Details of the Drug

General Information of Drug (ID: DM6Q7U4)

Drug Name
Lenalidomide
Synonyms
Revamid; Revimid; Revlimid; Celgene brand of lenalidomide; Lenalidomide [USAN]; CC 5013; CC5013; CDC 501; IMiD3; IMiD3cpd; ALBB-015321; CC-5013; CDC-501; CDC-5013; ENMD-0997; IMID-5013; Revlimid (Celgene); Revlimid (TN); Thalidomide analog CC-5013; Lenalidomide (USAN/INN); CC-5013, Revlimid, Lenalidomide; 3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione; 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione; 3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione; 3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione; Lenalidomide (Immunomodulator)
Indication
Disease Entry ICD 11 Status REF
Adult T-cell leukemia/lymphoma N.A. Approved [1]
Advanced cancer 2A00-2F9Z Approved [1]
Complex regional pain syndrome type 1 N.A. Approved [1]
Hepatosplenic T-cell lymphoma N.A. Approved [1]
Large granular lymphocytic leukemia 2A90.1 Approved [1]
Leukemia N.A. Approved [1]
MALT lymphoma N.A. Approved [1]
Multiple myeloma 2A83 Approved [2]
Nodal marginal zone lymphoma 2A85.0 Approved [1]
Pain MG30-MG3Z Approved [1]
Plasma cell myeloma 2A83.1 Approved [1]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified N.A. Approved [1]
Prolymphocytic leukaemia 2A82.1 Approved [1]
Recurrent adult burkitt lymphoma 2A85.6 Approved [1]
Small intestine lymphoma N.A. Approved [1]
Splenic marginal zone lymphoma N.A. Approved [1]
Testicular lymphoma N.A. Approved [1]
Urinary bladder neoplasm N.A. Approved [1]
Waldenstrom macroglobulinemia 2A85.4 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [3]
Colon cancer 2B90.Z Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Anticancer Agents
Affected Organisms
Humans and other mammals
ATC Code
L04AX04: Lenalidomide
L04AX: Other immunosuppressants
L04A: IMMUNOSUPPRESSANTS
L04: IMMUNOSUPPRESSANTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 259.26
Logarithm of the Partition Coefficient (xlogp) -0.5
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 4
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 4: low solubility and low permeability [4]
Elimination
66% of drug is excreted from urine in the unchanged form [4]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 1.375 micromolar/kg/day [5]
Water Solubility
The ability of drug to dissolve in water is measured as 0.00045 mg/mL [4]
Chemical Identifiers
Formula
C13H13N3O3
IUPAC Name
3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
Canonical SMILES
C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N
InChI
InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
InChIKey
GOTYRUGSSMKFNF-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
216326
ChEBI ID
CHEBI:63791
CAS Number
191732-72-6
UNII
F0P408N6V4
DrugBank ID
DB00480
TTD ID
D0Q5NX
VARIDT ID
DR00261
ACDINA ID
D00353
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tumor necrosis factor (TNF) TTF8CQI TNFA_HUMAN Inhibitor [6]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiopoietin-1 receptor (TEK) OT78YN57 TIE2_HUMAN Gene/Protein Processing [8]
DNA damage-binding protein 1 (DDB1) OTTR2L3Z DDB1_HUMAN Protein Interaction/Cellular Processes [9]
Fibroblast growth factor receptor 1 (FGFR1) OT4GLCXW FGFR1_HUMAN Gene/Protein Processing [10]
Fibroblast growth factor receptor 2 (FGFR2) OTLOPACK FGFR2_HUMAN Gene/Protein Processing [10]
Fibroblast growth factor receptor 3 (FGFR3) OTSAXDIL FGFR3_HUMAN Gene/Protein Processing [10]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Gene/Protein Processing [8]
Interleukin-6 receptor subunit beta (IL6ST) OT1N9C70 IL6RB_HUMAN Gene/Protein Processing [8]
Protein cereblon (CRBN) OTXH9MDC CRBN_HUMAN Drug Response [11]
Proteinase-activated receptor 1 (F2R) OT4WVWBO PAR1_HUMAN Gene/Protein Processing [8]
Sal-like protein 4 (SALL4) OTC08PR5 SALL4_HUMAN Protein Interaction/Cellular Processes [12]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Adult T-cell leukemia/lymphoma
ICD Disease Classification
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tumor necrosis factor (TNF) DTT TNF 8.64E-01 -0.06 -0.16
P-glycoprotein 1 (ABCB1) DTP P-GP 9.83E-01 3.92E-01 4.44E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1; GDSC2 5.6258 7.2968 2.7766 0.3603
SaOS-2 GDSC1; GDSC2 4.2157 6.1936 2.545 2.8472
EW-13 GDSC1; GDSC2 4.5252 6.7428 2.4798 2.6846
MG-63 GDSC1; GDSC2 4.8152 6.8304 2.6004 1.6494
ES6 GDSC1; GDSC2 4.9628 7.0262 2.5926 1.5137
CADO-ES1 GDSC1; GDSC2 5.0448 7.9507 2.2367 3.1891
HuO9 GDSC1; GDSC2 5.1554 7.6991 2.4064 2.168
SK-ES-1 GDSC1; GDSC2 5.1751 11.019 0.8868 10.4779
EW-24 GDSC1; GDSC2 5.2721 9.7261 1.5624 6.5261
A-673 GDSC1; GDSC2 5.2815 6.81 2.8192 0.4054
SK-PN-DW GDSC1; GDSC2 5.3563 7.649 2.5269 1.3933
CAL-78 GDSC1; GDSC2 5.4406 7.1709 2.7498 0.5187
EW-18 GDSC1; GDSC2 5.4875 8.1712 2.3758 1.9219
U-CH2 GDSC2 5.5802 7.3102 2.7541 0.4365
HOS GDSC1; GDSC2 5.5882 6.9514 2.8839 0.1593
H-EMC-SS GDSC1; GDSC2 5.5955 13.9424 -0.2336 15.2071
EW-7 GDSC1; GDSC2 5.6371 7.4375 2.73 0.4735
ES1 GDSC1; GDSC2 5.6793 7.4453 2.7437 0.4184
ES5 GDSC1; GDSC2 5.7002 8.5014 2.3432 1.8408
TC-71 GDSC1; GDSC2 5.7198 7.1785 2.8529 0.1775
U2OS GDSC1; GDSC2 5.7214 7.8216 2.6213 0.7494
MHH-ES-1 GDSC1; GDSC2 5.8048 7.3773 2.8148 0.2202
CAL-72 GDSC1; GDSC2 5.8424 7.4129 2.816 0.208
HuO-3N1 GDSC1; GDSC2 5.8614 7.7137 2.7171 0.4061
NOS-1 [Human HNSCC] GDSC1; GDSC2 5.8916 7.8994 2.6615 0.535
EW-1 GDSC1; GDSC2 5.8989 7.8093 2.6971 0.4391
EW-16 GDSC1; GDSC2 5.9184 8.3493 2.5034 1.0142
CHSA8926 GDSC1; GDSC2 5.9737 7.6212 2.7913 0.216
ES4 GDSC1; GDSC2 5.9792 8.1865 2.5906 0.6914
SJSA-1 GDSC1; GDSC2 6.0235 7.7441 2.7668 0.2456
EW-22 GDSC1; GDSC2 6.0412 7.7826 2.7599 0.2532
ES8 GDSC1; GDSC2 6.054 7.8173 2.7525 0.2632
CHSA0011 GDSC1; GDSC2 6.1165 8.3141 2.5985 0.5959
EW-11 GDSC1; GDSC2 6.3689 9.6385 2.1975 1.81
EW-3 GDSC1; GDSC2 6.5161 8.7639 2.5905 0.4425
EW-12 GDSC2 6.5555 8.1907 2.8013 0.0963
NY GDSC1; GDSC2 6.6003 8.913 2.5692 0.4588
G-292 clone A141B1 GDSC1; GDSC2 6.6598 8.2782 2.8074 0.0791
ES7 GDSC1; GDSC2 6.7301 8.8769 2.6299 0.295
CHSA0108 GDSC1; GDSC2 6.7501 8.9418 2.6146 0.3169
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 174 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1; GDSC2 5.3076 8.7463 2.0313 3.8838
KMS-12-BM GDSC1; GDSC2 -0.7096 1.9489 -0.7931 40.7936
CRO-AP2 GDSC1; GDSC2 1.0804 6.8098 -0.519 30.4115
SU-DHL-1 GDSC2 1.5908 15.5409 -4.2841 38.0405
MM1.S GDSC1; GDSC2 2.1124 11.1642 -1.6478 30.5051
NCI-H929 GDSC1; GDSC2 2.5204 6.5557 0.9966 17.1069
L-363 GDSC1; GDSC2 2.8704 12.2663 -1.5319 27.6653
VL51 GDSC1; GDSC2 3.281 4.7423 2.5773 4.8347
Reh GDSC1; GDSC2 3.385 7.9273 1.0716 13.904
Karpas-45 GDSC1; GDSC2 3.5158 5.3927 2.4433 5.0241
WSU-NHL GDSC1 3.5438 9.1736 -0.1466 14.6009
Farage GDSC1; GDSC2 3.5623 5.364 2.4937 4.5853
SCC-3 GDSC2 3.6164 7.2307 1.6072 9.9979
SUP-HD1 GDSC1; GDSC2 3.6312 8.6059 0.933 14.0079
BALL-1 GDSC1; GDSC2 3.6681 6.1417 2.1891 6.2254
JVM-2 GDSC1; GDSC2 3.6701 5.9189 2.3009 5.5198
SIG-M5 GDSC2 3.689 6.385 2.0846 6.8272
OCI-AML-5 GDSC1; GDSC2 3.7925 5.3068 2.689 2.8282
MV4-11 GDSC1; GDSC2 3.8082 8.3882 1.1818 12.0623
KE-37 GDSC1; GDSC2 3.8223 5.6805 2.5291 3.7379
GA-10 GDSC1; GDSC2 3.8312 5.5401 2.6032 3.2657
Jiyoye GDSC1; GDSC2 3.8503 6.7577 2.022 6.8111
P32/ISH GDSC1; GDSC2 3.8514 9.5586 0.6331 15.0915
JSC-1 GDSC1; GDSC2 3.8826 11.4415 -0.2806 19.648
OCI-Ly7 GDSC1; GDSC2 3.9011 8.1159 1.3889 10.5762
SU-DHL-10 GDSC2 3.92 6.1281 2.3806 4.4292
BC-3 GDSC2 3.9263 6.3088 2.2972 4.9268
CMK GDSC1 3.9471 5.2484 1.8927 0.4614
OPM-2 GDSC1; GDSC2 3.9491 9.2936 0.8413 13.6632
SUP-B15 GDSC1; GDSC2 3.9493 5.7634 2.5762 3.1789
EM-2 GDSC1; GDSC2 3.9884 8.0644 1.4806 9.798
RPMI-8402 GDSC1; GDSC2 4.0179 6.3185 2.3565 4.3603
MHH-CALL-2 GDSC1 4.0228 5.6016 1.7909 0.805
TK [Human B-cell lymphoma] GDSC1; GDSC2 4.05 5.956 2.551 3.1255
P12-Ichikawa GDSC1 4.0613 5.3719 1.8926 0.3931
MOLT-16 GDSC1; GDSC2 4.0696 6.5039 2.3027 4.5757
JeKo-1 GDSC1; GDSC2 4.073 9.8623 0.6547 14.3772
JJN-3 GDSC1; GDSC2 4.081 9.5569 0.8122 13.4794
Raji GDSC1; GDSC2 4.0826 6.0901 2.5089 3.3108
P31/FUJ GDSC1; GDSC2 4.1374 6.6692 2.2695 4.6314
KG-1 GDSC1; GDSC2 4.1691 6.3943 2.4214 3.6576
RC-K8 GDSC1 4.1923 5.5236 1.8883 0.3381
ALL-SIL GDSC1; GDSC2 4.2109 6.978 2.1712 5.0685
MEG-01 GDSC1; GDSC2 4.2133 6.1658 2.5564 2.7859
OCI-M1 GDSC1; GDSC2 4.2162 5.5228 2.8471 1.1976
MHH-PREB-1 GDSC1; GDSC2 4.237 6.5904 2.3729 3.8106
TUR GDSC1; GDSC2 4.2873 7.8235 1.8161 7.0486
RPMI-8866 GDSC1; GDSC2 4.2878 8.9585 1.2625 10.3611
RS4;11 GDSC1; GDSC2 4.308 7.9103 1.7885 7.1687
HC-1 GDSC1; GDSC2 4.3224 5.8204 2.775 1.4191
TALL-1 [Human adult T-ALL] GDSC2 4.3271 9.5293 1.0109 11.7269
SUP-M2 GDSC1; GDSC2 4.3323 5.8423 2.7708 1.427
ATN-1 GDSC1; GDSC2 4.3343 7.4984 2.0053 5.8046
HL-60 GDSC1; GDSC2 4.339 7.9514 1.7902 7.0888
SU-DHL-16 GDSC1; GDSC2 4.3477 7.0105 2.2465 4.3393
SR GDSC1; GDSC2 4.3514 7.962 1.7938 7.0401
Daudi GDSC1; GDSC2 4.3552 6.1921 2.6291 2.1399
DG-75 GDSC1; GDSC2 4.3721 7.59 1.987 5.8347
KY821 GDSC1; GDSC2 4.3777 8.1085 1.7412 7.2978
GR-ST GDSC1; GDSC2 4.3937 10.8103 0.4291 14.7644
CCRF-CEM GDSC1; GDSC2 4.4078 7.9221 1.8518 6.5682
A3/Kawakami GDSC1; GDSC2 4.4123 6.0273 2.7335 1.5078
697 GDSC1; GDSC2 4.4376 7.7378 1.9603 5.8564
Karpas-1106P GDSC1; GDSC2 4.4402 7.6169 2.0197 5.4975
Ramos.2G6.4C10 GDSC1; GDSC2 4.4403 7.0634 2.2808 3.9601
BC-1 GDSC1; GDSC2 4.4825 7.6553 2.0293 5.3545
JURL-MK1 GDSC1; GDSC2 4.5288 9.8615 0.9952 11.3287
MOLT-13 GDSC1; GDSC2 4.5297 12.0486 -0.0803 16.9872
Jurkat GDSC1; GDSC2 4.5328 6.1279 2.7533 1.2588
CML-T1 GDSC1; GDSC2 4.556 6.2956 2.6939 1.5173
KOPN-8 GDSC1; GDSC2 4.5685 6.8044 2.4771 2.6301
PF-382 GDSC1; GDSC2 4.5687 9.3685 1.2642 9.6908
KMOE-2 GDSC1; GDSC2 4.5811 9.7119 1.1058 10.5754
L-1236 GDSC1; GDSC2 4.5964 6.6619 2.5564 2.1635
JVM-3 GDSC1; GDSC2 4.6035 6.8329 2.4844 2.5357
U-698-M GDSC1; GDSC2 4.6407 8.5729 1.6975 6.9908
LAMA-84 GDSC1; GDSC2 4.648 7.4759 2.2185 3.9397
P30/OHK GDSC1; GDSC2 4.6559 8.2156 1.8776 5.9008
NB4 GDSC1; GDSC2 4.7204 8.9905 1.5514 7.6808
ALL-PO GDSC1; GDSC2 4.732 9.1228 1.4959 7.9802
RL GDSC1; GDSC2 4.7402 6.4448 2.7242 1.1601
CTB-1 GDSC1; GDSC2 4.7977 11.281 0.4952 13.429
YT GDSC1; GDSC2 4.8149 8.9129 1.6513 6.9026
ML-2 GDSC1; GDSC2 4.8182 8.1679 2.0034 4.861
L-428 GDSC1; GDSC2 4.8619 7.8983 2.1541 3.9318
Karpas-422 GDSC1; GDSC2 4.8634 7.6341 2.2746 3.2654
ST486 GDSC1 4.869 6.6513 1.7423 0.4296
L-540 GDSC1; GDSC2 4.8746 8.5669 1.8529 5.6194
Kasumi-1 GDSC1; GDSC2 4.8769 9.5226 1.4022 8.217
IM-9 GDSC1; GDSC2 4.8776 6.1283 2.9091 0.3599
CTV-1 GDSC1; GDSC2 4.896 9.7692 1.297 8.7801
HH [Human lymphoma] GDSC1; GDSC2 4.9063 7.6722 2.2822 3.1572
Sc-1 GDSC1 4.9087 6.1812 1.9172 0.0827
MHH-CALL-4 GDSC2 4.9327 7.6231 2.319 2.9201
MLMA GDSC1; GDSC2 4.9424 9.2518 1.5743 7.0916
Karpas-231 GDSC1; GDSC2 4.9619 6.4944 2.806 0.6367
SUP-T1 GDSC1; GDSC2 4.9659 7.8888 2.2194 3.4033
VAL GDSC1; GDSC2 4.9762 7.2471 2.5062 1.9063
MOLP-8 GDSC1; GDSC2 4.9849 8.9265 1.7546 5.9749
LC4-1 GDSC1; GDSC2 4.9917 11.7956 0.3832 13.5598
DoHH2 GDSC1; GDSC2 4.9931 6.6305 2.7668 0.7547
EHEB GDSC1 5.0016 6.7466 1.7579 0.3343
BL-41 GDSC1; GDSC2 5.052 6.2779 2.9228 0.2464
MOLM-13 GDSC1; GDSC2 5.0522 10.1012 1.2432 8.7574
MN-60 GDSC1; GDSC2 5.0829 8.9758 1.793 5.575
SU-DHL-8 GDSC2 5.098 6.4056 2.8946 0.2946
KCL-22 GDSC1; GDSC2 5.1077 7.3086 2.5468 1.5624
DB GDSC1; GDSC2 5.1316 6.772 2.7721 0.6357
BE-13 GDSC1; GDSC2 5.1356 7.157 2.6223 1.2036
Karpas-299 GDSC1; GDSC2 5.1405 7.9424 2.2934 2.7537
DND-41 GDSC1; GDSC2 5.1587 9.091 1.7865 5.4755
NKM-1 GDSC1; GDSC2 5.1713 12.3719 0.2302 13.9257
SK-MM-2 GDSC1; GDSC2 5.182 7.0666 2.6797 0.9318
HDLM-2 GDSC1; GDSC2 5.1985 7.0695 2.6859 0.8948
WIL2 NS GDSC1; GDSC2 5.2243 9.4887 1.6429 6.1628
NK-92MI GDSC2 5.2421 6.6946 2.8459 0.3537
EoL-1 GDSC1; GDSC2 5.2454 8.0103 2.3201 2.4775
A4/Fukuda GDSC1; GDSC2 5.2522 8.7204 2.0111 4.0788
Loucy GDSC1; GDSC2 5.2717 6.9216 2.774 0.5417
ME1 GDSC1; GDSC2 5.2824 6.4006 2.9638 0.1073
SU-DHL-6 GDSC1; GDSC2 5.2866 6.8651 2.801 0.4535
K-562 GDSC1; GDSC2 5.2914 7.7182 2.4672 1.7219
RCH-ACV GDSC1; GDSC2 5.3081 10.9048 1.0306 9.4141
Hs 445 GDSC2 5.3352 7.3476 2.6376 0.9674
HAL-01 GDSC1; GDSC2 5.3554 10.6171 1.1979 8.3982
Granta-519 GDSC1; GDSC2 5.3562 7.2284 2.6931 0.7515
DEL GDSC1; GDSC2 5.39 13.5759 -0.2005 15.5093
PL-21 GDSC1; GDSC2 5.4106 8.6467 2.1327 3.201
Karpas-620 GDSC1; GDSC2 5.4259 6.9158 2.8369 0.299
OCI-AML-2 GDSC1; GDSC2 5.4754 7.2067 2.7505 0.4982
CA46 GDSC1; GDSC2 5.5082 7.6057 2.6131 0.9238
CESS GDSC1; GDSC2 5.5187 7.1646 2.783 0.39
HEL GDSC1; GDSC2 5.5392 6.9392 2.8705 0.194
EB2 GDSC1; GDSC2 5.5425 7.236 2.7664 0.422
Namalwa GDSC1; GDSC2 5.5589 7.4145 2.7072 0.5792
KM-H2 GDSC1; GDSC2 5.6152 7.7735 2.5946 0.9112
RPMI-6666 GDSC1; GDSC2 5.6363 7.2765 2.7879 0.33
Mono-Mac-6 GDSC1; GDSC2 5.6851 10.2339 1.5803 5.7036
MY-M12 GDSC1; GDSC2 5.6925 7.9688 2.5526 1.0044
OCI-Ly19 GDSC1; GDSC2 5.7144 7.4347 2.761 0.3615
BONNA-12 GDSC2 5.7547 8.4219 2.4014 1.5397
ARH-77 GDSC1; GDSC2 5.7955 16.8487 -1.5071 20.0019
QIMR-WIL GDSC1; GDSC2 5.9927 10.2913 1.7308 4.4337
SUP-B8 GDSC1; GDSC2 6.008 7.8228 2.7336 0.3147
NALM-6 GDSC1; GDSC2 6.0235 8.3216 2.5582 0.7643
MOLT-4 GDSC1; GDSC2 6.0439 7.6158 2.8181 0.1581
ROS-50 GDSC1; GDSC2 6.1958 8.1321 2.6943 0.3328
BL-70 CTRP1 6.2125 9.9043 3.6363 10.3222
U266B1 GDSC1; GDSC2 6.2164 13.7577 0.2741 11.5226
H9 GDSC1; GDSC2 6.227 13.1649 0.5596 10.0944
BV-173 GDSC1; GDSC2 6.2519 12.9514 0.6748 9.4687
P3HR-1 CTRP1 6.3912 11.6629 2.9067 15.2314
NU-DUL-1 GDSC1; GDSC2; CTRP1 6.5879 12.4278 5.1067 21.7364
KE-97 CTRP1 6.6251 10.2645 3.7419 8.2404
MC116 GDSC1; GDSC2; CTRP1 6.7329 7.7441 4.8821 0.1392
HT GDSC1; GDSC2; CTRP1 6.8937 11.1875 3.4805 5.793
Ku812 GDSC1; GDSC2; CTRP1 7.6381 9.5362 4.5851 0.4255
LP-1 GDSC1; GDSC2; CTRP1 7.7604 12.7244 6.1352 15.1452
SU-DHL-5 GDSC1; GDSC2; CTRP1 8.2067 12.9834 6.4332 13.0151
KMS-11 GDSC1; GDSC2; CTRP1 8.6201 16.2457 5.1889 16.845
U-937 CTRP1 9.5888 11.5721 8.3274 6.5075
WSU-DLCL2 GDSC1; GDSC2; CTRP1 9.8208 11.2296 8.652 1.3185
OCI-Ly10 CTRP1 9.9046 17.999 5.3797 25.6034
PL21 CTRP1 10.5325 13.1776 8.1895 4.9285
SU-DHL-4 GDSC1; GDSC2; CTRP1 10.5543 12.0411 8.6956 0.5483
AMO1 GDSC1; GDSC2; CTRP1 10.6906 11.9753 8.7814 0.2819
EJM GDSC1; GDSC2; CTRP1 10.8956 13.0618 8.4408 1.0336
NOMO-1 GDSC1; GDSC2; CTRP1 10.9916 12.3064 8.7796 0.1874
SKM-1 GDSC1; GDSC2; CTRP1 11.0001 12.1387 8.8422 0.1016
THP-1 GDSC1; GDSC2; CTRP1 11.0016 13.6641 8.2388 1.5692
RPMI-8226 GDSC1; GDSC2; CTRP1 11.038 18.3536 6.0572 9.469
GDM-1 GDSC1; GDSC2; CTRP1 11.12 18.7551 5.92 9.8541
OCI-AML-3 GDSC1; GDSC2; CTRP1 11.2034 12.3505 8.8419 0.0715
MOLM-16 GDSC1; GDSC2; CTRP1 12.0158 33.6875 -0.7766 26.1632
⏷ Show the Full List of 174 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACP4 C GDSC1; GDSC2 4.6139 7.1547 2.3452 3.2838
KYAE-1 GDSC1; GDSC2 5.0526 8.2693 2.0983 3.9242
KYSE-50 GDSC1; GDSC2 5.1984 6.7855 2.7949 0.5203
ESO-51 GDSC1; GDSC2 5.2332 8.719 2.0008 4.1648
ESO-26 GDSC1; GDSC2 5.4135 7.3624 2.6661 0.8045
HCE-4 GDSC1; GDSC2 5.4659 14.6129 -0.6518 17.3507
OACM5.1 C GDSC1; GDSC2 5.6757 7.9342 2.5587 0.995
SK-GT-4 GDSC1; GDSC2 6.2964 8.8118 2.4866 0.8245
FLO-1 GDSC1; GDSC2 6.3085 8.4671 2.6177 0.4607
TE-12 GDSC1; GDSC2 6.3584 10.6112 1.7886 3.6516
KYSE-220 GDSC1; GDSC2 6.391 8.5509 2.6191 0.4254
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1; GDSC2 5.8899 8.5304 2.42 1.3451
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-BE(2)-M17 GDSC1; GDSC2 3.6071 5.2678 2.5753 3.9603
CHP-126 GDSC1; GDSC2 3.8944 6.3447 2.2571 5.2479
GOTO GDSC1; GDSC2 3.9428 6.0681 2.4255 4.1039
Kelly GDSC1; GDSC2 4.0718 5.8478 2.6158 2.7028
SJNB-13 GDSC1; GDSC2 4.3261 6.7312 2.3638 3.692
IMR-5 GDSC1; GDSC2 4.5025 8.9369 1.4271 8.8878
SJNB-14 GDSC1; GDSC2 4.5456 6.8715 2.4335 2.9065
SK-N-AS GDSC1; GDSC2 4.706 6.6896 2.6037 1.7705
SK-N-DZ GDSC1; GDSC2 4.7404 6.3635 2.7577 1.0139
KP-N-YS GDSC1; GDSC2 4.7631 9.0152 1.5683 7.4923
MHH-NB-11 GDSC1; GDSC2 4.8227 7.4507 2.3335 3.0101
SK-N-MC-IXC GDSC1; GDSC2 4.9008 5.8045 3.0324 0.0879
CHP-212 GDSC1; GDSC2 4.9054 10.328 1.0346 10.2458
TGW GDSC1; GDSC2 4.9869 6.5203 2.8068 0.6164
SJNB-6 GDSC1; GDSC2 5.287 7.3012 2.6343 1.0196
SJNB-5 GDSC1; GDSC2 5.3395 7.1305 2.7233 0.6609
NH-12 GDSC1; GDSC2 5.3531 6.9571 2.7937 0.4398
NB1 GDSC1; GDSC2 5.3644 6.9292 2.8083 0.395
SJNB-10 GDSC1; GDSC2 5.3669 7.1747 2.7181 0.6604
NB(TU)1 GDSC1; GDSC2 5.5117 7.672 2.5888 1.0103
NB69 GDSC1; GDSC2 5.6991 8.7012 2.2599 2.2159
SK-N-FI GDSC1; GDSC2 5.7647 7.3877 2.7965 0.2666
SJNB-17 GDSC1; GDSC2 5.87 8.0312 2.604 0.7135
SK-N-SH GDSC1; GDSC2 5.9252 8.0054 2.6359 0.5889
SJNB-7 GDSC1; GDSC2 5.9598 7.577 2.8016 0.2023
KP-N-YN GDSC1; GDSC2 6.133 8.1629 2.6598 0.432
LA-N-6 GDSC1; GDSC2 6.2328 8.0752 2.7278 0.2574
KP-N-RT-BM-1 GDSC2 6.2783 8.6214 2.5499 0.6489
SiMa GDSC1; GDSC2 6.3381 8.1442 2.7417 0.2077
SJNB-12 GDSC1; GDSC2 6.5446 8.4795 2.7003 0.2246
GI-ME-N GDSC1; GDSC2 6.8156 9.3726 2.4867 0.5661
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1; GDSC2 5.4367 6.9367 2.8335 0.3025
Cancer Drug Sensitivity Data Curated from 52 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-148 GDSC2 3.6247 5.7231 2.3634 5.2432
MDA-MB-453 GDSC1; GDSC2 3.916 5.664 2.6013 3.0967
HCC2157 GDSC1; GDSC2 3.9609 5.8233 2.5553 3.2803
DU4475 GDSC1; GDSC2 4.2376 6.5629 2.3863 3.7305
MRK-nu-1 GDSC1; GDSC2 4.442 7.1722 2.231 4.2471
HCC2218 GDSC1; GDSC2 4.4508 9.2132 1.2559 10.0118
JIMT-1 GDSC1; GDSC2 4.6239 7.0412 2.4026 2.9491
Hs 578T GDSC1; GDSC2 4.9794 7.8029 2.2654 3.1348
HCC38 GDSC1; GDSC2 5.0006 7.0193 2.614 1.3754
HCC1143 GDSC1; GDSC2 5.0219 7.1174 2.5839 1.488
HCC202 GDSC1 5.0397 7.1595 1.6248 0.7
BT-474 GDSC1; GDSC2 5.0416 7.0423 2.6244 1.2871
HCC1395 GDSC1; GDSC2 5.1024 7.1571 2.6066 1.3031
BT-20 GDSC1; GDSC2 5.1362 9.4301 1.615 6.4837
BT-483 GDSC1; GDSC2 5.1764 6.5932 2.8571 0.3548
HCC1500 GDSC1; GDSC2 5.1927 7.1622 2.6467 1.0519
MDA-MB-361 GDSC1; GDSC2 5.2189 12.9681 -0.0262 15.074
CAMA-1 GDSC1; GDSC2 5.2731 6.885 2.7882 0.4979
CAL-51 GDSC1; GDSC2 5.2798 6.6974 2.8594 0.3042
MDA-MB-175-VII GDSC1; GDSC2 5.416 6.8792 2.8461 0.2819
HCC1428 GDSC1; GDSC2 5.4715 7.058 2.8033 0.3599
OCUB-M GDSC1; GDSC2 5.5092 6.8889 2.8771 0.1906
MFM-223 GDSC1; GDSC2 5.518 6.8851 2.8816 0.1804
ZR-75-30 GDSC1; GDSC2 5.5314 7.4006 2.7011 0.6134
MDA-MB-157 GDSC1; GDSC2 5.5534 7.6317 2.6226 0.8571
HCC1806 GDSC1; GDSC2 5.6023 7.2719 2.7765 0.3702
MDA-MB-415 GDSC1; GDSC2 5.6049 7.0875 2.8428 0.226
CAL-120 GDSC1; GDSC2 5.6357 7.0858 2.8546 0.1959
HCC1937 GDSC1; GDSC2 5.6489 7.6027 2.6737 0.6289
HCC70 GDSC1; GDSC2 5.654 7.3681 2.7618 0.3842
HCC1419 GDSC1; GDSC2 5.6755 7.6003 2.6854 0.5792
MDA-MB-468 GDSC1; GDSC2 5.6826 7.204 2.8306 0.2261
Evsa-T GDSC1; GDSC2 5.6938 7.1154 2.8652 0.164
UACC-893 GDSC1; GDSC2 5.7016 12.2117 0.6694 10.5475
MDA-MB-231 GDSC1; GDSC2 5.7456 7.8922 2.6047 0.7879
EFM-192A GDSC1; GDSC2 5.781 7.7109 2.6868 0.5205
HDQ-P1 GDSC1; GDSC2 5.7939 7.5696 2.743 0.372
HCC1569 GDSC1; GDSC2 5.8002 8.1085 2.5452 0.952
HCC1599 GDSC2 5.8191 7.5229 2.7691 0.3048
HCC1187 GDSC1; GDSC2 5.9079 7.3492 2.8609 0.1265
UACC-812 GDSC2 5.9606 7.5639 2.8064 0.1943
BT-549 GDSC1; GDSC2 6.0311 8.153 2.6238 0.5691
COLO 824 GDSC1; GDSC2 6.0734 8.2482 2.6056 0.598
HCC1954 GDSC1; GDSC2 6.1888 8.1395 2.6892 0.3459
MDA-MB-436 GDSC1; GDSC2 6.1889 7.8866 2.777 0.1874
EFM-19 GDSC1; GDSC2 6.2245 7.8468 2.8029 0.144
MDA-MB-330 GDSC1; GDSC2 6.2801 10.2122 1.9179 3.133
CAL-85-1 GDSC1; GDSC2 6.3053 8.3655 2.6527 0.3827
T-47D GDSC1; GDSC2 6.4442 8.5349 2.6447 0.3522
YMB-1-E GDSC2 6.4448 8.2894 2.7299 0.2018
AU565 GDSC1; GDSC2 6.7657 8.7272 2.6937 0.1873
MCF-7 GDSC1; GDSC2; CTRP1 11.0327 12.8575 8.5888 0.553
⏷ Show the Full List of 52 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med GDSC1; GDSC2 3.7266 5.2021 2.694 2.942
H4 GDSC1; GDSC2 4.2008 5.9977 2.6262 2.4104
DK-MG GDSC1; GDSC2 4.4619 6.2256 2.674 1.7436
U-87MG ATCC GDSC1 4.4717 5.7554 1.9096 0.182
U-118MG GDSC1; GDSC2 4.6895 6.3787 2.7267 1.2037
SK-MG-1 GDSC1; GDSC2 4.7221 6.6353 2.6353 1.5951
SF539 GDSC1; GDSC2 4.7234 7.7261 2.1493 4.1997
GB-1 GDSC1; GDSC2 4.726 6.2356 2.8026 0.84
PFSK-1 GDSC1 4.8055 6.5924 1.7393 0.4685
YH-13 GDSC1; GDSC2 4.8394 7.862 2.1572 3.9526
CAS-1 GDSC1; GDSC2 4.8782 6.3079 2.8418 0.5715
LN-18 GDSC1; GDSC2 4.8852 6.0969 2.9237 0.3159
GI-1 GDSC1; GDSC2 4.9599 7.0913 2.5638 1.6505
42-MG-BA GDSC1; GDSC2 4.9758 9.6185 1.4223 7.8968
DBTRG-05MG GDSC1; GDSC2 5.0125 6.7654 2.7224 0.9081
U-251MG GDSC1; GDSC2 5.1053 6.4642 2.8762 0.3377
Hs 683 GDSC1; GDSC2 5.152 6.5085 2.8783 0.3116
LN-405 GDSC1; GDSC2 5.1674 7.6735 2.4235 2.0703
D-263MG GDSC1; GDSC2 5.2198 6.9206 2.7527 0.6418
8-MG-BA GDSC1; GDSC2 5.2674 7.2081 2.6622 0.929
SF126 GDSC1; GDSC2 5.2676 6.5559 2.905 0.2093
YKG-1 GDSC1; GDSC2 5.2736 6.3941 2.9629 0.1103
NMC-G1 GDSC1; GDSC2 5.2867 6.4826 2.9373 0.1458
SNB-75 GDSC1; GDSC2 5.3059 7.6846 2.4882 1.6121
Becker GDSC1; GDSC2 5.3143 8.1154 2.3113 2.4326
D-336MG GDSC1; GDSC2 5.3458 8.203 2.2902 2.4957
D-502MG GDSC1; GDSC2 5.4059 7.5697 2.5817 1.1244
M059J GDSC1; GDSC2 5.4399 7.1363 2.7623 0.4833
D-423MG GDSC1; GDSC2 5.4453 7.5862 2.593 1.0478
MOG-G-UVW GDSC1; GDSC2 5.5036 7.529 2.6407 0.8292
AM-38 GDSC1; GDSC2 5.5115 7.5058 2.653 0.7817
D-542MG GDSC1; GDSC2 5.5125 6.8591 2.8886 0.17
ONS-76 GDSC1; GDSC2 5.5136 10.1659 1.5081 6.3903
KNS-81-FD GDSC1; GDSC2 5.5982 7.3093 2.7615 0.4093
D-247MG GDSC1; GDSC2 5.6688 7.7078 2.6424 0.7144
LNZTA3WT4 GDSC1; GDSC2 5.6698 7.3268 2.7826 0.3291
MOG-G-CCM GDSC1; GDSC2 5.6707 7.7839 2.6143 0.8049
KINGS-1 GDSC1; GDSC2 5.6868 7.4429 2.7475 0.4056
KS-1 [Human Krukenberg tumour] GDSC1; GDSC2 5.7506 8.2829 2.455 1.3267
Onda 10 GDSC1; GDSC2 5.8407 7.6834 2.7201 0.4075
SW1783 GDSC1; GDSC2 5.8541 7.7104 2.7155 0.4131
KNS-42 GDSC1; GDSC2 5.857 7.133 2.9157 0.0736
Daoy GDSC1; GDSC2 5.8591 7.5039 2.7905 0.2492
D-566MG GDSC1; GDSC2 5.9498 8.0883 2.6151 0.6353
D-392MG GDSC1; GDSC2 5.9509 8.045 2.6316 0.5878
Onda 11 GDSC1; GDSC2 6.0513 8.1662 2.6269 0.5508
T98G GDSC1; GDSC2 6.1274 7.7709 2.7947 0.1744
SW1088 GDSC1; GDSC2 6.2317 8.0878 2.723 0.2663
A-172 GDSC1; GDSC2 6.3142 14.4012 0.0336 12.4812
KALS-1 GDSC1; GDSC2 6.3352 8.696 2.5451 0.6337
SF268 GDSC1; GDSC2 6.3895 8.0866 2.7793 0.1447
D-245MG GDSC2 6.484 9.0682 2.4674 0.776
SF295 GDSC1; GDSC2; CTRP1 7.1471 8.4436 4.7895 0.1831
GaMG GDSC1; GDSC2; CTRP1 7.2114 8.4905 4.7967 0.1552
LN-229 GDSC1; GDSC2; CTRP1 10.5609 13.9839 7.8326 3.446
⏷ Show the Full List of 55 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1; GDSC2 5.0816 6.9039 2.6988 0.942
ETK-1 GDSC1; GDSC2 5.9586 7.971 2.6617 0.5024
TGBC24TKB GDSC1; GDSC2 6.3458 8.1279 2.75 0.1933
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AN3-CA GDSC1; GDSC2 4.2575 7.4583 1.972 6.1713
ESS-1 GDSC1; GDSC2 5.0065 6.2411 2.9186 0.2744
MFE-280 GDSC1; GDSC2 5.2022 7.4274 2.5438 1.475
RL95-2 GDSC1; GDSC2 5.4334 6.9836 2.8154 0.3464
HEC-265 CTRP1 5.8052 9.4426 3.5665 12.2784
EN GDSC1; GDSC2 5.9448 7.3682 2.8673 0.1124
MFE-296 GDSC1; GDSC2 6.4656 8.3142 2.7288 0.1989
HEC-6 CTRP1 6.8779 8.3155 4.7309 0.7025
HEC-251 CTRP1 6.9825 12.3839 2.9706 12.9365
KLE GDSC1; GDSC2; CTRP1 7.099 8.7748 4.6494 0.5187
HEC-59 CTRP1 7.1435 8.6729 4.7057 0.5993
MFE-319 GDSC1; GDSC2; CTRP1 8.8409 16.3637 2.2896 8.2763
HEC-108 CTRP1 9.6021 16.9126 2.4862 9.7267
HEC-151 CTRP1 11.0298 12.8017 8.6094 1.1462
JHUEM-2 CTRP1 11.3431 14.3298 8.1327 3.6477
Ishikawa (Heraklio) 02 ER- CTRP1 6.537 7.5291 4.8847 0.3323
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB996-RCC GDSC2 4.3252 7.2572 2.1145 5.1688
SW13 GDSC1; GDSC2 4.5852 6.4606 2.6383 1.7565
NCC010 GDSC1; GDSC2 4.7727 6.8734 2.5598 1.9018
SW156 GDSC1; GDSC2 4.8079 7.7123 2.2067 3.7302
BB65-RCC GDSC1; GDSC2 4.9751 7.3534 2.4601 2.134
TK-10 GDSC1; GDSC2 5.0028 7.4247 2.4441 2.1775
A-498 GDSC1; GDSC2 5.0028 7.2036 2.5382 1.7208
CAL-54 GDSC1; GDSC2 5.0666 7.4503 2.4664 1.9869
KMRC-1 GDSC1; GDSC2 5.0817 6.6096 2.8128 0.5345
BFTC-909 GDSC1; GDSC2 5.1753 6.7567 2.7961 0.5302
786-O GDSC1; GDSC2 5.2562 6.7696 2.824 0.4048
769-P GDSC1; GDSC2 5.2786 6.7517 2.8394 0.3539
Caki-1 GDSC1; GDSC2 5.5134 7.9449 2.4811 1.4354
KMRC-20 GDSC1; GDSC2 5.5479 7.5773 2.6411 0.7971
HA7-RCC GDSC1; GDSC2 5.7109 7.5335 2.724 0.4546
KTCTL-195 GDSC1; GDSC2 5.7862 7.4464 2.7838 0.2852
ACHN GDSC1; GDSC2 5.7864 8.1685 2.516 1.0663
VMRC-RCZ GDSC1; GDSC2 5.9682 7.4594 2.8446 0.1366
RXF 393L GDSC1; GDSC2 5.9817 8.7535 2.3732 1.4501
OS-RC-2 GDSC1; GDSC2 5.9845 7.6614 2.7814 0.2304
NCC021 GDSC1; GDSC2 5.9907 7.7366 2.7575 0.2726
A-704 GDSC1; GDSC2 5.9959 7.8668 2.7135 0.3619
KTCTL-26A GDSC1; GDSC2 6.112 7.9938 2.712 0.3244
SN12C GDSC1; GDSC2 6.1865 7.6787 2.8462 0.0996
KTCTL-1M GDSC1; GDSC2 6.2147 8.0592 2.7268 0.2643
UO-31 GDSC1; GDSC2 6.2216 7.9438 2.769 0.1922
LB2241-RCC GDSC1; GDSC2 6.3652 8.0141 2.7953 0.1294
KTCTL-13 GDSC1; GDSC2 6.4756 8.2446 2.7559 0.1592
KTCTL-140 GDSC1; GDSC2 6.4956 8.4864 2.6804 0.2698
LB1047-RCC GDSC1; GDSC2 6.5843 8.4214 2.734 0.1678
KTCTL-21 GDSC1; GDSC2 6.8788 8.9195 2.6681 0.2003
VMRC-RCW GDSC1; GDSC2; CTRP1 6.9853 8.9975 4.5111 1.0383
RCC10RGB GDSC1; GDSC2; CTRP1 10.9088 12.0815 8.8286 0.1366
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 58 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-407 GDSC1; GDSC2 3.9315 6.2875 2.3113 4.8281
GP5d GDSC1; GDSC2 3.9971 5.4114 2.7719 1.9398
LS1034 GDSC1; GDSC2 4.2985 5.9755 2.6935 1.8799
SW1417 GDSC1; GDSC2 4.4752 6.6984 2.4705 2.8176
HCC2998 GDSC1; GDSC2 4.601 8.0055 1.9411 5.6375
HCT 15 GDSC1; GDSC2 4.6306 6.6351 2.5869 1.9563
COLO 320HSR GDSC1; GDSC2 5.0321 8.7379 1.8717 5.2221
SW1463 GDSC1; GDSC2 5.056 6.9225 2.6796 1.0409
SNU-283 GDSC2 5.0999 6.6038 2.8225 0.4933
T84 GDSC1; GDSC2 5.3515 7.2276 2.6913 0.7607
SW1116 GDSC1; GDSC2 5.378 7.9181 2.4269 1.81
SNU-C1 GDSC1; GDSC2 5.3961 6.9161 2.8254 0.3379
SW837 GDSC1; GDSC2 5.402 7.5374 2.5927 1.0846
NCI-H716 GDSC1; GDSC2 5.4094 9.3359 1.825 4.8342
CCK-81 GDSC1; GDSC2 5.4352 7.4659 2.6355 0.8977
NCI-H747 GDSC1; GDSC2 5.5086 7.5159 2.6479 0.8009
CaR-1 GDSC1; GDSC2 5.5464 8.2311 2.3798 1.8399
CL-11 GDSC1; GDSC2 5.9062 7.9803 2.6375 0.5941
DLD-1 CTRP1 5.9733 7.2902 4.7156 2.1109
DiFi GDSC1; GDSC2 6.0045 8.226 2.5861 0.6905
SW626 GDSC1; GDSC2 6.2504 8.0998 2.7256 0.2565
LS513 GDSC1; GDSC2; CTRP1 6.2902 7.8059 4.6628 1.1035
SNU-175 GDSC2; CTRP1 6.5606 14.1088 4.3107 24.4882
LS411N GDSC1; GDSC2; CTRP1 6.7737 8.0508 4.7872 0.3216
SW48 GDSC1; GDSC2; CTRP1 7.2306 9.2942 4.5054 0.8714
GP2d CTRP1 7.2933 8.9932 4.6474 0.7234
SNU-C2B GDSC1; GDSC2 7.3043 9.5494 2.6034 0.206
SK-CO-1 GDSC1; GDSC2; CTRP1 7.3049 8.8172 4.7162 0.2701
COLO205 GDSC1; GDSC2; CTRP1 7.4712 8.6777 4.8244 0.0747
C2BBe1 GDSC1; GDSC2; CTRP1 7.6728 9.5795 4.5829 0.4163
SW403 CTRP1 8.0033 12.1523 3.697 5.3839
SNU-C2A CTRP1 8.0408 11.0286 4.1847 2.2681
SNU-1040 CTRP1 10.2269 12.2378 8.4357 3.7163
SNU-C4 CTRP1 10.265 13.0346 8.0888 6.4461
LS180 GDSC1; GDSC2; CTRP1 10.3636 12.3467 8.4663 1.3982
RCM-1 [Human ESC] GDSC1; GDSC2; CTRP1 10.3789 11.7295 8.7392 0.5392
CL-34 CTRP1 10.3977 11.7894 8.7237 1.2896
MDST8 GDSC1; GDSC2; CTRP1 10.4739 11.7877 8.7599 0.4298
HT115 GDSC1; GDSC2; CTRP1 10.7049 12.2794 8.6697 0.5286
CL-40 CTRP1 10.7222 12.0532 8.7651 0.6846
NCI-H508 GDSC1; GDSC2; CTRP1 10.7392 12.1905 8.7198 0.3921
COLO 320 CTRP1 10.7456 14.3466 7.7804 7.6102
HCT 116 GDSC1; GDSC2; CTRP1 10.8746 12.3249 8.726 0.3214
SNU-81 GDSC1; GDSC2; CTRP1 10.882 14.214 7.9255 2.7415
CW-2 GDSC1; GDSC2; CTRP1 10.9043 14.4185 7.8453 3.0019
KM12 GDSC1; GDSC2; CTRP1 10.9206 12.402 8.716 0.3235
HT-55 GDSC1; GDSC2; CTRP1 10.9531 12.4263 8.7203 0.3028
SW948 GDSC1; GDSC2; CTRP1 10.9877 12.2364 8.8032 0.1535
HCT 8 CTRP1 10.9933 12.2111 8.8143 0.3107
SNU-C5 GDSC1; GDSC2; CTRP1 11.0543 12.6866 8.6642 0.3757
HT-29 GDSC1; GDSC2; CTRP1 11.1164 12.2899 8.8318 0.0935
SW620 GDSC1; GDSC2; CTRP1 11.1534 13.6667 8.3166 1.2112
SNU-61 GDSC1; GDSC2; CTRP1 11.1797 12.7067 8.7076 0.2502
LoVo GDSC1; GDSC2; CTRP1 11.3345 13.6245 8.4213 0.8045
LS123 GDSC1; GDSC2; CTRP1 11.4722 12.8895 8.7527 0.1201
COLO 678 GDSC1; GDSC2; CTRP1 11.4964 13.4221 8.5703 0.3926
RKO GDSC1; GDSC2; CTRP1 11.6797 13.0683 8.7651 0.0792
SW480 CTRP1 12.4444 14.4277 8.5713 0.3531
⏷ Show the Full List of 58 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1; GDSC2 4.2902 7.1172 2.1579 4.982
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-2 GDSC1; GDSC2 4.01 6.0206 2.494 3.5468
Hep-G2/C3A GDSC1; GDSC2 4.054 5.5028 2.7643 1.8843
SK-HEP-1 GDSC1; GDSC2 4.51 6.0095 2.7915 1.1064
Hep 3B2.1-7 GDSC1; GDSC2 4.602 6.3006 2.7156 1.3555
SNU-387 GDSC1; GDSC2 4.7363 6.7273 2.6034 1.733
HuH-1 GDSC1; GDSC2 4.8774 6.3032 2.8433 0.5669
JHH-1 GDSC1; GDSC2 5.2629 6.6748 2.861 0.3071
HLE GDSC1; GDSC2 5.4036 10.0644 1.4873 6.7031
JHH-7 GDSC1; GDSC2 5.5703 7.3689 2.7287 0.5108
Huh-7 GDSC1; GDSC2 5.7524 7.5204 2.7448 0.3845
JHH-4 GDSC1; GDSC2 5.9358 7.4765 2.8275 0.1672
SNU-423 GDSC1; GDSC2 6.1047 7.7842 2.7822 0.1986
JHH-6 GDSC1; GDSC2; CTRP1 6.449 7.4418 4.882 0.2377
SNU-449 GDSC1; GDSC2; CTRP1 7.7809 9.5051 4.6509 0.2452
SNU-398 GDSC1; GDSC2; CTRP1 10.402 14.8922 7.2902 5.7121
Hep-G2 CTRP1 10.8291 12.1186 8.7843 0.5148
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 205 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H720 GDSC1; GDSC2 3.7103 5.3733 2.5992 3.5631
NCI-H2170 GDSC1; GDSC2 3.8906 5.333 2.7416 2.3127
NCI-H211 GDSC1; GDSC2 3.9303 8.3045 1.3177 10.9289
NCI-H187 GDSC1 3.9506 5.1325 1.9362 0.3179
LOU-NH91 GDSC1; GDSC2 4.0296 6.1841 2.429 3.8966
NCI-H1092 GDSC1; GDSC2 4.1186 6.1636 2.4975 3.3068
NCI-H1155 GDSC1; GDSC2 4.1243 6.1464 2.5093 3.2263
NCI-H2066 GDSC1; GDSC2 4.1573 6.137 2.5347 3.0143
NCI-H1651 GDSC1; GDSC2 4.1604 5.8667 2.6618 2.2792
NCI-H2087 GDSC1; GDSC2 4.2148 6.2947 2.4974 3.1239
NCI-H446 GDSC1; GDSC2 4.2283 5.8452 2.7116 1.8906
NCI-H64 GDSC1; GDSC2 4.2557 6.6209 2.3706 3.7878
NCI-H526 GDSC1; GDSC2 4.2769 7.3765 2.0248 5.8103
NCI-H1304 GDSC1 4.3216 6.2457 1.6714 1.0624
NCI-H1341 GDSC1; GDSC2 4.3473 6.0006 2.7097 1.721
SBC-5 GDSC1; GDSC2 4.3768 5.7134 2.8488 0.9926
NCI-H1688 GDSC1; GDSC2 4.3844 6.1265 2.6748 1.8503
COR-L311 GDSC2 4.4007 7.6527 1.9762 5.8388
NCI-H196 GDSC1; GDSC2 4.4125 6.6591 2.4509 3.0347
NCI-H345 GDSC1; GDSC2 4.4199 5.5995 2.9162 0.6552
SW1271 GDSC1; GDSC2 4.4303 6.3302 2.6102 2.1255
Lu-135 GDSC1; GDSC2 4.4899 6.9555 2.3616 3.4053
NCI-H2373 GDSC1; GDSC2 4.5881 7.0786 2.3645 3.2193
IA-LM GDSC1; GDSC2 4.6304 6.8907 2.474 2.5503
UMC-11 GDSC1; GDSC2 4.6386 7.4302 2.2338 3.8693
NCI-H748 GDSC2 4.7147 6.8847 2.5236 2.1644
NCI-H209 GDSC1; GDSC2 4.715 7.4077 2.2902 3.421
NCI-H2444 GDSC1; GDSC2 4.8064 6.0486 2.91 0.3964
NCI-H1770 GDSC1; GDSC2 4.8285 6.3738 2.7943 0.7834
NCI-H226 GDSC1; GDSC2 4.9118 6.2268 2.8864 0.4075
NCI-H2731 GDSC1; GDSC2 4.9172 7.1941 2.4981 2.0208
RERF-LC-MS GDSC1; GDSC2 4.9477 6.6213 2.7502 0.8547
DMS 79 GDSC1; GDSC2 5.0124 6.5291 2.8143 0.5739
Lu-165 GDSC1; GDSC2 5.0567 6.9577 2.6659 1.0968
SK-MES-1 GDSC1; GDSC2 5.1218 7.9333 2.2871 2.8124
CPC-N GDSC1; GDSC2 5.1728 8.9885 1.8423 5.1386
NCI-H2171 GDSC2 5.1964 6.6926 2.8285 0.4224
NCI-H510A GDSC1; GDSC2 5.2425 6.8726 2.7803 0.5393
NCI-H1693 GDSC1; GDSC2 5.2649 7.3746 2.595 1.196
NCI-H322M GDSC1; GDSC2 5.2844 11.9547 0.5113 12.241
NCI-H292 GDSC1; GDSC2 5.2846 6.8061 2.8219 0.3967
NCI-H2227 GDSC1; GDSC2 5.2891 7.0142 2.7463 0.6183
NCI-H250 GDSC2 5.2905 7.535 2.5421 1.393
SBC-1 GDSC1; GDSC2 5.2912 7.2954 2.6385 1.0001
PaCa-3 GDSC1; GDSC2 5.2982 7.7841 2.4432 1.8241
NCI-H524 GDSC1; GDSC2 5.2994 8.837 1.986 4.1397
NCI-H1838 GDSC1; GDSC2 5.3545 8.0509 2.3595 2.1502
NCI-H838 GDSC1; GDSC2 5.3694 6.6787 2.8994 0.1895
A-427 GDSC1; GDSC2 5.3772 10.087 1.4603 6.9013
NCI-H1436 GDSC1; GDSC2 5.394 7.4408 2.6272 0.9599
ABC-1 GDSC1; GDSC2 5.4243 9.2516 1.8718 4.5568
NCI-H1581 GDSC1; GDSC2 5.4439 6.9741 2.8229 0.3244
NCI-H1869 GDSC1 5.4536 7.4032 1.694 0.3205
NCI-H2369 GDSC1; GDSC2 5.4727 6.9618 2.8381 0.2789
COR-L32 GDSC2 5.4747 7.7532 2.5401 1.2296
NCI-H290 GDSC1; GDSC2 5.4804 7.236 2.7418 0.5207
NCI-H2196 GDSC2 5.4937 7.0233 2.8242 0.302
Ms-1 GDSC1; GDSC2 5.5119 7.2233 2.759 0.4562
NCI-H740 GDSC2 5.5212 8.0135 2.4569 1.5298
NCI-H146 GDSC1; GDSC2 5.5558 7.2785 2.7561 0.4428
NCI-H2795 GDSC1; GDSC2 5.5722 11.0064 1.1541 8.2194
NCI-H835 GDSC1; GDSC2 5.6027 8.1285 2.4487 1.4859
COR-L303 GDSC2 5.6198 7.0939 2.8461 0.2157
COR-L321 GDSC1; GDSC2 5.6397 8.2568 2.4141 1.5957
EKVX GDSC1; GDSC2 5.6487 8.5018 2.318 2.0074
COR-L95 GDSC1; GDSC2 5.6498 6.9714 2.8988 0.1246
Lu-139 GDSC1; GDSC2 5.6513 7.082 2.8616 0.1801
DMS 53 GDSC1; GDSC2 5.6655 7.2939 2.7927 0.3083
HCC366 GDSC1; GDSC2 5.7131 7.646 2.6836 0.5641
IST-SL1 GDSC1; GDSC2 5.7252 7.7366 2.6548 0.6423
DMS 114 GDSC1; GDSC2 5.7328 7.1465 2.8684 0.1505
NCI-H2135 GDSC1; GDSC2 5.7591 7.0516 2.9095 0.093
NCI-H1563 GDSC1; GDSC2 5.7609 14.7516 -0.51 16.0866
NCI-H2291 GDSC1; GDSC2 5.7869 7.4131 2.7958 0.2611
LC-1/sq GDSC1; GDSC2 5.7959 9.7939 1.8409 4.1535
NCI-H2722 GDSC1; GDSC2 5.8013 7.2519 2.8566 0.1532
NCI-H2085 GDSC1; GDSC2 5.8027 8.9361 2.2135 2.3127
SBC-3 GDSC1; GDSC2 5.8058 7.3373 2.829 0.1954
LC-2/ad GDSC1; GDSC2 5.8181 7.9201 2.6242 0.6817
NCI-H513 GDSC1; GDSC2 5.8564 8.0682 2.5844 0.7834
RERF-LC-Sq1 GDSC1; GDSC2 5.8591 11.3681 1.1653 7.6304
NCI-H1993 GDSC1; GDSC2 5.8752 8.1786 2.5504 0.8828
IST-SL2 GDSC1; GDSC2 5.9169 8.0071 2.632 0.6043
LB647-SCLC GDSC1; GDSC2 5.9321 7.587 2.7882 0.2326
NCI-H847 GDSC1; GDSC2 5.9503 7.2918 2.8946 0.0822
NCI-H1623 GDSC1; GDSC2 5.955 8.2434 2.5593 0.8024
NCI-H2810 GDSC1; GDSC2 5.9761 12.2226 0.8412 9.1242
NCI-H2803 GDSC1; GDSC2 5.9789 7.6188 2.7941 0.21
HOP-92 GDSC1; GDSC2 6.0244 8.1779 2.6119 0.6051
NCI-H520 GDSC1; GDSC2 6.0254 7.6487 2.8004 0.1885
NCI-H647 GDSC1; GDSC2 6.0424 7.896 2.7206 0.3301
Lu-99A GDSC1; GDSC2 6.0439 8.0727 2.658 0.4736
NCI-H2804 GDSC1; GDSC2 6.0639 8.093 2.6584 0.464
LK-2 GDSC1; GDSC2 6.1234 7.7769 2.7913 0.1803
NCI-H1703 GDSC1; GDSC2 6.1449 7.9437 2.7415 0.2572
NCI-H2347 GDSC1; GDSC2 6.1727 8.2936 2.628 0.4926
PC-14 GDSC1; GDSC2 6.1923 7.7063 2.839 0.1065
NCI-H1734 GDSC1; GDSC2 6.1958 8.0943 2.7076 0.3061
EMC-BAC-2 GDSC1; GDSC2 6.2413 8.1964 2.6886 0.3296
NCI-H1648 GDSC1; GDSC2 6.273 8.1082 2.7309 0.2413
NCI-H2595 GDSC1; GDSC2 6.2918 8.0931 2.7428 0.2169
EMC-BAC-1 GDSC1; GDSC2 6.3399 8.783 2.515 0.7156
Lu-134-A GDSC1; GDSC2 6.3737 8.4929 2.6332 0.4005
NCI-H69 GDSC1; GDSC2 6.3989 8.4388 2.6617 0.3328
HOP-62 GDSC1; GDSC2 6.401 8.0233 2.8045 0.1136
NCI-H2461 GDSC1; GDSC2 6.4289 15.6907 -0.5041 14.6791
BEN GDSC1; GDSC2; CTRP1 6.4402 7.3743 4.9032 0.193
NCI-H1930 CTRP1 6.4657 15.702 0.9698 25.4356
HCC33 GDSC2; CTRP1 6.4727 8.537 4.4431 1.8362
NCI-H2228 GDSC1; GDSC2 6.4728 8.6709 2.6073 0.4214
NCI-H3122 GDSC1; GDSC2 6.513 8.3694 2.7267 0.1919
COR-L279 GDSC1; GDSC2; CTRP1 6.5364 8.0988 4.6636 0.8631
NCI-H2591 GDSC1; GDSC2 6.5706 8.9155 2.557 0.4984
NCI-H1650 GDSC1; GDSC2 6.589 8.6685 2.6511 0.2962
NCI-H2126 CTRP1 6.6076 9.1522 4.2454 4.3159
NCI-H2869 GDSC1; GDSC2 6.6083 8.776 2.6206 0.3477
NCI-H522 GDSC2; CTRP1 6.6248 8.7565 4.4303 1.7111
NCI-H650 GDSC1; GDSC2; CTRP1 6.6708 8.6007 4.5212 1.2854
LCLC-97TM1 GDSC1; GDSC2; CTRP1 6.7096 9.7381 4.0396 3.3744
SW1573 GDSC1; GDSC2 6.7102 8.7654 2.6612 0.2475
NCI-H1435 GDSC1; GDSC2; CTRP1 6.7403 8.4521 4.6167 0.8621
SHP-77 GDSC1; GDSC2; CTRP1 6.7531 8.3221 4.6745 0.6564
Calu-6 GDSC1; GDSC2; CTRP1 6.766 9.2296 4.3005 2.1071
NCI-H1048 GDSC1; GDSC2; CTRP1 6.7697 10.1827 3.8716 4.0874
NCI-H2029 GDSC1; GDSC2; CTRP1 6.815 8.8402 4.4932 1.2553
EPLC-272H GDSC1; GDSC2; CTRP1 6.8331 9.8787 4.049 3.1567
NCI-H2009 GDSC1; GDSC2; CTRP1 6.8853 8.9884 4.4663 1.2929
LC-1/sq-SF CTRP1 6.9272 10.0653 4.0197 5.3129
EBC-1 GDSC1; GDSC2; CTRP1 6.9284 8.9336 4.51 1.0898
NCI-H2818 GDSC1; GDSC2 6.9399 18.2796 -1.3989 17.2656
ChaGo-K-1 GDSC1; GDSC2; CTRP1 6.967 9.6235 4.2378 2.1423
NCI-H1666 GDSC1; GDSC2; CTRP1 6.9791 10.7904 3.7197 4.4998
NCI-H1573 GDSC1; GDSC2; CTRP1 7.0131 8.5026 4.7163 0.3864
VMRC-LCD GDSC1; GDSC2; CTRP1 7.0224 8.8315 4.5944 0.7287
NCI-H358 GDSC1; GDSC2; CTRP1 7.0246 9.1776 4.4562 1.2047
NCI-H1915 GDSC1; GDSC2; CTRP1 7.0435 9.0515 4.5166 0.9722
LCLC-103H GDSC1; GDSC2; CTRP1 7.0522 8.5581 4.7115 0.3803
KNS-62 GDSC1; GDSC2; CTRP1 7.0719 10.0344 4.1153 2.5492
NCI-H810 GDSC1; GDSC2; CTRP1 7.1581 8.8418 4.6487 0.4895
NCI-H1975 GDSC1; GDSC2; CTRP1 7.1817 9.0504 4.5791 0.6733
Lu-99 CTRP1 7.2267 8.9404 4.64 0.8085
COR-L88 GDSC1; GDSC2; CTRP1 7.2479 8.9455 4.6468 0.4501
NCI-H1568 GDSC1; GDSC2; CTRP1 7.2544 12.6058 3.0451 7.3085
NCI-H1373 CTRP1 7.2571 10.2509 4.1213 3.8852
Lu-65 GDSC1; GDSC2; CTRP1 7.2661 9.0559 4.6129 0.5294
NCI-H23 GDSC1; GDSC2; CTRP1 7.2754 9.2059 4.5596 0.6742
Calu-3 GDSC1; GDSC2; CTRP1 7.29 9.0648 4.6194 0.4997
NCI-H1355 GDSC1; GDSC2; CTRP1 7.31 10.1241 4.2032 1.9153
NCI-H1792 GDSC1; GDSC2; CTRP1 7.3127 12.8705 2.958 7.6277
DV-90 CTRP1 7.3329 8.9571 4.6765 0.5808
NCI-H661 GDSC1; GDSC2; CTRP1 7.391 9.1872 4.615 0.4624
NCI-H1299 GDSC1; GDSC2; CTRP1 7.3969 9.3137 4.5699 0.5766
NCI-H1944 GDSC1; GDSC2; CTRP1 7.3992 9.2297 4.6025 0.4899
HCC44 GDSC1; GDSC2; CTRP1 7.4413 9.0915 4.6699 0.3165
COLO 668 GDSC1; GDSC2; CTRP1 7.4499 9.3223 4.5886 0.5009
RERF-LC-KJ GDSC1; GDSC2; CTRP1 7.4979 8.7568 4.8071 0.0882
NCI-H2405 GDSC1; GDSC2; CTRP1 7.5098 9.9903 4.3557 1.1669
NCI-H1793 GDSC1; GDSC2; CTRP1 7.5175 8.9683 4.7418 0.1665
COR-L105 GDSC1; GDSC2 7.547 17.0143 -0.4053 12.1961
NCI-H2286 CTRP1 7.59 8.8186 4.8179 0.1123
HARA [Human squamous cell lung carcinoma] GDSC1; GDSC2; CTRP1 7.6158 9.2228 4.689 0.2257
NCI-H82 GDSC1; GDSC2; CTRP1 7.6254 13.9612 2.646 8.5747
NCI-H727 GDSC1; GDSC2; CTRP1 7.7273 9.4431 4.6528 0.257
NCI-H1437 GDSC1; GDSC2; CTRP1 7.7447 11.47 3.8541 2.8906
HCC78 GDSC1; GDSC2; CTRP1 7.7602 9.3683 4.691 0.1864
DMS 273 GDSC1; GDSC2; CTRP1 7.7941 9.2299 4.7503 0.1046
A-549 GDSC1; GDSC2; CTRP1 7.799 10.2661 4.3766 0.8997
LXF 289 GDSC1; GDSC2; CTRP1 8.3043 9.9553 4.6825 0.1023
COR-L51 CTRP1 9.5201 13.9755 7.0801 17.1681
NCI-H1694 GDSC1; GDSC2; CTRP1 9.7719 16.607 5.9684 11.8076
NCI-H2141 GDSC1; GDSC2; CTRP1 9.7802 11.8723 8.3185 2.6289
NCI-H1963 GDSC1; GDSC2; CTRP1 9.8661 14.688 6.9963 7.6712
SCLC-21H CTRP1 10.0311 11.5622 8.6268 2.6693
NCI-H2073 CTRP1 10.0639 12.0606 8.4175 4.2773
HCC1359 CTRP1 10.0948 11.1885 8.8241 1.1094
NCI-H2023 GDSC1; GDSC2; CTRP1 10.2119 12.3661 8.3677 1.9003
NCI-H596 GDSC1; GDSC2; CTRP1 10.3625 12.5761 8.3623 1.7567
SK-LU-1 GDSC1; CTRP1 10.7776 15.8612 7.0824 6.3684
NCI-H1876 GDSC1; GDSC2; CTRP1 10.9023 12.3877 8.7138 0.3351
NCI-H2030 GDSC1; GDSC2; CTRP1 10.9487 12.4974 8.6916 0.3618
NCI-H460 GDSC1; GDSC2; CTRP1 10.9722 11.9379 8.9008 0.0498
COR-L23 GDSC1; GDSC2; CTRP1 10.9796 12.287 8.782 0.1869
NCI-H1836 GDSC1; GDSC2; CTRP1 11.0555 12.4978 8.7351 0.2415
NCI-H1105 GDSC1; GDSC2; CTRP1 11.0862 13.5591 8.3279 1.2272
NCI-H2081 GDSC1; GDSC2; CTRP1 11.1057 12.8279 8.632 0.4215
HCC827 GDSC1; GDSC2; CTRP1 11.1418 13.0354 8.5675 0.5488
NCI-H3255 GDSC1; GDSC2; CTRP1 11.1666 12.5488 8.7595 0.173
NCI-H2342 GDSC1; GDSC2; CTRP1 11.191 13.0696 8.5757 0.5067
Sq-1 CTRP1 11.2565 12.5769 8.783 0.28
NCI-H1781 GDSC1; GDSC2; CTRP1 11.2637 12.4181 8.8401 0.0657
CAL-12T GDSC1; GDSC2; CTRP1 11.2708 12.7104 8.7414 0.1741
HCC4006 CTRP1 11.2875 12.8592 8.6943 0.5446
COLO 699 CTRP1 11.2894 12.9677 8.6553 0.6941
NCI-H1755 GDSC1; GDSC2; CTRP1 11.3182 13.1624 8.5943 0.4127
HCC1195 CTRP1 11.3189 12.857 8.7073 0.4795
NCI-H441 GDSC1; GDSC2; CTRP1 11.3211 12.9777 8.6643 0.2805
NCI-H2172 GDSC1; GDSC2; CTRP1 11.3223 12.5736 8.8078 0.0869
HCC2935 CTRP1 11.3855 12.9229 8.709 0.4362
NCI-H2110 GDSC1; GDSC2; CTRP1 11.4138 13.4012 8.5438 0.4781
HCC2108 CTRP1 11.4365 12.9993 8.7011 0.4342
T3M-10 CTRP1 11.4654 13.0117 8.7075 0.3995
NCI-H2122 GDSC1; GDSC2; CTRP1 11.4859 12.6764 8.8298 0.0508
NCI-H841 GDSC1; GDSC2; CTRP1 11.5264 13.0255 8.7252 0.1419
HCC15 GDSC1; GDSC2; CTRP1 11.673 13.4094 8.6444 0.216
HCC1833 CTRP1 11.685 13.4852 8.6218 0.5567
⏷ Show the Full List of 205 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1; GDSC2 5.9145 7.9203 2.6629 0.5202
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-9 GDSC1; GDSC2 4.3731 6.4428 2.5262 2.6784
EC-GI-10 GDSC1; GDSC2 4.7653 6.8674 2.5584 1.9185
OE33 GDSC1; GDSC2 4.9792 9.6532 1.4081 7.9711
KYSE-520 GDSC1; GDSC2 4.9803 8.3846 2.0028 4.5752
TE-15 GDSC1; GDSC2 5.009 7.1973 2.544 1.6863
KYSE-70 GDSC1; GDSC2 5.1127 8.6905 1.9425 4.6844
TE-5 GDSC1; GDSC2 5.2231 6.9235 2.7531 0.6386
TE-11 GDSC1; GDSC2 5.322 7.3745 2.6211 1.0418
T.T GDSC1; GDSC2 5.4051 7.2173 2.7179 0.637
KYSE-150 GDSC1; GDSC2 5.4052 6.7349 2.8929 0.1912
OE19 GDSC1; GDSC2 5.4624 7.4901 2.6379 0.8687
COLO 680N GDSC1; GDSC2 5.6063 7.7396 2.6039 0.885
KYSE-270 GDSC1; GDSC2 5.6627 7.4889 2.7213 0.4847
KYSE-510 GDSC1; GDSC2 5.702 7.2673 2.8156 0.2487
TE-1 GDSC1; GDSC2 5.7093 7.3996 2.7716 0.3391
OE21 GDSC1; GDSC2 5.779 8.6099 2.3366 1.7894
KYSE-180 GDSC1; GDSC2 5.8412 7.6003 2.75 0.3381
TE-6 GDSC1; GDSC2 6.0781 7.742 2.7872 0.197
TE-4 GDSC1; GDSC2 6.2132 7.9875 2.751 0.2227
TE-10 GDSC1; GDSC2 6.2879 8.0137 2.7686 0.1785
TE-8 GDSC1; GDSC2 6.8429 8.8613 2.6753 0.1974
KYSE-410 GDSC1; GDSC2; CTRP1 6.9612 10.0997 4.0238 3.0993
KYSE-450 GDSC1; GDSC2; CTRP1 7.2759 9.033 4.6255 0.4908
KYSE-140 GDSC1; GDSC2; CTRP1 7.793 10.6704 4.2137 1.4385
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DOV13 GDSC1; GDSC2 4.2883 5.9785 2.6864 1.9339
OV56 GDSC1; GDSC2 4.6785 5.6623 3.0009 0.212
Kuramochi GDSC1; GDSC2 4.7913 7.0784 2.4807 2.2784
Caov-4 GDSC1; GDSC2 4.8594 6.953 2.571 1.7366
FU-OV-1 GDSC1; GDSC2 4.9525 7.1112 2.5516 1.7168
TOV-21G GDSC1; GDSC2 4.9534 10.9118 0.7857 11.5141
OC 314 GDSC1; GDSC2 5.4266 6.8108 2.8742 0.22
OVISE GDSC1; GDSC2 5.4354 11.7379 0.7183 10.8343
ES-2 GDSC1; GDSC2 5.5965 7.1017 2.8348 0.2441
OVCAR-5 GDSC1; GDSC2 5.7314 7.3936 2.7821 0.3078
TOV-112D GDSC1; GDSC2 5.7509 7.4078 2.7843 0.2962
OVCAR-3 GDSC1; GDSC2 5.7702 7.3431 2.8141 0.2312
OVTOKO GDSC1; GDSC2 5.7956 7.9879 2.5894 0.8058
JHOS-2 GDSC1; GDSC2 6.1435 7.9575 2.7363 0.2672
OAW28 GDSC1; GDSC2 6.4429 8.2375 2.7469 0.1776
JHOS-4 GDSC1; GDSC2; CTRP1 6.7756 8.6315 4.5603 1.0367
COV318 CTRP1 6.8823 7.8637 4.8946 0.149
OVMANA CTRP1 7.3135 8.5578 4.8101 0.1946
SK-OV-3 GDSC1; GDSC2; CTRP1 7.3946 8.7729 4.7651 0.1601
HEY A8 CTRP1 7.4 11.6997 3.5572 7.6433
EFO-21 GDSC1; GDSC2; CTRP1 7.6326 9.2331 4.6916 0.2169
OAW42 GDSC1; CTRP1 10.3676 11.2845 8.9074 0.1695
COV644 CTRP1 10.4685 12.203 8.586 2.0832
Caov-3 GDSC2; CTRP1 10.5988 15.3783 7.1921 5.812
OV7 CTRP1 10.6609 12.5135 8.5528 1.9808
OVKATE GDSC1; GDSC2; CTRP1 10.7687 13.8225 8.0364 2.4716
OV-90 GDSC1; GDSC2; CTRP1 10.816 13.7259 8.108 2.1743
JHOM-1 CTRP1 11.0504 12.3916 8.7716 0.4172
IGROV-1 GDSC1; GDSC2; CTRP1 11.0544 13.4357 8.3637 1.1447
RMG-I GDSC1; GDSC2; CTRP1 11.2876 15.0422 7.7889 2.7976
OVCAR-4 GDSC1; GDSC2; CTRP1 11.3453 13.9114 8.3098 1.0972
OVCAR-8 GDSC1; GDSC2; CTRP1 11.4537 13.0487 8.69 0.2034
COV434 CTRP1 11.5776 13.8577 8.4385 1.4389
EFO-27 GDSC1; GDSC2; CTRP1 11.6006 13.0655 8.7381 0.1149
TYK-nu GDSC1; GDSC2; CTRP1 11.6264 13.1099 8.7321 0.1171
SNU-840 CTRP1 11.6503 19.9699 5.7025 18.5267
COV362 CTRP1 11.659 13.0924 8.7497 0.2156
JHOC-5 CTRP1 11.7431 12.8829 8.8479 0.0559
RMUG-S CTRP1 12.142 20.385 5.8361 16.5276
OVK18 GDSC1; GDSC2; CTRP1 12.6028 21.3962 5.6589 8.7947
A2780 GDSC1; GDSC2; CTRP1 12.6655 21.0786 5.8485 8.0665
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HPAF-II GDSC1 2.8211 4.4289 1.6498 3.7421
PaTu 8988t GDSC1; GDSC2 4.3181 9.2021 1.1651 10.8582
Capan-1 GDSC1; GDSC2 4.607 6.1734 2.7713 1.0916
SU.86.86 GDSC1; GDSC2 4.7587 6.2207 2.8234 0.7293
PL4 GDSC1; GDSC2 4.8486 7.0219 2.5359 1.9218
Panc 02.03 GDSC1; GDSC2 4.9425 7.5427 2.36 2.6898
YAPC GDSC1; GDSC2 5.2041 6.5462 2.8847 0.275
DAN-G GDSC1; GDSC2 5.2426 6.9019 2.7694 0.5735
MIA PaCa-2 GDSC1; GDSC2 5.3214 6.8463 2.8216 0.3801
Panc 04.03 GDSC1; GDSC2 5.4817 7.9305 2.4719 1.5044
Panc 08.13 GDSC1; GDSC2 5.4821 7.6176 2.597 1.003
KP-4 GDSC1; GDSC2 5.5277 7.0523 2.8267 0.284
PSN1 GDSC1; GDSC2 5.5661 7.1208 2.8168 0.2917
KP-2 GDSC1; GDSC2 5.6382 7.2494 2.7982 0.3062
BxPC-3 GDSC1; GDSC2 5.765 7.6143 2.7158 0.4512
SW1990 GDSC1; GDSC2 5.7855 8.0697 2.5539 0.9323
HuP-T3 GDSC1; GDSC2 5.8534 14.1553 -0.1578 14.3052
AsPC-1 GDSC1; GDSC2 6.0951 7.995 2.7053 0.3442
KP-1N GDSC1; GDSC2 6.1003 12.7676 0.665 9.7985
MZ-PC-1 GDSC1; GDSC2 6.1196 8.1329 2.6654 0.4241
Hs 766T GDSC1; GDSC2 6.5271 13.5344 0.5754 9.4717
QGP-1 GDSC1; GDSC2; CTRP1 6.6492 9.0465 4.3163 2.1803
HPAC GDSC1; GDSC2; CTRP1 6.6814 8.5051 4.5665 1.0981
KP-3 GDSC1; GDSC2; CTRP1 6.8917 9.8777 4.0835 2.919
Capan-2 GDSC1; CTRP1 6.896 9.811 4.1158 3.0114
HuP-T4 GDSC1; GDSC2; CTRP1 7.1759 8.9647 4.6096 0.5876
SUIT-2 GDSC1; GDSC2; CTRP1 7.3028 9.6397 4.4004 1.1733
PaTu 8902 GDSC1; GDSC2; CTRP1 7.329 8.7909 4.7347 0.2274
Panc 10.05 GDSC1; GDSC2; CTRP1 7.452 9.3298 4.5867 0.5046
Panc 03.27 GDSC1; GDSC2; CTRP1 7.5295 10.8371 4.0129 2.4633
CFPAC-1 GDSC1; GDSC2; CTRP1 7.5995 9.3458 4.6392 0.3235
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 GDSC1; GDSC2 5.3195 8.6721 2.071 3.6544
IST-Mes1 GDSC1; GDSC2 6.0508 7.8399 2.7434 0.2814
NCI-H2452 GDSC1; GDSC2 6.9728 9.0838 2.6453 0.2133
NCI-H2052 GDSC1; GDSC2; CTRP1 7.4353 9.4372 4.5391 0.6406
NCI-H28 GDSC1; GDSC2; CTRP1 7.4389 9.4085 4.5516 0.6041
MSTO-211H GDSC1; GDSC2; CTRP1 8.5138 19.8109 0.4454 16.1133
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H660 GDSC2 5.0901 6.331 2.9183 0.2423
VCaP GDSC1; GDSC2 5.2046 6.8222 2.7836 0.5517
DU145 GDSC1; GDSC2 5.8537 7.5559 2.7704 0.2905
LNCaP clone FGC GDSC1; GDSC2 5.8741 7.5819 2.7687 0.2871
22Rv1 GDSC1; GDSC2 6.2303 8.3223 2.6398 0.4401
PC-3 GDSC1; GDSC2 6.5581 8.5227 2.6903 0.2373
PaCa-3 CTRP1 7.4197 10.8844 3.9334 4.8922
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1; GDSC2 5.6256 7.2297 2.8005 0.3057
Cancer Drug Sensitivity Data Curated from 61 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-31 GDSC1; GDSC2 3.8662 5.4951 2.6486 2.9161
WM793 GDSC1; GDSC2 3.8917 5.3549 2.7321 2.3666
COLO 829 GDSC1; GDSC2 3.9234 6.0454 2.423 4.1623
SK-MEL-2 GDSC1; GDSC2 4.0588 5.7203 2.667 2.43
UACC-62 GDSC1; GDSC2 4.4547 5.8612 2.8259 1.0108
M14 GDSC1 4.6557 6.1054 1.855 0.2366
451Lu GDSC1; GDSC2 4.6895 6.9229 2.4929 2.3609
SK-MEL-30 GDSC1; GDSC2 4.7434 6.1202 2.856 0.6191
IGR-1 GDSC1; GDSC2 4.8278 6.5047 2.7416 0.997
UACC-257 GDSC1; GDSC2 4.8455 6.1106 2.9028 0.3959
IPC-298 GDSC1; GDSC2 4.8866 6.1915 2.8893 0.413
SK-MEL-24 GDSC1; GDSC2 4.9096 6.4255 2.81 0.6607
SK-MEL-3 GDSC1; GDSC2 4.996 6.4645 2.8319 0.5265
LB373-MEL-D GDSC1; GDSC2 5.0088 6.2934 2.9006 0.3188
A2058 GDSC1; GDSC2 5.0248 6.1251 2.9665 0.1649
WT2-iPS GDSC1; GDSC2 5.0808 6.9589 2.6765 1.0311
IGR-37 GDSC1; GDSC2 5.0875 6.4275 2.8826 0.3294
CP66-MEL GDSC1; GDSC2 5.1493 6.2495 2.9684 0.129
A101D GDSC1; GDSC2 5.154 6.9341 2.7192 0.8059
COLO 783 GDSC1; GDSC2 5.1551 6.5696 2.8573 0.3641
Hs 938.T GDSC1; GDSC2 5.2025 7.1504 2.6559 1.0071
GAK GDSC1; GDSC2 5.2086 6.7499 2.8123 0.4625
LB2518-MEL GDSC1; GDSC2 5.2152 6.5156 2.8997 0.2376
RVH-421 GDSC1; GDSC2 5.2318 6.5715 2.8861 0.2613
COLO 679 GDSC1; GDSC2 5.3591 7.1514 2.7236 0.6475
Mel Ho GDSC1; GDSC2 5.3641 6.8058 2.8527 0.2865
DJM-1 GDSC1; GDSC2 5.3863 7.9581 2.4144 1.8577
MZ-MEL-2 GDSC1; GDSC2 5.4044 8.5087 2.1894 2.921
MZ-MEL-7 GDSC1; GDSC2 5.4294 7.3401 2.6815 0.7409
HT-144 GDSC1; GDSC2 5.4317 7.4706 2.6322 0.9123
Mel JuSo GDSC1; GDSC2 5.4329 8.4915 2.2121 2.7696
MeWo GDSC1; GDSC2 5.4735 6.9177 2.854 0.2452
RPMI-7951 GDSC1; GDSC2 5.4876 6.7874 2.9043 0.1507
MMAc-SF GDSC1; GDSC2 5.4882 7.0483 2.8132 0.3294
CP50-MEL-B GDSC1; GDSC2 5.5021 6.7153 2.9339 0.1058
COLO 800 GDSC1; GDSC2 5.578 7.2109 2.7892 0.3499
VMRC-MELG GDSC1; GDSC2 5.6099 6.9976 2.8758 0.1671
G-mel GDSC1; GDSC2 5.6365 7.1981 2.8157 0.2695
COLO 792 GDSC1; GDSC2 5.7913 7.6214 2.7234 0.4204
LOX-IMVI GDSC1; GDSC2 5.8018 7.2584 2.8546 0.1561
A-388 GDSC1; GDSC2 5.8369 8.3607 2.4632 1.223
IST-MEL1 GDSC1; GDSC2 5.8798 7.6287 2.7544 0.3149
SH-4 GDSC1; GDSC2 5.9314 7.5783 2.791 0.2279
A-431 GDSC1; GDSC2 5.9369 7.5069 2.8175 0.1822
WM35 GDSC1; GDSC2 5.9883 8.1052 2.6243 0.5889
WM1552C GDSC1; GDSC2 6.1196 7.6118 2.8457 0.1099
Hs 940.T GDSC1; GDSC2 6.1589 7.6921 2.8323 0.1191
HMV-II GDSC1; GDSC2 6.2177 7.9132 2.7781 0.1795
CHL-1 GDSC1; GDSC2 6.261 8.0178 2.7577 0.2007
WM278 GDSC1; GDSC2 6.2798 8.2994 2.6666 0.362
G-361 GDSC1; GDSC2; CTRP1 6.6765 8.6885 4.4869 1.418
Hs 852.T CTRP1 7.085 9.3535 4.4131 2.219
COLO 741 CTRP1 7.2002 9.1043 4.5663 1.1857
Hs 936.T CTRP1 7.2125 12.0276 3.2901 10.0433
WM115 GDSC1; GDSC2 7.3339 16.6279 -0.3588 12.3655
Hs 944.T CTRP1 7.4394 10.0289 4.3069 2.3572
SK-MEL-28 GDSC1; GDSC2; CTRP1 9.8506 13.5854 7.5301 5.599
SK-MEL-1 GDSC1; GDSC2; CTRP1 10.7322 12.546 8.5744 0.7643
SK-MEL-5 GDSC1; GDSC2; CTRP1 10.7957 11.9625 8.8282 0.1648
A-375 GDSC1; GDSC2; CTRP1 10.8774 12.2429 8.7578 0.259
EquiPSC Line K2 GDSC1; GDSC2 6.7289 14.9228 0.0554 11.5976
⏷ Show the Full List of 61 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1; GDSC2 5.4053 6.9706 2.8093 0.3738
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Rh18 GDSC1 4.0043 5.4461 1.8423 0.6085
MES-SA GDSC1; GDSC2 4.0653 5.6102 2.7219 2.104
VA-ES-BJ GDSC1; GDSC2 4.7398 6.7138 2.611 1.6914
Rh30 GDSC1; GDSC2 5.0652 6.8767 2.7021 0.9429
SW684 GDSC1; GDSC2 5.0788 6.2038 2.9588 0.1636
EW-8 GDSC1; GDSC2 5.2497 6.7698 2.8214 0.4152
MFH-ino GDSC1; GDSC2 5.2506 7.0097 2.7318 0.6915
TE 441.T GDSC2 5.3962 6.6762 2.9099 0.1638
SK-LMS-1 GDSC1; GDSC2 5.4298 7.5296 2.6083 1.0024
SK-UT-1 GDSC1; GDSC2 5.4353 10.0318 1.522 6.4538
Hs 633.T GDSC1; GDSC2 5.4682 7.0283 2.8127 0.3386
SW982 GDSC1; GDSC2 5.7372 7.164 2.864 0.1561
SW872 GDSC1; GDSC2 5.8249 7.3675 2.8255 0.1965
GCT GDSC1; GDSC2 6.0152 7.8764 2.7173 0.3465
STS-0421 GDSC1; GDSC2 6.0431 8.2378 2.5973 0.6368
RD GDSC1; GDSC2 6.0686 8.088 2.662 0.4531
KYM-1 GDSC1; GDSC2 6.0988 14.5341 -0.1729 13.8676
G-402 GDSC1; GDSC2 6.2162 8.4256 2.5971 0.552
Rh41 GDSC1; GDSC2 6.3129 14.5029 -0.0155 12.7133
A-204 GDSC1; GDSC2 6.3829 8.6214 2.5908 0.4946
G-401 GDSC1; GDSC2; CTRP1 6.8669 9.4618 4.254 2.1892
HT-1080 GDSC1; GDSC2; CTRP1 11.2551 12.5113 8.8052 0.0994
RKN GDSC1; GDSC2; CTRP1 11.2885 12.2869 8.8921 0.0294
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-N87 GDSC1 3.3047 5.8838 1.2783 5.2705
Hs 746.T GDSC1; GDSC2 3.9467 5.7466 2.5825 3.1466
SNU-1 GDSC1; GDSC2 3.9599 6.0528 2.4446 3.9508
SNU-16 GDSC1; GDSC2 4.1315 6.3611 2.4125 3.7854
ECC12 GDSC2 4.2794 7.6626 1.8885 6.6283
MKN45 GDSC1; GDSC2 4.562 5.4968 3.0156 0.2255
SNU-5 GDSC1; GDSC2 4.6398 7.6886 2.1148 4.5493
MKN1 GDSC1; GDSC2 4.9287 7.0872 2.5496 1.755
SCH GDSC1; GDSC2 5.0561 6.3119 2.9122 0.2695
23132/87 GDSC1; GDSC2 5.1208 6.479 2.8768 0.3291
ECC10 GDSC1; GDSC2 5.152 7.2853 2.5779 1.3773
RERF-GC-1B GDSC1; GDSC2 5.2586 11.3701 0.7751 10.9039
HSC-39 GDSC1; GDSC2 5.2949 7.2497 2.6581 0.9225
KATO III GDSC1; GDSC2 5.4219 7.1523 2.7491 0.5311
GCIY GDSC1; GDSC2 5.4436 7.0376 2.7999 0.3806
TMK-1 GDSC1; GDSC2 5.6406 7.5126 2.7038 0.5446
TGBC11TKB GDSC1; GDSC2 5.6971 7.277 2.8104 0.2605
IM95 GDSC1; GDSC2 5.9605 7.9275 2.6782 0.4596
RF-48 GDSC1; GDSC2 6.066 8.5346 2.4954 0.9398
SK-GT-2 GDSC1; GDSC2 6.1176 11.2317 1.3824 6.0465
NUGC-3 GDSC1; GDSC2 6.1336 7.8909 2.7557 0.2352
OCUM-1 GDSC1; GDSC2 6.1634 8.1393 2.6797 0.375
NUGC-4 GDSC1; GDSC2; CTRP1 6.3726 12.2492 2.6056 11.0907
MKN28 GDSC1; GDSC2 6.4865 8.3383 2.728 0.1956
MKN74 CTRP1 7.1414 9.8132 4.2484 3.216
Fu97 GDSC1; GDSC2; CTRP1 7.2323 8.6706 4.741 0.2457
SH-10-TC CTRP1 7.4045 8.7598 4.7732 0.2474
MKN7 GDSC1; GDSC2; CTRP1 7.767 9.3896 4.6861 0.1922
HGC-27 GDSC1; GDSC2 8.5189 17.829 -0.1949 9.7656
AGS GDSC1; GDSC2; CTRP1 10.9952 12.5938 8.6745 0.3783
SNG-M GDSC1; GDSC2; CTRP1 8.0013 9.7801 4.6355 0.2137
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ASH-3 GDSC1; GDSC2 4.585 6.3411 2.6896 1.5018
CAL-62 GDSC1; GDSC2 4.6618 6.6632 2.5915 1.8902
B-CPAP GDSC1; GDSC2 4.6859 7.3712 2.2894 3.4739
8505C GDSC1; GDSC2 5.0734 7.8207 2.31 2.7627
HTC-C3 GDSC1; GDSC2 5.0839 6.85 2.7211 0.8541
CGTH-W-1 GDSC1; GDSC2 5.4722 7.0223 2.8164 0.3283
WRO GDSC1; GDSC2 5.4824 6.8323 2.887 0.1805
BHT-101 GDSC1; GDSC2 5.5341 8.7771 2.1426 2.9828
8305C GDSC1; GDSC2 5.5478 6.8643 2.8994 0.1447
K5 GDSC1; GDSC2 5.5944 7.2815 2.7701 0.3893
TT GDSC1; GDSC2 5.603 8.1747 2.4301 1.5637
FTC-133 GDSC1; GDSC2 5.7286 6.9869 2.9207 0.0853
ML-1 [Human leukemia] GDSC1; GDSC2 5.842 7.6482 2.7332 0.3759
IHH-4 GDSC1; GDSC2 5.9071 7.2304 2.9004 0.082
KMH-2 GDSC1; GDSC2 6.1619 7.8466 2.7811 0.1871
TT2609-C02 GDSC1; GDSC2 6.3734 8.176 2.7434 0.1972
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 41 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LB771-HNC GDSC1; GDSC2 2.9838 10.2457 -0.4256 22.9746
BICR 10 GDSC1 4.5981 6.4194 1.7212 0.6446
BB49-HNC GDSC1 4.719 6.8316 1.6166 0.9542
PCI-38 GDSC1 4.8004 6.804 1.6603 0.7284
HO-1-u-1 GDSC1; GDSC2 4.8826 7.4137 2.3837 2.6525
PCI-15A GDSC1; GDSC2 4.9192 6.3584 2.8399 0.5501
KON GDSC1; GDSC2 5.0193 6.8967 2.673 1.1023
KOSC-2 GDSC1; GDSC2 5.0296 7.4052 2.4665 2.0329
BICR 22 GDSC1; GDSC2 5.1392 9.6771 1.5011 7.123
HSC-3 GDSC1; GDSC2 5.1719 6.6738 2.8257 0.4435
CAL-27 GDSC1; GDSC2 5.3024 6.6982 2.8677 0.2761
CAL-33 GDSC1; GDSC2 5.3205 7.7675 2.4611 1.7181
DOK GDSC1; GDSC2 5.3224 11.9607 0.5347 12.0373
UPCI-SCC-090 GDSC1; GDSC2 5.4081 7.4859 2.6158 0.9914
FaDu GDSC1; GDSC2 5.4132 6.8551 2.8536 0.2666
SAS GDSC1; GDSC2 5.4848 7.7924 2.529 1.2649
HO-1-N-1 GDSC1; GDSC2 5.5266 7.3287 2.726 0.5415
BHY GDSC1; GDSC2 5.5359 7.1516 2.7944 0.3547
OSC-20 GDSC1; GDSC2 5.5743 7.5797 2.6514 0.7452
PCI-06A GDSC1; GDSC2 5.5744 8.6159 2.2327 2.4899
SKN-3 GDSC1; GDSC2 5.5812 7.8978 2.5311 1.1735
JHU-022 GDSC1; GDSC2 5.6008 9.8398 1.7093 5.148
BB30-HNC GDSC1; GDSC2 5.6846 7.9698 2.5487 1.0244
PCI-30 GDSC1; GDSC2 5.7625 8.5178 2.3663 1.6791
SCC-25 GDSC1; GDSC2 5.7786 7.7414 2.6746 0.5555
Detroit 562 GDSC1; GDSC2 5.8225 7.6802 2.7142 0.4297
BICR 31 GDSC2 5.8237 7.5892 2.7473 0.3507
Ca9-22 GDSC1; GDSC2 5.8795 7.7822 2.6994 0.4418
JHU-029 GDSC1; GDSC2 5.884 8.3714 2.4799 1.1238
SCC-4 GDSC1; GDSC2 5.9192 7.5261 2.8046 0.2076
HSC-4 GDSC1; GDSC2 5.9971 19.2864 -2.5554 23.0412
OSC-19 GDSC1; GDSC2 6.0211 7.4427 2.8685 0.0994
BICR 78 GDSC1; GDSC2 6.0262 8.1326 2.6293 0.5565
SCC-15 GDSC1; GDSC2 6.1034 8.1396 2.6568 0.4512
JHU-011 GDSC1; GDSC2 6.1988 10.0771 1.9335 3.1573
SAT [Human HNSCC] GDSC1; GDSC2 6.2317 9.8632 2.04 2.6246
PCI-04B GDSC1; GDSC2 6.4141 8.8186 2.5314 0.6323
NCI-H3118 GDSC1; GDSC2 6.4142 8.8288 2.5277 0.6422
PE/CA-PJ15 GDSC1; GDSC2 6.4538 8.0444 2.8154 0.0954
HSC-2 GDSC1; GDSC2; CTRP1 6.9972 8.3716 4.7582 0.2945
SCC-9 GDSC1; GDSC2; CTRP1 11.2266 12.5324 8.7876 0.1238
⏷ Show the Full List of 41 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 17 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KU-19-19 GDSC1; GDSC2 3.9727 5.2311 2.8397 1.6
HT-1197 GDSC1; GDSC2 4.7052 6.4194 2.7176 1.228
TCCSUP GDSC1; GDSC2 4.9609 6.7629 2.6997 1.0462
639V GDSC1; GDSC2 5.1131 6.5704 2.8403 0.4325
BFTC-905 GDSC1; GDSC2 5.1441 6.5451 2.8619 0.3571
J82 GDSC1; GDSC2 5.4075 7.4067 2.6464 0.879
RT-112 GDSC1; GDSC2 5.6438 7.0851 2.8578 0.1884
647V GDSC1; GDSC2 5.7992 7.087 2.9114 0.0852
SW780 GDSC1; GDSC2 5.7996 7.0082 2.9376 0.0607
CAL-29 GDSC1; GDSC2 5.9872 7.6292 2.7934 0.209
T24 GDSC1; GDSC2 6.2649 16.4381 -0.975 16.9717
SW1710 GDSC1; GDSC2 6.4009 8.0255 2.8037 0.1144
5637 GDSC1; GDSC2; CTRP1 6.8055 9.5247 4.192 2.5395
RT-4 GDSC1; GDSC2; CTRP1 6.961 8.6879 4.6235 0.6781
KMBC-2 CTRP1 7.2041 10.897 3.8058 6.2815
UM-UC-3 GDSC1; GDSC2; CTRP1 7.6882 9.2007 4.723 0.1565
HT-1376 GDSC1; GDSC2; CTRP1 7.8686 9.4284 4.7091 0.1398
⏷ Show the Full List of 17 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PA-1 GDSC1; GDSC2 3.856 6.0908 2.3534 4.7425
ME-180 GDSC1; GDSC2 4.0732 6.9047 2.1115 5.7327
HEC-1 GDSC1; GDSC2 4.3885 6.5606 2.4815 2.9028
NEC8 GDSC1; GDSC2 4.3912 7.5906 1.9995 5.7192
NT2-D1 GDSC1; GDSC2 4.404 6.0303 2.7277 1.5485
KGN GDSC1; GDSC2 4.4202 7.7135 1.9602 5.8933
OVCA420 GDSC1; GDSC2 4.7579 6.8887 2.5453 1.9946
NCC-IT GDSC2 4.9787 7.0188 2.6035 1.4461
SKG-IIIa GDSC1; GDSC2 5.0034 6.5582 2.7993 0.6309
HeLa GDSC1; GDSC2 5.0074 5.861 3.0501 0.0506
SiHa GDSC1; GDSC2 5.1014 6.1594 2.9822 0.1186
JEG-3 GDSC1; GDSC2 5.2525 7.3213 2.6106 1.1439
DoTc2 4510 GDSC1; GDSC2 5.3438 7.2934 2.6626 0.8683
JAR GDSC1; GDSC2 5.352 7.0079 2.7745 0.4949
SW756 GDSC1; GDSC2 5.4386 7.3371 2.6865 0.7178
CAL-39 GDSC1; GDSC2 5.5455 7.4396 2.6923 0.6322
OMC-1 [Human cervical carcinoma] GDSC1; GDSC2 5.674 7.3802 2.7651 0.368
MS751 GDSC1; GDSC2 5.7561 7.2748 2.8327 0.202
Ca Ski GDSC1; GDSC2 5.7637 8.1583 2.51 1.1058
SW954 GDSC1; GDSC2 5.7739 7.5136 2.7554 0.3511
SW962 GDSC1; GDSC2 5.7879 7.5582 2.7448 0.3703
JHOS-3 GDSC1; GDSC2 5.9041 7.6051 2.7717 0.2718
LB831-BLC GDSC1; GDSC2 5.942 7.6945 2.7543 0.2942
ACC-OV7 GDSC1; GDSC2 5.9589 10.9861 1.4005 6.209
TC-YIK GDSC1; GDSC2 6.0232 7.717 2.7761 0.2292
PWR-1E GDSC1; GDSC2 6.0699 7.8354 2.7519 0.2596
DSH1 GDSC1; GDSC2 6.0841 7.9063 2.7324 0.2925
OV17R GDSC1; GDSC2 6.108 8.0243 2.6997 0.3515
HT-3 GDSC1; GDSC2 6.1131 7.9894 2.7139 0.3201
C-33 A GDSC1; GDSC2 6.116 7.9195 2.7395 0.2693
PEO1 GDSC1; GDSC2 6.1178 8.0855 2.6817 0.3876
BPH-1 GDSC1; GDSC2 6.1366 8.1435 2.6681 0.4111
OVCA433 GDSC1; GDSC2 6.1472 7.8214 2.7845 0.1853
C-4-I GDSC1; GDSC2 6.2232 7.6083 2.8818 0.0631
SKN GDSC1; GDSC2 6.3041 8.4227 2.6319 0.4294
SiSo GDSC1; GDSC2 6.3478 8.3519 2.6733 0.3259
HEY GDSC1; GDSC2 6.4119 8.3698 2.6905 0.2746
OVMIU GDSC1; GDSC2 6.4352 8.8466 2.5295 0.6273
UWB1.289 GDSC1; GDSC2 7.2097 9.6333 2.5412 0.3214
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Lenalidomide (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Midostaurin DMI6E0R Moderate Decreased clearance of Lenalidomide due to the transporter inhibition by Midostaurin. Acute myeloid leukaemia [2A60] [13]
Arn-509 DMT81LZ Moderate Accelerated clearance of Lenalidomide due to the transporter induction by Arn-509. Acute myeloid leukaemia [2A60] [13]
Bedaquiline DM3906J Moderate Increased risk of hepatotoxicity by the combination of Lenalidomide and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [14]
Roflumilast DMPGHY8 Moderate Additive immunosuppressive effects by the combination of Lenalidomide and Roflumilast. Asthma [CA23] [13]
Erdafitinib DMI782S Moderate Decreased clearance of Lenalidomide due to the transporter inhibition by Erdafitinib. Bladder cancer [2C94] [15]
Pexidartinib DMS2J0Z Major Increased risk of hepatotoxicity by the combination of Lenalidomide and Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [16]
Tucatinib DMBESUA Moderate Decreased clearance of Lenalidomide due to the transporter inhibition by Tucatinib. Breast cancer [2C60-2C6Y] [17]
Cannabidiol DM0659E Moderate Increased risk of hepatotoxicity by the combination of Lenalidomide and Cannabidiol. Epileptic encephalopathy [8A62] [13]
GS-5885 DMSL3DX Moderate Decreased clearance of Lenalidomide due to the transporter inhibition by GS-5885. Hepatitis virus infection [1E50-1E51] [18]
Brentuximab vedotin DMWLC57 Moderate Increased risk of hepatotoxicity by the combination of Lenalidomide and Brentuximab vedotin. Hodgkin lymphoma [2B30] [19]
Efavirenz DMC0GSJ Moderate Increased risk of hepatotoxicity by the combination of Lenalidomide and Efavirenz. Human immunodeficiency virus disease [1C60-1C62] [20]
Mipomersen DMGSRN1 Major Increased risk of hepatotoxicity by the combination of Lenalidomide and Mipomersen. Hyper-lipoproteinaemia [5C80] [21]
Teriflunomide DMQ2FKJ Major Increased risk of hepatotoxicity by the combination of Lenalidomide and Teriflunomide. Hyper-lipoproteinaemia [5C80] [22]
Methotrexate DM2TEOL Moderate Increased risk of hepatotoxicity by the combination of Lenalidomide and Methotrexate. Leukaemia [2A60-2B33] [13]
Denosumab DMNI0KO Moderate Additive immunosuppressive effects by the combination of Lenalidomide and Denosumab. Low bone mass disorder [FB83] [23]
Capmatinib DMYCXKL Moderate Decreased clearance of Lenalidomide due to the transporter inhibition by Capmatinib. Lung cancer [2C25] [24]
Calaspargase pegol DMQZBXI Moderate Increased risk of hepatotoxicity by the combination of Lenalidomide and Calaspargase pegol. Malignant haematopoietic neoplasm [2B33] [25]
Idelalisib DM602WT Moderate Increased risk of hepatotoxicity by the combination of Lenalidomide and Idelalisib. Mature B-cell leukaemia [2A82] [26]
Lasmiditan DMXLVDT Moderate Decreased clearance of Lenalidomide due to the transporter inhibition by Lasmiditan. Migraine [8A80] [27]
Siponimod DM2R86O Major Additive immunosuppressive effects by the combination of Lenalidomide and Siponimod. Multiple sclerosis [8A40] [28]
Fingolimod DM5JVAN Major Additive immunosuppressive effects by the combination of Lenalidomide and Fingolimod. Multiple sclerosis [8A40] [29]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Lenalidomide and Ocrelizumab. Multiple sclerosis [8A40] [30]
Ozanimod DMT6AM2 Major Additive immunosuppressive effects by the combination of Lenalidomide and Ozanimod. Multiple sclerosis [8A40] [13]
Nilotinib DM7HXWT Moderate Decreased clearance of Lenalidomide due to the transporter inhibition by Nilotinib. Myeloproliferative neoplasm [2A20] [31]
Omacetaxine mepesuccinate DMPU2WX Moderate Additive immunosuppressive effects by the combination of Lenalidomide and Omacetaxine mepesuccinate. Myeloproliferative neoplasm [2A20] [32]
Enzalutamide DMGL19D Moderate Accelerated clearance of Lenalidomide due to the transporter induction by Enzalutamide. Prostate cancer [2C82] [33]
Canakinumab DM8HLO5 Moderate Additive immunosuppressive effects by the combination of Lenalidomide and Canakinumab. Rheumatoid arthritis [FA20] [34]
Rilonacept DMGLUQS Moderate Additive immunosuppressive effects by the combination of Lenalidomide and Rilonacept. Rheumatoid arthritis [FA20] [34]
Golimumab DMHZV7X Major Additive immunosuppressive effects by the combination of Lenalidomide and Golimumab. Rheumatoid arthritis [FA20] [35]
Leflunomide DMR8ONJ Major Additive immunosuppressive effects by the combination of Lenalidomide and Leflunomide. Rheumatoid arthritis [FA20] [22]
Anthrax vaccine DM9GSWY Moderate Antagonize the effect of Lenalidomide when combined with Anthrax vaccine. Sepsis [1G40-1G41] [36]
Trabectedin DMG3Y89 Moderate Increased risk of hepatotoxicity by the combination of Lenalidomide and Trabectedin. Solid tumour/cancer [2A00-2F9Z] [13]
Naltrexone DMUL45H Moderate Increased risk of hepatotoxicity by the combination of Lenalidomide and Naltrexone. Substance abuse [6C40] [37]
Fostamatinib DM6AUHV Moderate Decreased clearance of Lenalidomide due to the transporter inhibition by Fostamatinib. Thrombocytopenia [3B64] [38]
Azathioprine DMMZSXQ Moderate Additive immunosuppressive effects by the combination of Lenalidomide and Azathioprine. Transplant rejection [NE84] [28]
Ganciclovir DM1MBYQ Moderate Additive myelosuppressive effects by the combination of Lenalidomide and Ganciclovir. Virus infection [1A24-1D9Z] [28]
Valganciclovir DMS2IUH Moderate Additive myelosuppressive effects by the combination of Lenalidomide and Valganciclovir. Virus infection [1A24-1D9Z] [28]
⏷ Show the Full List of 37 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Beta-D-lactose E00099 6134 Diluent; Dry powder inhaler carrier; Lyophilization aid
Carmellose sodium E00625 Not Available Disintegrant
Magnesium stearate E00208 11177 lubricant
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Lenalidomide 10 mg capsule 10 mg Oral Capsule Oral
Lenalidomide 15 mg capsule 15 mg Oral Capsule Oral
Lenalidomide 2.5 mg capsule 2.5 mg Oral Capsule Oral
Lenalidomide 20 mg capsule 20 mg Oral Capsule Oral
Lenalidomide 25 mg capsule 25 mg Oral Capsule Oral
Lenalidomide 5 mg capsule 5 mg Oral Capsule Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Lenalidomide FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7331).
3 Low-dose Lenalidomide for Non-severe COVID-19 Treatment Trial (GETAFE)
4 BDDCS applied to over 900 drugs
5 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
6 Thalidomide and thalidomide analogues for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD007351.
7 DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. (ID: DB00480)
8 Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005 Apr 15;105(8):3286-94. doi: 10.1182/blood-2004-06-2101. Epub 2004 Dec 23.
9 Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nat Struct Mol Biol. 2014 Sep;21(9):803-9. doi: 10.1038/nsmb.2874. Epub 2014 Aug 10.
10 Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity. Chem Res Toxicol. 2019 Apr 15;32(4):589-602. doi: 10.1021/acs.chemrestox.8b00286. Epub 2019 Mar 15.
11 A Dual Color Immunohistochemistry Assay for Measurement of Cereblon in Multiple Myeloma Patient Samples. Appl Immunohistochem Mol Morphol. 2016 Nov/Dec;24(10):695-702. doi: 10.1097/PAI.0000000000000246.
12 Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. Elife. 2018 Aug 1;7:e38430. doi: 10.7554/eLife.38430.
13 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
14 Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
15 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
16 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
17 Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
18 Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
19 Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
20 Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
21 Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
22 Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
23 Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
24 Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
25 Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
26 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
27 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
28 Cerner Multum, Inc. "Australian Product Information.".
29 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
30 Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
31 Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
32 Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
33 Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
34 Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
35 Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
36 CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]
37 Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
38 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.