Details of the Drug Transporter (DTP)
General Information of Drug Transporter (DTP) (ID: DT48T0N)
Molecular Interaction Atlas (MIA) of This DTP
Molecular Interaction Atlas (MIA) | ||||||||||||||||||||||||||||||||||||||||||||||
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4 Approved Drug(s) Transported by This DTP
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1 Investigative Drug(s) Transported by This DTP
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Molecular Expression Atlas (MEA) of This DTP
Drug Affinity of This DTP Assessed by Cell Line
Approved Drug(s) |
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The Drug Therapeutic Target (DTT) Role of This DTP
DTP DTT Name | Large neutral amino acids transporter 1 (SLC7A5) | |||||||||||||||||||||||||||||||||||||||
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DTP DTT Type | Literature-reported | |||||||||||||||||||||||||||||||||||||||
3 Investigative Drug(s) Targeting This DTP
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References
1 | Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3688-91. | ||||
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2 | Amino acid transporter molecule as a drug target. Nippon Yakurigaku Zasshi. 1999 Oct;114 Suppl 1:11P-16P. | ||||
3 | Transport of gabapentin by LAT1 (SLC7A5). Biochem Pharmacol. 2013 Jun 1;85(11):1672-83. | ||||
4 | Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009 Feb 6;136(3):521-34. | ||||
5 | Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. Sci Rep. 2017 Mar 8;7:43580. | ||||
6 | Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line. Pharm Res. 2018 Oct 29;35(12):246. | ||||