Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DME0WX2)

Drug Name

Org-43902 Drug Info

Synonyms

LH-ago1; ORG-41247; ORG-42619; ORG-43311; SC-20565; Luteinizing hormone receptor (LHR) agonist, NV Organon; Oral LH agonist, Schering-Plough; Low molecular weight luteinizing hormone (LMW LH) receptor agonist, Merck & Co; Luteinizing hormone agonist (oral), Merck & Co; Luteinizing hormone agonist (oral), Schering-Plough

Indication

Disease Entry	ICD 11	Status	REF
Infertility	GB04	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DME0WX2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Luteinizing hormone receptor (LHCGR)	TT2O4W9	LSHR_HUMAN	Agonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Luteinizing hormone receptor (LHCGR)	DTT	LHCGR	4.009	2.561	3.365	4.828

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Infertility

ICD Disease Classification

GB04

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Luteinizing hormone receptor (LHCGR)	DTT	LHCGR	3.55E-01	5.41E-04	4.54E-03

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800042073)
2	First evidence of ovulation induced by oral LH agonists in healthy female volunteers of reproductive age. J Clin Endocrinol Metab. 2013 Apr;98(4):1558-66.