Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMHCWY8)

Drug Name

8-methoxy-2-oxo-2H-chromene-3-carboxylic acid Drug Info

Synonyms

8-Methoxy-2-oxo-2H-chromene-3-carboxylic acid; 2555-20-6; 8-methoxy-2-oxochromene-3-carboxylic acid; 8-methoxycoumarin-3-carboxylic acid; CHEMBL568348; SFAPWVZFUHJZIC-UHFFFAOYSA-N; 2H-1-Benzopyran-3-carboxylic acid, 8-methoxy-2-oxo-; NSC34647; AC1L5SHQ; AC1Q5T4B; 3-Carboxy-8-methoxycoumarin; Oprea1_510137; Oprea1_497732; 8-methoxy-3-carboxy-coumarin; SCHEMBL980310; methoxyoxochromenecarboxylicacid; SCHEMBL3659230; ZINC84532; KS-00001VYM; CTK4F6014; DTXSID30283980; MolPort-000-145-720; ALBB-000306; NSC-34647; STK411116; BBL013903

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 234562
CAS Number: CAS 2555-20-6
TTD Drug ID: DMHCWY8

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[1]
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[1]
Carbonic anhydrase XIV (CA-XIV)	TTEYTKG	CAH14_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase XII (CA-XII)	DTT	CA12	6.015	9.06	10.222	5.773
Carbonic anhydrase I (CA-I)	DTT	CA1	5.564	11.952	6.146	7.235
Carbonic anhydrase XIV (CA-XIV)	DTT	CA14	6.263	6.538	6.531	6.293
Carbonic anhydrase IX (CA-IX)	DTT	CA9	5.04	6.156	4.609	6.756

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase XII (CA-XII)	DTT	CA12	3.29E-21	1.27	1.02
Carbonic anhydrase I (CA-I)	DTT	CA1	5.23E-14	-0.11	-0.41
Carbonic anhydrase XIV (CA-XIV)	DTT	CA14	5.79E-07	-0.09	-0.16
Carbonic anhydrase IX (CA-IX)	DTT	CA9	1.12E-10	-0.03	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44.