Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUMJ7B)

Drug Name

Poly-ICR Drug Info

Synonyms

Poly-ICR (topical, keratosis/genital warts); Poly-ICR (topical, keratosis/genital warts), Akela; Poly-ICR (topical, keratosis/genital warts), Nventa; TLR-3 agonist (topical, acitinic keratosis/genital warts), Nventa; Poly IC-poly-arginine (topical, keratosis/genital warts), Nventa

Indication

Disease Entry	ICD 11	Status	REF
Keratosis	ED56	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMUMJ7B

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Toll-like receptor 3 (TLR3)	TTD24Y0	TLR3_HUMAN	Agonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Toll-like receptor 3 (TLR3)	DTT	TLR3	4.256	5.833	5.916	6.583

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Keratosis

ICD Disease Classification

ED56

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Toll-like receptor 3 (TLR3)	DTT	TLR3	4.85E-01	0.63	0.83
Toll-like receptor 3 (TLR3)	DTT	TLR3	8.00E-01	0.11	0.1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1753).