Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMU3IET)

• Drug Name: Thiethylperazine Drug Info
• Synonyms: ETHYLTHIOPERAZINE; Theithylperazine; Thiethylperazinum; Thiethylpipezazine; Thioethylperazine; Tietilperazina; Torecan; Tietilperazina [DCIT]; Thiethylperazinum [INN-Latin]; Torecan (TN); Thiethylperazine (USAN/INN); Thiethylperazine [USAN:INN:BAN]; Norzine (*Dimaleate*); GS-95 (*Dimaleate*)

Indication

Disease Entry	ICD 11	Status	REF
Nausea	MD90	Approved	[1]
Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[2]

• Therapeutic Class: Antiemetics
• Cross-matching ID:
  PubChem CID: 5440
  ChEBI ID: CHEBI:9544
  CAS Number: CAS 1420-55-9
  TTD Drug ID: DMU3IET

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Antagonist	[3]
HUMAN clathrin-mediated endocytosis (RME)	TTAIY2U	.	Inhibitor	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine D2 receptor (D2R)	DTT	DRD2	5.345	5.634	5.789	5.901

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Nausea
• ICD Disease Classification: MD90

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine D2 receptor (D2R)	DTT	DRD2	2.50E-02	-0.08	-0.49

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7306).
• [2] Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93.
• [3] Antiemetic specificity of dopamine antagonists. Psychopharmacology (Berl). 1982;78(3):210-3.