Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMLN280)

Drug Name

RQ-00000010 Drug Info

Synonyms

CJ-033466; PF-01354082; RQ-10; 5-HT 4 receptor partial agonist (GERD), RaQualia; 5-HT4 receptor partial agonist (gastric motility disorder), Pfizer; 5-hydroxytryptamine 4 receptor partial agonist (gastric motility disorder), Pfizer; 5-hydroxytryptamine 4 receptor partial agonist (gastroesophageal reflux), RaQualia

Indication

Disease Entry	ICD 11	Status	REF
Gastric motility disorder	DA21	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMLN280

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 4 receptor (HTR4)	TT07C3Y	5HT4R_HUMAN	Agonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 4 receptor (HTR4)	DTT	HTR4	5.776	4.945	5.062	4.828

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Gastric motility disorder

ICD Disease Classification

DA21

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 4 receptor (HTR4)	DTT	HTR4	6.16E-01	-0.03	-0.24

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 9).