Details of the Drug

General Information of Drug (ID: DM1C4UM)

Drug Name
LAMB3-transduced autologous epidermal stem cells
Synonyms
LAMB3-transduced autologous epidermal stem cells (retroviral vector, junctionalepidermolysis bullosa), University of Modena and Reggio Emilia/Holostem; LAMB3-transduced autologous epidermal stem cells (ZFN-mediated transduction, epidermolysis bullosa), University of Modena and Reggio Amilia/San Raffaele-Telethon Institute for Gene Therapy/Sangamo
Indication
Disease Entry ICD 11 Status REF
Epidermolysis bullosa EC3Z Phase 1 [1]
Cross-matching ID
TTD ID
D09PFR

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Laminin beta-3 chain (LAMB3) TT2WOUQ LAMB3_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Long-Term Stability and Safety of Transgenic Cultured Epidermal Stem Cells in Gene Therapy of Junctional Epidermolysis Bullosa. Stem Cell Reports. 2014 January 14; 2(1): 1-8.
2 Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nat Med. 2006 Dec;12(12):1397-402.