Details of the Drug

General Information of Drug (ID: DMB7685)

• Drug Name: EAPB0203
• Synonyms: UNII-KXZ9LA2QV7; KXZ9LA2QV7; EAPB-0203; N-Methyl-1-(2-phenylethyl)imidazo(1,2-a)quinoxalin-4-amine; n-methyl-1-(2-phenylethyl)imidazo[1,2-a]quinoxalin-4-amine; CHEMBL488644; SCHEMBL2815787; EAPB 0203; Imidazo(1,2-a)quinoxalin-4-amine, N-methyl-1-(2-phenylethyl)-; 681284-86-6

Indication

Disease Entry	ICD 11	Status	REF
T-cell leukaemia	2A90	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 302.4
  Logarithm of the Partition Coefficient (xlogp); 4.7
  Rotatable Bond Count (rotbonds); 4
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C19H18N4
  IUPAC Name: N-methyl-1-(2-phenylethyl)imidazo[1,2-a]quinoxalin-4-amine
  Canonical SMILES: CNC1=NC2=CC=CC=C2N3C1=NC=C3CCC4=CC=CC=C4
  InChI: InChI=1S/C19H18N4/c1-20-18-19-21-13-15(12-11-14-7-3-2-4-8-14)23(19)17-10-6-5-9-16(17)22-18/h2-10,13H,11-12H2,1H3,(H,20,22)
  InChIKey: HOACPUXUWCASLE-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 24779760
  CAS Number: 681284-86-6
  TTD ID: D2SJZ9
• Drug-Molecule Activity Atlas (DMA)NEW: Click to Jump to the Detailed DMA Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apoptosis regulator Bcl-xL (BCL-xL)	TTU1E82	B2CL1_HUMAN	Inhibitor	[1]
Cellular inhibitor of apoptosis 1 (BIRC2)	TTQ5LRD	BIRC2_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: T-cell leukaemia
• ICD Disease Classification: 2A90

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Apoptosis regulator Bcl-xL (BCL-xL)	DTT	BCL2L1	7.28E-13	-0.55	-0.68

References

• [1] EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I-associated adult T-cell leukemia/lymphoma. Blood. 2008 Apr 1;111(7):3770-7.