Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMW8AOM)

Drug Name

5-Indan-(1E)-ylidenemethyl-1H-imidazole Drug Info

Synonyms

Imidazolylmethyleneindane 2a; AC1O70GB; SCHEMBL4235335; BDBM8873; CHEMBL177468; SCHEMBL13877092; 5-[(E)-2,3-dihydroinden-1-ylidenemethyl]-1H-imidazole; 5-[(E)-2,3-Dihydro-1H-inden-1-ylidenemethyl]-1H-imidazole

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6540032
TTD Drug ID: DMW8AOM

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aromatase (CYP19A1)	TTSZLWK	CP19A_HUMAN	Inhibitor	[1]
Steroid 11-beta-hydroxylase (CYP11B1)	TTIQUX7	C11B1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	5.647	4.954	5.678	6.194

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	4.31E-04	-0.03	-0.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 24;48(6):1796-805.