Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOUMDV)

Drug Name
Penciclovir Drug Info
Synonyms penciclovir; 39809-25-1; Denavir; Penciclovirum; Vectavir; Penciclovirum [INN-Latin]; Pencyclovir; BRL-39123; BRL 39123; Penciclovir [USAN:INN:BAN]; Penciceovir; UNII-359HUE8FJC; CCRIS 9213; PE2
Indication
Disease Entry ICD 11 Status REF
Herpes simplex labialis 1F00.01 Approved [1]
Human immunodeficiency virus infection 1C62 Approved [2]
Meniere disease AB31.0 Approved [1]
Recurrent herpes labialis 1F00.01 Approved [3]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [4]
Therapeutic Class
Antiviral Agents
Cross-matching ID
PubChem CID
135398748
ChEBI ID
CHEBI:7956
CAS Number
CAS 39809-25-1
TTD Drug ID
DMOUMDV
VARIDT Drug ID
DR01263

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30) TTIU7X1 DPOL_HHV11 Inhibitor [5]
Thymidine kinase 1 (TK1) TTP3QRF KITH_HUMAN Inhibitor [6]
COVID-19 RNA-directed RNA polymerase (RdRp) TTV1095 R1AB_SARS2 (4393-5324) Inhibitor [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Approved [7]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Thymidine kinase 1 (TK1) DTT TK1 5.524 5.296 5.963 6.272
Organic anion transporter 2 (SLC22A7) DTP OAT2 6.588 1.202 4.42 4.07
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Herpes simplex labialis
ICD Disease Classification 1F00.01
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Thymidine kinase 1 (TK1) DTT TK1 1.14E-03 0.26 0.75
Organic anion transporter 2 (SLC22A7) DTP OAT2 7.54E-01 4.87E-02 1.11E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Penciclovir FDA Label
2 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.
5 Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides. Drugs. 2009;69(2):151-66.
6 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7 In vitro studies with two human organic anion transporters: OAT2 and OAT7. Xenobiotica. 2018 Oct;48(10):1037-1049.