Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTN1P2)

Drug Name

CSL-324 Drug Info

Synonyms

Anti-GCSF human mAb (inflammation), CSL; Anti-GCSF human monoclonal antibody (inflammation), CSL; Soluble human GCSFR extracellular domain-Fc (inflammation), CSL; Soluble human GCSFR extracellular domain-Fc (arthritis), MuriGen/CSL LTd; Soluble human granulocyte-colony stimulating factor receptor extracellular domain-Fc (arthritis), MuriGen/CSL LTd; Soluble human granulocyte-colony stimulating factor receptor extracellular domain-Fc (arthritis), MuriGen/Zenyth

Indication

Disease Entry	ICD 11	Status	REF
Inflammation	1A00-CA43.1	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMTN1P2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Granulocyte colony-stimulating factor receptor (G-CSF-R)	TTC70AJ	CSF3R_HUMAN	Not Available	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Granulocyte colony-stimulating factor receptor (G-CSF-R)	DTT	CSF3R	4.087	3.406	3.17	3.322

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Inflammation

ICD Disease Classification

1A00-CA43.1

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Granulocyte colony-stimulating factor receptor (G-CSF-R)	DTT	CSF3R	2.08E-08	0.36	0.96

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719).