Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1XBWR)

Drug Name

N-Acetyl-D-glucosamine Drug Info

Synonyms

Aflexa; GlcNAc; NAcGlc; NDG; Crab Shell Chitin; Glucosamine Complex; Maxi GS; Natures Blend Glucosamine; Pharmaceutical aid; JFD00446; SB01966; GS-500; N-Acetylchitosamine; N-Acetylchondrosamine; N-Acetylgalactosamine; N-Acetylhexosamine; Glucosamine, N-acetyl; N-Acetyl-D-Allosamine; N-Acetyl-D-galactosamine; N-Acetyl-D-hexosamine; N-acetyl-D-mannosamine; N-Acetyl-D-glucosamine-Agarose; N-Acetyl-alpha-D-glucosamine; N-acetyl-alpha-D-glucosaminides; N-[2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide; N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide; N-[(2R,3R,4S,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide; N-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide; 2-(Acetylamino)-2-deoxyhexopyranose; 2-ACETAMIDO-2-DEOXY-D-ALLOSE; 2-Acetamido-2-deoxy-D-glucose; 2-Acetamido-2-deoxyglucose; 2-Acetamido-D-glucose; 2-acetamido-2-deoxy-D-glucopyranose; 2-acetamido-2-deoxyhexopyranose; 6-Acetamido-6-deoxy-.alpha.-D-glucopyranose; 6-Acetamido-6-deoxy-acpha-D-glucopyranose

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune diabetes	5A10	Approved	[1]

Therapeutic Class

Antiinflammatory Agents

Cross-matching ID

PubChem CID: 439174
ChEBI ID: CHEBI:506227
CAS Number: CAS 72-87-7
TTD Drug ID: DM1XBWR
INTEDE Drug ID: DR1930

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Alpha-N-acetylglucosaminidase (NAGLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABO-101	DMUBLC3	Mucopolysaccharidosis	5C56.3	Phase 1/2	[4]
BMN 250	DMM25B1	Mucopolysaccharidosis type IIIB	5C56.3Y	Phase 1/2	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Alpha-N-acetylglucosaminidase (NAGLU)	TTDM6HZ	ANAG_HUMAN	Activator	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
N-acetyl-D-glucosamine 2-epimerase (AGE)^{Main DME}	DEROYHE	RENBP_HUMAN	Substrate	[3]

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References

1	Drug information of N-Acetyl-D-glucosamine, 2008. eduDrugs.
2	Development of bFGF-Chitosan Matrices and Their Interactions with Human Dermal Fibroblast Cells. J Biomater Sci Polym Ed. 2009;20(10):1335-51.
3	Production of N-acetyl-d-neuraminic acid by whole cells expressing Bacteroides thetaiotaomicron N-acetyl-d-glucosamine 2-epimerase and Escherichia coli N-acetyl-d-neuraminic acid aldolase. J Agric Food Chem. 2019 Jun 5;67(22):6285-6291.
4	Clinical pipeline report, company report or official report of Abeona Therapeutics.
5	Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B. Drug Deliv Transl Res. 2020 Apr;10(2):425-439.