Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1C90Y)

Drug Name
(3-Phenyl-propyl)-quinazolin-4-yl-amine Drug Info
Synonyms CHEMBL42565; N-(3-phenylpropyl)quinazolin-4-amine; (3-Phenyl-propyl)-quinazolin-4-yl-amine; MolPort-011-928-362; BDBM50282106; ZINC13476428; AKOS009045718; MCULE-1024483265; Z127145812
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44288306
TTD Drug ID
DM1C90Y

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Fungal Scytalone dehydratase (Fung SDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isoquinolin-1-yl-(3-phenyl-propyl)-amine DMDF26N Discovery agent N.A. Investigative [1]
Carpropamid DMBKQ03 Discovery agent N.A. Investigative [2]
2-Hydroxy-N-(3-phenyl-propyl)-benzamide DMWSR13 Discovery agent N.A. Investigative [1]
5-Fluoro-2-hydroxy-N-isopropyl-benzamide DMOI7ME Discovery agent N.A. Investigative [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fungal Scytalone dehydratase (Fung SDH1) TT64EPS SCYD_MAGO7 Inhibitor [1]

References

1 A diazine heterocycle replaces a six-membered hydrogen-bonded array in the active site of scytalone dehydratase, Bioorg. Med. Chem. Lett. 3(8):1605-1608 (1993).
2 Enzymatic characterization of scytalone dehydratase Val75Met variant found in melanin biosynthesis dehydratase inhibitor (MBI-D) resistant strains of the rice blast fungus. Biosci Biotechnol Biochem.2004 Mar;68(3):615-21.
3 Binding dynamics of two water molecules constrained within the scytalone dehydratase binding pocket. Bioorg Med Chem Lett. 2000 Jan 3;10(1):23-6.