Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1AQLW)

Drug Name

Otilimab Drug Info

Synonyms

Otilimab [USAN]; UNII-Y8127R3VCH; Y8127R3VCH; MOR103; GSK3196165; 1638332-55-4; human monoclonal antibody

Indication

Therapeutic Class

Antiviral Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

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Drug(s) Targeting HUMAN colony-stimulating factor (GM-CSF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lenzilumab	DMSRIT4	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3 Trial	[3]
TJ003234	DM0VXIM	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 1/2 Trial	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HUMAN colony-stimulating factor (GM-CSF)	TTPZGYX	CSF2_HUMAN	Inhibitor	[3]

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References

1	ClinicalTrials.gov (NCT04333147) Long-term Safety and Efficacy of GSK3196165 (Otilimab) in the Treatment of Rheumatoid Arthritis (RA). U.S. National Institutes of Health.
2	ClinicalTrials.gov (NCT04376684) Investigating Otilimab in Patients With Severe Pulmonary COVID-19 Related Disease. U.S. National Institutes of Health.
3	The anti-viral facet of anti-rheumatic drugs: Lessons from COVID-19. J Autoimmun. 2020 Apr 17:102468.