Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM39FSQ)

Drug Name

Racemic DOI Drug Info

Synonyms

1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine; 4-DOI; 64584-34-5; 2,5-Dimethoxy-4-iodoamphetamine; DOI-P; 2,5-Dimethoxy-4-iodophenylisopropylamine; 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane; 1-(4-Iodo-2,5-dimethoxyphenyl)-2-aminopropane; 4-Iodo-2,5-dimethoxyamphetamine; C11H16INO2; 2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine; CHEMBL6616; CHEBI:64629; 4-Iodo-2,5-dimethoxy-alpha-methylbenzeneethanamine; Benzeneethanamine, 4-iodo-2,5-dimethoxy-alpha-methyl-; 82830-53-3

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1229
ChEBI ID: CHEBI:64629
CAS Number: CAS 64584-34-5
TTD Drug ID: DM39FSQ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Inhibitor	[2]
5-HT 2B receptor (HTR2B)	TT0K1SC	5HT2B_HUMAN	Inhibitor	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 2A receptor (HTR2A)	DTT	HTR2A	4.84	4.904	4.652	4.129
5-HT 2B receptor (HTR2B)	DTT	HTR2B	0.485	3.536	0.379	4.667

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 2A receptor (HTR2A)	DTT	HTR2A	1.68E-01	-0.3	-0.14
5-HT 2A receptor (HTR2A)	DTT	HTR2A	5.59E-01	0.15	0.21
5-HT 2B receptor (HTR2B)	DTT	HTR2B	1.29E-01	-0.04	-0.14
5-HT 2B receptor (HTR2B)	DTT	HTR2B	1.13E-01	-0.04	-0.26

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 157).
2	The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9.
3	cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8.