Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAOGBP)

• Drug Name: 2,4-Diamino-butyric acid(GABA) Drug Info
• Synonyms: 2,4-Diaminobutanoic acid; 2,4-Diaminobutyric acid; 305-62-4; 2,4-Diamino-butyric acid; alpha,gamma-Diaminobutyric acid; 2,4-diamino-butanoic acid; DL-2,4-Diaminobutyric acid; Butanoic acid, 2,4-diamino-; CHEBI:64307; EINECS 206-166-2; Butyric acid, 2,4-diamino-; CHEMBL307931; OGNSCSPNOLGXSM-UHFFFAOYSA-N; Butanoic acid, 2,4-diamino-, (+)-; Butanoic acid, 2,4-diamino-, dihydrochloride; 6970-28-1; 2,4-Diaminobutyrate; 2,4-Diaminobutanoate; NSC41117; 2,4-diamino-butanoate; DL-2,4-Diaminobutanoate; AC1Q28UL; SCHEMBL34705

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 470
  ChEBI ID: CHEBI:64307
  CAS Number: CAS 305-62-4
  TTD Drug ID: DMAOGBP

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA transporter GAT-1 (SLC6A1)	TTPRKM0	SC6A1_HUMAN	Inhibitor	[1]
GABA transporter-3 (SLC6A11)	TT8RXO5	S6A11_HUMAN	Inhibitor	[1]
Gamma-aminobutyric acid receptor (GAR)	TTNJYV2	NOUNIPROTAC	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
GABA transporter GAT-1 (SLC6A1)	DTT	SLC6A1	8.477	4.548	4.194	5.53

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
GABA transporter GAT-1 (SLC6A1)	DTT	SLC6A1	4.99E-02	-0.24	-0.62

References

• [1] Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions. J Med Chem. 1986 Feb;29(2):224-9.