Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6Q7U4)

Drug Name

Lenalidomide Drug Info

Synonyms

Revamid; Revimid; Revlimid; Celgene brand of lenalidomide; Lenalidomide [USAN]; CC 5013; CC5013; CDC 501; IMiD3; IMiD3cpd; ALBB-015321; CC-5013; CDC-501; CDC-5013; ENMD-0997; IMID-5013; Revlimid (Celgene); Revlimid (TN); Thalidomide analog CC-5013; Lenalidomide (USAN/INN); CC-5013, Revlimid, Lenalidomide; 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione; 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione; 3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione; Lenalidomide (Immunomodulator)

Indication

Disease Entry	ICD 11	Status	REF
Adult T-cell leukemia/lymphoma		Approved	[1]
Advanced cancer	2A00-2F9Z	Approved	[1]
Complex regional pain syndrome type 1		Approved	[1]
Hepatosplenic T-cell lymphoma		Approved	[1]
Large granular lymphocytic leukemia	2A90.1	Approved	[1]
Leukemia		Approved	[1]
MALT lymphoma		Approved	[1]
Multiple myeloma	2A83	Approved	[2]
Nodal marginal zone lymphoma	2A85.0	Approved	[1]
Pain	MG30-MG3Z	Approved	[1]
Plasma cell myeloma	2A83.1	Approved	[1]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified		Approved	[1]
Prolymphocytic leukaemia	2A82.1	Approved	[1]
Recurrent adult burkitt lymphoma	2A85.6	Approved	[1]
Small intestine lymphoma		Approved	[1]
Splenic marginal zone lymphoma		Approved	[1]
Testicular lymphoma		Approved	[1]
Urinary bladder neoplasm		Approved	[1]
Waldenstrom macroglobulinemia	2A85.4	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3	[3]
Colon cancer	2B90.Z	Investigative	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 216326
ChEBI ID: CHEBI:63791
CAS Number: CAS 191732-72-6
TTD Drug ID: DM6Q7U4
VARIDT Drug ID: DR00261
ACDINA Drug ID: D00353

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tumor necrosis factor (TNF)	TTF8CQI	TNFA_HUMAN	Inhibitor	[4]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	Highest Status	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Approved	[5]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tumor necrosis factor (TNF)	DTT	TNF	5.692	3.07	4.413	1.202
P-glycoprotein 1 (ABCB1)	DTP	P-GP	7.009	6.988	7.442	8.135

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Adult T-cell leukemia/lymphoma

ICD Disease Classification

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tumor necrosis factor (TNF)	DTT	TNF	8.64E-01	-0.06	-0.16
P-glycoprotein 1 (ABCB1)	DTP	P-GP	9.83E-01	3.92E-01	4.44E-01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Lenalidomide FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7331).
3	Low-dose Lenalidomide for Non-severe COVID-19 Treatment Trial (GETAFE)
4	Thalidomide and thalidomide analogues for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD007351.
5	DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB00480)