Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMDVP3B)

Drug Name
Pregabalin Drug Info
Synonyms Pregabalin CR; Pregabalin (controlled-release, oral); Pregabalin (controlled-release, oral), Pfizer
Indication
Disease Entry ICD 11 Status REF
Chronic obstructive pulmonary disease CA22 Approved [1]
Epilepsy 8A60-8A68 Approved [2]
Pain MG30-MG3Z Approved [2]
Postherpetic neuralgia 1E91.5 Approved [2]
Vulvodynia Approved [2]
Chronic pain MG30 Investigative [2]
Neuralgia Investigative [2]
Cross-matching ID
PubChem CID
5486971
ChEBI ID
CHEBI:64356
CAS Number
CAS 148553-50-8
TTD Drug ID
DMDVP3B
VARIDT Drug ID
DR01255
ACDINA Drug ID
D00553

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) TTFK1JQ CA2D1_HUMAN Modulator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
L-type amino acid transporter 1 (SLC7A5) DT48T0N LAT1_HUMAN Approved [4]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 5.083 4.833 5.343 2.536
L-type amino acid transporter 1 (SLC7A5) DTP LAT1 4.209 6.366 5.878 4.385
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 12 Disease of the respiratory system
Disease Class ICD-11: CA23 Asthma
The Studied Tissue Lung tissue
The Studied Disease Chronic obstructive pulmonary disease [ICD-11:CA23]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 9.36E-01 -0.03 -0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 2.81E-05 -0.15 -0.68
L-type amino acid transporter 1 (SLC7A5) DTP LAT1 8.50E-01 1.70E-01 1.79E-01
L-type amino acid transporter 1 (SLC7A5) DTP LAT1 2.96E-04 3.30E-01 8.32E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5484).
2 Pregabalin FDA Label
3 Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons. Mol Pharmacol. 2006 Aug;70(2):467-76.
4 Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line. Pharm Res. 2018 Oct 29;35(12):246.