Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM02Q8N)

• Drug Name: 4-Benzo[b]thiophen-4-yl-1H-imidazole Drug Info
• Synonyms: CHEMBL30534; 4-Benzo[b]thiophen-4-yl-1H-imidazole; 1H-Imidazole, 5-benzo[b]thien-4-yl-; SCHEMBL1502418; BDBM50085681; 4-(1H-Imidazole-4-yl)benzo[b]thiophene

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 10176567
  TTD Drug ID: DM02Q8N

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor alpha-2A (ADRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lofexidine	DM1WXA6	Heroin and opiate withdrawal	6C43	Approved	[3]
MOXONIDINE	DMGFB0E	Alcohol dependence	6C40.2	Approved	[4]
Connexyn	DMF29Q5	Attention deficit hyperactivity disorder	6A05.Z	Approved	[5]
Guanfacine	DMPN5IH	Attention deficit hyperactivity disorder	6A05.Z	Phase 4	[6]
A295	DM55GO2	Aggressive cancer	2A00-2F9Z	IND submitted	[7]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[8]
DSP-1200	DM4WSHG	Depression	6A70-6A7Z	Phase 1	[9]
MAZAPERTINE	DMRHYAU	N. A.	N. A.	Discontinued in Phase 2	[10]
NMI-870	DMU596F	Sexual dysfunction	HA00-HA01	Discontinued in Phase 2	[11]
SNAP-5089	DMROJEN	Heart arrhythmia	BC65	Terminated	[12]

Drug(s) Targeting Adrenergic receptor alpha-1B (ADRA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methamphetamine	DMPM4SK	Anxiety		Approved	[13]
Propericiazine	DME9JNL	Psychiatric disorder	6E8Z	Approved	[14]
Methoxamine	DMF5XQH	Hypertension	BA00-BA04	Approved	[15]
Phendimetrazine	DM6TS1N	Obesity	5B81	Approved	[16]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[8]
TIOSPIRONE	DME5QDP	N. A.	N. A.	Discontinued in Phase 3	[17]
Sunepitron	DM6M8ZX	N. A.	N. A.	Discontinued in Phase 3	[18]
MAZAPERTINE	DMRHYAU	N. A.	N. A.	Discontinued in Phase 2	[10]
SOU-001	DMPAEK5	Urinary incontinence	MF50.2	Discontinued in Phase 2	[19]
SNAP-5089	DMROJEN	Heart arrhythmia	BC65	Terminated	[20]

Drug(s) Targeting Adrenergic receptor alpha-2B (ADRA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MOXONIDINE	DMGFB0E	Alcohol dependence	6C40.2	Approved	[4]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[8]
AGN-199981	DMP5Y1A	Neuropathic pain	8E43.0	Phase 2	[21]
INDORAMIN	DMNSJFD	Hypertension	BA00-BA04	Withdrawn from market	[22]
MAZAPERTINE	DMRHYAU	N. A.	N. A.	Discontinued in Phase 2	[10]
SNAP-5089	DMROJEN	Heart arrhythmia	BC65	Terminated	[12]
A-80426	DMBC3DG	N. A.	N. A.	Terminated	[23]
WB-4101	DMQU8B1	N. A.	N. A.	Terminated	[24]
SK&F-104078	DMRADBU	N. A.	N. A.	Terminated	[22]
(+/-)-nantenine	DM0L3GE	Discovery agent	N.A.	Investigative	[25]

Drug(s) Targeting Adrenergic receptor alpha-1D (ADRA1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxazosin	DM9PLRH	Benign prostatic hyperplasia	GA90	Approved	[26]
Armodafinil	DMGB035	Malignant glioma	2A00.0	Approved	[27]
Alfuzosin	DMZVMKF	Benign prostatic hyperplasia	GA90	Approved	[28]
Moxisylyte	DMFCLYW	Erectile dysfunction	HA01.1	Approved	[29]
Terazosin	DM3JCVS	Benign prostatic hyperplasia	GA90	Approved	[30]
Bunazosin	DM4I8O7	Glaucoma/ocular hypertension	9C61	Approved	[31]
Trimazosin	DM1QLST	Congestive heart failure	BD10	Approved	[32]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[8]
DL-017	DMM8GZT	Hypertension	BA00-BA04	Phase 1	[33]
PMID30124346-Compound-LDT8	DM5MUNG	Benign prostatic hyperplasia	GA90	Patented	[34]

Drug(s) Targeting Adrenergic receptor alpha-1A (ADRA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SILODOSIN	DMJSBT6	Benign prostatic hyperplasia	GA90	Approved	[35]
NAFTOPIDIL	DMQ8R4E	Hypertension	BA00-BA04	Approved	[35]
Tamsulosin	DM5QF9V	Benign prostatic hyperplasia	GA90	Approved	[36]
Xatral	DMLHOA0	Benign prostatic hyperplasia	GA90	Approved	[37]
Dutasteride + tamsulosin	DM6P8HU	Benign prostatic hyperplasia	GA90	Phase 3	[38]
Besipirdine	DMLVNTA	Cognitive impairment	6D71	Phase 3	[39]
MEDETOMIDINE	DMX9Y7V	Pain	MG30-MG3Z	Phase 2	[8]
PMID30124346-Compound-LDT8	DM5MUNG	Benign prostatic hyperplasia	GA90	Patented	[34]
PMID30124346-Compound-LDT66	DMJMTNL	Benign prostatic hyperplasia	GA90	Patented	[34]
TIOSPIRONE	DME5QDP	N. A.	N. A.	Discontinued in Phase 3	[17]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1B (ADRA1B)	TTBRKXS	ADA1B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2A (ADRA2A)	TTWG9A4	ADA2A_HUMAN	Inhibitor	[2]
Adrenergic receptor alpha-2B (ADRA2B)	TTWM4TY	ADA2B_HUMAN	Inhibitor	[1]

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