Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMB7685)

Drug Name

EAPB0203 Drug Info

Synonyms

UNII-KXZ9LA2QV7; KXZ9LA2QV7; EAPB-0203; N-Methyl-1-(2-phenylethyl)imidazo(1,2-a)quinoxalin-4-amine; n-methyl-1-(2-phenylethyl)imidazo[1,2-a]quinoxalin-4-amine; CHEMBL488644; SCHEMBL2815787; EAPB 0203; Imidazo(1,2-a)quinoxalin-4-amine, N-methyl-1-(2-phenylethyl)-; 681284-86-6

Indication

Disease Entry	ICD 11	Status	REF
T-cell leukaemia	2A90	Investigative	[1]

Cross-matching ID

PubChem CID: 24779760
CAS Number: CAS 681284-86-6
TTD Drug ID: DMB7685

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apoptosis regulator Bcl-xL (BCL-xL)	TTU1E82	B2CL1_HUMAN	Inhibitor	[1]
Cellular inhibitor of apoptosis 1 (BIRC2)	TTQ5LRD	BIRC2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Apoptosis regulator Bcl-xL (BCL-xL)	DTT	BCL2L1	4.863	5.664	6.092	5.843

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

T-cell leukaemia

ICD Disease Classification

2A90

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Apoptosis regulator Bcl-xL (BCL-xL)	DTT	BCL2L1	7.28E-13	-0.55	-0.68

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I-associated adult T-cell leukemia/lymphoma. Blood. 2008 Apr 1;111(7):3770-7.