Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1VE6S)

Drug Name

Acetyl-Ile-Glu-Thr-Asp-aldehyde Drug Info

Synonyms

Ac-IETD-CHO; 191338-86-0; CHEMBL478695; Ac-Ile-Glu-Thr-Asp-CHO; SCHEMBL20257131; N-acetyl-Ile-Glu-Thr-Asp-aldehyde; ZINC14947181; BDBM50340547; Acetyl-isoleucyl-glutamyl-threonyl-aspartal; 338A860; N-Acetyl-Ile-Glu-Thr-Asp-al, ~99% (TLC), powder; (4S)-4-{[(1S,2R)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}-2-hydroxypropyl]carbamoyl}-4-[(2S,3S)-2-acetamido-3-methylpentanamido]butanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11466200
TTD Drug ID: DM1VE6S

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glionitrin A	DM98CSW	Solid tumour/cancer	2A00-2F9Z	Investigative	[3]
Amooranin	DMC15DM	Autoimmune diabetes	5A10	Investigative	[3]
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Drug(s) Targeting Caspase 8 messenger RNA (CASP8 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoquinoline-1,3,4(2H)-trione	DMT4RI2	Discovery agent	N.A.	Investigative	[4]
ISIS 107612	DMBWCZR	Discovery agent	N.A.	Investigative	[5]
ISIS 107676	DMUE64H	Discovery agent	N.A.	Investigative	[5]
ISIS 107681	DMB9VFS	Discovery agent	N.A.	Investigative	[5]
ISIS 107652	DMOX8JF	Discovery agent	N.A.	Investigative	[5]
ISIS 107642	DMPR7OD	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Caspase 8 messenger RNA (CASP8 mRNA)	TT6SZNG	CASP8_HUMAN	Inhibitor	[2]
Caspase-8 (CASP8)	TTEVCT0	CASP8_HUMAN	Inhibitor	[1]

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References

1	The atomic-resolution structure of human caspase-8, a key activator of apoptosis. Structure. 1999 Sep 15;7(9):1135-43.
2	Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem. 2009 Apr 23;52(8):2188-91.
3	Glionitrin A, a new diketopiperazine disulfide, activates ATM-ATR-Chk1/2 via 53BP1 phosphorylation in DU145 cells and shows antitumor effect in xenograft model. Biol Pharm Bull. 2014;37(3):378-86.
4	Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. J Med Chem. 2006 Mar 9;49(5):1613-23.
5	US patent application no. 6,258,600, Antisense modulation of caspase 8 expression.