Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMB1IU4)

Drug Name
Lenvatinib Drug Info
Synonyms E 7080; E-7080, E7080; 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxy-quinoline-6-carboxamide
Indication
Disease Entry ICD 11 Status REF
Thyroid cancer 2D10 Approved [1]
Thyroid gland follicular carcinoma Approved [2]
Thyroid gland papillary carcinoma Approved [2]
Hepatocellular carcinoma 2C12.02 Phase 3 [3]
Renal cell carcinoma 2C90 Phase 3 [4]
Melanoma 2C30 Phase 2 [3]
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [4]
Ovarian cancer 2C73 Phase 1 [5]
Non-small-cell lung cancer 2C25.Y Application submitted [4]
Cross-matching ID
PubChem CID
9823820
ChEBI ID
CHEBI:85994
CAS Number
CAS 417716-92-8
TTD Drug ID
DMB1IU4
VARIDT Drug ID
DR00265

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Approved [6]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
P-glycoprotein 1 (ABCB1) DTP P-GP 7.009 6.988 7.442 8.135
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Thyroid cancer
ICD Disease Classification 2D10
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Vascular endothelial growth factor receptor 2 (KDR) DTT KDR 1.98E-01 0.11 0.2
P-glycoprotein 1 (ABCB1) DTP P-GP 9.39E-02 1.07E-01 2.80E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 FDA Approved Drug Products from FDA Official Website. 2018. Application Number: (ANDA) 208627.
2 Lenvatinib FDA Label
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Emerging drugs for ovarian cancer. Expert Opin Emerg Drugs. 2008 Sep;13(3):523-36.
6 Influence of CYP3A4/5 and ABC transporter polymorphisms on lenvatinib plasma trough concentrations in Japanese patients with thyroid cancer. Sci Rep. 2019 Apr 1;9(1):5404.