Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMEF9JW)

Drug Name

IM0-8400 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Diffuse large B-cell lymphoma	2A81	Discontinued in Phase 1/2	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Toll-like receptor 7 (TLR7)	TTRJ1K4	TLR7_HUMAN	Antagonist	[2]
Toll-like receptor 8 (TLR8)	TT8CWFK	TLR8_HUMAN	Antagonist	[2]
Toll-like receptor 9 (TLR9)	TTSHG0T	TLR9_HUMAN	Antagonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Toll-like receptor 7 (TLR7)	DTT	TLR7	3.7	0.848	-0.152	3.121

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Diffuse large B-cell lymphoma

ICD Disease Classification

2A81

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Toll-like receptor 7 (TLR7)	DTT	TLR7	3.32E-25	0.44	0.88

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Clinical pipeline report, company report or official report of Idera Pharmaceuticals.
2	Clinical pipeline report, company report or official report of Idera Pharmaceuticals.