Details of the Drug

General Information of Drug (ID: DMB1IU4)

Drug Name
Lenvatinib
Synonyms E 7080; E-7080, E7080; 4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxy-quinoline-6-carboxamide
Indication
Disease Entry ICD 11 Status REF
Thyroid cancer 2D10 Approved [1]
Thyroid gland follicular carcinoma N.A. Approved [2]
Thyroid gland papillary carcinoma N.A. Approved [2]
Hepatocellular carcinoma 2C12.02 Phase 3 [3]
Renal cell carcinoma 2C90 Phase 3 [4]
Melanoma 2C30 Phase 2 [3]
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [4]
Ovarian cancer 2C73 Phase 1 [5]
Non-small-cell lung cancer 2C25.Y Application submitted [4]
⏷ Show the Full List of Indication(s)
ATC Code
L01EX08: Lenvatinib
L01EX: Other protein kinase inhibitors
L01E: PROTEIN KINASE INHIBITORS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 426.9
Logarithm of the Partition Coefficient (xlogp) 2.8
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 5
ADMET Property
Half-life
The concentration or amount of drug in body reduced by one-half in 28 hours [6]
Metabolism
The drug is metabolized via the CYP3A and aldehyde oxidase []
Chemical Identifiers
Formula
C21H19ClN4O4
IUPAC Name
4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide
Canonical SMILES
COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl
InChI
InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)
InChIKey
WOSKHXYHFSIKNG-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
9823820
ChEBI ID
CHEBI:85994
CAS Number
417716-92-8
UNII
EE083865G2
DrugBank ID
DB09078
TTD ID
D0R0FO
VARIDT ID
DR00265
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Vascular endothelial growth factor receptor 2 (KDR) TTUTJGQ VGFR2_HUMAN Inhibitor [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [7]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Thyroid cancer
ICD Disease Classification 2D10
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Vascular endothelial growth factor receptor 2 (KDR) DTT KDR 1.98E-01 0.11 0.2
P-glycoprotein 1 (ABCB1) DTP P-GP 9.39E-02 1.07E-01 2.80E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 147 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 0.8727 6.7322 0.1985 36.4034
MEC1 CTRP2 5.3821 7.6658 4.6321 7.3518
JM1 CTRP2 5.7317 11.7455 2.9292 13.6259
EoL-1 CTRP2 -10.1842 -8.1219 -10.1842 98.4904
Kasumi-1 CTRP2 -3.4093 2.1359 -3.5257 61.6102
MOLM-13 CTRP2 -0.5308 3.0075 -0.5842 43.9275
MV4-11 CTRP2 0.6055 5.3111 0.2918 37.1554
OPM-2 CTRP2 1.109 3.2154 1.0979 32.9173
Ku812 CTRP2 1.2028 4.1855 1.1281 32.5026
NCO2 CTRP2 1.2709 5.8716 0.8811 33.0557
KMS-11 CTRP2 1.413 8.9927 -0.0367 35.0807
JURL-MK1 CTRP2 1.8016 3.4992 1.7953 28.2871
EM-2 CTRP2 1.8244 4.1975 1.7819 28.2568
GA-10 CTRP2 2.0036 5.811 1.696 27.9697
MOLM-6 CTRP2 2.1158 5.1228 1.9689 26.6725
KYO-1 CTRP2 2.247 3.2039 2.2468 25.2995
CML-T1 CTRP2 2.2726 4.7937 2.1899 25.4082
Pfeiffer CTRP2 2.3261 7.2271 1.6116 27.248
KMS-34 CTRP2 2.331 4.8473 2.2448 25.0312
NU-DUL-1 CTRP2 2.3456 12.2421 -1.5191 28.5382
697 CTRP2 2.5392 6.5336 2.0751 24.9747
EB1 CTRP2 2.5822 6.9707 1.9779 25.1892
KMS-18 CTRP2 2.7098 11.3765 0.2647 30.2755
BV-173 CTRP2 2.885 4.8912 2.8294 21.2362
KMS-21-BM CTRP2 2.897 6.9667 2.3198 23.02
KMS-26 CTRP2 3.0026 5.8202 2.7832 21.0264
SEM CTRP2 3.2852 6.2061 2.9875 19.4285
Daudi CTRP2 3.4858 5.8735 3.2968 17.7026
WSU-DLCL2 CTRP2 3.7039 6.529 3.343 16.8785
NALM-6 CTRP2 3.7736 6.2178 3.5168 16.0329
CA46 CTRP2 3.8401 11.7443 1.1991 24.3902
HuT 78 CTRP2 3.8923 15.4221 -0.5399 29.2382
KMS-28BM CTRP2 3.9823 7.5304 3.2665 16.381
Mono-Mac-1 CTRP2 4.1828 8.7677 2.9337 17.1513
REC-1 CTRP2 4.2199 7.5092 3.5245 14.7365
L-540 CTRP2 4.2661 6.5709 3.9381 13.025
K-562 CTRP2 4.3078 6.5778 3.9807 12.7449
A4/Fukuda CTRP2 4.3182 8.6565 3.1204 16.0706
Hs 611.T CTRP2 4.383 11.428 1.8678 20.7197
MOLT-16 CTRP2 4.4248 6.0702 4.2698 11.3331
Kasumi-2 CTRP2 4.4629 7.744 3.6762 13.4964
DEL CTRP2 4.5077 5.1671 4.5041 10.2495
KMS-20 CTRP2 4.5337 8.5498 3.3846 14.4764
RS4;11 CTRP2 4.5533 7.0033 4.0827 11.6657
RCH-ACV CTRP2 4.5633 8.588 3.3963 14.3562
KE-37 CTRP2 4.6041 6.0461 4.4722 10.0569
SUP-T11 CTRP2 4.6075 7.3355 4.0019 11.8337
MHH-CALL-3 CTRP2 4.6188 7.3693 3.9992 11.8141
KE-97 CTRP2 4.6377 6.4886 4.3685 10.3396
Namalwa CTRP2 4.6438 11.523 2.0653 19.3722
ST486 CTRP2 4.6486 9.612 2.9963 15.7516
MOLT-3 CTRP2 4.7604 8.3211 3.7155 12.5841
KMS-12-BM CTRP2 4.8103 8.13 3.8536 11.9038
P12-Ichikawa CTRP2 4.8446 6.475 4.5966 8.8881
OCI-Ly3 CTRP2 4.8461 8.6628 3.6391 12.6844
NU-DHL-1 CTRP2 4.957 6.5997 4.6704 8.2899
F-36P CTRP2 5.0006 7.4017 4.377 9.3234
Granta-519 CTRP2 5.0207 10.5832 2.8741 15.376
JJN-3 CTRP2 5.0694 7.7717 4.2767 9.5543
SUP-HD1 CTRP2 5.0773 11.9454 2.2537 17.6723
SET-2 CTRP2 5.1158 7.4018 4.4933 8.5658
U-937 CTRP2 5.1498 6.759 4.8103 7.2208
SUP-M2 CTRP2 5.1617 6.3457 4.9848 6.518
Ri-1 CTRP2 5.2091 11.3561 2.6639 15.7912
DB CTRP2 5.2916 10.7046 3.0606 14.0247
KMS-27 CTRP2 5.3447 7.9693 4.4509 8.1834
TALL-1 [Human adult T-ALL] CTRP2 5.44 9.2507 3.9133 10.194
Toledo CTRP2 5.4776 9.9348 3.6088 11.376
OCI-AML-3 CTRP2 5.4893 6.5151 5.2673 4.5247
THP-1 CTRP2 5.5076 6.7495 5.1837 4.8074
MOLP-8 CTRP2 5.5096 13.4668 1.8786 18.1312
SUP-B15 CTRP2 5.5312 8.8708 4.1836 8.8714
OCI-Ly19 CTRP2 5.5641 8.7699 4.2632 8.4681
BL-70 CTRP2 5.5746 6.053 5.5293 3.2885
OCI-AML-5 CTRP2 5.5941 16.191 0.5912 22.2735
HPB-ALL CTRP2 5.6894 8.0668 4.724 6.2758
U266B1 CTRP2 5.6916 9.7884 3.8708 9.8361
SK-MM-2 CTRP2 5.6942 7.4706 5.0218 5.0256
SIG-M5 CTRP2 5.7037 6.136 5.644 2.4835
Mono-Mac-6 CTRP2 5.8033 14.0971 1.8154 17.7491
KO52 CTRP2 5.8073 8.0326 4.8464 5.5125
A3/Kawakami CTRP2 5.8097 6.6077 5.5493 2.583
Karpas-620 CTRP2 5.887 7.4527 5.2051 3.844
KM-H2 CTRP2 5.9695 13.6286 2.1897 16.0302
HD-MY-Z CTRP2 5.9795 8.0617 4.9812 4.5961
OCI-M1 CTRP2 5.9994 6.7994 5.6288 1.8359
L-428 CTRP2 6.003 9.2464 4.4087 6.9553
HL-60 CTRP2 6.0242 6.8288 5.6353 1.759
JeKo-1 CTRP2 6.0914 10.8288 3.6912 9.7877
BL-41 CTRP2 6.1291 16.2936 0.9902 19.9241
EJM CTRP2 6.2405 14.8367 1.8106 16.8921
TF-1 CTRP2 6.279 7.732 5.3872 2.3413
MOLP-2 CTRP2 6.5124 8.7974 5.0358 3.4171
L-363 CTRP2 6.5172 8.8339 5.0213 3.4692
OCI-AML-2 CTRP2 6.5329 8.1295 5.3755 1.9966
Peer CTRP2 6.5555 13.2686 2.8489 12.3513
Ci-1 CTRP2 6.619 7.624 5.6665 0.7634
OCI-Ly10 CTRP2 6.652 11.7732 3.6693 8.8514
MC116 CTRP2 6.7377 7.9069 5.6078 0.8523
SR CTRP2 6.8783 9.3472 5.0256 2.915
LAMA-84 CTRP2 6.9354 12.8674 3.344 9.6933
LP-1 CTRP2 7.0419 19.2931 0.2319 20.5268
AML-193 CTRP2 7.1123 9.9177 4.909 3.0619
MOTN-1 CTRP2 7.1585 13.1164 3.3884 9.142
Reh CTRP2 7.1841 9.6065 5.0998 2.235
SKM-1 CTRP2 7.3099 8.8145 5.5178 0.6675
SU-DHL-10 CTRP2 7.3356 8.3204 5.7213 0.1629
MOLM-16 CTRP2 7.3654 9.0324 5.4548 0.8164
P31/FUJ CTRP2 7.4358 10.8651 4.6715 3.5727
HEL CTRP2 7.4539 8.9648 5.5248 0.5549
NB4 CTRP2 7.4928 8.5449 5.701 0.1513
JVM-3 CTRP2 7.4993 15.6594 2.389 12.4831
SU-DHL-1 CTRP2 7.5117 8.9001 5.5762 0.3938
Karpas-422 CTRP2 7.5367 13.4507 3.4992 8.0998
SU-DHL-8 CTRP2 7.5399 13.264 3.5922 7.7234
SU-DHL-4 CTRP2 7.5412 12.1212 4.1447 5.5111
Raji CTRP2 7.5444 8.7976 5.6289 0.2645
Jurkat CTRP2 7.5534 9.4588 5.3704 0.9342
HEL 92.1.7 CTRP2 7.6102 11.6453 4.4166 4.3429
SU-DHL-6 CTRP2 7.6192 12.2199 4.1499 5.3821
DND-41 CTRP2 7.6193 15.086 2.7595 10.8776
SUP-T1 CTRP2 7.6291 15.5296 2.549 11.6664
CMK CTRP2 7.7303 8.8525 5.6811 0.1231
AMO1 CTRP2 7.7637 9.0519 5.6226 0.2027
RPMI-8226 CTRP2 7.8166 11.6474 4.546 3.5866
RL CTRP2 7.8201 11.681 4.5326 3.6334
P3HR-1 CTRP2 7.8363 9.4399 5.5078 0.4005
Karpas-299 CTRP2 7.864 9.4774 5.5052 0.3943
KHM-1B CTRP2 7.8695 9.701 5.4212 0.5895
NOMO-1 CTRP2 7.8801 9.11 5.6459 0.1378
KCL-22 CTRP2 7.9168 10.0173 5.3166 0.8403
MM1.S CTRP2 7.9177 14.4023 3.3049 8.2981
NCI-H929 CTRP2 7.9342 13.6898 3.6588 6.8856
MHH-CALL-4 CTRP2 8.0642 12.4634 4.3213 4.1441
ME1 CTRP2 8.0957 9.6632 5.5301 0.2607
HT CTRP2 8.1678 13.2673 4.012 5.1991
M-07e CTRP2 8.2396 16.9542 2.293 11.6593
EHEB CTRP2 8.2849 13.884 3.7975 5.8749
Ki-JK CTRP2 8.3009 10.2273 5.4039 0.4292
RPMI-8402 CTRP2 8.3166 14.6989 3.4328 7.2382
HDLM-2 CTRP2 8.4433 10.712 5.2793 0.6428
PF-382 CTRP2 8.4844 10.397 5.415 0.3413
MOLT-13 CTRP2 8.509 10.0641 5.5431 0.1427
KMM-1 CTRP2 8.5413 11.1271 5.1602 0.8873
PL21 CTRP2 8.5688 10.2631 5.4954 0.1909
GDM-1 CTRP2 8.787 16.7738 2.7572 9.1512
RPMI-6666 CTRP2 9.0223 18.7858 1.9522 11.7196
⏷ Show the Full List of 147 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 3.7153 7.4279 3.0258 18.0401
TE15 CTRP2 5.7005 9.9345 3.8058 10.0886
TE-5 CTRP2 5.3546 10.0613 3.4356 12.3563
OE21 CTRP2 5.7055 8.2126 4.6664 6.4815
EC-GI-10 CTRP2 5.8965 7.3917 5.2439 3.6616
TE-4 CTRP2 5.9056 9.264 4.3175 7.5306
TE-6 CTRP2 5.9274 8.6343 4.6507 6.0877
KYSE-150 CTRP2 6.1249 7.0502 5.6069 1.6892
KYSE-410 CTRP2 6.1967 7.867 5.2567 3.0283
KYSE-140 CTRP2 6.31 12.9159 2.8274 12.894
TE-14 CTRP2 6.3852 9.5918 4.5461 5.6698
KYSE-30 CTRP2 7.2214 9.3683 5.2306 1.7071
COLO 680N CTRP2 7.5504 10.7209 4.8102 2.9
OE19 CTRP2 7.7046 10.0804 5.1843 1.405
KYSE-520 CTRP2 7.8946 11.7573 4.543 3.5061
KYSE-510 CTRP2 7.9105 10.6571 5.0449 1.6881
KYSE-450 CTRP2 8.0991 9.4119 5.6207 0.1257
KYSE-180 CTRP2 8.2776 11.2519 4.982 1.5846
TE-9 CTRP2 8.3634 9.7429 5.6015 0.1028
KYSE-70 CTRP2 8.3712 13.1597 4.1881 4.2855
TE-11 CTRP2 8.4762 18.5959 1.6618 13.5371
OE33 CTRP2 8.6494 10.016 5.6086 0.0624
TE-1 CTRP2 8.7129 10.477 5.4736 0.1893
TE-10 CTRP2 8.8373 10.6452 5.4604 0.1809
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 7.9797 10.1246 5.3027 0.8392
SNU-410 CTRP2 5.7732 8.3852 4.6409 6.4445
KP-4 CTRP2 5.9443 9.1375 4.4137 7.0498
SU.86.86 CTRP2 5.9842 6.7938 5.6184 1.9101
MIA PaCa-2 CTRP2 6.046 7.3974 5.3692 2.835
PANC-1 CTRP2 6.1735 7.6045 5.3692 2.5987
PSN1 CTRP2 6.1797 7.3533 5.4991 2.044
SW1990 CTRP2 6.2711 9.0815 4.7104 5.1846
Capan-1 CTRP2 6.4975 8.0563 5.3864 2.0039
Panc 08.13 CTRP2 6.5152 8.7481 5.062 3.3049
Panc 03.27 CTRP2 6.6117 11.455 3.7961 8.398
PaTu 8988s CTRP2 6.6807 8.4528 5.3203 2.0124
BxPC-3 CTRP2 6.8401 12.3168 3.5442 9.0408
KP-3 CTRP2 7.2601 13.591 3.2301 9.6112
PaTu 8902 CTRP2 7.276 8.5277 5.6177 0.4134
Panc 04.03 CTRP2 7.2938 9.8123 5.0718 2.2133
HuP-T3 CTRP2 7.5185 10.2997 4.9835 2.2903
Capan-2 CTRP2 7.5923 9.6101 5.3264 1.0404
AsPC-1 CTRP2 7.5958 10.9719 4.7222 3.18
TCC-Pan2 CTRP2 7.7051 9.1309 5.57 0.3222
PK-45H CTRP2 7.7377 9.7353 5.3462 0.8744
SUIT-2 CTRP2 7.8388 9.7586 5.3845 0.7024
HuP-T4 CTRP2 7.8834 11.7419 4.5432 3.5183
SNU-213 CTRP2 7.8858 9.3834 5.5495 0.2948
Panc 05.04 CTRP2 7.9618 9.4817 5.5436 0.2796
YAPC CTRP2 8.0677 9.3133 5.6435 0.1049
HPAC CTRP2 8.1226 9.5833 5.5691 0.1903
KP-2 CTRP2 8.1273 10.0022 5.4166 0.4746
L3.3 CTRP2 8.1399 9.1653 5.7183 0.0347
Hs 766T CTRP2 8.1644 9.7412 5.5285 0.243
PaTu 8988t CTRP2 8.1759 9.5296 5.6078 0.127
HPAF-II CTRP2 8.3521 9.9191 5.5361 0.1833
Panc 02.03 CTRP2 8.3575 11.2279 5.0321 1.3682
PK-59 CTRP2 8.3666 10.3331 5.3912 0.4294
CFPAC-1 CTRP2 8.3938 9.8023 5.5919 0.1079
QGP-1 CTRP2 9.4496 19.6067 1.8482 11.479
DAN-G CTRP2 10.9291 29.6537 -1.9787 20.1336
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 11.7607 28.7922 -0.9906 16.7422
Hs 940.T CTRP2 5.9445 8.9658 4.4996 6.6885
WM88 CTRP2 5.99 8.3608 4.8406 5.166
Hs 294T CTRP2 6.1322 6.9945 5.6404 1.5361
RPMI-7951 CTRP2 6.345 9.3294 4.6452 5.3259
Hs 944.T CTRP2 6.3555 8.0645 5.2804 2.6586
WM115 CTRP2 6.3786 9.33 4.6711 5.1585
MeWo CTRP2 6.3855 7.8723 5.3968 2.1302
WM266-4 CTRP2 6.4468 9.5336 4.6228 5.2425
HT-144 CTRP2 6.5554 9.8757 4.5362 5.4186
SK-MEL-24 CTRP2 6.593 8.744 5.12 2.9459
IGR-1 CTRP2 6.6597 14.6662 2.235 14.5325
UACC-62 CTRP2 6.685 9.4273 4.8525 3.9003
WM983B CTRP2 6.7057 9.2696 4.9441 3.4938
WT2-iPS CTRP2 6.8319 9.8986 4.7276 4.187
RVH-421 CTRP2 6.8442 10.968 4.2132 6.2815
Hs 895.T CTRP2 6.9554 13.6279 2.9825 11.1088
COLO 829 CTRP2 7.0014 9.4002 5.0812 2.531
Hs 934.T CTRP2 7.047 13.5606 3.0857 10.5417
SK-MEL-28 CTRP2 7.2463 7.9671 5.8128 0.0553
CJM [Human melanoma] CTRP2 7.4658 8.7493 5.6144 0.3272
Mel JuSo CTRP2 7.4814 9.3263 5.3898 0.9287
SK-MEL-2 CTRP2 7.5678 8.553 5.7262 0.0983
A2058 CTRP2 7.5901 8.7125 5.6781 0.1612
SK-MEL-5 CTRP2 7.6326 9.0918 5.5544 0.3874
Mel Ho CTRP2 7.6558 8.927 5.6258 0.2308
Hs 688(A).T CTRP2 7.6849 13.1955 3.7265 6.9731
SK-MEL-3 CTRP2 7.6966 8.8415 5.6724 0.1427
HMCB CTRP2 7.7163 12.699 3.9862 5.8972
COLO 792 CTRP2 7.7549 10.8521 4.8721 2.4432
IPC-298 CTRP2 7.8006 8.989 5.6591 0.1375
SK-MEL-1 CTRP2 7.8365 9.0809 5.64 0.1561
UACC-257 CTRP2 7.9667 12.9772 4.0193 5.4294
K029AX CTRP2 7.9731 9.4563 5.5574 0.2512
MDA-MB-435S CTRP2 7.9733 9.2028 5.6477 0.1168
Hs 936.T CTRP2 8.0654 9.0924 5.7173 0.041
G-361 CTRP2 8.0706 12.215 4.4396 3.6908
Hs 852.T CTRP2 8.0901 11.1554 4.9251 1.9296
SK-MEL-30 CTRP2 8.0971 9.3298 5.6483 0.0951
IGR-39 CTRP2 8.161 9.5248 5.604 0.1345
LOX-IMVI CTRP2 8.1914 9.6274 5.5792 0.1601
COLO 800 CTRP2 8.2741 9.9525 5.4945 0.2676
A101D CTRP2 8.2846 9.6594 5.602 0.1146
A-375 CTRP2 8.3189 9.9237 5.5221 0.2114
SK-MEL-31 CTRP2 8.3622 9.6922 5.6183 0.0867
WM1799 CTRP2 8.4253 9.7606 5.6171 0.0797
WM793 CTRP2 8.4684 9.8415 5.6048 0.0852
Hs 839.T CTRP2 8.9922 23.0887 -0.1633 18.3997
COLO 741 CTRP2 9.4836 21.3618 1.0279 14.1324
IGR-37 CTRP2 10.6914 25.0227 0.0929 15.2577
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IMR-32 CTRP2 3.3665 7.9821 2.4338 21.2502
MHH-NB-11 CTRP2 4.5883 6.2484 4.3952 10.3849
CHP-126 CTRP2 5.5623 6.7255 5.2498 4.404
NH-6 CTRP2 5.926 8.5557 4.6887 5.9309
SK-N-DZ CTRP2 6.0749 14.7838 1.7001 17.6147
SK-N-AS CTRP2 6.0998 7.7901 5.2173 3.371
SK-N-BE(2) CTRP2 6.1114 9.8253 4.2095 7.5828
CHP-212 CTRP2 6.2673 7.6033 5.442 2.133
KP-N-SI9s CTRP2 7.2001 9.308 5.2454 1.6758
Kelly CTRP2 7.288 8.7424 5.5369 0.6268
KP-N-YN CTRP2 7.3499 12.9404 3.6146 7.9244
SK-N-SH CTRP2 7.7879 12.7446 4.0122 5.696
SK-N-FI CTRP2 8.0544 23.573 -1.1063 22.3467
NB1 CTRP2 8.3126 9.7915 5.5664 0.1516
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 CTRP2 6.0168 8.332 4.8775 4.9585
SNU-245 CTRP2 6.6587 8.9482 5.0671 3.0628
SNU-869 CTRP2 7.194 16.1048 1.9372 14.671
SNU-308 CTRP2 8.0792 9.5338 5.5704 0.1994
SNU-1079 CTRP2 8.0892 17.0195 2.1536 12.4005
HuH-28 CTRP2 8.1323 9.7516 5.5122 0.2806
SNU-478 CTRP2 8.4052 9.9178 5.5561 0.1463
SNU-1196 CTRP2 8.4739 9.8028 5.6197 0.0719
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CAL-78 CTRP2 2.3185 4.9722 2.2128 25.1815
G-292 clone A141B1 CTRP2 3.1926 10.4549 1.1701 26.2018
SK-ES-1 CTRP2 5.2495 7.2781 4.6838 7.4645
Hs 888.T CTRP2 5.863 16.7692 0.5301 21.9047
SaOS-2 CTRP2 5.9691 8.007 4.9997 4.5386
SJSA-1 CTRP2 6.0518 9.916 4.1148 8.0944
A-673 CTRP2 6.4118 9.4095 4.6574 5.1583
U2OS CTRP2 6.5616 18.2026 0.3907 20.9501
Hs 822.T CTRP2 6.7781 13.6622 2.8284 12.03
HOS CTRP2 6.8225 11.0558 4.1539 6.5616
SK-N-MC CTRP2 6.9954 8.9647 5.2801 1.7747
TC71 CTRP2 8.0314 15.0226 3.084 8.99
MG-63 CTRP2 8.7087 19.6746 1.3019 14.3929
MHH-ES-1 CTRP2 9.0657 20.6747 1.0686 14.6127
SW1353 CTRP2 11.5324 26.2618 0.0619 14.2661
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 71 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-157 CTRP2 1.4082 5.1651 1.1949 31.5933
Hs 578T CTRP2 2.5616 10.7651 0.3943 30.346
MDA-MB-453 CTRP2 5.3593 9.5347 3.6999 11.2553
ZR-75-30 CTRP2 5.823 8.2451 4.7545 5.8648
HDQ-P1 CTRP2 5.8359 7.7509 5.0117 4.7605
DU4475 CTRP2 6.1149 7.2551 5.4967 2.1696
HCC1500 CTRP2 6.2904 13.8676 2.3359 14.8462
HCC1419 CTRP2 6.3004 8.1522 5.1955 3.1034
BT-20 CTRP2 6.4899 8.2219 5.3008 2.3632
CAL-85-1 CTRP2 6.5523 11.3464 3.8039 8.4699
HCC1428 CTRP2 6.625 9.9067 4.5732 5.1493
MDA-MB-361 CTRP2 6.6398 8.162 5.4312 1.6294
CAL-120 CTRP2 6.6585 9.8514 4.6253 4.879
Hs 578Bst CTRP2 6.7135 8.5353 5.3027 2.038
CAL-148 CTRP2 7.0124 8.9079 5.3163 1.6199
T-47D CTRP2 7.0202 10.635 4.5027 4.8209
KPL-1 CTRP2 7.1845 7.931 5.803 0.0776
HCC38 CTRP2 7.3286 11.5274 4.2852 5.2499
HCC2218 CTRP2 7.3556 12.7647 3.7044 7.5537
CAL-51 CTRP2 7.5666 12.3466 4.0539 5.8374
EFM-192A CTRP2 7.671 13.1321 3.7474 6.9098
HMC-1-8 CTRP2 7.7343 8.8957 5.6673 0.1411
HCC202 CTRP2 7.796 10.6583 4.9819 2.0099
ZR-75-1 CTRP2 7.8205 9.0578 5.6422 0.1568
BT-549 CTRP2 7.8241 9.7595 5.3773 0.7306
MDA-MB-468 CTRP2 7.8551 14.3839 3.2703 8.5261
BT-474 CTRP2 7.9578 9.9424 5.3656 0.6832
CAMA-1 CTRP2 7.9913 9.7426 5.458 0.4427
JIMT-1 CTRP2 8.1484 9.7563 5.5168 0.2676
MCF-7 CTRP2 8.2071 10.3643 5.3111 0.6855
HCC1806 CTRP2 8.2811 9.5956 5.6226 0.0937
MDA-MB-231 CTRP2 8.3255 10.5524 5.2899 0.6762
HCC1954 CTRP2 8.443 10.292 5.4371 0.3151
HCC1395 CTRP2 8.5742 12.8133 4.4632 3.0655
HCC1143 CTRP2 8.713 11.4296 5.118 0.9004
HCC1937 CTRP2 8.7282 10.6814 5.4068 0.2824
SK-BR-3 CTRP2 8.7664 10.6679 5.4261 0.243
BT 440 CTRP2 0.4132 5.1021 0.1282 38.3226
BT 482 CTRP2 4.2871 8.8821 2.9858 16.6813
BT 416 CTRP2 5.1403 7.3389 4.5465 8.2905
BT 428 CTRP2 5.8243 9.5304 4.1147 8.5445
BT 172 CTRP2 6.0969 9.4777 4.3713 6.9313
BT 179 CTRP2 6.3219 7.613 5.4776 1.8973
BT 245 CTRP2 6.3304 7.8945 5.3456 2.4294
BT147 CTRP2 6.3885 11.3345 3.6803 9.2763
BT 145 CTRP2 6.4473 8.3138 5.2254 2.7385
BT 271 CTRP2 6.4905 9.3758 4.7343 4.7035
BT 328 CTRP2 6.946 9.9073 4.8029 3.7136
BT 231 CTRP2 6.9659 16.8872 1.3705 17.0679
BT 228 CTRP2 6.973 14.4975 2.5646 12.7135
BT 248 CTRP2 6.9928 9.8441 4.865 3.398
BT 333 CTRP2 7.1795 10.9874 4.443 4.8291
BT 131 CTRP2 7.2219 8.606 5.561 0.6018
BT 286 CTRP2 7.315 12.7093 3.7024 7.6246
BT 232 CTRP2 7.3375 10.6812 4.6948 3.6083
BT 320 CTRP2 7.4018 8.4102 5.7145 0.1548
BT 444 CTRP2 7.5926 12.6828 3.9101 6.3746
BT 216 CTRP2 7.6329 13.937 3.3308 8.6225
BT 330 CTRP2 7.8681 14.4417 3.2514 8.5808
BT 359 CTRP2 7.9726 9.3616 5.5914 0.1949
BT 112 CTRP2 7.9943 12.4842 4.2681 4.4318
BT 340 CTRP2 8.0149 12.3439 4.3461 4.1091
BT 239 CTRP2 8.0187 9.149 5.6823 0.073
BT 224 CTRP2 8.3717 12.5157 4.4808 3.2094
BT 498 CTRP2 8.5549 22.5216 -0.207 19.203
BT 504 CTRP2 8.7492 16.5239 2.8512 8.8539
BT164 CTRP2 9.0707 17.2237 2.731 8.8641
BT 139 CTRP2 9.2337 21.7315 0.6737 15.598
BT 159 CTRP2 9.591 18.6077 2.4154 9.3175
BT 422 CTRP2 10.5083 25.2495 -0.1407 16.153
BT 187 CTRP2 13.2399 27.3677 0.615 10.7718
⏷ Show the Full List of 71 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 8.0233 8.9463 5.7513 0.0251
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF539 CTRP2 2.3888 7.1733 1.6982 26.7576
A-172 CTRP2 4.592 13.5277 1.0327 23.0982
SNU-738 CTRP2 4.8467 9.1991 3.384 13.7187
D283 Med CTRP2 4.9908 11.9746 2.1612 18.2163
SNU-626 CTRP2 5.2843 9.3028 3.7452 11.2338
KNS-60 CTRP2 5.5654 10.3773 3.4669 11.7762
42-MG-BA CTRP2 5.7891 17.3154 0.1948 23.0474
GaMG CTRP2 5.7911 13.348 2.1794 16.43
SF126 CTRP2 5.9132 12.163 2.8751 13.4757
SF268 CTRP2 6.0193 10.3049 3.8932 9.085
SW1783 CTRP2 6.079 14.7897 1.7005 17.6048
SNU-489 CTRP2 6.1263 10.8279 3.7205 9.5988
YKG-1 CTRP2 6.139 6.8949 5.6952 1.2949
GB-1 CTRP2 6.2389 12.5897 2.9324 12.6106
KG-1-C CTRP2 6.3657 7.7394 5.4475 1.9527
Daoy CTRP2 6.4084 8.6923 5.0102 3.6934
U-118MG CTRP2 6.5901 15.402 1.8122 16.217
CAS-1 CTRP2 6.6499 8.8881 5.0901 2.9823
KALS-1 CTRP2 6.714 8.6625 5.2425 2.2761
Hs 683 CTRP2 6.7338 11.1776 4.0273 7.2319
SNU-201 CTRP2 6.8487 16.8012 1.3207 17.4511
KNS-81 CTRP2 6.9224 13.1327 3.2027 10.2854
NMC-G1 CTRP2 7.008 8.6156 5.4453 1.1572
SNB-75 CTRP2 7.0607 9.1259 5.2457 1.8287
KNS-42 CTRP2 7.3393 12.8804 3.6363 7.8536
SNU-466 CTRP2 7.3924 8.6581 5.618 0.3529
GMS-10 CTRP2 7.5361 8.9359 5.5729 0.3898
LN-18 CTRP2 7.5721 8.4968 5.7471 0.0734
TM-31 CTRP2 7.5876 10.2426 5.0491 1.98
SW1088 CTRP2 7.6826 14.6992 2.9947 9.8662
YH-13 CTRP2 7.8496 15.7428 2.605 11.1022
Becker CTRP2 7.9595 12.8815 4.0598 5.2811
8-MG-BA CTRP2 7.9792 9.4747 5.5531 0.2568
U-251MG CTRP2 8.0892 12.3809 4.3746 3.9131
LN-229 CTRP2 8.1192 9.725 5.5167 0.2768
U-87MG ATCC CTRP2 8.1336 9.3882 5.6413 0.0968
SF295 CTRP2 8.2505 9.8154 5.5348 0.2096
ONS-76 CTRP2 8.3556 10.2603 5.4139 0.3881
DBTRG-05MG CTRP2 8.5067 9.873 5.6075 0.0782
CCF-STTG1 CTRP2 8.6937 18.1413 2.0363 11.9014
GOS-3 CTRP2 8.7406 14.3558 3.8628 5.0699
T98G CTRP2 9.0231 22.328 0.2319 17.2315
SNU-1105 CTRP2 9.7351 18.5451 2.5369 8.7056
M059K CTRP2 10.7295 21.1837 1.9317 9.5599
DK-MG CTRP2 11.5648 25.0276 0.6645 12.5079
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-2 CTRP2 0.3856 4.3863 0.2297 38.1592
AN3-CA CTRP2 2.5193 13.5651 -0.9451 33.7275
KLE CTRP2 5.3654 7.5713 4.6611 7.2731
ESS-1 CTRP2 5.58 8.9512 4.1879 8.7478
JHUEM-1 CTRP2 5.666 6.4183 5.492 3.1736
HEC-151 CTRP2 5.9183 7.1555 5.3805 3.044
JHUEM-3 CTRP2 6.1933 8.3472 5.0147 4.0493
HEC-1-A CTRP2 6.3076 8.2207 5.167 3.21
EFE-184 CTRP2 6.5044 8.8168 5.0204 3.4935
MFE-319 CTRP2 6.5815 7.9006 5.5166 1.3707
JHUEM-7 CTRP2 6.9881 11.1396 4.234 5.9674
MFE-296 CTRP2 7.329 12.1487 3.9852 6.4593
EN CTRP2 7.361 10.1945 4.9369 2.6434
RL95-2 CTRP2 7.5451 9.3049 5.43 0.7623
HEC-59 CTRP2 7.7726 9.0969 5.6098 0.222
HEC-265 CTRP2 7.7918 8.993 5.6544 0.146
HEC-108 CTRP2 7.8208 9.0719 5.6373 0.164
HEC-1-B CTRP2 7.9715 9.8594 5.4044 0.5775
HEC-251 CTRP2 8.0599 9.4834 5.5811 0.1881
HEC-6 CTRP2 8.3117 9.7574 5.5779 0.1375
HEC-50B CTRP2 8.7848 10.2011 5.593 0.0607
Ishikawa (Heraklio) 02 ER- CTRP2 7.4928 8.3549 5.7676 0.0644
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 19 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KMRC-2 CTRP2 4.5159 9.8645 2.7479 17.0556
UO-31 CTRP2 4.8384 8.6557 3.6351 12.7192
CAL-54 CTRP2 5.1385 9.3759 3.5743 12.2659
TUHR4TKB CTRP2 5.9266 7.2378 5.3469 3.1673
TUHR14TKB CTRP2 6.6829 21.9329 -1.3742 25.3595
Caki-1 CTRP2 6.7036 11.8498 3.6711 8.7544
RCC10RGB CTRP2 7.3628 12.1712 3.998 6.3574
BFTC-909 CTRP2 7.4018 9.3706 5.3299 1.1863
KMRC-1 CTRP2 7.5986 12.08 4.2029 5.2005
Caki-2 CTRP2 7.6891 9.907 5.2503 1.2039
ACHN CTRP2 7.9332 10.6696 5.0515 1.646
SNU-1272 CTRP2 7.971 9.7932 5.4299 0.5164
OS-RC-2 CTRP2 8.2012 10.2392 5.3572 0.5764
KMRC-20 CTRP2 8.2882 10.3134 5.366 0.5159
769-P CTRP2 8.3763 9.7244 5.6123 0.0904
KMRC-3 CTRP2 8.631 18.1995 1.9642 12.249
786-O CTRP2 8.6883 15.7925 3.1584 7.7847
VMRC-RCZ CTRP2 9.0538 16.3987 3.1089 7.4945
VMRC-RCW CTRP2 9.5966 18.2893 2.5686 8.7676
⏷ Show the Full List of 19 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H716 CTRP2 -2.9246 2.5167 -3.0536 58.8084
SW48 CTRP2 2.7428 9.4012 1.1838 27.4304
KM12 CTRP2 5.0777 8.1762 4.0948 10.2733
T84 CTRP2 5.3484 7.3316 4.7573 6.9227
SNU-C1 CTRP2 5.8154 9.743 4.0009 9.0389
SNU-C5 CTRP2 5.9078 9.662 4.1205 8.3523
NCI-H747 CTRP2 5.9912 8.8635 4.5902 6.2157
CL-11 CTRP2 5.9979 8.52 4.7676 5.4572
DLD-1 CTRP2 6.0699 7.2677 5.4539 2.4334
C2BBe1 CTRP2 6.1058 9.2225 4.5062 6.3476
SNU-503 CTRP2 6.5578 8.4181 5.2534 2.4548
LS1034 CTRP2 6.7328 8.513 5.3258 1.9213
SNU-1033 CTRP2 7.0007 11.1549 4.2356 5.9412
SW948 CTRP2 7.0194 10.2867 4.6705 4.1421
RKO CTRP2 7.1931 9.789 5.0208 2.5251
HCT 8 CTRP2 7.2852 9.1548 5.361 1.1857
COLO201 CTRP2 7.3135 10.4614 4.7828 3.2952
HCC-56 CTRP2 7.3501 8.3193 5.7273 0.1485
SW1417 CTRP2 7.4174 9.4952 5.2842 1.3253
GP2d CTRP2 7.5956 11.7579 4.3539 4.6082
COLO205 CTRP2 7.6996 8.8983 5.6533 0.1708
HT115 CTRP2 7.7595 9.0514 5.6211 0.2064
SNU-C4 CTRP2 7.7816 8.9617 5.6616 0.1382
HCT 116 CTRP2 7.7866 9.3654 5.5152 0.4059
HT-55 CTRP2 7.8375 9.2107 5.5937 0.2299
LS411N CTRP2 7.8448 9.1258 5.6272 0.1731
LS123 CTRP2 7.9241 9.3658 5.5711 0.2423
SK-CO-1 CTRP2 7.9687 9.8064 5.4238 0.532
HT-29 CTRP2 8.0048 9.0331 5.7165 0.0469
LS513 CTRP2 8.0249 11.6056 4.6894 2.82
COLO 678 CTRP2 8.0415 13.3748 3.8801 5.873
HCT 15 CTRP2 8.0465 13.7955 3.6835 6.6331
LS180 CTRP2 8.0733 9.6735 5.5175 0.2904
RCM-1 [Human ESC] CTRP2 8.1159 9.3788 5.6382 0.1028
MDST8 CTRP2 8.1863 9.3417 5.6755 0.0591
NCI-H508 CTRP2 8.2082 9.6938 5.5621 0.1799
SNU-61 CTRP2 8.2629 10.2666 5.3731 0.5112
LoVo CTRP2 8.265 17.1049 2.2378 11.8219
SNU-407 CTRP2 8.2824 10.3192 5.3613 0.529
CCK-81 CTRP2 8.5044 11.8752 4.834 1.8735
CW-2 CTRP2 8.7067 10.6965 5.3931 0.3108
SW620 CTRP2 9.0527 10.6633 5.5303 0.08
SNU-C2A CTRP2 10.6159 21.6539 1.6411 10.6492
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-398 CTRP2 -10.4759 -1.9223 -10.5861 86.9383
Li-7 CTRP2 1.3392 11.771 -1.2969 37.9134
SNU-886 CTRP2 2.7733 11.3134 0.357 29.8394
HuH-6 CTRP2 4.253 9.8704 2.4905 21.4731
Hep 3B2.1-7 CTRP2 5.1882 12.1018 2.2756 17.3435
PLC/PRF/5 CTRP2 6.1862 7.2048 5.5777 1.7043
JHH-2 CTRP2 6.2045 7.9959 5.1986 3.2579
SNU-182 CTRP2 6.4119 15.2466 1.7459 16.7928
JHH-4 CTRP2 6.5868 15.6256 1.698 16.6313
SNU-449 CTRP2 6.6607 10.6209 4.2473 6.4428
JHH-5 CTRP2 6.7902 12.2044 3.5617 9.0546
SNU-423 CTRP2 6.8214 12.9218 3.2299 10.3504
JHH-6 CTRP2 7.2085 8.1143 5.7466 0.1584
SNU-475 CTRP2 7.3744 12.6069 3.7947 7.1607
SNU-761 CTRP2 7.4704 11.6884 4.3041 4.9746
JHH-1 CTRP2 7.5566 9.3248 5.4274 0.762
HuH-1 CTRP2 7.6603 9.1909 5.5281 0.4352
SK-HEP-1 CTRP2 7.8056 11.7689 4.4829 3.8402
Hep-G2 CTRP2 7.9292 9.3274 5.5871 0.2138
SNU-387 CTRP2 8.0046 14.9312 3.1096 8.9305
HLF CTRP2 8.4005 15.7091 3.0066 8.754
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 140 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1703 CTRP2 -6.8131 30.4568 -18.0293 57.7017
NCI-H510A CTRP2 1.4387 75.198 -32.4417 47.851
NCI-H1581 CTRP2 2.2033 9.2096 0.7054 30.53
PC-14 CTRP2 3.3763 6.1346 3.1075 18.718
Lu-99 CTRP2 3.9227 6.8522 3.4671 15.7811
NCI-H211 CTRP2 4.1518 9.3606 2.63 18.4156
NCI-H1694 CTRP2 4.1825 6.3816 3.9113 13.3684
NCI-H1563 CTRP2 4.3866 6.1408 4.208 11.6723
NCI-H2141 CTRP2 4.5913 15.1177 0.2464 25.4986
NCI-H1155 CTRP2 4.6752 6.5536 4.3856 10.1677
NCI-H522 CTRP2 4.7551 9.3742 3.2123 14.6308
NCI-H1341 CTRP2 4.8499 11.8994 2.0702 18.8767
COR-L51 CTRP2 4.8569 7.1548 4.3379 9.8522
DMS 53 CTRP2 4.9145 8.1047 3.9686 11.182
NCI-H1650 CTRP2 4.9148 10.7891 2.6755 16.4043
NCI-H446 CTRP2 4.9324 7.9288 4.068 10.7361
NCI-H1568 CTRP2 5.089 12.0539 2.2105 17.8103
HCC2279 CTRP2 5.1317 9.7576 3.3813 13.0723
NCI-H2081 CTRP2 5.1345 9.8644 3.3317 13.2688
HCC44 CTRP2 5.1401 8.5278 3.987 10.5667
NCI-H810 CTRP2 5.3131 8.5791 4.1257 9.5962
NCI-H520 CTRP2 5.3375 11.739 2.5885 15.8082
HCC4006 CTRP2 5.371 6.9886 4.9377 6.1391
EPLC-272H CTRP2 5.5271 9.4325 3.902 10.0528
NCI-H358 CTRP2 5.5575 9.0834 4.1022 9.1534
DV-90 CTRP2 5.6272 8.3252 4.5401 7.1773
HCC2935 CTRP2 5.6309 8.9876 4.2154 8.5245
LC-1F CTRP2 5.6718 10.7206 3.389 11.8761
CAL-12T CTRP2 5.7056 7.7181 4.9107 5.4621
DMS 273 CTRP2 5.7108 8.5796 4.489 7.2114
HCC15 CTRP2 5.7203 8.9296 4.3236 7.8837
COR-L105 CTRP2 5.7581 7.4815 5.0753 4.6619
ChaGo-K-1 CTRP2 5.7955 9.7341 3.9883 9.1321
NCI-H2110 CTRP2 5.8308 8.4217 4.6734 6.1887
NCI-H2170 CTRP2 5.8782 7.0574 5.3935 3.0746
NCI-H2228 CTRP2 5.8935 10.2688 3.8052 9.7
NCI-H1693 CTRP2 5.9258 10.6049 3.6646 10.2213
DMS 454 CTRP2 5.9676 10.9943 3.5051 10.8004
NCI-H2085 CTRP2 5.9681 14.8377 1.584 18.2391
NCI-H841 CTRP2 6.0577 11.8024 3.1764 11.9738
COLO 668 CTRP2 6.0766 9.3638 4.4114 6.8017
NCI-H1355 CTRP2 6.1305 7.8643 5.2052 3.3646
HARA [Human squamous cell lung carcinoma] CTRP2 6.1317 8.5599 4.8586 4.8182
Calu-3 CTRP2 6.1318 8.9205 4.6785 5.575
NCI-H1092 CTRP2 6.1588 12.5477 2.8876 12.9433
LK2 CTRP2 6.1635 7.304 5.5109 2.023
NCI-H1838 CTRP2 6.1974 8.7859 4.799 4.9471
NCI-H1573 CTRP2 6.2087 9.7726 4.3154 6.9556
SW1271 CTRP2 6.2186 9.4482 4.4854 6.2243
NCI-H1666 CTRP2 6.2656 12.1586 3.1697 11.6023
RERF-LC-A1 CTRP2 6.2822 9.9081 4.307 6.8556
NCI-H1915 CTRP2 6.2868 8.4801 5.0222 3.8511
LUDLU-1 CTRP2 6.2978 10.4081 4.07 7.8194
NCI-H2029 CTRP2 6.2986 13.0334 2.7594 13.1852
SK-MES-1 CTRP2 6.3155 9.2719 4.6507 5.3554
NCI-H292 CTRP2 6.3253 8.0645 5.2578 2.8022
NCI-H1339 CTRP2 6.3316 7.4502 5.5641 1.5275
HCC1438 CTRP2 6.367 8.0335 5.3042 2.5412
HCC1588 CTRP2 6.372 10.0154 4.3249 6.6187
Sq-1 CTRP2 6.3786 10.1154 4.2803 6.7933
NCI-H322 CTRP2 6.3787 7.452 5.596 1.329
HCC1195 CTRP2 6.3805 9.3881 4.6437 5.2697
T3M-10 CTRP2 6.3865 8.3911 5.1425 3.1796
NCI-H2171 CTRP2 6.4131 11.0062 3.8637 8.47
NCI-H2106 CTRP2 6.4707 11.5205 3.653 9.2404
LCLC-97TM1 CTRP2 6.4762 8.1976 5.303 2.3753
HOP-92 CTRP2 6.4821 8.7623 5.0307 3.4867
COR-L95 CTRP2 6.4891 9.5038 4.6699 4.9739
SBC-5 CTRP2 6.4943 8.1961 5.3166 2.2924
DMS 114 CTRP2 6.5504 11.5346 3.7088 8.8672
NCI-H647 CTRP2 6.6055 9.8026 4.61 5.029
NCI-H889 CTRP2 6.6356 13.2314 2.9309 11.8793
NCI-H2444 CTRP2 6.6818 8.5648 5.2676 2.2205
NCI-H2087 CTRP2 6.7109 11.1419 4.0275 7.2695
RERF-LC-Ad1 CTRP2 6.7235 8.791 5.1875 2.4827
NCI-H2196 CTRP2 6.7481 11.5164 3.8705 7.8561
DMS 79 CTRP2 6.7996 15.9061 1.7279 16.1293
Calu-1 CTRP2 6.8114 8.3177 5.4655 1.2909
HCC366 CTRP2 6.8769 13.3671 3.0516 10.9697
HOP-62 CTRP2 6.8848 9.0863 5.1538 2.3981
NCI-H226 CTRP2 6.8942 11.805 3.838 7.7452
HCC1171 CTRP2 6.9248 10.3332 4.582 4.641
KNS-62 CTRP2 7.0311 8.7389 5.4035 1.2821
NCI-H1944 CTRP2 7.0475 11.7829 3.9621 6.9879
A-549 CTRP2 7.1617 9.1331 5.3019 1.5121
COR-L88 CTRP2 7.1702 11.3207 4.2754 5.5209
NCI-H2342 CTRP2 7.2251 10.6805 4.6211 4.0504
BEN CTRP2 7.2826 8.1789 5.752 0.1275
LOU-NH91 CTRP2 7.2885 18.0856 1.0266 17.6325
NCI-H1869 CTRP2 7.4052 11.6717 4.2682 5.2093
MOR/CPR CTRP2 7.4439 8.4362 5.7213 0.1327
HCC827 CTRP2 7.5786 17.5376 1.5209 15.4758
NCI-H1734 CTRP2 7.6042 10.7444 4.832 2.7563
IA-LM CTRP2 7.6312 10.1446 5.1169 1.6993
NCI-H1755 CTRP2 7.7106 9.6051 5.3865 0.7767
NCI-H2122 CTRP2 7.7388 9.2541 5.5374 0.3778
HCC1833 CTRP2 7.7696 21.1229 -0.1098 20.2241
NCI-H2126 CTRP2 7.7712 10.1894 5.1725 1.387
LC-1/sq-SF CTRP2 7.7794 9.1542 5.5915 0.2526
RERF-LC-Ad2 CTRP2 7.8576 9.4232 5.5231 0.3587
LCLC-103H CTRP2 7.8917 9.0105 5.6847 0.089
HCC2108 CTRP2 7.9291 9.8251 5.399 0.6133
NCI-H838 CTRP2 8.005 11.7312 4.6211 3.091
NCI-H2030 CTRP2 8.0134 10.1002 5.3282 0.7496
NCI-H1184 CTRP2 8.0458 11.2266 4.8699 2.1591
NCI-H1105 CTRP2 8.0835 20.2069 0.5824 17.6753
NCI-H1623 CTRP2 8.0912 10.3673 5.2569 0.896
NCI-H526 CTRP2 8.0989 9.4696 5.6005 0.1515
NCI-H1395 CTRP2 8.1019 10.2655 5.3027 0.7654
NCI-H460 CTRP2 8.1024 9.0372 5.7478 0.0224
NCI-H2023 CTRP2 8.1418 10.0223 5.415 0.4717
NCI-H2291 CTRP2 8.1662 9.8671 5.4833 0.3223
VMRC-LCD CTRP2 8.203 9.8894 5.4897 0.2982
NCI-H1651 CTRP2 8.2069 10.1252 5.4033 0.4692
SK-LU-1 CTRP2 8.2194 13.9371 3.7302 6.2198
SHP-77 CTRP2 8.2308 9.6255 5.5944 0.1329
HCC95 CTRP2 8.2362 9.7726 5.5447 0.1985
NCI-H441 CTRP2 8.2586 11.1127 5.031 1.4459
NCI-H650 CTRP2 8.2699 13.5559 3.9417 5.3403
RERF-LC-MS CTRP2 8.3266 9.7105 5.5995 0.1105
NCI-H69 CTRP2 8.3269 10.2248 5.4155 0.3957
NCI-H2009 CTRP2 8.33 14.9388 3.3275 7.625
NCI-H1435 CTRP2 8.3359 9.7036 5.6051 0.1032
NCI-H1373 CTRP2 8.4351 10.696 5.282 0.6404
NCI-H196 CTRP2 8.4378 17.4982 2.1687 11.8099
HCC78 CTRP2 8.523 10.0571 5.5505 0.1317
EBC-1 CTRP2 8.5374 10.4694 5.4095 0.3342
NCI-H1299 CTRP2 8.5476 10.1884 5.5138 0.1712
NCI-H2405 CTRP2 8.5696 14.5722 3.6564 6.0525
NCI-H2172 CTRP2 8.5732 9.8578 5.6353 0.0512
Calu-6 CTRP2 8.6829 10.3509 5.5065 0.1541
NCI-H1792 CTRP2 8.8153 17.0808 2.6296 9.5829
NCI-H727 CTRP2 8.8207 10.6903 5.4385 0.2129
NCI-H661 CTRP2 8.9325 10.6543 5.4914 0.1293
COLO 699 CTRP2 9.0812 19.3079 1.7411 12.3637
Lu-65 CTRP2 9.174 17.864 2.4951 9.5821
NCI-H23 CTRP2 9.3576 19.7972 1.6948 12.1282
NCI-H2286 CTRP2 9.4581 19.9071 1.7102 11.9359
LXF 289 CTRP2 10.6169 21.308 1.8034 10.1175
Hs 888.Lu CTRP2 8.2492 16.5333 2.5045 10.8648
⏷ Show the Full List of 140 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 -0.3093 13.0824 -3.5618 45.804
A2780 CTRP2 3.9012 9.32 2.3991 19.9434
ONCO-DG-1 CTRP2 5.0412 17.0926 -0.3364 26.0849
SNU-119 CTRP2 5.4765 9.8145 3.6674 11.1355
SNU-840 CTRP2 5.5401 9.5767 3.8422 10.2737
TOV-112D CTRP2 5.8928 11.9611 2.9588 13.181
EFO-21 CTRP2 6.2104 7.5815 5.4094 2.3654
TYK-nu CTRP2 6.2402 7.9135 5.2676 2.9065
IGROV-1 CTRP2 6.2861 12.3378 3.0968 11.8593
EFO-27 CTRP2 6.382 9.5435 4.5676 5.5853
OAW42 CTRP2 6.5824 8.2485 5.352 2.021
COV434 CTRP2 6.7401 16.7089 1.2802 17.7887
COV362 CTRP2 6.9534 11.6494 3.9586 7.1528
OVCAR-5 CTRP2 7.0446 9.4903 5.0666 2.5328
OC 314 CTRP2 7.1599 8.7533 5.4677 0.94
Kuramochi CTRP2 7.3433 14.441 2.8733 10.8849
MCAS CTRP2 7.4571 12.0264 4.1331 5.6763
OV56 CTRP2 7.4725 8.6255 5.6637 0.2227
OVK18 CTRP2 7.4805 12.9974 3.6798 7.462
ES2 CTRP2 7.4832 8.677 5.6489 0.2475
OVISE CTRP2 7.6008 8.8468 5.6334 0.2354
RMG-I CTRP2 7.9017 10.7053 5.0192 1.7822
COV644 CTRP2 7.9172 9.896 5.3656 0.7066
DOV13 CTRP2 7.9265 9.4002 5.5595 0.2622
SNU-8 CTRP2 7.9365 8.9683 5.7147 0.0552
TOV-21G CTRP2 7.9703 9.2543 5.6286 0.1416
OV-90 CTRP2 7.9845 9.8757 5.4037 0.5725
JHOM-1 CTRP2 8.2421 13.696 3.8584 5.6957
Caov-3 CTRP2 8.3143 10.8193 5.1788 0.9723
JHOC-5 CTRP2 8.3413 9.6403 5.6286 0.0801
OVCAR-4 CTRP2 8.3983 10.52 5.3338 0.5388
FU-OV-1 CTRP2 8.5332 19.9204 1.0554 15.4678
HEY A8 CTRP2 8.5861 9.792 5.6613 0.0355
OVCAR-8 CTRP2 8.5934 10.2278 5.5168 0.1584
OVTOKO CTRP2 8.6764 10.9065 5.3036 0.4877
SK-OV-3 CTRP2 8.7618 10.6038 5.4471 0.2143
OV7 CTRP2 8.9407 25.6219 -1.4479 21.7558
OAW28 CTRP2 9.3113 16.0749 3.4196 6.0395
JHOS-2 CTRP2 10.6342 22.1607 1.4149 11.3551
OVSAHO CTRP2 14.1666 27.0884 1.2719 8.024
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
H-STS CTRP2 6.8673 8.0803 5.6028 0.7472
P-STS CTRP2 8.0128 9.6667 5.4956 0.3541
SYO-1 CTRP2 9.4786 23.7449 -0.1327 17.5843
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 7.6386 9.5156 5.3886 0.9459
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Aska-SS CTRP2 7.9933 9.0138 5.719 0.0462
Yamato-SS CTRP2 11.8965 28.5966 -0.8067 16.114
A-204 CTRP2 -2.0958 4.8358 -2.5408 53.5099
G-402 CTRP2 -1.4298 6.7246 -2.3079 49.8425
G-401 CTRP2 2.5633 6.8196 2.0086 25.1378
Rh41 CTRP2 3.5212 10.2437 1.5952 23.8778
TTC-709 CTRP2 3.5319 10.7213 1.3838 24.5747
Rh18 CTRP2 4.5188 7.9038 3.6629 13.4042
TE 617.T CTRP2 4.9554 8.3992 3.8703 11.4818
KYM-1 CTRP2 5.362 6.642 5.0811 5.5937
TE 441.T CTRP2 5.7507 9.3085 4.1615 8.499
MES-SA CTRP2 5.8612 7.974 4.923 5.0793
GCT CTRP2 6.4246 9.506 4.6193 5.2952
Hs 729.T CTRP2 6.4823 12.6304 3.1089 11.4449
BT-12 CTRP2 6.8652 9.4349 4.9748 3.1366
SK-LMS-1 CTRP2 7.3318 12.9865 3.579 8.0961
HT-1080 CTRP2 7.4927 8.9369 5.5535 0.4587
BT-16 CTRP2 7.6002 8.7263 5.677 0.1602
SW982 CTRP2 7.8956 9.0655 5.6671 0.108
RKN CTRP2 8.1534 9.1526 5.727 0.0292
Tm87-16 CTRP2 10.5357 20.7564 2.0095 9.534
SK-UT-1 CTRP2 11.6077 23.6661 1.3254 10.4683
RD CTRP2 13.7935 28.8226 0.2819 11.117
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP2 3.5264 9.4477 1.9639 22.5508
NCI-H28 CTRP2 5.0768 6.4429 4.858 7.239
NCI-H2452 CTRP2 5.1994 9.167 3.733 11.4747
MPP 89 CTRP2 6.2428 10.9056 3.7771 9.1435
IST-Mes1 CTRP2 7.896 15.3539 2.8279 10.1806
NCI-H2052 CTRP2 7.9729 11.7144 4.6097 3.1682
ACC-MESO-1 CTRP2 8.0137 12.4754 4.2844 4.3459
JL-1 CTRP2 8.1485 11.5458 4.7861 2.3515
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 4.9585 8.3791 3.8828 11.4232
PaCa-3 CTRP2 6.4457 7.9486 5.4025 2.0151
VCaP CTRP2 7.5622 9.9653 5.1577 1.6238
DU145 CTRP2 7.7519 13.0796 3.8279 6.4744
22Rv1 CTRP2 8.8812 11.861 5.0231 1.0519
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 6.7001 8.802 5.1664 2.6006
YD-15 CTRP2 7.5089 8.675 5.66 0.217
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-16 CTRP2 -1.2117 6.6975 -2.0619 48.708
GSS CTRP2 3.9032 10.5155 1.8447 21.9957
ECC10 CTRP2 3.9536 9.5732 2.3348 20.0522
KATO III CTRP2 3.9934 16.8524 -1.1514 30.4112
NUGC-4 CTRP2 5.2935 8.9523 3.9254 10.4686
HGC-27 CTRP2 5.4003 9.8258 3.5933 11.6066
ECC12 CTRP2 5.8544 9.6798 4.066 8.6876
Hs 746.T CTRP2 6.1279 8.2083 5.0312 4.1005
OCUM-1 CTRP2 6.2866 9.2698 4.6288 5.4989
IM95 CTRP2 6.3504 17.6063 0.5165 20.9772
SNU-601 CTRP2 6.651 9.2821 4.8991 3.7621
GSU CTRP2 6.801 7.2746 5.8918 0.0422
23132/87 CTRP2 6.9043 12.0673 3.7161 8.2286
SH-10-TC CTRP2 6.9064 9.0165 5.2006 2.1871
SNU-216 CTRP2 7.0667 9.0147 5.2999 1.6205
MKN7 CTRP2 7.1588 11.2187 4.3168 5.3699
LMSU CTRP2 7.267 24.129 -2.0003 25.7061
MKN74 CTRP2 7.391 9.6205 5.2147 1.5902
MKN1 CTRP2 7.4124 9.3789 5.3319 1.1703
MKN45 CTRP2 7.4355 8.3988 5.7314 0.1198
SNU-5 CTRP2 7.9507 9.248 5.6235 0.1528
SNU-668 CTRP2 7.9673 9.1495 5.664 0.0991
AGS CTRP2 8.0442 9.7788 5.4664 0.4019
SNU-620 CTRP2 8.0717 9.2392 5.6702 0.0772
SNU-719 CTRP2 8.1639 13.3264 3.9818 5.3201
SNU-1 CTRP2 8.3476 16.1576 2.7547 9.7829
KE-39 CTRP2 8.4919 14.8381 3.4817 6.8169
NUGC-3 CTRP2 8.5043 10.0097 5.5601 0.1242
HuG1-N CTRP2 8.7811 21.0393 0.6873 16.2406
NCI-N87 CTRP2 8.912 11.1023 5.3257 0.3639
SNG-M CTRP2 5.8564 7.3888 5.2097 3.889
SNU-1077 CTRP2 6.2514 12.3481 3.0633 12.0602
SNU-685 CTRP2 7.6536 11.5248 4.5011 3.9585
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW579 CTRP2 -1.5434 5.6265 -2.1262 50.4508
CGTH-W-1 CTRP2 -0.6445 3.8821 -0.7989 44.8466
ML-1 [Human leukemia] CTRP2 5.2075 9.7226 3.4685 12.5449
TT CTRP2 5.7222 8.9924 4.294 8.0037
CAL-62 CTRP2 6.3362 7.9796 5.308 2.5758
FTC-133 CTRP2 6.3931 8.4698 5.1086 3.3095
TT2609-C02 CTRP2 6.4375 9.3096 4.7267 4.825
8505C CTRP2 7.4423 11.1756 4.5293 4.1208
B-CPAP CTRP2 7.7762 9.566 5.4326 0.6116
BHT-101 CTRP2 7.905 9.4264 5.5413 0.3038
FTC-238 CTRP2 8.2209 10.0549 5.4356 0.3955
8305C CTRP2 8.3058 9.6131 5.6254 0.0876
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-8 CTRP2 5.1281 12.4722 2.0382 18.3698
PE/CA-PJ34 (clone C12) CTRP2 5.5319 9.1885 4.0272 9.5212
SCC-25 CTRP2 5.5503 8.3325 4.4664 7.6524
PE/CA-PJ49 CTRP2 5.7365 7.3056 5.1418 4.4334
BICR 6 CTRP2 5.9678 10.1194 3.9427 8.9784
BICR 16 CTRP2 6.0267 8.9934 4.5551 6.2939
HSC-2 CTRP2 6.2165 8.881 4.7669 5.0468
PE/CA-PJ15 CTRP2 6.2201 12.461 2.9813 12.4502
HSC-4 CTRP2 6.2664 10.1389 4.1791 7.4206
CAL-33 CTRP2 6.3376 8.0151 5.2914 2.6422
BICR 18 CTRP2 6.5673 15.4383 1.7758 16.3905
SCC-9 CTRP2 7.0012 12.0832 3.7806 7.8053
FaDu CTRP2 7.0899 10.1085 4.8037 3.5087
SCC-4 CTRP2 7.6123 9.1749 5.5133 0.4957
YD-10B CTRP2 7.6403 8.8819 5.6362 0.2171
HSC-3 CTRP2 7.7352 9.0898 5.5975 0.2564
BICR 22 CTRP2 7.7726 11.7922 4.4514 4.0017
BICR 56 CTRP2 7.8684 9.1566 5.6251 0.1702
CAL-27 CTRP2 7.9234 9.5075 5.5185 0.342
SNU-1214 CTRP2 7.9755 10.309 5.2254 1.0641
SNU-1076 CTRP2 7.9787 8.9756 5.7267 0.0422
SNU-899 CTRP2 8.0316 9.5524 5.5453 0.254
SNU-1066 CTRP2 8.2936 9.8328 5.5448 0.1845
Detroit 562 CTRP2 8.4837 10.1256 5.5123 0.1867
SNU-46 CTRP2 8.6752 10.3678 5.4979 0.166
BHY CTRP2 8.7755 10.2579 5.5709 0.0778
BICR 31 CTRP2 9.9606 18.8589 2.5324 8.4433
SNU-1041 CTRP2 10.8196 19.4774 2.7665 6.667
PE/CA-PJ41 (clone D2) CTRP2 11.5901 23.3716 1.4505 10.1008
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JMSU-1 CTRP2 0.1355 5.7292 -0.3208 40.4853
UM-UC-1 CTRP2 0.3552 9.0599 -1.1865 41.1364
RT-112 CTRP2 3.3916 11.8903 0.6964 27.1495
253J CTRP2 4.6656 6.5226 4.3865 10.1921
U-BLC1 CTRP2 5.2287 9.6251 3.5359 12.2208
VM-CUB-1 CTRP2 5.4335 7.4992 4.7612 6.7013
5637 CTRP2 5.5475 14.0217 1.6345 18.9288
SW1710 CTRP2 5.7027 8.8291 4.3579 7.7769
TCCSUP CTRP2 6.0786 10.2089 3.9906 8.563
CAL-29 CTRP2 6.1538 7.8939 5.2092 3.3052
253J-BV CTRP2 6.1656 7.9874 5.172 3.4396
BFTC-905 CTRP2 6.4797 8.092 5.3568 2.1502
UM-UC-3 CTRP2 6.4894 9.4581 4.6927 4.8785
RT-4 CTRP2 6.7284 15.2989 1.9741 15.3731
HT-1197 CTRP2 6.8117 10.2933 4.5205 5.0673
BC-3C CTRP2 6.8754 11.5297 3.9597 7.2754
T24 CTRP2 7.5763 13.5474 3.4802 8.115
KU-19-19 CTRP2 7.7009 8.8053 5.6868 0.1218
639V CTRP2 7.7744 9.3524 5.515 0.412
KMBC-2 CTRP2 7.8459 10.2572 5.1822 1.2945
647V CTRP2 7.9996 9.3075 5.6207 0.1458
HT-1376 CTRP2 8.6077 10.3188 5.4902 0.1895
J82 CTRP2 9.2565 18.902 2.0553 11.03
SCaBER CTRP2 10.9803 19.158 3.0008 5.7216
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.4943 8.3526 5.7689 0.0629

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Lenvatinib (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Remdesivir DMBFZ6L Moderate Increased risk of hepatotoxicity by the combination of Lenvatinib and Remdesivir. 1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019] [8]
Ivosidenib DM8S6T7 Major Increased risk of prolong QT interval by the combination of Lenvatinib and Ivosidenib. Acute myeloid leukaemia [2A60] [9]
Arn-509 DMT81LZ Moderate Increased risk of prolong QT interval by the combination of Lenvatinib and Arn-509. Acute myeloid leukaemia [2A60] [10]
Gilteritinib DMTI0ZO Moderate Increased risk of prolong QT interval by the combination of Lenvatinib and Gilteritinib. Acute myeloid leukaemia [2A60] [11]
Oliceridine DM6MDCF Moderate Increased risk of prolong QT interval by the combination of Lenvatinib and Oliceridine. Acute pain [MG31] [12]
Ivabradine DM0L594 Major Increased risk of ventricular arrhythmias by the combination of Lenvatinib and Ivabradine. Angina pectoris [BA40] [10]
Levalbuterol DM5YBO1 Moderate Increased risk of ventricular arrhythmias by the combination of Lenvatinib and Levalbuterol. Asthma [CA23] [13]
Pexidartinib DMS2J0Z Major Increased risk of hepatotoxicity by the combination of Lenvatinib and Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [14]
PF-04449913 DMSB068 Moderate Increased risk of prolong QT interval by the combination of Lenvatinib and PF-04449913. Chronic myelomonocytic leukaemia [2A40] [15]
Olodaterol DM62B78 Moderate Increased risk of ventricular arrhythmias by the combination of Lenvatinib and Olodaterol. Chronic obstructive pulmonary disease [CA22] [16]
Vilanterol DMF5EK1 Moderate Increased risk of ventricular arrhythmias by the combination of Lenvatinib and Vilanterol. Chronic obstructive pulmonary disease [CA22] [13]
Revefenacin DMMP5SI Moderate Decreased clearance of Lenvatinib due to the transporter inhibition by Revefenacin. Chronic obstructive pulmonary disease [CA22] [17]
Osilodrostat DMIJC9X Moderate Increased risk of prolong QT interval by the combination of Lenvatinib and Osilodrostat. Cushing syndrome [5A70] [10]
Deutetrabenazine DMUPFLI Moderate Additive CNS depression effects by the combination of Lenvatinib and Deutetrabenazine. Dystonic disorder [8A02] [18]
Ingrezza DMVPLNC Moderate Increased risk of prolong QT interval by the combination of Lenvatinib and Ingrezza. Dystonic disorder [8A02] [19]
GS-9857 DMYU6P5 Moderate Decreased clearance of Lenvatinib due to the transporter inhibition by GS-9857. Hepatitis virus infection [1E50-1E51] [20]
Fostemsavir DM50ILT Moderate Increased risk of prolong QT interval by the combination of Lenvatinib and Fostemsavir. Human immunodeficiency virus disease [1C60-1C62] [21]
Polyethylene glycol DM4I1JP Moderate Increased risk of ventricular arrhythmias by the combination of Lenvatinib and Polyethylene glycol. Irritable bowel syndrome [DD91] [10]
Osimertinib DMRJLAT Major Increased risk of prolong QT interval by the combination of Lenvatinib and Osimertinib. Lung cancer [2C25] [22]
Selpercatinib DMZR15V Major Increased risk of prolong QT interval by the combination of Lenvatinib and Selpercatinib. Lung cancer [2C25] [10]
Calaspargase pegol DMQZBXI Moderate Increased risk of hepatotoxicity by the combination of Lenvatinib and Calaspargase pegol. Malignant haematopoietic neoplasm [2B33] [23]
Arry-162 DM1P6FR Moderate Decreased clearance of Lenvatinib due to the transporter inhibition by Arry-162. Melanoma [2C30] [8]
LGX818 DMNQXV8 Moderate Increased risk of prolong QT interval by the combination of Lenvatinib and LGX818. Melanoma [2C30] [24]
Siponimod DM2R86O Major Increased risk of ventricular arrhythmias by the combination of Lenvatinib and Siponimod. Multiple sclerosis [8A40] [8]
Ozanimod DMT6AM2 Major Increased risk of ventricular arrhythmias by the combination of Lenvatinib and Ozanimod. Multiple sclerosis [8A40] [25]
Entrectinib DMMPTLH Moderate Increased risk of prolong QT interval by the combination of Lenvatinib and Entrectinib. Non-small cell lung cancer [2C25] [8]
Rucaparib DM9PVX8 Moderate Increased risk of prolong QT interval by the combination of Lenvatinib and Rucaparib. Ovarian cancer [2C73] [12]
Triclabendazole DMPWGBR Moderate Increased risk of prolong QT interval by the combination of Lenvatinib and Triclabendazole. Parasitic worm infestation [1F90] [12]
Macimorelin DMQYJIR Major Increased risk of prolong QT interval by the combination of Lenvatinib and Macimorelin. Pituitary gland disorder [5A60-5A61] [26]
Lefamulin DME6G97 Major Increased risk of prolong QT interval by the combination of Lenvatinib and Lefamulin. Pneumonia [CA40] [27]
Relugolix DMK7IWL Moderate Increased risk of prolong QT interval by the combination of Lenvatinib and Relugolix. Prostate cancer [2C82] [10]
LEE011 DMMX75K Major Increased risk of prolong QT interval by the combination of Lenvatinib and LEE011. Solid tumour/cancer [2A00-2F9Z] [12]
Pitolisant DM8RFNJ Moderate Increased risk of prolong QT interval by the combination of Lenvatinib and Pitolisant. Somnolence [MG42] [12]
⏷ Show the Full List of 33 DDI Information of This Drug

References

1 FDA Approved Drug Products from FDA Official Website. 2018. Application Number: (ANDA) 208627.
2 Lenvatinib FDA Label
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Emerging drugs for ovarian cancer. Expert Opin Emerg Drugs. 2008 Sep;13(3):523-36.
6 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
7 Influence of CYP3A4/5 and ABC transporter polymorphisms on lenvatinib plasma trough concentrations in Japanese patients with thyroid cancer. Sci Rep. 2019 Apr 1;9(1):5404.
8 Cerner Multum, Inc. "Australian Product Information.".
9 Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
10 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
11 Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
12 Canadian Pharmacists Association.
13 Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
14 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
15 Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
16 Bengtsson B, Fagerstrom PO "Extrapulmonary effects of terbutaline during prolonged administration." Clin Pharmacol Ther 31 (1982): 726-32. [PMID: 7042176]
17 Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
18 Product Information. Austedo (deutetrabenazine). Teva Pharmaceuticals USA, North Wales, PA.
19 Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
20 Product Information. Vosevi (sofosbuvir/velpatasvir/voxilaprevir). Gilead Sciences, Foster City, CA.
21 Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
22 Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
23 Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
24 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
25 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
26 Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
27 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.