Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3IPSX)

Drug Name

ATLCAR.CD30.CCR4 cells Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Immune System disease	4A01-4B41	Phase 1	[1]
Immunoproliferative disorder	2B32	Phase 1	[1]
Lymphatic disease	BD9Z	Phase 1	[1]
Lymphoma	2A80-2A86	Phase 1	[1]
Neoplasm	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-C chemokine receptor type 4 (CCR4)	TT7HQD0	CCR4_HUMAN	CAR-T-Cell-Therapy(Dual specific)	[1]
Lymphocyte activation antigen CD30 (TNFRSF8)	TT2GM5R	TNR8_HUMAN	CAR-T-Cell-Therapy(Dual specific)	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
C-C chemokine receptor type 4 (CCR4)	DTT	CCR4	5.07	5.952	5.771	5.138

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Immune System disease

ICD Disease Classification

4A01-4B41

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
C-C chemokine receptor type 4 (CCR4)	DTT	CCR4	2.33E-02	3.98E-03	0.03

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT03602157) Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and NHL