Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMX0G4F)

Drug Name
PHENETHYLAMINE Drug Info
Synonyms
Phenethylamine; 2-phenylethylamine; 2-Phenylethanamine; 64-04-0; Benzeneethanamine; phenylethylamine; 2-Phenethylamine; beta-phenylethylamine; beta-Phenethylamine; 1-Amino-2-phenylethane; beta-Aminoethylbenzene; (2-Aminoethyl)benzene; 2-Amino-1-phenylethane; 1-Phenyl-2-aminoethane; Ethylamine, 2-phenyl-; Ethanamine, 2-phenyl-; 2-Phenylethan-1-Amine; 1-Phenyl-2-amino-athan; 2-Fenylethylamin; 2-Amino-fenylethan; 2-Fenylethylamin [Czech]; PHENETHYLAMINE, BETA; 2-Amino-fenylethan [Czech]; beta-Phenylaethylamin [German]
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1001
ChEBI ID
CHEBI:18397
CAS Number
CAS 64-04-0
TTD Drug ID
DMX0G4F
INTEDE Drug ID
DR1960

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 2A receptor (HTR2A) TTJQOD7 5HT2A_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Monoamine oxidase type A (MAO-A) DERE4TU AOFA_HUMAN Investigative [3]
Copper amine oxidase (AOC3) DE6SOC5 AOC3_HUMAN Investigative [4]
Semicarbazide-sensitive amine oxidase (AOC2) DE8DP90 AOC2_HUMAN Investigative [4]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 2A receptor (HTR2A) DTT HTR2A 4.84 4.904 4.652 4.129
Monoamine oxidase type A (MAO-A) DME MAOA 7.207 8.159 9.043 7.711
Semicarbazide-sensitive amine oxidase (AOC2) DME AOC2 6.219 5.075 5.612 5.744
Copper amine oxidase (AOC3) DME AOC3 7.055 8.263 6.709 7.374
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 2A receptor (HTR2A) DTT HTR2A 1.68E-01 -0.3 -0.14
5-HT 2A receptor (HTR2A) DTT HTR2A 5.59E-01 0.15 0.21
Monoamine oxidase type A (MAO-A) DME MAOA 8.83E-02 -1.87E-01 -2.55E-01
Monoamine oxidase type A (MAO-A) DME MAOA 9.94E-01 6.93E-02 2.31E-01
Semicarbazide-sensitive amine oxidase (AOC2) DME AOC2 3.62E-01 8.79E-02 2.56E-01
Semicarbazide-sensitive amine oxidase (AOC2) DME AOC2 6.09E-01 2.73E-02 1.40E-01
Copper amine oxidase (AOC3) DME AOC3 3.34E-01 -1.10E-01 -3.27E-01
Copper amine oxidase (AOC3) DME AOC3 3.77E-01 -3.35E-02 -2.16E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2144).
2 Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin rec... Bioorg Med Chem Lett. 2001 Feb 26;11(4):563-6.
3 Do monomeric vs dimeric forms of MAO-A make a difference? A direct comparison of the catalytic properties of rat and human MAO-A's. J Neural Transm (Vienna). 2007;114(6):721-4.
4 The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase. Cell Mol Life Sci. 2009 Aug;66(16):2743-57.