Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTY43L)

Drug Name

Nortropinyl-arylsulfonylurea 3 Drug Info

Synonyms

CHEMBL333727; BDBM50134335; Benzeneacetic acid (1alpha,5alpha)-8-[3-(4-chlorophenylsulfonyl)ureido]-8-azabicyclo[3.2.1]octane-3beta-yl ester; 8-[N-(4-chlorophenylsulfonamido)-carbonyl amino]-8-azabicyclo[3.2.1]oct-3-yl 2-phenylacetate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10367758
TTD Drug ID: DMTY43L

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steryl-sulfatase (STS)	TTHM0R1	STS_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steryl-sulfatase (STS)	DTT	STS	4.722	6.048	5.125	4.768

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steryl-sulfatase (STS)	DTT	STS	1.80E-38	-0.79	-1.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Nortropinyl-arylsulfonylureas as novel, reversible inhibitors of human steroid sulfatase. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3673-7.