Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1C4UM)

Drug Name

LAMB3-transduced autologous epidermal stem cells Drug Info

Synonyms

LAMB3-transduced autologous epidermal stem cells (retroviral vector, junctionalepidermolysis bullosa), University of Modena and Reggio Emilia/Holostem; LAMB3-transduced autologous epidermal stem cells (ZFN-mediated transduction, epidermolysis bullosa), University of Modena and Reggio Amilia/San Raffaele-Telethon Institute for Gene Therapy/Sangamo

Indication

Disease Entry	ICD 11	Status	REF
Epidermolysis bullosa	EC3Z	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DM1C4UM

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Laminin beta-3 chain (LAMB3)	TT2WOUQ	LAMB3_HUMAN	Modulator	[2]

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References

1	Long-Term Stability and Safety of Transgenic Cultured Epidermal Stem Cells in Gene Therapy of Junctional Epidermolysis Bullosa. Stem Cell Reports. 2014 January 14; 2(1): 1-8.
2	Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nat Med. 2006 Dec;12(12):1397-402.