Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1C9NQ)

Drug Name

SCY-635 Drug Info

Synonyms

SCY-635; CHEMBL1269597; UNII-WSU5343074; WSU5343074; SCY 635; CID6479267; AC1O57KA; 210759-10-7; BDBM50136473; DB12451; (3S,6S,9S,12R,15S,18S,21S,24S,27R,30S,33S)-27-(2-dimethylaminoethylsulfanyl)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-24-(2-hydroxy-2-methylpropyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18-tris(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Phase 2	[1]

Cross-matching ID

PubChem CID: 6479267
CAS Number: CAS 210759-10-7
TTD Drug ID: DM1C9NQ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Preclinical Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Calcium signal-modulating cyclophilin ligand (CAML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alisporivir	DM83EBP	Duchenne dystrophy	8C70	Phase 3	[2]
SCY-641	DMELFBU	Ocular inflammation	9C61.24	Preclinical	[3]
D-43787	DM0YFZ6	Allergy	4A80-4A85	Terminated	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium signal-modulating cyclophilin ligand (CAML)	TTATDGJ	CAMLG_HUMAN	Modulator	[1]

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References

1	SCY-635, a novel nonimmunosuppressive analog of cyclosporine that exhibits potent inhibition of hepatitis C virus RNA replication in vitro. Antimicrob Agents Chemother. 2010 Feb;54(2):660-72.
2	DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. PLoS One. 2010 Oct 27;5(10):e13687.
3	2011 Pipeline of SCYNEXIS.
4	Anti-inflammatory effects of a cyclosporine receptor-binding compound, D-43787. J Pharmacol Exp Ther. 2002 May;301(2):738-46.