Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMB6FMH)

Drug Name
BMTP-11 Drug Info
Synonyms IL-11Ralpha targeted proapoptotic peptide (prostate cancer), MD Anderson Cancer Center; IL-11Ralpha targeted proapoptotic peptide (prostate cancer), Mercator
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMB6FMH

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin 11 receptor alpha (IL11RA) TTZPLJS I11RA_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Interleukin 11 receptor alpha (IL11RA) DTT IL11RA 6.248 6.525 4.591 6.246
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Prostate cancer
ICD Disease Classification 2C82.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Interleukin 11 receptor alpha (IL11RA) DTT IL11RA 1.95E-01 0.44 0.53
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT00872157) BMTP-11 in Patients With Castrate-Resistant Prostate Cancer With Bone Mets. U.S. National Institutes of Health.
2 Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens. Clin Cancer Res. 2015 Jul 1;21(13):3041-51.