Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMSZ7UE)

• Drug Name: Dichloroisoproterenol Drug Info
• Synonyms: Dichloroisoproterenol; Dichlorisoproterenol; Dichloroisoprenaline; Dichlorisoprenaline [German]; 59-61-0; 3,4-Dichlor-isoproterenol [German]; 1-(3,4-Dichlorophenyl)-2-isopropylaminoethanol; BRN 2807251; CHEMBL30816; beta-Hydroxy-N-isopropyl-3,4-dichlorophenethylamine; 3,4-Dichloro-alpha-(isopropylaminomethyl)benzyl alcohol; N-(beta-(3,4-Dichlorophenyl)-beta-hydroxyethyl)isopropylamine; 3,4-Dichloro-alpha-(((1-methylethyl)amino)methyl)benzenemethanol; 1-(3,4-Dichlorophenyl)-2-(isopropylamino)ethanol; BENZYL ALCOHOL, 3,4-D

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5806
  CAS Number: CAS 59-61-0
  TTD Drug ID: DMSZ7UE

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-1 (ADRB1)	TTR6W5O	ADRB1_HUMAN	Inhibitor	[1]
Adrenergic receptor beta-2 (ADRB2)	TT2CJVK	ADRB2_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor beta-2 (ADRB2)	DTT	ADRB2	7.09	5.67	5.558	5.603

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor beta-2 (ADRB2)	DTT	ADRB2	4.88E-01	-0.05	-0.12
Adrenergic receptor beta-2 (ADRB2)	DTT	ADRB2	7.10E-01	0.06	0.09

References

• [1] The [(methyloxy)imino]methyl moiety as a bioisoster of aryl. A novel class of completely aliphatic beta-adrenergic receptor antagonists. J Med Chem. 1994 May 13;37(10):1518-25.