Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM145QS)

Drug Name

1-(4-hydroxyphenyl)prop-2-en-1-one Drug Info

Synonyms

1-(4-hydroxyphenyl)prop-2-en-1-one; 4-acryloylphenol; CHEMBL378577; 95605-38-2; 4-hydroxyphenyl Vinyl Ketone; SCHEMBL2394894; GTPL8841; MolPort-007-991-476; NKPPNPJUBLEKAD-UHFFFAOYSA-N; ZINC28567957; BDBM50177407; AKOS005200150; FCH1599833; 1-(4-Hydroxyphenyl)-2-propene-1-one; EN300-246996

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 16036927
TTD Drug ID: DM145QS

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Patented Agent(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Succinate-semialdehyde dehydrogenase (ALDH5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlormerodrin	DMSF4PR	Diagnostic imaging	N.A.	Approved	[2]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[3]
T83193	DMHO29Y	Discovery agent	N.A.	Patented	[1]
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Drug(s) Targeting GABA transaminase (ABAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Alanine	DMZDN4W	Dietary shortage	5B5K	Approved	[4]
Pyridoxal Phosphate	DMO2K0J	Malnutrition	5B50-5B71	Approved	[4]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[4]
Vigabatrin	DMYT0OG	Alcohol dependence	6C40.2	Approved	[5]
Divalproex sodium	DM4RK0G	Seizure disorder	8A6Z	Approved	[4]
CPP-115	DMK9NQI	Tourette syndrome	8A05.00	Phase 2	[6]
K-828-AB	DMJLNZQ	Dementia	6D80-6D86	Phase 2	[7]
CPP -15	DMQCHU3	Infantile spasm	8A62.0	Phase 1	[6]
T83193	DMHO29Y	Discovery agent	N.A.	Patented	[1]
4-hydroxybenzaldehyde	DM471P5	Discovery agent	N.A.	Patented	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA transaminase (ABAT)	TTT2LD9	GABT_HUMAN	Inhibitor	[1]
Succinate-semialdehyde dehydrogenase (ALDH5A1)	TTJUWVB	SSDH_HUMAN	Inhibitor	[1]

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References

1	Inhibition of GABA shunt enzymes' activity by 4-hydroxybenzaldehyde derivatives. Bioorg Med Chem Lett. 2006 Feb;16(3):592-5.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68.
4	DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
5	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
6	Clinical pipeline report, company report or official report of Catalyst Pharma.
7	Phase II clinical trial of K-828-AB for treating behavioral and psychological symptoms of dementia. Kowa Co. Ltd.
8	Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one. Bioorg Med Chem Lett. 2009 Feb 1;19(3):731-4.