Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMGJTL3)

Drug Name

SMaRT FVIII Drug Info

Synonyms

SMaRT FVIII (hemophilia A); Factor VIII modulator (SMaRT), Intronn; Factor VIII modulator (SMaRT), VIRxSYS; Hemophilia therapeutic (SMaRT), Intronn; Hemophilia therapeutic (SMaRT), VIRxSYS; SMaRT FVIII (hemophilia A), Intronn; SMaRT FVIII (hemophilia A), VIRxSYS

Indication

Disease Entry	ICD 11	Status	REF
Hemophilia	3B10.0	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMGJTL3

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Coagulation factor VIII (F8)	TT1290U	FA8_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Coagulation factor VIII (F8)	DTT	F8	7.637	6.9	7.644	6.975

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Hemophilia

ICD Disease Classification

3B10.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Coagulation factor VIII (F8)	DTT	F8	1.08E-22	0.89	1.82

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607).