7569 28.5656
SNU-1040 GDSC1; GDSC2 0.2106 12.2095 -5.9301 28.9799
C2BBe1 GDSC1; GDSC2; CTRP2 0.4917 17.7982 -4.9215 42.8217
SNU-503 CTRP2 0.5901 18.6397 -5.2247 44.1842
SNU-283 GDSC2 0.6266 13.7564 -6.3633 29.0933
COLO 320HSR GDSC1; GDSC2 1.5763 5.2788 -1.4699 5.5608
SNU-81 GDSC1; GDSC2 1.7812 10.3204 -3.7615 17.2124
HCT 15 GDSC1; GDSC2; CTRP2 2.1413 12.7069 -0.9152 33.0325
CaR-1 GDSC1; GDSC2 2.5847 16.8938 -6.4015 24.6843
COLO 320 CTRP2 5.6524 10.5291 3.4675 11.5924
HCT 8 CTRP2 7.5283 13.2976 3.5677 7.8389
SNU-C4 CTRP2 8.6835 22.8325 -0.2646 19.1576
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 1.4042 4.9572 -1.4289 5.6719
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hep 3B2.1-7 GDSC1; GDSC2 -5.3621 -2.8389 -5.3834 53.7091
JHH-5 CTRP2 -5.2853 -1.2976 -5.2923 74.0086
JHH-2 GDSC1; GDSC2; CTRP2 -2.0074 4.2692 -2.3295 50.2603
JHH-4 GDSC1; GDSC2; CTRP2 -0.6447 6.0687 -1.2622 42.9255
Hep-G2/C3A GDSC1; GDSC2 -0.0869 11.194 -5.6696 29.1279
JHH-1 GDSC1; GDSC2; CTRP2 0.154 18.2922 -5.4842 44.0815
Huh-7 GDSC1; GDSC2 0.1989 10.7314 -5.2009 26.9042
SNU-387 GDSC1; GDSC2; CTRP2 0.7064 12.7992 -2.3994 39.7728
HLE GDSC1; GDSC2 1.1814 8.9967 -3.5557 17.7812
SNU-398 GDSC1; GDSC2 1.667 15.4676 -6.3923 26.6903
JHH-7 GDSC1; GDSC2 2.7056 11.923 -3.8851 15.7511
SNU-423 GDSC1; GDSC2; CTRP2 4.7314 14.9262 0.4669 23.2829
SNU-449 GDSC1; GDSC2; CTRP2 4.7359 16.6181 -0.369 25.5891
JHH-6 GDSC1; GDSC2; CTRP2 7.1537 7.8777 5.8103 0.0698
PLC/PRF/5 CTRP2 7.4965 17.2909 1.5808 15.4092
SNU-475 CTRP2 9.1636 17.4993 2.6612 8.9952
HLF CTRP2 9.6269 18.2721 2.596 8.6317
HuH-1 GDSC1; GDSC2; CTRP2 11.9605 30.9577 -1.8933 17.942
SK-HEP-1 GDSC1; GDSC2; CTRP2 13.7663 31.765 -1.0915 14.0859
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 201 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DV-90 CTRP2 -7.0341 11.727 -10.1021 64.9052
NCI-H292 GDSC1; GDSC2 -6.487 11.0477 -11.5551 54.5534
EBC-1 GDSC1; GDSC2 -6.1832 -3.2835 -6.2073 61.437
NCI-H2122 GDSC1; GDSC2 -6.135 -0.8967 -6.4735 58.9504
NCI-H727 GDSC1; GDSC2 -5.7971 10.3697 -10.5569 52.6641
Calu-6 GDSC1; GDSC2 -5.6156 -1.1156 -5.8639 55.3152
NCI-H2291 GDSC1; GDSC2 -5.6044 0.6936 -6.3189 54.3658
A-549 GDSC1; GDSC2 -5.1331 3.5841 -6.8679 50.8413
NCI-H2795 GDSC1; GDSC2 -5.1115 -0.9177 -5.3572 51.1167
Lu-65 GDSC1; GDSC2; CTRP2 -5.048 6.6094 -6.2199 62.0968
NCI-H1666 GDSC1; GDSC2 -5.0034 6.5462 -8.0108 50.0926
NCI-H1437 GDSC1; GDSC2 -4.9314 8.7143 -8.9307 49.8045
NCI-H1792 GDSC1; GDSC2 -3.8954 0.3596 -4.3546 40.7027
LCLC-97TM1 GDSC1; GDSC2 -3.8875 6.4923 -6.8654 44.7069
NCI-H3122 GDSC1; GDSC2 -3.5972 4.8075 -5.8048 42.0988
HCC44 GDSC1; GDSC2 -3.4191 3.2165 -4.9217 39.4945
NCI-H358 GDSC1; GDSC2 -3.3671 6.6507 -6.4251 41.9929
SK-MES-1 GDSC1; GDSC2; CTRP2 -3.0977 4.2184 -3.5 55.9096
COR-L105 GDSC1; GDSC2; CTRP2 -3.0623 8.4861 -4.6537 54.4093
NCI-H2009 GDSC1; GDSC2 -2.9212 4.8018 -5.1234 37.6073
EPLC-272H GDSC1; GDSC2 -2.8438 11.3182 -8.1743 42.1565
RERF-LC-Sq1 GDSC1; GDSC2 -2.5432 10.257 -7.3764 40.2456
T3M-10 CTRP2 -2.5103 10.4361 -4.7733 53.9279
HOP-92 GDSC1; GDSC2; CTRP2 -2.4936 3.9481 -2.7961 52.9214
NCI-H23 GDSC1; GDSC2; CTRP2 -2.3736 12.9907 -5.6605 51.3346
NCI-H2405 GDSC1; GDSC2 -2.3727 14.4196 -9.2715 41.8244
EMC-BAC-1 GDSC1; GDSC2 -2.3608 10.0353 -7.0992 39.2428
NCI-H1993 GDSC1; GDSC2 -2.3042 6.4937 -5.3222 35.5221
NCI-H2087 GDSC1; GDSC2 -2.2387 15.7425 -9.8068 41.9364
NCI-H1915 GDSC1; GDSC2; CTRP2 -2.1796 5.7863 -2.8615 51.0983
EMC-BAC-2 GDSC1; GDSC2 -1.8924 7.0758 -5.2167 33.6687
Lu-99A GDSC1; GDSC2 -1.6206 8.0781 -5.458 33.347
A-427 GDSC1; GDSC2 -1.4365 9.1536 -5.8229 33.6569
NCI-H460 GDSC1; GDSC2 -1.1922 11.8728 -6.9571 35.3526
NCI-H1648 GDSC1; GDSC2 -1.1877 9.1943 -5.6209 32.3238
NCI-H1734 GDSC2 -1.1861 3.5592 -2.8441 21.4119
HCC4006 CTRP2 -1.0402 4.522 -1.3311 47.4742
NCI-H322M GDSC1; GDSC2 -0.8508 18.2104 -9.8236 38.6082
NCI-H1975 GDSC1; GDSC2 -0.7873 15.6275 -8.4791 36.7699
NCI-H2228 GDSC2 -0.7442 7.2001 -4.2376 26.3479
NCI-H2810 GDSC1; GDSC2 -0.5607 7.919 -4.436 26.5135
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2 -0.4934 6.6949 -3.767 23.5586
NCI-H1755 GDSC1; GDSC2 -0.4585 7.6215 -4.1993 25.2693
LC-2/ad GDSC1; GDSC2 -0.4261 5.3378 -3.0318 19.7868
EKVX GDSC1; GDSC2; CTRP2 -0.3491 10.2026 -2.3858 43.1673
NCI-H513 GDSC1; GDSC2 -0.3447 11.1129 -5.8463 30.3515
NCI-H1693 GDSC1; GDSC2; CTRP2 -0.3122 24.6348 -8.9639 46.5197
Calu-3 GDSC1; GDSC2 -0.1902 4.9032 -2.6119 16.7578
CAL-12T GDSC1; GDSC2 -0.1563 15.3051 -7.7832 34.0852
NCI-H290 GDSC1; GDSC2 -0.1105 6.7404 -3.4627 20.9481
LXF 289 GDSC1; GDSC2 -0.0066 6.7852 -3.3981 20.3205
SW1271 GDSC1; GDSC2 0.004 14.4097 -7.2015 32.577
NCI-H2030 GDSC1; GDSC2 0.0443 20.0691 -9.9977 36.8529
NCI-H1573 GDSC1; GDSC2 0.1028 10.375 -5.1021 26.854
COR-L23 GDSC1; GDSC2 0.1321 10.8701 -5.3253 27.4855
NCI-H2347 GDSC1; GDSC2 0.1752 14.4151 -7.0621 31.8544
NCI-H2135 GDSC1; GDSC2 0.2403 2.1473 -0.8805 4.9143
PC-14 GDSC1; GDSC2 0.2584 11.183 -5.3777 27.2977
SK-LU-1 GDSC1; GDSC2 0.3482 16.6014 -8.0123 33.2796
NCI-H2373 GDSC1; GDSC2 0.3826 13.9831 -6.6753 30.4685
NCI-H1299 GDSC1; GDSC2 0.4688 12.4798 -5.8537 28.1375
RERF-LC-MS GDSC1; GDSC2; CTRP2 0.4689 16.026 -4.1128 42.2887
BEN GDSC1; GDSC2 0.6653 3.2294 -1.0994 5.2472
SBC-3 GDSC1; GDSC2 0.8096 8.9592 -3.8241 19.9747
NCI-H510A GDSC2 0.9334 3.9563 -1.2647 5.6606
NCI-H322 CTRP2 0.9426 20.2061 -5.6355 43.5705
HOP-62 GDSC1; GDSC2; CTRP2 0.9977 19.9805 -5.4744 42.0672
NCI-H446 GDSC1; GDSC2 1.0124 6.5052 -2.4523 12.5109
COR-L303 GDSC2 1.0278 3.425 -0.9505 3.6032
NCI-H2461 GDSC1; GDSC2 1.0665 14.2941 -6.2788 27.7927
NCI-H1355 GDSC1; GDSC2 1.1761 10.089 -4.101 20.2096
LCLC-103H GDSC1; GDSC2 1.1853 3.6681 -0.9656 3.4052
NCI-H2444 GDSC1; GDSC2 1.2232 3.9751 -1.0842 4.0152
NCI-H2023 GDSC1; GDSC2 1.2238 11.6946 -4.8613 23.0353
SHP-77 GDSC1; GDSC2 1.2272 4.5894 -1.3702 5.6789
NCI-H2722 GDSC1; GDSC2 1.2714 8.0363 -3.0141 14.8971
NCI-H441 GDSC1; GDSC2 1.293 16.3352 -7.1167 29.3075
NCI-H2227 GDSC1; GDSC2 1.2997 9.1005 -3.5177 17.3055
NCI-H3255 GDSC1; GDSC2 1.3096 10.8857 -4.3937 21.0631
NCI-H250 GDSC2 1.3294 4.2029 -1.124 4.0512
NCI-H2803 GDSC1; GDSC2 1.3738 11.2745 -4.5373 21.4618
NCI-H345 GDSC1; GDSC2 1.4044 2.2878 -0.2847 0.1209
NCI-H1963 GDSC2 1.4195 5.8425 -1.8396 8.0393
LB647-SCLC GDSC1; GDSC2 1.4377 3.781 -0.8695 2.471
SBC-5 GDSC1; GDSC2 1.4688 6.8148 -2.2745 10.4286
NCI-H1770 GDSC1; GDSC2 1.4853 4.7021 -1.2587 4.5393
NCI-H1781 GDSC1; GDSC2 1.5166 10.8618 -4.2246 19.8719
LK-2 GDSC1; GDSC2 1.5304 10.6754 -4.1221 19.4151
NCI-H1581 GDSC1; GDSC2 1.5349 16.563 -7.0397 28.5893
NCI-H209 GDSC1; GDSC2 1.5638 7.9823 -2.7749 12.9495
NCI-H720 GDSC1; GDSC2 1.5768 3.3628 -0.6198 1.0953
HCC78 GDSC1; GDSC2 1.5879 12.3308 -4.8972 22.2709
NCI-H526 GDSC1; GDSC2 1.6166 3.6149 -0.7042 1.4255
NCI-H64 GDSC2 1.633 3.2538 -0.5505 0.7677
LC-1/sq GDSC1; GDSC2 1.6707 11.1257 -4.2393 19.5597
COR-L321 GDSC1; GDSC2 1.6744 3.0507 -0.4554 0.4196
NCI-H2731 GDSC1; GDSC2 1.7042 10.8683 -4.0875 18.8514
NCI-H1155 GDSC1; GDSC2 1.7341 6.9687 -2.1666 9.2444
COR-L32 GDSC1; GDSC2 1.7365 8.0198 -2.6711 12.0056
ABC-1 GDSC1; GDSC2 1.7718 11.9528 -4.5717 20.6313
NCI-H1876 GDSC1; GDSC2 1.7877 6.1335 -1.7357 6.6969
Lu-165 GDSC1; GDSC2 1.8049 3.3072 -0.4979 0.4732
NCI-H2804 GDSC1; GDSC2 1.8089 4.7336 -1.0835 3.0526
NCI-H1435 GDSC1; GDSC2 1.8108 7.953 -2.5873 11.3926
NCI-H187 GDSC1 1.8131 3.279 -0.4841 0.5334
NCI-H82 GDSC1; GDSC2 1.8401 3.4561 -0.5393 0.5812
Ms-1 GDSC1; GDSC2 1.843 3.54 -0.5701 0.682
DMS 79 GDSC1; GDSC2 1.853 3.4364 -0.5265 0.5327
NCI-H748 GDSC2 1.8654 4.1769 -0.815 1.6557
COR-L279 GDSC1; GDSC2 1.8689 4.0314 -0.7533 1.378
NCI-H524 GDSC1; GDSC2 1.8734 3.8159 -0.6644 1.0067
NCI-H847 GDSC1; GDSC2 1.8839 3.608 -0.5787 0.6833
SBC-1 GDSC1; GDSC2 1.8975 3.7637 -0.633 0.867
DMS 53 GDSC1; GDSC2; CTRP2 1.9216 10.8795 -0.3072 32.3094
HCC15 GDSC1; GDSC2 1.955 17.9615 -7.408 28.5136
NCI-H196 GDSC1; GDSC2 1.9724 3.2952 -0.4286 0.224
UMC-11 GDSC1; GDSC2 2.0127 7.0949 -2.0431 7.9904
NCI-H1048 GDSC1; GDSC2 2.0337 6.1756 -1.6026 5.5036
NCI-H1304 GDSC1 2.0486 3.6254 -0.5178 0.5021
NCI-H1838 GDSC1; GDSC2 2.088 8.7251 -2.769 11.7547
PaCa-3 GDSC1; GDSC2 2.1001 10.4939 -3.6164 15.8697
NCI-H2818 GDSC1; GDSC2 2.1046 13.4398 -5.0568 21.6308
NCI-H69 GDSC1; GDSC2 2.1588 4.676 -0.878 1.6258
IST-SL2 GDSC1; GDSC2 2.1626 9.2111 -2.9517 12.5318
HCC33 GDSC2 2.1722 3.7925 -0.5303 0.3792
Lu-135 GDSC1; GDSC2 2.1743 4.6291 -0.8514 1.4964
NCI-H740 GDSC2 2.2003 5.0585 -1.0163 2.2065
NCI-H596 GDSC1; GDSC2 2.2097 14.1291 -5.3182 22.2826
NCI-H1688 GDSC1; GDSC2 2.2284 8.5097 -2.5718 10.4296
COR-L311 GDSC2 2.2851 4.2454 -0.6522 0.6658
NCI-H1836 GDSC1; GDSC2 2.2865 3.8795 -0.5179 0.3042
CPC-N GDSC1; GDSC2 2.2899 4.3794 -0.701 0.8223
NCI-H2369 GDSC1; GDSC2 2.3147 11.9458 -4.171 17.7983
IST-SL1 GDSC1; GDSC2 2.3184 4.2601 -0.644 0.6212
Lu-139 GDSC1; GDSC2 2.3206 3.9437 -0.5278 0.3137
Lu-134-A GDSC1; GDSC2 2.3671 5.5992 -1.1599 2.6887
NCI-H1436 GDSC1; GDSC2 2.369 4.3824 -0.6691 0.6682
HCC827 GDSC1; GDSC2 2.4412 9.7194 -3.0066 12.2229
NCI-H2066 GDSC1; GDSC2 2.4709 13.4518 -4.7943 19.8808
NCI-H2110 GDSC1; GDSC2; CTRP2 2.5563 17.9544 -3.0194 35.7984
NCI-H835 GDSC1; GDSC2 2.567 4.6372 -0.6835 0.6006
NCI-H2085 GDSC1; GDSC2 2.5692 11.1255 -3.5945 14.7516
SW1573 GDSC1; GDSC2 2.6213 8.0064 -2.0869 7.1117
NCI-H2869 GDSC1; GDSC2 2.6335 13.5444 -4.7226 19.2653
NCI-H1944 GDSC1; GDSC2; CTRP2 2.7836 21.9933 -4.7875 37.5579
NCI-H1650 GDSC2 2.922 4.9886 -0.6727 0.4132
NCI-H650 GDSC1; GDSC2 3.0906 16.6261 -5.8992 22.2552
NCI-H226 GDSC1; GDSC2 3.1666 13.8595 -4.5012 17.3207
NCI-H211 GDSC1; GDSC2 3.3034 15.7299 -5.3109 19.9614
COLO 668 GDSC1; GDSC2; CTRP2 3.3595 17.4283 -2.0152 32.2766
LOU-NH91 GDSC1; GDSC2 3.5519 18.6502 -6.5562 23.226
NCI-H1395 CTRP2 3.5864 13.9796 -0.1204 28.9391
NCI-H1623 GDSC1; GDSC2; CTRP2 3.5915 23.5993 -4.8526 36.0271
NCI-H2591 GDSC1; GDSC2 3.6254 16.9263 -5.6653 20.4841
NCI-H2595 GDSC1; GDSC2 3.6615 15.405 -4.9059 17.8574
NCI-H661 GDSC1; GDSC2 3.8651 13.9991 -4.1 14.3857
HCC366 GDSC1; GDSC2 4.2208 17.3839 -5.4757 18.7649
NCI-H647 GDSC1; GDSC2; CTRP2 4.3079 18.162 -1.5162 29.1995
NCI-H2172 GDSC1; GDSC2 4.4639 17.8994 -5.5585 18.5974
NCI-H146 GDSC1; GDSC2; CTRP2 4.7531 8.116 3.8031 11.4853
RERF-LC-KJ GDSC1; GDSC2 4.8098 16.2952 -4.5729 14.5742
NCI-H520 GDSC1; GDSC2; CTRP2 4.8939 10.0413 3.0215 14.1473
NCI-H2141 GDSC1; GDSC2; CTRP2 5.0442 9.7446 3.3065 12.7355
NCI-H810 GDSC1; GDSC2; CTRP2 5.1707 8.9307 3.8212 10.4808
DMS 454 CTRP2 5.3606 24.4829 -3.7507 32.2897
KNS-62 GDSC1; GDSC2; CTRP2 5.4496 45.1616 -14.012 40.0472
ChaGo-K-1 GDSC1; GDSC2; CTRP2 5.4725 9.5526 3.7935 9.9603
RERF-LC-Ad2 CTRP2 5.4964 63.6213 -23.202 43.5056
COR-L88 GDSC1; GDSC2; CTRP2 5.521 14.6733 1.2864 19.0961
HCC2935 CTRP2 5.6036 21.3646 -1.9861 28.7245
NCI-H1105 GDSC1; GDSC2; CTRP2 5.703 7.1452 5.1888 4.0451
LUDLU-1 CTRP2 5.7895 17.5212 0.0922 23.3399
NCI-H2029 GDSC1; GDSC2; CTRP2 6.2532 13.1156 2.6813 12.7729
NCI-H2170 GDSC1; GDSC2; CTRP2 6.2583 7.8172 5.3293 2.454
NCI-H1341 GDSC1; GDSC2; CTRP2 6.4578 19.6944 -0.4392 22.4271
NCI-H2196 GDSC2; CTRP2 6.4713 12.7346 3.0481 11.0025
NCI-H2171 GDSC2; CTRP2 6.5765 11.213 3.889 7.5737
COR-L95 GDSC1; GDSC2; CTRP2 6.742 13.3522 2.9544 10.9
LK2 CTRP2 6.7951 10.0011 4.6514 4.5553
NCI-H1568 GDSC1; GDSC2; CTRP2 7.1149 26.126 -3.1188 27.1921
NCI-H1869 GDSC1; GDSC2; CTRP2 7.2445 34.132 -7.0123 32.5734
NCI-H1092 GDSC1; GDSC2; CTRP2 7.5429 10.5846 4.8682 2.5227
NCI-H2081 GDSC1; GDSC2; CTRP2 7.8327 13.6373 3.6152 6.7607
NCI-H1651 GDSC1; GDSC2; CTRP2 7.9993 22.2696 -0.5022 19.9966
NCI-H1694 GDSC1; GDSC2; CTRP2 8.0252 10.8869 5.0066 1.6079
NCI-H1563 GDSC1; GDSC2; CTRP2 8.0313 10.9396 4.9871 1.6634
HCC1438 CTRP2 8.4789 22.441 -0.224 19.371
NCI-H841 GDSC1; GDSC2; CTRP2 8.5822 19.4522 1.3198 13.7797
NCI-H1339 CTRP2 8.5927 23.992 -0.9043 20.9785
DMS 273 GDSC1; GDSC2; CTRP2 8.6743 19.2889 1.4654 13.1765
NCI-H1793 GDSC1; GDSC2; CTRP2 8.6914 20.938 0.6718 15.6336
IA-LM GDSC1; GDSC2; CTRP2 9.1281 28.7255 -2.84 23.6212
NCI-H522 GDSC1; GDSC2; CTRP2 9.4196 32.0382 -4.258 25.7834
VMRC-LCD GDSC1; GDSC2; CTRP2 9.6994 21.7757 0.977 13.2992
NCI-H1703 GDSC1; GDSC2; CTRP2 9.8315 22.767 0.5901 14.2794
LC-1/sq-SF CTRP2 11.9308 25.4062 0.7189 11.9158
NCI-H838 GDSC1; GDSC2; CTRP2 12.402 32.7921 -2.4737 18.6748
NCI-H2342 GDSC1; GDSC2; CTRP2 12.7536 27.2021 0.3966 11.3671
DMS 114 GDSC1; GDSC2; CTRP2 13.3589 29.4978 -0.2918 12.5463
Calu-1 CTRP2 16.4303 38.0083 -2.3352 14.7526
Hs 888.Lu CTRP2 6.6527 21.8897 -1.3772 25.4216
⏷ Show the Full List of 201 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 1.9128 4.3352 -0.8574 1.7971
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 1.176 6.1898 0.6909 33.958
OV-90 GDSC1; GDSC2; CTRP2 -7.7587 34.8758 -21.0325 57.3144
OVCAR-5 GDSC1; GDSC2; CTRP2 -5.2071 40.34 -21.1926 53.8601
Caov-4 GDSC1; GDSC2 -4.4192 2.6045 -5.7194 46.3183
IGROV-1 GDSC1; GDSC2 -4.2649 5.4098 -6.7521 46.3169
A2780 GDSC1; GDSC2 -3.8844 4.3278 -5.8839 43.6089
ES-2 GDSC1; GDSC2 -1.2476 13.0635 -7.5985 36.6411
TYK-nu GDSC1; GDSC2 -1.1345 26.0696 -13.9919 42.3921
OV7 CTRP2 0.2826 13.2365 -3.0256 43.4994
JHOS-4 GDSC1; GDSC2 0.4065 17.1127 -8.22 33.5068
RMG-I GDSC1; GDSC2 0.7709 19.5751 -9.1528 34.197
DOV13 GDSC1; GDSC2 1.3933 7.5249 -2.6739 12.8094
FU-OV-1 GDSC1; GDSC2 1.401 16.4369 -7.082 28.9856
OVCAR-4 GDSC1; GDSC2 1.4723 12.1221 -4.882 22.4959
OVISE GDSC1; GDSC2 1.5559 12.7354 -5.1221 23.1318
OVCAR-3 GDSC1; GDSC2 1.6787 4.3596 -0.9909 2.757
OVK18 GDSC1; GDSC2 1.7086 10.2744 -3.7921 17.5647
Caov-3 GDSC2 1.8061 9.7992 -3.4881 15.9469
OVTOKO GDSC1; GDSC2 2.6657 13.8324 -4.8401 19.6287
SK-OV-3 GDSC1; GDSC2 2.6906 14.2717 -5.0367 20.2786
Kuramochi GDSC1; GDSC2 2.7682 14.5379 -5.111 20.3735
OVKATE GDSC1; GDSC2 3.2651 14.9378 -4.9538 18.8034
OVCAR-8 GDSC1; GDSC2 3.8076 13.2719 -3.7945 13.2166
EFO-21 GDSC1; GDSC2; CTRP2 4.5227 19.4844 -1.9823 29.7124
COV434 CTRP2 5.7338 21.272 -1.8298 28.1489
OAW42 GDSC1; GDSC2; CTRP2 5.9593 9.8226 4.0839 7.8806
COV362 CTRP2 7.5296 17.3993 1.5522 15.4514
TOV-112D GDSC1; GDSC2; CTRP2 7.9014 23.692 -1.2836 22.1001
JHOS-2 GDSC1; GDSC2; CTRP2 8.3951 33.8366 -5.9445 29.6866
JHOM-1 CTRP2 8.7045 10.0589 5.613 0.0545
TOV-21G GDSC1; GDSC2; CTRP2 9.7763 25.4667 -0.7597 18.043
COV644 CTRP2 9.7887 48.0997 -11.9501 34.6216
EFO-27 GDSC1; GDSC2; CTRP2 10.4533 27.378 -1.2088 18.2422
OV56 GDSC1; GDSC2; CTRP2 11.6146 25.0057 0.7064 11.7464
OC 314 GDSC1; GDSC2; CTRP2 11.6453 26.044 0.2383 13.0234
OAW28 GDSC1; GDSC2; CTRP2 13.1687 30.7976 -1.018 14.5441
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 3.3642 26.3004 -6.3956 39.0888
Aska-SS CTRP2 6.8926 21.0186 -0.7481 23.4669
TE 617.T CTRP2 -2.9397 7.7169 -4.2631 56.3671
G-401 GDSC1; GDSC2; CTRP2 -2.2353 5.2953 -2.7985 51.4143
Hs 633.T GDSC1; GDSC2 -2.1417 9.7096 -6.7377 37.9225
STS-0421 GDSC1; GDSC2 -0.9893 4.2368 -2.9905 21.4791
G-402 GDSC1; GDSC2; CTRP2 -0.229 5.9648 -0.7803 40.4433
Rh18 GDSC1 -0.1726 10.5708 -5.4299 32.2215
MFH-ino GDSC1; GDSC2 0.6928 12.5403 -5.7026 27.1209
SW684 GDSC1; GDSC2 1.0216 8.7312 -3.5462 18.1475
HT-1080 GDSC1; GDSC2; CTRP2 1.0246 11.4848 -1.4925 37.4253
RD GDSC1; GDSC2; CTRP2 1.0864 22.9629 -6.8338 42.785
EW-8 GDSC1; GDSC2 1.2183 3.2111 -0.7399 2.1108
Rh30 GDSC1; GDSC2 1.7952 8.2672 -2.7499 12.2923
Rh41 GDSC1; GDSC2 2.1075 9.3123 -3.0383 13.0864
VA-ES-BJ GDSC1; GDSC2 2.1266 10.1986 -3.4541 15.06
BT-12 CTRP2 2.2306 11.6106 -0.3225 33.1721
RKN GDSC1; GDSC2 2.7344 19.8378 -7.7424 27.6654
SW872 GDSC1; GDSC2 3.0806 14.5085 -4.8749 18.8915
Tm87-16 CTRP2 3.1933 22.3186 -4.5758 37.6491
TTC-709 CTRP2 3.7708 16.5357 -1.1986 31.0406
SK-LMS-1 GDSC1; GDSC2; CTRP2 4.3344 17.83 -1.3279 28.7356
A-204 GDSC1; GDSC2; CTRP2 4.4525 15.5425 -0.0888 25.4531
BT-16 CTRP2 5.2189 14.4552 1.1327 21.3533
TE 441.T GDSC2; CTRP2 5.3048 9.1328 3.8475 10.0948
MES-SA GDSC1; GDSC2; CTRP2 5.4033 10.1548 3.4332 11.502
Hs 729.T CTRP2 7.1066 15.8752 1.9837 14.6557
GCT GDSC1; GDSC2; CTRP2 8.236 24.0983 -1.2274 21.4435
SW982 GDSC1; GDSC2; CTRP2 8.8154 22.4333 0.0289 17.3128
KYM-1 GDSC1; GDSC2; CTRP2 11.6037 25.128 0.6422 11.9418
SK-UT-1 GDSC1; GDSC2; CTRP2 14.3164 31.7585 -0.7474 12.7062
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 7.1877 8.349 5.6485 0.3831
P-STS CTRP2 7.6085 15.6542 2.4725 11.9888
SYO-1 CTRP2 9.4872 18.309 2.489 9.1906
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 10.646 34.1673 -4.3907 25.15
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 GDSC1; GDSC2 1.2733 13.2309 -5.5865 25.3181
MSTO-211H GDSC2 1.4293 11.1051 -4.411 20.8341
NCI-H28 GDSC1; GDSC2 2.6018 13.5648 -4.7553 19.4545
MPP 89 GDSC1; GDSC2; CTRP2 3.2122 13.6147 -0.2995 28.873
NCI-H2052 GDSC2 5.3589 17.6369 -4.853 14.693
JL-1 CTRP2 6.1768 25.358 -3.5023 30.4213
IST-Mes1 GDSC1; GDSC2; CTRP2 14.5785 32.0432 -0.719 12.3817
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PC-3 GDSC1; GDSC2 2.2801 4.5063 -0.7543 1.0183
LNCaP clone FGC GDSC1; GDSC2; CTRP2 5.5151 9.6639 3.7766 9.9406
NCI-H660 GDSC2; CTRP2 5.8257 11.9571 2.9039 12.7175
22Rv1 GDSC1; GDSC2 5.908 23.4066 -7.2212 20.9182
PaCa-3 CTRP2 6.2821 7.1804 5.6603 1.2094
VCaP GDSC1; GDSC2; CTRP2 7.5538 12.0648 4.1802 5.0199
DU145 GDSC1; GDSC2; CTRP2 8.6983 19.3247 1.465 13.1433
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2; CTRP2 7.0958 22.1546 -1.1521 23.1032
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 -1.0757 5.2429 -3.5643 24.6198
Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCUM-1 GDSC1; GDSC2 -9.5551 -4.9169 -9.6003 83.3883
AGS GDSC2 -8.0473 -2.7541 -8.2122 72.5959
MKN45 GDSC1; GDSC2 -4.1989 0.8326 -4.8341 43.7622
RERF-GC-1B GDSC1; GDSC2 -1.755 12.3878 -7.711 38.2668
HSC-39 GDSC1; GDSC2 -1.6712 1.9917 -2.5887 21.8847
TGBC11TKB GDSC1; GDSC2 -1.3025 9.9685 -6.1073 33.9026
SNU-5 GDSC1; GDSC2 -1.2855 13.4168 -7.8077 37.0783
ECC10 GDSC1; GDSC2 -0.9859 5.9762 -3.8448 25.5535
MKN28 GDSC2 -0.7058 8.3668 -4.7852 28.2317
GCIY GDSC2 -0.5593 5.7382 -3.3475 21.8183
SK-GT-2 GDSC1; GDSC2 -0.5207 8.3404 -4.6117 27.0333
NUGC-3 GDSC1; GDSC2 -0.4354 9.5502 -5.1426 28.5647
Hs 746.T GDSC1; GDSC2; CTRP2 -0.3538 15.0925 -4.5052 44.85
SNU-601 CTRP2 -0.31 12.1476 -3.1564 45.567
NCI-N87 GDSC1; GDSC2 -0.0711 9.0397 -4.5793 25.539
NUGC-4 GDSC1; GDSC2 -0.0484 27.6965 -13.8885 40.4723
KATO III GDSC1; GDSC2; CTRP2 0.2422 6.9785 -0.5654 38.2564
NCC-StC-K140 CTRP2 0.2768 74.9839 -33.3424 48.7279
23132/87 GDSC1; GDSC2 0.2972 9.4562 -4.4827 24.1068
TMK-1 GDSC1; GDSC2 0.5495 15.4818 -7.2879 31.4096
Fu97 GDSC1; GDSC2 1.0771 15.3967 -6.8202 29.12
ECC12 GDSC2 1.1122 2.4571 -0.4721 0.9251
SNU-1 GDSC1; GDSC2; CTRP2 1.1263 12.6691 -1.9154 37.8253
SCH GDSC1; GDSC2 1.1615 4.6143 -1.4257 6.1426
IM95 GDSC2; CTRP2 1.4006 32.432 -11.1945 44.2301
SNU-16 GDSC1; GDSC2; CTRP2 1.7584 6.7488 1.1573 28.6919
RF-48 GDSC1; GDSC2 1.7863 4.9881 -1.2096 3.7588
MKN1 GDSC1; GDSC2 1.8584 12.8903 -4.9695 21.8888
HuG1-N CTRP2 3.7775 40.3391 -13.0268 42.321
HGC-27 GDSC1; GDSC2; CTRP2 5.2051 7.7854 4.4037 8.1645
KE-39 CTRP2 7.5995 45.7542 -12.5299 37.4268
SH-10-TC CTRP2 8.7403 16.2508 2.9753 8.4029
MKN74 CTRP2 9.24 31.7813 -4.2676 26.8509
MKN7 GDSC1; GDSC2; CTRP2 10.7591 34.3968 -4.4202 24.3153
SNU-216 CTRP2 12.3107 38.9736 -5.535 24.9153
LMSU CTRP2 13.0652 30.5278 -0.9576 15.1074
SNG-M GDSC1; GDSC2 1.7825 9.1096 -3.1683 14.4597
SNU-685 CTRP2 8.3959 16.1125 2.8097 9.5059
⏷ Show the Full List of 38 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
BHT-101 GDSC1; GDSC2 -6.8155 -1.9037 -7.0181 64.5285
KMH-2 GDSC1; GDSC2 -6.4111 -2.72 -6.4834 62.7838
HTC-C3 GDSC1; GDSC2 -5.2893 8.5847 -9.2263 51.1552
K5 GDSC1; GDSC2 -5.2052 20.2835 -14.7502 50.4727
IHH-4 GDSC1; GDSC2 -3.0186 11.7609 -8.5531 43.0604
TT2609-C02 GDSC1; GDSC2; CTRP2 -1.8465 23.22 -9.7625 49.7604
ML-1 [Human leukemia] GDSC1; GDSC2 -0.4463 8.5711 -4.6629 26.9838
CAL-62 GDSC1; GDSC2 -0.2153 11.1461 -5.7534 29.7274
ASH-3 GDSC1; GDSC2 0.2516 11.1766 -5.38 27.3237
8505C GDSC1; GDSC2 1.0926 21.5232 -9.8652 34.5553
CGTH-W-1 GDSC1; GDSC2 1.2259 7.3316 -2.7011 13.3581
B-CPAP GDSC1; GDSC2 1.25 17.2957 -7.6295 30.5029
8305C GDSC1; GDSC2 2.0116 22.4125 -9.5771 32.3779
SW579 CTRP2 2.0117 9.9389 0.1963 32.5464
TT GDSC1; GDSC2 2.2813 14.775 -5.5831 22.9802
WRO GDSC1; GDSC2 3.0339 16.2177 -5.7405 21.8854
FTC-133 GDSC1; GDSC2; CTRP2 8.1119 16.0215 2.6562 9.8956
FTC-238 CTRP2 12.2233 26.2265 0.5202 12.1518
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DOK GDSC1; GDSC2 -6.7034 15.1145 -13.6762 54.2339
BB30-HNC GDSC1; GDSC2 -4.8096 5.668 -7.4218 49.1678
UPCI-SCC-090 GDSC1; GDSC2 -4.7924 9.1422 -8.9931 49.2868
SAS GDSC1; GDSC2 -4.2923 7.1571 -7.575 46.9232
JHU-022 GDSC1; GDSC2 -4.0426 23.4469 -15.2422 48.1471
PCI-15A GDSC1; GDSC2 -3.762 3.8359 -5.5433 42.4893
NCI-H3118 GDSC1; GDSC2 -3.701 10.0741 -8.3771 45.1571
BB49-HNC GDSC1; GDSC2 -3.6714 9.0158 -7.8416 44.6701
HO-1-N-1 GDSC1; GDSC2 -3.1507 5.6811 -5.7586 39.992
JHU-029 GDSC1; GDSC2 -2.8217 7.0714 -6.0948 39.2476
PCI-38 GDSC1 -2.726 15.1303 -9.9419 46.1656
JHU-011 GDSC2 -2.6792 6.5684 -5.7172 37.9362
KOSC-2 GDSC1; GDSC2 -1.4221 8.0684 -5.2731 32.1473
PCI-04B GDSC1; GDSC2 -1.402 6.4622 -4.4628 29.4733
KON GDSC1; GDSC2 -1.2551 8.4255 -5.2995 31.6557
Ca9-22 GDSC1; GDSC2 -1.1122 9.9965 -5.9529 32.9325
SAT [Human HNSCC] GDSC1; GDSC2 -0.8194 25.6203 -13.4993 41.553
BICR 22 GDSC1; GDSC2; CTRP2 -0.7531 9.4474 -2.518 44.7569
HSC-3 GDSC1; GDSC2 -0.6485 9.8942 -5.4974 30.284
SCC-25 GDSC1; GDSC2 -0.3107 9.753 -5.1378 28.1738
CAL-27 GDSC1; GDSC2; CTRP2 -0.2466 52.083 -22.407 48.2186
SKN-3 GDSC1; GDSC2 -0.1196 12.1376 -6.1688 30.5594
SCC-15 GDSC1; GDSC2 0.5069 14.3473 -6.7558 30.3445
Detroit 562 GDSC1; GDSC2 0.609 10.3228 -4.6631 23.9179
OSC-19 GDSC1; GDSC2 0.6579 10.4612 -4.693 23.8955
BICR 78 GDSC1; GDSC2 0.8094 14.2488 -6.4616 28.8882
PE/CA-PJ41 (clone D2) CTRP2 0.8163 27.8674 -9.4807 45.5259
BICR 56 CTRP2 0.9305 27.4708 -9.1809 45.2184
BICR 18 CTRP2 1.0154 11.1085 -1.3382 39.0376
PE/CA-PJ34 (clone C12) CTRP2 1.0874 20.0184 -5.4072 43.083
HO-1-u-1 GDSC1; GDSC2 1.2253 13.4542 -5.7352 25.8842
PCI-06A GDSC1; GDSC2 1.3084 16.3978 -7.1357 29.3155
PCI-30 GDSC1; GDSC2 2.0914 12.5485 -4.6281 20.1055
LB771-HNC GDSC1; GDSC2 2.1575 11.7124 -4.17 18.145
BICR 10 GDSC1; GDSC2 2.2466 12.4633 -4.473 19.1602
BHY GDSC1; GDSC2 2.2972 10.6593 -3.5578 15.166
OSC-20 GDSC1; GDSC2 2.8678 13.3858 -4.4798 17.8485
HSC-2 GDSC1; GDSC2; CTRP2 3.006 12.5271 0.0198 28.5574
BICR 31 GDSC2; CTRP2 3.6615 31.4893 -8.7146 39.4153
HSC-4 GDSC1; GDSC2 3.8099 16.3594 -5.2635 18.8212
PE/CA-PJ15 GDSC1; GDSC2; CTRP2 3.9125 28.6708 -7.0911 37.7365
SCC-9 GDSC1; GDSC2; CTRP2 4.3458 29.5051 -7.1299 37.0558
PE/CA-PJ49 CTRP2 4.8412 21.6793 -2.7971 31.7555
BICR 6 CTRP2 6.366 36.4087 -8.8705 36.3821
BICR 16 CTRP2 8.0955 21.0908 0.1547 18.9265
CAL-33 GDSC1; GDSC2; CTRP2 8.1657 26.8376 -2.6415 24.6395
SCC-4 GDSC1; GDSC2; CTRP2 10.1341 35.5852 -5.4716 26.7476
FaDu GDSC2; CTRP2 10.5279 30.2395 -2.5506 21.1357
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-BLC1 CTRP2 -9.1505 4.8166 -10.2198 74.968
KU-19-19 GDSC1; GDSC2 -7.3656 -3.9152 -7.3942 71.3038
BFTC-905 GDSC1; GDSC2 -5.3645 0.3576 -5.9558 52.8448
UM-UC-1 CTRP2 -4.8112 1.0397 -4.9001 69.2369
SCaBER CTRP2 -2.9398 20.9928 -9.7962 53.2622
RT-4 GDSC1; GDSC2 -1.0286 7.7442 -4.7594 29.2042
CAL-29 GDSC1; GDSC2 -0.2417 13.5258 -6.9654 32.7258
SW780 GDSC1; GDSC2 0.3407 13.57 -6.5032 30.1656
RT-112 GDSC1; GDSC2 0.3883 15.3471 -7.3524 31.931
5637 GDSC1; GDSC2 1.1457 11.4826 -4.8166 23.0715
SW1710 GDSC1; GDSC2 1.3729 9.4729 -3.6466 17.7216
TCCSUP GDSC1; GDSC2 1.5934 7.3284 -2.4363 11.0517
639V GDSC1; GDSC2 2.4477 17.1988 -6.6545 25.6813
HT-1376 GDSC1; GDSC2 2.8153 15.0796 -5.3417 21.0573
HT-1197 GDSC1; GDSC2; CTRP2 3.6855 19.4963 -2.7361 32.8408
UM-UC-3 GDSC1; GDSC2 4.3121 13.8737 -3.7573 12.1754
KMBC-2 CTRP2 5.7745 46.6153 -14.4664 40.5136
BC-3C CTRP2 6.4893 13.6312 2.6151 13.3929
J82 GDSC1; GDSC2; CTRP2 8.062 10.3135 5.265 0.8365
647V GDSC1; GDSC2; CTRP2 12.575 36.1339 -3.9666 21.3648
T24 GDSC1; GDSC2; CTRP2 12.6518 35.419 -3.5676 20.5485
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-39 GDSC1; GDSC2 -5.0213 7.6558 -8.532 50.1584
BPH-1 GDSC1; GDSC2 -5.0071 2.6139 -6.3485 50.1522
HEY GDSC1; GDSC2 -5.0021 5.2877 -7.452 50.0959
JHOS-3 GDSC1; GDSC2 -4.5043 5.7704 -7.1566 47.6622
OVCA420 GDSC1; GDSC2 -3.5968 9.1609 -7.8392 44.3968
SW954 GDSC1; GDSC2 -2.6867 5.298 -5.1226 36.5784
OVMIU GDSC1; GDSC2 -2.2878 20.0707 -12.0003 43.5443
OVCA433 GDSC1; GDSC2 -0.7628 11.6738 -6.4841 33.1247
ACC-OV7 GDSC1; GDSC2 -0.7204 14.7684 -7.9928 35.8638
TC-YIK GDSC1; GDSC2 -0.2536 18.3524 -9.3883 36.7432
C-33 A GDSC1; GDSC2 0.0681 11.3188 -5.6028 28.5011
SW962 GDSC1; GDSC2 0.1323 11.3978 -5.5891 28.2831
KGN GDSC1; GDSC2 0.1586 10.9557 -5.3462 27.4767
NT2-D1 GDSC1; GDSC2 0.4351 4.7625 -2.0291 11.536
DSH1 GDSC1; GDSC2 0.5811 7.3714 -3.2133 17.7119
UWB1.289 GDSC1; GDSC2 0.6295 8.5343 -3.7545 20.1526
PEO1 GDSC1; GDSC2 0.8261 14.2131 -6.4304 28.7686
NEC8 GDSC2 0.8946 4.2746 -1.4454 6.8417
SW756 GDSC1; GDSC2 0.8964 13.5046 -6.0206 27.5116
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 1.0687 13.3695 -5.8163 26.5059
OV17R GDSC1; GDSC2 1.1175 9.5843 -3.8957 19.4814
NCC-IT GDSC2 1.1891 4.282 -1.2497 5.0442
PWR-1E GDSC1; GDSC2 1.2159 9.9746 -4.0138 19.74
PA-1 GDSC2 1.3397 10.2226 -4.0423 19.5494
C-4-I GDSC2 1.3912 13.041 -5.4005 24.4482
HT-3 GDSC1; GDSC2 1.4093 12.1504 -4.9444 22.8709
JAR GDSC1; GDSC2 1.421 7.286 -2.5374 12.0015
JEG-3 GDSC1; GDSC2 1.4375 4.6568 -1.2673 4.6747
SiSo GDSC1; GDSC2 1.4593 8.563 -3.1346 15.052
DoTc2 4510 GDSC1; GDSC2 1.5901 8.56 -3.038 14.253
HEC-1 GDSC1; GDSC2 1.6627 3.5765 -0.666 1.2082
ME-180 GDSC1; GDSC2 1.6934 19.098 -8.177 30.6306
SKN GDSC1; GDSC2 1.7552 9.3445 -3.3025 15.18
SKG-IIIa GDSC1; GDSC2 2.5578 15.904 -5.9341 23.457
Ca Ski GDSC1; GDSC2 2.5608 17.1863 -6.5635 25.2094
LB831-BLC GDSC1; GDSC2 3.3692 11.9176 -3.4394 12.4602
MS751 GDSC1; GDSC2 3.5884 17.8161 -6.1235 21.9433
SiHa GDSC1; GDSC2 4.3537 18.2118 -5.7827 19.502
HeLa GDSC1; GDSC2; CTRP2 7.5512 8.4975 5.7394 0.0801
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Trametinib (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Gilteritinib DMTI0ZO Moderate Decreased clearance of Trametinib due to the transporter inhibition by Gilteritinib. Acute myeloid leukaemia [2A60] [7]
Erdafitinib DMI782S Moderate Decreased clearance of Trametinib due to the transporter inhibition by Erdafitinib. Bladder cancer [2C94] [8]
Tucatinib DMBESUA Moderate Decreased clearance of Trametinib due to the transporter inhibition by Tucatinib. Breast cancer [2C60-2C6Y] [9]
Lasmiditan DMXLVDT Moderate Decreased clearance of Trametinib due to the transporter inhibition by Lasmiditan. Migraine [8A80] [10]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Mannitol E00103 6251 Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Carmellose sodium E00625 Not Available Disintegrant
Eisenoxyd E00585 56841934 Colorant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Hypromellose E00634 Not Available Coating agent
Magnesium stearate E00208 11177 lubricant
Polyethylene glycol 4000 E00654 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polysorbate 80 E00665 Not Available Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Haematite red E00236 14833 Colorant
Hydrophobic colloidal silica E00285 24261 Anticaking agent; Emulsion stabilizing agent; Glidant; Suspending agent; Viscosity-controlling agent
Cellulose microcrystalline E00698 Not Available Adsorbent; Suspending agent; Diluent
⏷ Show the Full List of 14 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Trametinib 2 mg tablet 2 mg Oral Tablet Oral
Trametinib 0.5 mg tablet 0.5 mg Oral Tablet Oral
Trametinib 1 mg tablet 1 mg Oral Tablet Oral
Trametinib Dimethyl Sulfoxide eq 2mg tablet eq 2mg Tablet Oral
Trametinib Dimethyl Sulfoxide eq 0.5mg tablet eq 0.5mg Tablet Oral
Trametinib Dimethyl Sulfoxide eq 1mg tablet eq 1mg Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6495).
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
4 Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
5 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
6 Clinical resistance associated with a novel MAP2K1 mutation in a patient with Langerhans cell histiocytosis. Pediatr Blood Cancer. 2018 Sep;65(9):e27237. doi: 10.1002/pbc.27237. Epub 2018 May 16.
7 Cerner Multum, Inc. "Australian Product Information.".
8 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
9 Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
10 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.