Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMN5T2A)

Drug Name

Ciclopirox Drug Info

Synonyms

Ciclopiroxum; Cyclopirox; Cyclopyroxolamine; Loprox; Penlac; Stieprox; Terit; Ciclopirox Olamin; Ciclopirox gel; Loprox Gel; Loprox Shampoo; Loprox cream; Penlac nail lacquer; HOE 296b; Batrafen (TN); Ciclopirox-Olamin; Ciclopiroxum [INN-Latin]; Dafnegin-CSC; HOE-296; HOE-296b; Loprox (TN); Penlac (TN); Stieprox (TN); Ciclopirox (USP/INN); Ciclopirox [USAN:BAN:INN]; (6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone); 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone; 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone; 6-Cyclohexyl-1-hydroxy-4-methyl-2-(1H)-pyridone; 6-cyclohexyl-1-hydroxy-4-methyl-2(1 H)-pyridinone; 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one; 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one

Indication

Disease Entry	ICD 11	Status	REF
Cutaneous candidiasis	1F23.14	Approved	[1]
Fungal infection	1F29-1F2F	Approved	[2]
Mycoses	1F2Z	Approved	[1]
Onychomycosis	EE12.1	Approved	[1]
Pityriasis simplex		Approved	[1]
Tinea corporis	1F28.Y	Approved	[1]
Tinea cruris	1F28.3	Approved	[1]
Tinea versicolor	1F2D.0	Approved	[1]
Tinea pedis	1F28.2	Investigative	[1]

Therapeutic Class

Antifungal Agents

Cross-matching ID

PubChem CID: 2749
ChEBI ID: CHEBI:453011
CAS Number: CAS 29342-05-0
TTD Drug ID: DMN5T2A
VARIDT Drug ID: DR00986
ACDINA Drug ID: D00945

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HIF-prolyl hydroxylase (HPH)	TTJQFBG	NOUNIPROTAC	Modulator	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
HIF-prolyl hydroxylase (HPH)	DTT	HPH	6.61	7.198	6.148	6.784

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Cutaneous candidiasis

ICD Disease Classification

1F23.14

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
HIF-prolyl hydroxylase (HPH)	DTT	NO-GeName	7.70E-01	4.40E-03	0.02

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Ciclopirox FDA Label
2	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076435.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.