Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMD5YKO)

Drug Name
3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione Drug Info
Synonyms CHEMBL29863; 3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
13660218
ChEBI ID
CHEMBL29863
TTD Drug ID
DMD5YKO

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aromatase (CYP19A1) TTSZLWK CP19A_HUMAN Inhibitor [1]
Cholesterol desmolase (CYP11A1) TTSYVO6 CP11A_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Cholesterol desmolase (CYP11A1) DTT CYP11A1 5.409 4.385 5.19 5.6
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cholesterol desmolase (CYP11A1) DTT CYP11A1 1.09E-47 -0.41 -1.12
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. J Med Chem. 1986 Aug;29(8):1362-9.